Integrating gene selection and deep learning for enhanced Autisms' disease prediction: a comparative study using microarray data

Mahmoud M. Abdelwahab; Khamis A. Al-Karawi; H. E. Semary; Mahmoud M. Abdelwahab; Khamis A. Al-Karawi; H. E. Semary

doi:10.3934/math.2024867

AIMS Mathematics

2024, Volume 9, Issue 7: 17827-17846. doi: 10.3934/math.2024867

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Research article Special Issues

Integrating gene selection and deep learning for enhanced Autisms' disease prediction: a comparative study using microarray data

1.
Department of Mathematics and Statistics, College of Science, Imam Mohammad Ibn Saud Islamic University, Saudi Arabia
2.
Department of Basic Sciences Higher Institute of Administrative Sciences, Osim, Egypt
3.
School of Science, Engineering, and Environment, Salford University, Great Manchester, UK
4.
Diyala University, Baqubah, Diyala, Iraq
5.
Department of Statistics and Insurance, Faculty of Commerce, Zagazig University, Egypt

Received: 09 February 2024 Revised: 10 May 2024 Accepted: 20 May 2024 Published: 24 May 2024
MSC : 00A05, 00A71, 97K80, 65C60, 92D10

In this article, Autism Spectrum Disorder (ASD) is discussed, with an emphasis placed on the multidimensional nature of the disorder, which is anchored in genetic and neurological components. Identifying genes related to ASD is essential to comprehend the mechanisms that underlie the illness, yet the condition's complexity has impeded precise information in this field. In ASD research, the analysis of gene expression data helps choose and categorize significant genes. The study used microarray data to provide a novel approach that integrated gene selection techniques with deep learning models to improve the accuracy of ASD prediction. It offered a detailed comparative examination of gene selection approaches and deep learning architectures, including singular value decompositions (SVD), principal component analyses (PCA), and convolutional neural networks (CNNs). This paper combines gene selection methods (PCA and SVD) with deep learning models (CNN) to improve ASD prediction. Compared to more traditional approaches, the study revealed that its integrated methodology was more effective in improving the accuracy of ASD prediction results through experimentation. There was a difference in the accuracy between the PCA-CNN model, which achieved 94.33% with a loss of 0.4312, and the SVD-CNN model, which achieved 92.21% with a loss less than or equal to 0.3354. These discoveries help in the development of more accurate diagnostic and prognostic tools for ASD, which is a complicated neurodevelopmental disorder. Additionally, they provide insights into the molecular pathways that underlie ASD.

Keywords:

Citation: Mahmoud M. Abdelwahab, Khamis A. Al-Karawi, H. E. Semary. Integrating gene selection and deep learning for enhanced Autisms' disease prediction: a comparative study using microarray data[J]. AIMS Mathematics, 2024, 9(7): 17827-17846. doi: 10.3934/math.2024867

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Abstract

1. Introduction

For a convex function $\sigma:\mathrm{I}\subseteq \bf{R}\to \bf{R}$ on $\mathrm{I}$ with $\nu_{1}, \nu_{2}\in \mathrm{I}$ and $\nu_{1} < \nu_{2}$ , the Hermite-Hadamard inequality is defined by ^[1]:

$\begin{equation} \sigma\left(\frac{\nu_{1}+\nu_{2}}{2}\right) \leq \frac{1}{\nu_{2}-\nu_{1}}\int_{\nu_{1}}^{\nu_{2}}\sigma(\eta)d\eta \leq \frac{\sigma(\nu_{1})+\sigma(\nu_{2})}{2}. \end{equation}$

(1.1)

The Hermite-Hadamard integral inequality (1.1) is one of the most famous and commonly used inequalities. The recently published papers ^[2,3,4] are focused on extending and generalizing the convexity and Hermite-Hadamard inequality.

The situation of the fractional calculus (integrals and derivatives) has won vast popularity and significance throughout the previous five decades or so, due generally to its demonstrated applications in numerous seemingly numerous and great fields of science and engineering ^[5,6,7].

Now, we recall the definitions of Riemann-Liouville fractional integrals.

Definition 1.1 (^[5,6,7]). Let $\sigma\in L_{1}[\nu_{1}, \nu_{2}].$ The Riemann-Liouville integrals $J_{\nu_{1}+}^{\vartheta }\sigma$ and $J_{\nu_{2}-}^{\vartheta }\sigma$ of order $\vartheta > 0$ with $\nu_{1}\geq 0$ are defined by

$\begin{equation} J_{\nu_{1}+}^{\vartheta }\sigma(x) = \frac{1}{\Gamma (\vartheta )}\int_{\nu_{1}}^{x}(x-\eta)^{\vartheta -1}\sigma(\eta)d\eta,\; \ \ \ \nu_{1} < x \end{equation}$

(1.2)

and

$\begin{equation} J_{\nu_{2}-}^{\vartheta }\sigma(x) = \frac{1}{\Gamma (\vartheta )}\int_{x}^{\nu_{2}}(\eta-x)^{\vartheta -1}\sigma(\eta)d\eta,\; \ \ x < \nu_{2}, \end{equation}$

(1.3)

respectively. Here $\Gamma (\vartheta)$ is the well-known Gamma function and $J_{\nu_{1}+}^{0}\sigma(x) = J_{\nu_{2}-}^{0}\sigma(x) = \sigma(x).$

With a huge application of fractional integration and Hermite-Hadamard inequality, many researchers in the field of fractional calculus extended their research to the Hermite-Hadamard inequality, including fractional integration rather than ordinary integration; for example see ^{[8,9,10,11,12,13,14,15,16,17,18,19,20,21]}.

In this paper, we consider the integral inequality of Hermite-Hadamard-Mercer type that relies on the Hermite-Hadamard and Jensen-Mercer inequalities. For this purpose, we recall the Jensen-Mercer inequality: Let $0 < x_{1}\leq x_{2}\leq \cdots\leq x_{n}$ and $\mu = (\mu _{1}, \mu_{2}, \ldots, \mu _{n})$ nonnegative weights such that $\sum_{i = 1}^{n}\mu_{i} = 1$ . Then, the Jensen inequality ^[22,23] is as follows, for a convex function $\sigma$ on the interval $[\nu_{1}, \nu_{2}]$ , we have

$\begin{equation} \sigma\Bigg(\sum\limits_{i = 1}^{n}\mu _{i}x_{i}\Bigg)\leq \sum\limits_{i = 1}^{n}\mu _{i}\sigma(x_{i}), \end{equation}$

(1.4)

where for all $x_{i}\in \lbrack \nu_{1}, \nu_{2}]$ and $\mu_{i}\in \lbrack 0, 1]$ , $(i = \overline{1, n})$ .

Theorem 1.1 (^[2,23]). If $\sigma$ is convex function on $[\nu_{1}, \nu_{2}]$ , then

$\begin{equation} \sigma\left(\nu_{1}+\nu_{2}-\sum\limits^{n}_{i = 1}\mu_{i}x_{i}\right)\leq \sigma(\nu_{1})+\sigma(\nu_{2})-\sum\limits^{n}_{i = 1}\mu_{i}\sigma(x_{i}), \end{equation}$

(1.5)

for each $x_{i}\in[\nu_{1}, \nu_{2}]$ and $\mu_{i}\in[0, 1]$ , $(i = \overline{1, n})$ with $\sum^{n}_{i = 1}\mu_{i} = 1$ . For some results related with Jensen-Mercer inequality, see ^[24,25,26].

