Numerical investigation of quantitative pulmonary pressure ratio in different degrees of stenosis

Fan He; Minru Li; Xinyu Wang; Lu Hua; Tingting Guo; Fan He; Minru Li; Xinyu Wang; Lu Hua; Tingting Guo

doi:10.3934/mbe.2024078

Mathematical Biosciences and Engineering

2024, Volume 21, Issue 2: 1806-1818. doi: 10.3934/mbe.2024078

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Research article

Numerical investigation of quantitative pulmonary pressure ratio in different degrees of stenosis

1.
School of Science, Beijing University of Civil Engineering and Architecture, Beijing 100044, China
2.
Thrombosis Center, National Clinical Research Center for Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China

Academic Editor: Hermann J. Eberl

Received: 12 October 2023 Revised: 26 November 2023 Accepted: 30 November 2023 Published: 03 January 2024

Background
Pulmonary artery stenosis endangers people's health. Quantitative pulmonary pressure ratio (QPPR) is very important for clinicians to quickly diagnose diseases and develop treatment plans.
Objective
Our purpose of this paper is to investigate the effects of different degrees (50% and 80%) of pulmonary artery stenosis on QPPR.
Methods
An idealized model is established based on the normal size of human pulmonary artery. The hemodynamic governing equations are solved using fluid-structure interaction.
Results
The results show that the QPPR decreases with the increase of stenosis degree, and it is closely related to the pressure drop at both ends of stenosis. Blood flow velocity and wall shear stress are sensitive to the stenosis degree. When the degree of stenosis is 80%, the amplitude of changes of blood flow velocity and wall shear stress at both ends of stenosis is lower.
Conclusions
The results suggest that the degree of pulmonary artery stenosis has a significant impact on QPPR and hemodynamic changes. This study lays a theoretical foundation for further study of QPPR.
- stenosis,
- pulmonary artery,
- hemodynamics,
- numerical simulation,
- fluid-structure interaction
Citation: Fan He, Minru Li, Xinyu Wang, Lu Hua, Tingting Guo. Numerical investigation of quantitative pulmonary pressure ratio in different degrees of stenosis[J]. Mathematical Biosciences and Engineering, 2024, 21(2): 1806-1818. doi: 10.3934/mbe.2024078

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Abstract

Background

Pulmonary artery stenosis endangers people's health. Quantitative pulmonary pressure ratio (QPPR) is very important for clinicians to quickly diagnose diseases and develop treatment plans.

Objective

Our purpose of this paper is to investigate the effects of different degrees (50% and 80%) of pulmonary artery stenosis on QPPR.

Methods

An idealized model is established based on the normal size of human pulmonary artery. The hemodynamic governing equations are solved using fluid-structure interaction.

Results

The results show that the QPPR decreases with the increase of stenosis degree, and it is closely related to the pressure drop at both ends of stenosis. Blood flow velocity and wall shear stress are sensitive to the stenosis degree. When the degree of stenosis is 80%, the amplitude of changes of blood flow velocity and wall shear stress at both ends of stenosis is lower.

Conclusions

The results suggest that the degree of pulmonary artery stenosis has a significant impact on QPPR and hemodynamic changes. This study lays a theoretical foundation for further study of QPPR.

References

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