MBE focuses on new developments in the fast-growing fields of mathematical biosciences and engineering. Areas covered include most areas of mathematical and computational biology, medicine and engineering with an emphasis on integrative and interdisciplinary research bridging mathematics, biology and engineering.

General topics appropriate for MBE include, but are not limited to, all areas of mathematical and computational biology and medicine, computational neuroscience, cancer biology and medicine, Bioinformatics, systems biology, genetics and genomics, ecology, population dynamics, computational pharmacology, physiology, immunology, molecular and structural biology, cell and developmental biology, epidemiology, biomedical signal processing and data analysis, Bioengineering, Biophysics, models based on differential equations, nonlinear dynamics, stochastic processes, as well as computational approaches that aim to understand complex living systems, and engineering problems, and modeling and designing of biologically inspired engineering systems, computational intelligence and complexity.

To be considered by MBE, a paper (except for invited expository papers) should be in one (or a combination) of the three categories. (a) papers developing and (mathematically) analyzing mathematical models that have concrete applications in biomedical sciences and engineering; (b) papers devoted to mathematical theory and methods, with a clear scientific and engineering motivation, whose results must lead to an improved understanding of the underlying problem; and (c) papers using numerical simulations, experiments, or both to reveal or explain some new scientific and engineering phenomena, where mathematical analysis plays a major role in the analysis and process.