In view of above indices, we establish new integral inequalities of Hermite-Hadamard-Mercer type for convex functions via the Riemann-Liouville fractional integrals in the current project. Particularly, we see that our results can cover the previous researches.

2. Main results

Theorem 2.1. For a convex function $\sigma:[\nu_{1}, \nu_{2}]\subseteq \bf{R} \to\bf{R}$ with $x, y\in[\nu_{1}, \nu_{2}]$ , we have:

$\begin{multline} \sigma\left(\nu_{1}+\nu_{2}-\frac{x+y}{2}\right)\leq \frac{2^{\vartheta -1} \Gamma\left(\vartheta +1\right)}{\left( y-x\right)^{\vartheta}} \Biggl[ J_{\left(\nu_{1}+\nu_{2}-y\right)+}^{\vartheta}\sigma\left(\nu_{1}+\nu_{2}-\frac{x+y}{2}\right) \\ +\; J_{\left(\nu_{1}+\nu_{2}-x\right)-}^{\vartheta}\sigma\left(\nu_{1}+\nu_{2}-\frac{x+y}{2}\right)\Biggr] \leq \sigma\left(\nu_{1}\right)+\sigma\left(\nu_{2}\right)-\frac{\sigma\left(x\right)+\sigma\left(y\right)}{2}. \end{multline}$

(2.1)

Proof. By using the convexity of $\sigma$ , we have

$\begin{equation} \sigma\left( \nu_{1}+\nu_{2}-\frac{u+v}{2}\right) \leq \frac{1}{2}\left[ \sigma\left( \nu_{1}+\nu_{2}-u\right) +\sigma\left( \nu_{1}+\nu_{2}-v\right) \right], \end{equation}$

(2.2)

and above with $u = \frac{1-\eta}{2}x+\frac{1+\eta}{2}y$ , $v = \frac{1+\eta}{2}x+\frac{1-\eta}{2}y$ , where $x, y\in[\nu_{1}, \nu_{2}]$ and $\eta\in [0, 1]$ , leads to

$\begin{multline} \sigma\left( \nu_{1}+\nu_{2}-\frac{x+y}{2}\right)\leq\frac{1}{2} \Biggl[\sigma\left(\nu_{1}+\nu_{2}-\left(\frac{1-\eta}{2}x+\frac{1+\eta}{2}y\right)\right) \\ +\sigma\left(\nu_{1}+\nu_{2}-\left(\frac{1+\eta}{2}x+\frac{1-\eta}{2}y\right)\right)\Biggr]. \end{multline}$

(2.3)

Multiplying both sides of (2.3) by $\eta^{\vartheta -1}$ and then integrating with respect to $\eta$ over $[0, 1]$ , we get

$\begin{align*} \frac{1}{\vartheta }\sigma\left( \nu_{1}+\nu_{2}-\frac{x+y}{2}\right) &\leq \frac{1}{2}\left[\int_{0}^{1}\eta^{\vartheta-1} \sigma\left(\nu_{1}+\nu_{2}-\left(\frac{1-\eta}{2}x+\frac{1+\eta}{2}y\right)\right)d\eta\right. \\ &+\left. \int_{0}^{1}\eta^{\vartheta -1}\sigma\left( \nu_{1}+\nu_{2}-\left( \frac{1+\eta}{2}x+\frac{1-\eta}{2}y\right)\right)d\eta\right] \\ & = \frac{1}{2}\left[ \frac{2^{\vartheta }}{\left( y-x\right) ^{\vartheta }}\int_{\nu_{1}+\nu_{2}-y}^{\nu_{1}+\nu_{2}-\frac{x+y}{2}} \left( \left( \nu_{1}+\nu_{2}-\frac{x+y}{2}\right)-w\right) ^{\vartheta -1}\sigma\left( w\right) dw\right. \\ &\left. +\frac{2^{\vartheta}}{\left(y-x\right)^{\vartheta}}\int_{\nu_{1}+\nu_{2}-\frac{x+y}{2}}^{\nu_{1}+\nu_{2}-x} \left( w-\left( \nu_{1}+\nu_{2}-\frac{x+y}{2}\right) \right) ^{\vartheta-1}\sigma\left( w\right) dw\right] \\ & = \frac{2^{\vartheta-1}\Gamma \left(\vartheta\right)}{\left(y-x\right)^{\vartheta}} \left[J_{\left(\nu_{1}+\nu_{2}-y\right)+}^{\vartheta}\sigma\left(\nu_{1}+\nu_{2}-\frac{x+y}{2}\right) +\; J_{\left(\nu_{1}+\nu_{2}-x\right)-}^{\vartheta}\sigma\left( \nu_{1}+\nu_{2}-\frac{x+y}{2}\right) \right], \end{align*}$

and thus the proof of first inequality in (2.1) is completed.

On the other hand, we have by using the Jensen-Mercer inequality:

$\begin{eqnarray} \sigma\left( \nu_{1}+\nu_{2}-\left( \frac{1-\eta}{2}x+\frac{1+\eta}{2}y\right) \right) &\leq &\sigma\left( \nu_{1}\right) +\sigma\left( \nu_{2}\right) -\left( \frac{1-\eta}{2}\sigma\left( x\right) +\frac{1+\eta}{2}\sigma\left( y\right) \right) \end{eqnarray}$

(2.4)

$\begin{eqnarray} \sigma\left( \nu_{1}+\nu_{2}-\left( \frac{1+\eta}{2}x+\frac{1-\eta}{2}y\right) \right) &\leq &\sigma\left( \nu_{1}\right) +\sigma\left( \nu_{2}\right) -\left( \frac{1+\eta}{2}\sigma\left( x\right) +\frac{1-\eta}{2}\sigma\left( y\right) \right). \end{eqnarray}$

(2.5)

Adding inequalities (2.4) and (2.5) to get

$\begin{multline} \sigma\left( \nu_{1}+\nu_{2}-\left( \frac{1-\eta}{2}x+\frac{1+\eta}{2}y\right) \right) +\sigma\left(\nu_{1}+\nu_{2}-\left( \frac{1+\eta}{2}x+\frac{1-\eta}{2}y\right) \right) \\ \leq 2\left[\sigma\left(\nu_{1}\right)+\sigma\left(\nu_{2}\right)\right]-\left[\sigma\left(x\right)+\sigma\left(y\right)\right]. \end{multline}$

(2.6)

Multiplying both sides of (2.6) by $\eta^{\vartheta -1}$ and then integrating with respect to $\eta$ over $[0, 1]$ to obtain

$\begin{multline*} \int_{0}^{1}\eta^{\vartheta -1}\sigma\left( \nu_{1}+\nu_{2}-\left( \frac{1-\eta}{2}x+\frac{1+\eta}{2}y\right) \right)d\eta +\int_{0}^{1}\eta^{\vartheta-1}\sigma\left(\nu_{1}+\nu_{2}-\left(\frac{1+\eta}{2}x+\frac{1-\eta}{2}y\right)\right)d\eta \\ \leq \frac{2}{\vartheta}\left[\sigma\left(\nu_{1}\right)+\sigma\left(\nu_{2}\right)\right] -\frac{1}{\vartheta }\left[ \sigma\left( x\right) +\sigma\left( y\right) \right]. \end{multline*}$

By making use of change of variables and then multiplying by $\frac{\vartheta }{2}$ , we get the second inequality in (2.1).

Remark 2.1. If we choose $\vartheta = 1$ , $x = \nu_{1}$ and $y = \nu_{2}$ in Theorem 2.1, then the inequality (2.1) reduces to (1.1).

Corollary 2.1. Theorem 2.1 with

● $\vartheta = 1$ becomes [24, Theorem 2.1].

● $x = \nu_{1}$ and $y = \nu_{2}$ becomes:

$\begin{align*} \sigma\left(\frac{\nu_{1}+\nu_{2}}{2}\right)\leq\frac{2^{\vartheta-1}\Gamma\left(\vartheta+1\right)}{\left(\nu_{2}-\nu_{1}\right)^{\vartheta}} \left[J_{\nu_{1}+}^{\vartheta }\sigma\left(\frac{\nu_{1}+\nu_{2}}{2}\right)+\; J_{\nu_{2}-}^{\vartheta }\sigma\left(\frac{\nu_{1}+\nu_{2}}{2}\right)\right] \leq \frac{\sigma\left(\nu_{1}\right)+\sigma\left(\nu_{2}\right) }{2}, \end{align*}$

which is obtained by Mohammed and Brevik in ^[10].

The following Lemma linked with the left inequality of (2.1) is useful to obtain our next results.

Lemma 2.1. Let $\sigma:[\nu_{1}, \nu_{2}]\subseteq\bf{R} \to\bf{R}$ be a differentiable function on $(\nu_{1}, \nu_{2})$ and $\sigma'\in L[\nu_{1}, \nu_{2}]$ with $\nu_{1}\leq \nu_{2}$ and $x, y\in[\nu_{1}, \nu_{2}]$ . Then, we have:

$\begin{multline} \frac{2^{\vartheta -1}\Gamma \left( \vartheta +1\right) }{\left( y-x\right)^{\vartheta}} \left[ J_{\left( \nu_{1}+\nu_{2}-y\right) +}^{\vartheta }\sigma\left(\nu_{1}+\nu_{2}-\frac{x+y}{2}\right) +\; J_{\left( \nu_{1}+\nu_{2}-x\right)-}^{\vartheta}\sigma\left(\nu_{1}+\nu_{2}-\frac{x+y}{2}\right)\right] \\ -\sigma\left(\nu_{1}+\nu_{2}-\frac{x+y}{2}\right) = \frac{\left(y-x\right)}{4}\int_{0}^{1}\eta^{\vartheta} \Bigl[\sigma'\left(\nu_{1}+\nu_{2}-\left(\frac{1-\eta}{2}x+\frac{1+\eta}{2}y\right)\right) \\ -\sigma'\left(\nu_{1}+\nu_{2}-\left(\frac{1+\eta}{2}x+\frac{1-\eta}{2}y\right)\right)\Bigr]d\eta. \end{multline}$

(2.7)

Proof. From right hand side of (2.7), we set

$\begin{align} \varpi_{1}-\varpi_{2}&:= \int_{0}^{1}\eta^{\vartheta}\left[\sigma'\left(\nu_{1}+\nu_{2} -\left(\frac{1-\eta}{2}x+\frac{1+\eta}{2}y\right)\right) -\sigma'\left( \nu_{1}+\nu_{2}-\left( \frac{1+\eta}{2}x+\frac{1-\eta}{2}y\right)\right)\right]d\eta \\ & = \int_{0}^{1}\eta^{\vartheta }\sigma'\left(\nu_{1}+\nu_{2}-\left(\frac{1-\eta}{2}x+\frac{1+\eta}{2}y\right)\right)d\eta \\ &-\int_{0}^{1}\eta^{\vartheta}\sigma'\left(\nu_{1}+\nu_{2}-\left(\frac{1+\eta}{2}x+\frac{1-\eta}{2}y\right)\right) d\eta. \end{align}$

(2.8)

By integrating by parts with $w = \nu_{1}+\nu_{2}-\left(\frac{1-\eta}{2}x+\frac{1+\eta}{2}y\right)$ , we can deduce:

$\begin{align*} \varpi_{1}& = -\frac{2}{\left( y-x\right) }\sigma\left(\nu_{1}+\nu_{2}-y\right)+\frac{2\vartheta }{\left(y-x\right)} \int_{0}^{1}\eta^{\vartheta -1}\sigma\left( \nu_{1}+\nu_{2}-\left( \frac{1-\eta}{2}x+\frac{1+\eta}{2}y\right) \right) d\eta \\ & = -\frac{2}{\left(y-x\right)}\sigma\left(\nu_{1}+\nu_{2}-y\right)+\frac{2^{\vartheta+1}\vartheta}{\left(y-x\right)^{\vartheta+1}} \int_{\nu_{1}+\nu_{2}-y}^{\nu_{1}+\nu_{2}-\frac{x+y}{2}}\sigma\left(\left( \nu_{1}+\nu_{2}-\frac{x+y}{2}\right)-w\right)^{\vartheta -1} \sigma\left(w\right) dw \\ & = -\frac{2}{\left(y-x\right)}\sigma\left( \nu_{1}+\nu_{2}-y\right) +\frac{2^{\vartheta+1}\Gamma\left(\vartheta+1\right)}{\left( y-x\right) ^{\vartheta +1}} J_{\left(\nu_{1}+\nu_{2}-y\right)+}^{\vartheta }\sigma\left( \nu_{1}+\nu_{2}-\frac{x+y}{2}\right). \end{align*}$

Similarly, we can deduce:

$\begin{equation*} \varpi_{2} = \frac{2}{y-x}\sigma\left(\nu_{1}+\nu_{2}-x\right) -\frac{2^{\vartheta+1}\Gamma\left(\vartheta+1\right)}{\left( y-x\right) ^{\vartheta +1}} J_{\left( \nu_{1}+\nu_{2}-x\right)-}^{\vartheta }\sigma\left(\nu_{1}+\nu_{2}-\frac{x+y}{2}\right). \end{equation*}$

By substituting $\varpi_{1}$ and $\varpi_{2}$ in (2.8) and then multiplying by $\frac{\left(y-x\right)}{4}$ , we obtain required identity (2.7).

Corollary 2.2. Lemma 2.1 with

● $\vartheta = 1$ becomes:

$\begin{multline*} \frac{1}{y-x}\int_{\nu_{1}+\nu_{2}-y}^{\nu_{1}+\nu_{2}-x}\sigma\left(w\right) dw-\sigma\left( \nu_{1}+\nu_{2}-\frac{x+y}{2}\right) = \frac{\left( y-x\right) }{4}\int_{0}^{1}\eta\left[ \sigma'\left( \nu_{1}+\nu_{2}-\left( \frac{1-\eta}{2}x+\frac{1+\eta}{2}y\right) \right) \right. \\ \left. -\sigma'\left( \nu_{1}+\nu_{2}-\left( \frac{1+\eta}{2}x+\frac{1-\eta}{2}y\right)\right) \right] d\eta. \end{multline*}$

● $\vartheta = 1$ , $x = \nu_{1}$ and $y = \nu_{2}$ becomes:

$\begin{multline*} \frac{1}{\nu_{2}-\nu_{1}}\int_{\nu_{1}}^{\nu_{2}}\sigma\left( w\right) dw-\sigma\left(\frac{\nu_{1}+\nu_{2}}{2}\right) = \frac{\left( \nu_{2}-\nu_{1}\right) }{4}\int_{0}^{1}\eta \left[ \sigma'\left(\nu_{1}+\nu_{2}-\left( \frac{1-\eta}{2}\nu_{1}+\frac{1+\eta}{2}\nu_{2}\right) \right) \right. \\ \left. -\sigma'\left( \nu_{1}+\nu_{2}-\left( \frac{1+\eta}{2}\nu_{1}+\frac{1-\eta}{2}\nu_{2}\right)\right) \right] d\eta. \end{multline*}$

● $x = \nu_{1}$ and $y = \nu_{2}$ becomes:

$\begin{multline*} \frac{2^{\vartheta -1}\Gamma \left( \vartheta +1\right) }{\left( \nu_{2}-\nu_{1}\right)^{\vartheta }} \left[ J_{\nu_{1}+}^{\vartheta }\sigma\left(\frac{\nu_{1}+\nu_{2}}{2}\right) +\; J_{\nu_{2}-}^{\vartheta }\sigma\left(\frac{\nu_{1}+\nu_{2}}{2}\right) \right]-\sigma\left(\frac{\nu_{1}+\nu_{2}}{2}\right) \\ = \frac{\left( \nu_{2}-\nu_{1}\right) }{4}\int_{0}^{1}\eta^{\vartheta } \left[\sigma'\left( \nu_{1}+\nu_{2}-\left( \frac{1-\eta}{2}\nu_{1}+\frac{1+\eta}{2}\nu_{2}\right) \right) \right. \left. -\sigma'\left( \nu_{1}+\nu_{2}-\left( \frac{1+\eta}{2}\nu_{1}+\frac{1-\eta}{2}\nu_{2}\right) \right) \right] d\eta. \end{multline*}$

Theorem 2.2. Let $\sigma:[\nu_{1}, \nu_{2}]\subseteq\bf{R}\to\bf{R}$ be a differentiable function on $(\nu_{1}, \nu_{2})$ and $|\sigma'|$ is convex on $[\nu_{1}, \nu_{2}]$ with $\nu_{1}\leq \nu_{2}$ and $x, y\in[\nu_{1}, \nu_{2}]$ . Then, we have:

$\begin{multline} \Biggl| \frac{2^{\vartheta -1}\Gamma \left( \vartheta +1\right) }{\left(y-x\right) ^{\vartheta }} \Biggl[ J_{\left( \nu_{1}+\nu_{2}-y\right) +}^{\vartheta }\sigma\left( \nu_{1}+\nu_{2}-\frac{x+y}{2}\right) +\; J_{\left( \nu_{1}+\nu_{2}-x\right) -}^{\vartheta }\sigma\left( \nu_{1}+\nu_{2}-\frac{x+y}{2}\right) \Biggr] \\ -\sigma\left( \nu_{1}+\nu_{2}-\frac{x+y}{2}\right)\Biggr| \leq \frac{\left( y-x\right) }{2\left( 1+\vartheta \right) }\left[ \left| \sigma'\left( \nu_{1}\right) \right| +\left| \sigma'\left(\nu_{2}\right) \right| -\frac{\left| \sigma'\left( x\right) \right| +\left| \sigma'\left( y\right) \right| }{2}\right]. \end{multline}$

(2.9)

Proof. By taking modulus of identity (2.7), we get

$\begin{multline*} \Biggl|\frac{2^{\vartheta-1}\Gamma\left(\vartheta+1\right)}{\left(y-x\right)^{\vartheta}} \left[J_{\left(\nu_{1}+\nu_{2}-y\right)+}^{\vartheta}\sigma\left(\nu_{1}+\nu_{2}-\frac{x+y}{2}\right) +\; J_{\left( \nu_{1}+\nu_{2}-x\right) -}^{\vartheta }\sigma\left( \nu_{1}+\nu_{2}-\frac{x+y}{2}\right) \right] \\ -\sigma\left( \nu_{1}+\nu_{2}-\frac{x+y}{2}\right) \Biggr|\leq \frac{\left( y-x\right) }{4} \left[\int_{0}^{1}\eta^{\vartheta }\left|\sigma'\left( \nu_{1}+\nu_{2}-\left( \frac{1-\eta}{2}x+\frac{1+\eta}{2}y\right) \right) \right| d\eta\right. \\ \left. +\int_{0}^{1}\eta^{\vartheta }\left| \sigma'\left( \nu_{1}+\nu_{2}-\left( \frac{1+\eta}{2}x+\frac{1-\eta}{2}y\right) \right) \right| d\eta\right]. \end{multline*}$

Then, by applying the convexity of $|\sigma'|$ and the Jensen-Mercer inequality on above inequality, we get

$\begin{align*} &\Biggl|\frac{2^{\vartheta-1}\Gamma\left(\vartheta+1\right)}{\left(y-x\right)^{\vartheta}} \left[J_{\left(\nu_{1}+\nu_{2}-y\right)+}^{\vartheta}\sigma\left(\nu_{1}+\nu_{2}-\frac{x+y}{2}\right) +\; J_{\left( \nu_{1}+\nu_{2}-x\right) -}^{\vartheta }\sigma\left( \nu_{1}+\nu_{2}-\frac{x+y}{2}\right) \right] \\ &-\sigma\left( \nu_{1}+\nu_{2}-\frac{x+y}{2}\right) \Biggr|\leq \frac{\left( y-x\right) }{4}\left[ \int_{0}^{1}\eta^{\vartheta }\left[ \left| \sigma'\left( \nu_{1}\right) \right| +\left| \sigma'\left( \nu_{2}\right) \right| -\left( \frac{1+\eta}{2}\left| \sigma^{\prime }\left( x\right) \right| +\frac{1-\eta}{2}\right) \left| \sigma'\left( y\right) \right| \right] d\eta\right. \\ &\left. +\int_{0}^{1}\eta^{\vartheta }\left[ \left| \sigma'\left(\nu_{1}\right) \right| +\left| \sigma'\left( \nu_{2}\right) \right| -\left(\frac{1-\eta}{2}\left|\sigma'\left(x\right) \right| +\frac{1+\eta}{2}\right)\left| \sigma'\left( y\right)\right| \right] d\eta\right] \\ & = \frac{\left(y-x\right)}{2\left(1+\vartheta \right)}\left[ \left|\sigma'\left( \nu_{1}\right)\right| +\left|\sigma'(\nu_{2})\right|-\frac{\left|\sigma'\left(x\right)\right|+\left|\sigma'\left(y\right)\right|}{2}\right], \end{align*}$

which completes the proof of Theorem 2.2.

Corollary 2.3. Theorem 2.2 with

● $\vartheta = 1$ becomes:

$\begin{align*} \left|\frac{1}{y-x}\int_{\nu_{1}+\nu_{2}-y}^{\nu_{1}+\nu_{2}-x}\sigma(w)dw-\sigma\left(\nu_{1}+\nu_{2}-\frac{x+y}{2}\right)\right| \leq \frac{\left(y-x\right)}{4}\left[\left| \sigma'\left(\nu_{1}\right)\right|+\left|\sigma'\left(\nu_{2}\right)\right| -\frac{\left|\sigma'\left(x\right)\right|+\left|\sigma'\left(y\right)\right|}{2}\right]. \end{align*}$

● $\vartheta = 1$ , $x = \nu_{1}$ and $y = \nu_{2}$ becomes [27, Theorem 2.2].

● $x = \nu_{1}$ and $y = \nu_{2}$ becomes:

$\begin{align*} \left\vert \frac{1}{\nu_{2}-\nu_{1}}\int_{\nu_{1}}^{\nu_{2}}\sigma\left( w\right) dw-\sigma\left(\frac{\nu_{1}+\nu_{2}}{2}\right) \right\vert \leq \frac{\left( \nu_{2}-\nu_{1}\right) }{4}\left[ \frac{\left\vert \sigma^{\prime }\left( \nu_{1}\right) \right\vert +\left\vert \sigma^{\prime }\left( \nu_{2}\right) \right\vert }{2}\right] . \end{align*}$

Theorem 2.3. Let $\sigma:[\nu_{1}, \nu_{2}]\subseteq\bf{R}\to\bf{R}$ be a differentiable function on $(\nu_{1}, \nu_{2})$ and $\left| \sigma'\right|^{q}, q > 1$ is convex on $[\nu_{1}, \nu_{2}]$ with $\nu_{1}\leq \nu_{2}$ and $x, y\in[\nu_{1}, \nu_{2}]$ . Then, we have:

$\begin{multline} \left| \frac{2^{\vartheta -1}\Gamma \left( \vartheta +1\right) }{\left( y-x\right) ^{\vartheta }}\left[ J_{\left( \nu_{1}+\nu_{2}-y\right) +}^{\vartheta }\sigma\left( \nu_{1}+\nu_{2}- \frac{x+y}{2}\right) \right. \right. \\ \left. \left. +\; J_{\left( \nu_{1}+\nu_{2}-x\right) -}^{\vartheta }\sigma\left(\nu_{1}+\nu_{2}-\frac{x+y}{2}\right) \right] -\sigma\left( \nu_{1}+\nu_{2}-\frac{x+y}{2}\right) \right| \\ \leq \frac{\left( y-x\right) }{4\sqrt[p]{\vartheta p+1}} \left[ \left( \left| \sigma'\left( \nu_{1}\right) \right|^{q}+\left| \sigma'\left(\nu_{2}\right)\right| ^{q} -\left(\frac{\left|\sigma'(x) \right|^{q}+3\left|\sigma'(y)\right|^{q}}{4}\right)\right)^{\frac{1}{q}}\right. \\ \left. +\left( \left| \sigma'\left( \nu_{1}\right) \right|^{q}+\left|\sigma'\left(\nu_{2}\right)\right|^{q} -\left(\frac{3\left|\sigma'(x)\right|^{q}+\left|\sigma'(y)\right|^{q}}{4}\right)\right)^{\frac{1}{q}}\right], \end{multline}$

(2.10)

where $\frac{1}{p}+\frac{1}{q} = 1$ .

Proof. By taking modulus of identity (2.7) and using Hölder's inequality, we get

$\begin{multline*} \left| \frac{2^{\vartheta -1}\Gamma \left( \vartheta +1\right) }{\left(y-x\right)^{\vartheta }} \left[ J_{\left( \nu_{1}+\nu_{2}-y\right)+}^{\vartheta }\sigma\left( \nu_{1}+\nu_{2}-\frac{x+y}{2}\right) \right. \right. \\ \left. \left. +\; J_{\left(\nu_{1}+\nu_{2}-x\right)-}^{\vartheta }\sigma\left(\nu_{1}+\nu_{2}-\frac{x+y}{2}\right) \right] -\sigma\left( \nu_{1}+\nu_{2}-\frac{x+y}{2}\right) \right| \\ \leq \frac{\left( y-x\right) }{4}\left( \int_{0}^{1}\eta^{\vartheta p}\right)^{\frac{1}{p}} \left\{\left(\int_{0}^{1} \left|\sigma'\left(\nu_{1}+\nu_{2}-\left(\frac{1-\eta}{2}x+\frac{1+\eta}{2}y\right)\right)\right|^{q}d\eta\right) ^{\frac{1}{q}}\right. \\ \left. +\left(\int_{0}^{1} \left|\sigma'\left(\nu_{1}+\nu_{2}-\left(\frac{1+\eta}{2}x+\frac{1-\eta}{2}y\right)\right)\right|^{q}d\eta\right) ^{\frac{1}{q}}\right\}. \end{multline*}$

Then, by applying the Jensen-Mercer inequality with the convexity of $\left|\sigma'\right|^{q}$ , we can deduce

$\begin{align*} &\left| \frac{2^{\vartheta -1}\Gamma \left( \vartheta +1\right) }{\left(y-x\right) ^{\vartheta }} \left[J_{\left(\nu_{1}+\nu_{2}-y\right)+}^{\vartheta }\sigma\left( \nu_{1}+\nu_{2}-\frac{x+y}{2}\right) \right. \right. \\ &\left. \left. +\; J_{\left( \nu_{1}+\nu_{2}-x\right) -}^{\vartheta }\sigma\left( \nu_{1}+\nu_{2}-\frac{x+y}{2}\right) \right] -\sigma\left( \nu_{1}+\nu_{2}-\frac{x+y}{2}\right) \right| \\ &\leq \frac{\left( y-x\right) }{4}\left( \int_{0}^{1}\eta^{\vartheta p}\right)^{\frac{1}{p}} \left\{ \left( \int_{0}^{1}\left| \sigma'\left( \nu_{1}\right)\right| ^{q}+\left| \sigma'\left( \nu_{2}\right) \right|^{q} -\left(\frac{1-\eta}{2}\left|\sigma'(x)\right|^{q}+\frac{1+\eta}{2}\left|\sigma'(y)\right|^{q}\right)\right)^{\frac{1}{q}}\right. \\ &\left. +\left( \int_{0}^{1}\left| \sigma'\left( \nu_{1}\right)\right| ^{q}+\left| \sigma'\left( \nu_{2}\right) \right|^{q} -\left(\frac{1+\eta}{2}\left| \sigma'\left( x\right)\right|^{q}+\frac{1-\eta}{2}\left| \sigma'\left( y\right) \right|^{q} \right) \right)^{\frac{1}{q}}\right\} \\ & = \frac{\left(y-x\right)}{4\sqrt[p]{\vartheta p+1}}\left[\left( \left| \sigma'\left( \nu_{1}\right) \right| ^{q} +\left|\sigma'\left( \nu_{2}\right) \right| ^{q}-\left( \frac{\left|\sigma'\left( x\right) \right|^{q} +3\left| \sigma'\left(y\right) \right|^{q} }{4}\right) \right) ^{\frac{1}{q}}\right. \\ &\left. +\left( \left| \sigma'\left( \nu_{1}\right) \right|^{q}+\left| \sigma'\left( \nu_{2}\right) \right| ^{q} -\left(\frac{3\left|\sigma'(x)\right|^{q}+\left|\sigma'(y)\right|^{q}}{4}\right)\right)^{\frac{1}{q}}\right], \end{align*}$

which completes the proof of Theorem 2.3.

Corollary 2.4. Theorem 2.3 with

● $\vartheta = 1$ becomes:

$\begin{multline*} \left|\frac{1}{y-x}\int_{\nu_{1}+\nu_{2}-y}^{\nu_{1}+\nu_{2}-x}\sigma\left(w\right)dw -\sigma\left(\nu_{1}+\nu_{2}-\frac{x+y}{2}\right)\right| \\ \leq \frac{\left( y-x\right)}{4\sqrt[p]{p+1}}\left[\left( \left| \sigma'\left( \nu_{1}\right) \right|^{q} +\left|\sigma'\left( \nu_{2}\right) \right| ^{q}-\left( \frac{\left|\sigma'\left( x\right) \right|^{q} +3\left|\sigma'\left(y\right) \right|^{q}}{4}\right)\right)^{\frac{1}{q}}\right. \\ \left. +\left(\left|\sigma'\left( \nu_{1}\right)\right|^{q}+\left| \sigma'\left( \nu_{2}\right)\right|^{q} -\left(\frac{3\left|\sigma'(x)\right|^{q}+\left|\sigma'(y)\right|^{q} }{4}\right)\right)^{\frac{1}{q}}\right]. \end{multline*}$

● $\vartheta = 1$ , $x = \nu_{1}$ and $y = \nu_{2}$ becomes:

$\begin{align*} &&\left\vert \frac{1}{\nu_{2}-\nu_{1}}\int_{\nu_{1}}^{\nu_{2}}\sigma\left( w\right) dw-\sigma\left(\frac{\nu_{1}+\nu_{2}}{2}\right) \right\vert \leq \frac{\left( \nu_{2}-\nu_{1}\right) }{2^{\frac{2}{p}}}\left(\frac{1}{p+1}\right)^{\frac{1}{p}}\left[ \left\vert \sigma^{\prime }\left( \nu_{1}\right) \right\vert +\left\vert \sigma^{\prime }\left( \nu_{2}\right) \right\vert \right] . \end{align*}$

● $x = \nu_{1}$ and $y = \nu_{2}$ becomes:

$\begin{align*} &\left\vert \frac{2^{\vartheta-1}\Gamma\left(\vartheta+1\right)}{\left(\nu_{2}-\nu_{1}\right)^{\vartheta}} \left[ J_{\nu_{1}+}^{\vartheta }\sigma\left(\frac{\nu_{1}+\nu_{2}}{2}\right) \right. \right. \left. \left. +\; J_{\nu_{2}-}^{\vartheta }\sigma\left(\frac{\nu_{1}+\nu_{2}}{2}\right) \right] -\sigma\left(\frac{\nu_{1}+\nu_{2}}{2}\right) \right\vert \\ &\leq \frac{2^{\vartheta-1-\frac{2}{q}}}{\nu_{2}-\nu_{1}}\left(\frac{1}{p+1}\right)^{\frac{1}{p}}\left[ \left\vert \sigma'\left( \nu_{1}\right) \right\vert +\left\vert \sigma'\left( \nu_{2}\right) \right\vert \right]. \end{align*}$

Theorem 2.4. Let $\sigma:[\nu_{1}, \nu_{2}]\subseteq\bf{R}\to\bf{R}$ be a differentiable function on $(\nu_{1}, \nu_{2})$ and $\left|\sigma'\right|^{q}, q\geq 1$ is convex on $[\nu_{1}, \nu_{2}]$ with $\nu_{1}\leq \nu_{2}$ and $x, y\in[\nu_{1}, \nu_{2}]$ . Then, we have:

$\begin{multline} \left| \frac{2^{\vartheta -1}\Gamma \left( \vartheta +1\right) }{\left(y-x\right) ^{\vartheta }} \left[ J_{\left( \nu_{1}+\nu_{2}-y\right) +}^{\vartheta }\sigma\left( \nu_{1}+\nu_{2}-\frac{x+y}{2}\right)\right.\right. \\ \left. \left. +\; J_{\left( \nu_{1}+\nu_{2}-x\right) -}^{\vartheta }\sigma\left( \nu_{1}+\nu_{2}-\frac{x+y}{2}\right) \right] -\sigma\left( \nu_{1}+\nu_{2}-\frac{x+y}{2}\right) \right| \\ \leq \frac{\left(y-x\right)}{4\left(\vartheta+1\right)}\left[\left(\left|\sigma'(\nu_{1})\right|^{q} +\left|\sigma'\left(\nu_{2}\right)\right|^{q}-\left( \frac{\left| \sigma'\left(x\right)\right|^{q} +\left( 2\vartheta+3\right)\left|\sigma'(y)\right|^{q}}{2\left(\vartheta+2\right) }\right)\right)^{\frac{1}{q}}\right. \\ \left. +\left( \left|\sigma'\left(\nu_{1}\right)\right|^{q}+\left| \sigma'\left( \nu_{2}\right)\right|^{q} -\left(\frac{\left(2\vartheta+3\right)\left|\sigma'(x)\right|^{q}+\left|\sigma'(y)\right|^{q}}{2\left( \vartheta+2\right) }\right) \right) ^{\frac{1}{q}}\right]. \end{multline}$

(2.11)

Proof. By taking modulus of identity (2.7) with the well-known power mean inequality, we can deduce

$\begin{multline*} \left| \frac{2^{\vartheta -1}\Gamma \left( \vartheta +1\right) }{\left(y-x\right) ^{\vartheta }} \left[ J_{\left( \nu_{1}+\nu_{2}-y\right) +}^{\vartheta }\sigma\left( \nu_{1}+\nu_{2}-\frac{x+y}{2}\right) \right. \right. \\ \left. \left. +\; J_{\left( \nu_{1}+\nu_{2}-x\right) -}^{\vartheta }\sigma\left( \nu_{1}+\nu_{2}-\frac{x+y}{2}\right) \right] -\sigma\left( \nu_{1}+\nu_{2}-\frac{x+y}{2}\right) \right| \\ \leq \frac{\left( y-x\right) }{4}\left( \int_{0}^{1}\eta^{\vartheta }\right) ^{1-\frac{1}{q}} \left\{\left(\int_{0}^{1}\eta^{\vartheta} \left|\sigma'\left(\nu_{1}+\nu_{2}-\left(\frac{1-\eta}{2}x+\frac{1+\eta}{2}y\right)\right)\right|^{q}d\eta\right)^{\frac{1}{q}}\right. \\ \left. +\left( \int_{0}^{1}\eta^{\vartheta } \left|\sigma'\left(\nu_{1}+\nu_{2}-\left(\frac{1+\eta}{2}x+\frac{1-\eta}{2}y\right)\right)\right|^{q}d\eta\right)^{\frac{1}{q}}\right\} . \end{multline*}$

By applying the Jensen-Mercer inequality with the convexity of $\left|\sigma'\right|^{q}$ , we can deduce

$\begin{align*} &\left| \frac{2^{\vartheta -1}\Gamma \left( \vartheta +1\right) }{\left(y-x\right)^{\vartheta}} \left[ J_{\left( \nu_{1}+\nu_{2}-y\right)+}^{\vartheta}\sigma\left(\nu_{1}+\nu_{2}-\frac{x+y}{2}\right) \right. \right. \\ &\left. \left. +\; J_{\left( \nu_{1}+\nu_{2}-x\right) -}^{\vartheta }\sigma\left( \nu_{1}+\nu_{2}-\frac{x+y}{2}\right)\right] -\sigma\left( \nu_{1}+\nu_{2}-\frac{x+y}{2}\right) \right| \\ &\leq \frac{\left( y-x\right)}{4}\left(\int_{0}^{1}\eta^{\vartheta }\right)^{1-\frac{1}{q}} \left\{ \left( \int_{0}^{1}\eta^{\vartheta }\left[ \left|\sigma'\left( \nu_{1}\right) \right|^{q} +\left| \sigma'\left(\nu_{2}\right) \right| ^{q}-\left( \frac{1-\eta}{2}\left| \sigma'\left(x\right)\right|^{q} +\frac{1+\eta}{2}\left| \sigma'\left( y\right)\right| ^{q}\right) \right] \right) ^{\frac{1}{q}}\right. \\ &\left. +\left( \int_{0}^{1}\eta^{\vartheta }\left[ \left| \sigma'\left(\nu_{1}\right)\right|^{q} +\left| \sigma'\left( \nu_{2}\right) \right|^{q}-\left( \frac{1+\eta}{2}\left| \sigma'\left( x\right) \right|^{q} +\frac{1-\eta}{2}\left| \sigma'\left( y\right) \right|^{q}\right) \right] \right) ^{\frac{1}{q}}\right\} \\ & = \frac{\left( y-x\right) }{4\left( \vartheta +1\right) }\left[\left(\left|\sigma'\left(\nu_{1}\right)\right|^{q} +\left|\sigma'\left( \nu_{2}\right) \right| ^{q}-\left( \frac{\left| \sigma'\left(x\right) \right|^{q} +\left(2\vartheta +3\right)\left|\sigma'(y)\right|^{q}}{2\left(\vartheta+2\right)}\right)\right)^{\frac{1}{q}}\right. \\ &\left. +\left( \left| \sigma'\left( \nu_{1}\right) \right|^{q}+\left|\sigma'\left( \nu_{2}\right)\right|^{q} -\left( \frac{\left( 2\vartheta +3\right) \left| \sigma'\left( x\right) \right|^{q} +\left|\sigma'\left( y\right)\right|^{q}}{2\left(\vartheta+2\right)}\right)\right)^{\frac{1}{q}}\right], \end{align*}$

which completes the proof of Theorem 2.4.

Corollary 5. Theorem 2.4 with

● $q = 1$ becomes Theorem 2.2.

● $\vartheta = 1$ becomes:

$\begin{multline*} \left| \frac{1}{y-x}\int_{\nu_{1}+\nu_{2}-y}^{\nu_{1}+\nu_{2}-x}\sigma\left(w\right) dw -\sigma\left( \nu_{1}+\nu_{2}-\frac{x+y}{2}\right) \right| \\ \leq \frac{\left( y-x\right) }{8}\left[ \left( \left|\sigma'\left( \nu_{1}\right)\right|^{q} +\left| \sigma'\left( \nu_{2}\right)\right|^{q}-\left( \frac{\left| \sigma'\left( x\right)\right|^{q} +5\left|\sigma'\left(y\right)\right|^{q}}{6}\right)\right)^{\frac{1}{q}}\right. \\ \left. +\left( \left| \sigma'\left( \nu_{1}\right) \right|^{q}+\left|\sigma'\left(\nu_{2}\right)\right|^{q} -\left(\frac{5\left|\sigma'(x)\right|^{q}+\left|\sigma'(y)\right|^{q}}{6}\right)\right)^{\frac{1}{q}}\right]. \end{multline*}$

● $\vartheta = 1$ , $x = \nu_{1}$ and $y = \nu_{2}$ becomes:

$\begin{multline*} \left| \frac{1}{\nu_{2}-\nu_{1}}\int_{\nu_{1}}^{\nu_{2}}\sigma\left( w\right) dw -\sigma\left(\frac{\nu_{1}+\nu_{2}}{2}\right)\right| \\ \leq \frac{\left(y-x\right)}{8}\left[\left(\frac{5\left|\sigma'\left(\nu_{1}\right)\right|^{q} +\left| \sigma'\left( \nu_{2}\right)\right| ^{q}}{6}\right)^{\frac{1}{q}} +\left(\frac{\left|\sigma'(\nu_{1})\right|^{q}+5\left| \sigma'(\nu_{2})\right|^{q}}{6}\right)^{\frac{1}{q}}\right]. \end{multline*}$

● $x = \nu_{1}$ and $y = \nu_{2}$ becomes:

$\begin{multline*} \left| \frac{2^{\vartheta-1}\Gamma\left(\vartheta+1\right)}{\left(\nu_{2}-\nu_{1}\right)^{\vartheta}} \left[J_{\nu_{1} +}^{\vartheta}\sigma\left(\frac{\nu_{1}+\nu_{2}}{2}\right)+\; J_{\nu_{2} -}^{\vartheta }\sigma\left( \frac{\nu_{1}+\nu_{2}}{2}\right)\right] -\sigma\left( \frac{\nu_{1}+\nu_{2}}{2}\right)\right| \\ \leq \frac{\left(\nu_{2}-\nu_{1}\right)}{4\left(\vartheta+1\right)} \left[\left(\frac{\left(2\vartheta+3\right)\left|\sigma'(\nu_{1})\right|^{q}+\left|\sigma'(\nu_{2})\right|^{q}}{2\left(\vartheta+2\right)}\right)^{\frac{1}{q}} +\left(\frac{\left|\sigma'(\nu_{1})\right|^{q}+\left(2\vartheta+3\right)\left|\sigma'(\nu_{2})\right|^{q}}{2\left(\vartheta+2\right)}\right) ^{\frac{1}{q}}\right]. \end{multline*}$

3. Applications to special means

Here, we consider the following special means:

● The arithmetic mean:

$\mathcal{A}(\nu_{1},\nu_{2}) = \frac{\nu_{1}+\nu_{2}}{2}, \quad \nu_{1}, \nu_{2}\geq 0.$

● The harmonic mean:

$\mathcal{H}(\nu_{1},\nu_{2}) = \frac{2\nu_{1}\nu_{2}}{\nu_{1}+\nu_{2}}, \quad \nu_{1}, \nu_{2} > 0.$

● The logarithmic mean:

$\begin{equation*} \mathcal{L}(\nu_{1},\nu_{2}) = \begin{cases} \frac{\nu_{2}-\nu_{1}}{\ln \nu_{2}-\ln \nu_{1}}, & \text{if}\; \nu_{1}\neq \nu_{2}, \\ \nu_{1}, & \text{if}\; \nu_{1} = \nu_{2}, \end{cases} \quad \nu_{1}, \nu_{2} > 0. \end{equation*}$

● The generalized logarithmic mean:

$\begin{equation*} \mathcal{L}_{n}(\nu_{1},\nu_{2}) = \begin{cases} \left[\frac{\nu_{2}^{n+1}-\nu_{1}^{n+1}}{\left(n+1\right)(\nu_{2}-\nu_{1})}\right]^{\frac{1}{n}}, & \text{if}\; \nu_{1}\neq \nu_{2} \\ \nu_{1}, & \text{if}\; \nu_{1} = \nu_{2}, \end{cases} \quad \nu_{1},\nu_{2} > 0;\; n\in\bf{Z}\setminus \{-1,0\}. \end{equation*}$

Proposition 3.1. Let $0 < \nu_{1} < \nu_{2}$ and $n\in\bf{N}$ , $n \geq 2$ . Then, for all $x, y\in[\nu_{1}, \nu_{2}]$ , we have:

(3.1)

Proof. By applying Corollary 2.3 (first item) for the convex function $\sigma(x) = x^{n}, \, x > 0$ , one can obtain the result directly.

Proposition 3.2. Let $0 < \nu_{1} < \nu_{2}$ . Then, for all $x, y\in[\nu_{1}, \nu_{2}]$ , we have:

(3.2)

Proof. By applying Corollary 2.3 (first item) for the convex function $\sigma(x) = \frac{1}{x}, \, x > 0$ , one can obtain the result directly.

Proposition 3.3. Let $0 < \nu_{1} < \nu_{2}$ and $n\in\bf{N}$ , $n \geq 2$ . Then, we have:

$\begin{equation} \left| \mathcal{L}_{n}^{n}(\nu_{1},\nu_{2}) -\mathcal{A}^{n}(\nu_{1},\nu_{2}) \right| \leq \frac{n(\nu_{2}-\nu_{1})}{4} \left[ \mathcal{A}\left(\nu_{1}^{n-1}, \nu_{2}^{n-1}\right) \right], \end{equation}$

(3.3)

and

$\begin{equation} \left| \mathcal{L}^{-1}(\nu_{1},\nu_{2}) -\mathcal{A}^{-1}(\nu_{1},\nu_{2}) \right| \leq \frac{(\nu_{2}-\nu_{1})}{4}\mathcal{H}^{-1}\left( \nu_{1}^{2},\nu_{2}^{2}\right) . \end{equation}$

(3.4)

Proof. By setting $x = \nu_{1}$ and $y = \nu_{2}$ in results of Proposition 3.1 and Proposition 3.2, one can obtain the Proposition 3.3.

Proposition 3.4. Let $0 < \nu_{1} < \nu_{2}$ and $n\in\bf{N}$ , $n \geq 2$ . Then, for $q > 1, \, \frac{1}{p}+\frac{1}{q} = 1$ and for all $x, y\in[\nu_{1}, \nu_{2}],$ we have:

$\begin{multline} \left| \mathcal{L}_{n}^{n}\left( \nu_{1}+\nu_{2}-y,\nu_{1}+\nu_{2}-x\right) -\left( 2\mathcal{A}(\nu_{1},\nu_{2}) -\mathcal{A}\left( x,y\right) \right) ^{n}\right| \\ \leq \frac{n(y-x)}{4\sqrt[p]{p+1}}\Bigg\{\left[ 2\mathcal{A}\left( \nu_{1}^{q(n-1)}, \nu_{2}^{q(n-1)}\right) -\frac{1}{2}\mathcal{A}\left(x^{q(n-1)}, 3y^{q(n-1)}\right) \right]^{\frac{1}{q}} \\ +\left[ 2\mathcal{A}\left( \nu_{1}^{q(n-1)}, \nu_{2}^{q(n-1)}\right) -\frac{1}{2}\mathcal{A}\left(3x^{q(n-1)}, y^{q(n-1)}\right) \right]^{\frac{1}{q}}\Bigg\}. \end{multline}$

(3.5)

Proof. By applying Corollary 2.4 (first item) for convex function $\sigma\left(x\right) = x^{n}, \, x > 0$ , one can obtain the result directly.

Proposition 3.5. Let $0 < \nu_{1} < \nu_{2}$ . Then, for $q > 1, \, \frac{1}{p}+\frac{1}{q} = 1$ and for all $x, y\in[\nu_{1}, \nu_{2}]$ , we have:

$\begin{multline} \left| \mathcal{L}^{-1}\left( \nu_{1}+\nu_{2}-y,\nu_{1}+\nu_{2}-x\right) -\left( 2\mathcal{A}(\nu_{1},\nu_{2}) -\mathcal{A}\left(x,y\right)\right)^{-1}\right| \\ \leq \frac{\sqrt[q]{2}(y-x)}{4\sqrt[p]{p+1}}\Bigg\{\left[ \mathcal{H}^{-1}\left(\nu_{1}^{2q},\nu_{2}^{2q}\right) -\frac{3}{4}\mathcal{H}^{-1}\left(x^{2q}, 3y^{2q}\right) \right]^{\frac{1}{q}} \\ +\left[\mathcal{H}^{-1}\left(\nu_{1}^{2q},\nu_{2}^{2q}\right) -\frac{3}{4}\mathcal{H}^{-1}\left(3x^{2q}, y^{2q}\right) \right]^{\frac{1}{q}}\Bigg\}. \end{multline}$

(3.6)

Proof. By applying Corollary 2.4 (first item) for the convex function $\sigma\left(x\right) = \frac{1}{x}, \, x > 0$ , one can obtain the result directly.

Proposition 3.6. Let $0 < \nu_{1} < \nu_{2}$ and $n\in\bf{N}$ , $n \geq 2$ . Then, for $q > 1$ and $\frac{1}{p}+\frac{1}{q} = 1$ , we have:

$\begin{multline} \left| \mathcal{L}_{n}^{n}(\nu_{1},\nu_{2}) -\mathcal{A}^{n}(\nu_{1},\nu_{2}) \right| \leq \frac{n(\nu_{2}-\nu_{1})}{4\sqrt[p]{p+1}} \Bigg\{\left[ 2\mathcal{A}\left( \nu_{1}^{q(n-1)}, \nu_{2}^{q(n-1)}\right) -\frac{1}{2}\mathcal{A}\left( \nu_{1}^{q(n-1)}, 3\nu_{2}^{q(n-1)}\right) \right]^{\frac{1}{q}} \\ +\left[ 2\mathcal{A}\left( \nu_{1}^{q(n-1)}, \nu_{2}^{q(n-1)}\right) -\frac{1}{2}\mathcal{A}\left(3\nu_{1}^{q(n-1)}, \nu_{2}^{q(n-1)}\right) \right]^{\frac{1}{q}}\Bigg\}, \end{multline}$

(3.7)

and

$\begin{multline} \left| \mathcal{L}^{-1}(\nu_{1},\nu_{2}) -\mathcal{A}^{-1}(\nu_{1},\nu_{2}) \right| \leq \frac{\sqrt[q]{2}(\nu_{2}-\nu_{1})}{4\sqrt[p]{p+1}} \Bigg\{\left[ \mathcal{H}^{-1}\left( \nu_{1}^{2q}, \nu_{2}^{2q}\right) -\frac{3}{4}\mathcal{H}^{-1}\left(\nu_{1}^{2q}, 3\nu_{2}^{2q}\right) \right]^{\frac{1}{q}} \\ +\left[ \mathcal{H}^{-1}\left( \nu_{1}^{2q}, \nu_{2}^{2q}\right) -\frac{3}{4}\mathcal{H}^{-1}\left(3\nu_{1}^{2q}, \nu_{2}^{2q}\right) \right]^{\frac{1}{q}}\Bigg\}. \end{multline}$

(3.8)

Proof. By setting $x = \nu_{1}$ and $y = \nu_{2}$ in results of Proposition 3.4 and Proposition 3.5, one can obtain the Proposition 3.6.

4. Conclusions

As we emphasized in the introduction, integral inequality is the most important field of mathematical analysis and fractional calculus. By using the well-known Jensen-Mercer and power mean inequalities, we have proved new inequalities of Hermite-Hadamard-Mercer type involving Riemann-Liouville fractional operators. In the last section, we have considered some propositions in the context of special functions; these confirm the efficiency of our results.

Acknowledgements

We would like to express our special thanks to the editor and referees. Also, the first author would like to thank Prince Sultan University for funding this work through research group Nonlinear Analysis Methods in Applied Mathematics (NAMAM) group number RG-DES-2017-01-17.

Conflict of interest

The authors declare no conflict of interest.

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