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Research article

Novel R225C variant identified in the HGD gene in Jordanian patients with alkaptonuria

  • Received: 18 December 2020 Accepted: 18 February 2021 Published: 25 February 2021
  • Alkaptonuria (AKU) is a rare metabolic disease which is inherited as an autosomal recessive trait. It is characterized by the accumulation of homogentisic acid over time in various tissues of the body particularly connective tissues. This genetic disease is caused by mutation of the Homogentisate 1,2-dioxygenase (HGD) gene which encodes for enzyme essential for the catabolism of phenylalanine and tyrosine. The aim of the present study is to investigate variant types in Jordanian patients with alkaptonuria. Genomic DNA was extracted from whole blood samples of the participated AKU family members (n = 23). The 14 exons of HGD gene for the proband were amplified using specific PCR primers. The sequenced data were analysed and the pathogenicity of the identified variants were predicted using the online bioinformatics programs: PolyPhen2, SIFT and Mutation taster. The analysis showed that the proband was compound heterozygous for the missense mutations A122V and R225C found within E6 and E10, respectively. R225C variant is novel and the genotyping of the family members indicated that HGDA122V and HGDR225C alleles were fully segregated. Moreover, the cousins of the proband who are AKU patients inherited the homozygous pattern of the novel mutation. This study extends the pathogenic mutations spectrum of the HGD gene. It identified the novel mutation R225C and at the same time confirmed the high prevalence of the founder mutation A122V in Jordanian AKU patients.

    Citation: Nesrin R. Mwafi, Dema A. Ali, Raida W. Khalil, Ibrahim N. Alsbou', Ahmad M. Saraireh. Novel R225C variant identified in the HGD gene in Jordanian patients with alkaptonuria[J]. AIMS Molecular Science, 2021, 8(1): 60-75. doi: 10.3934/molsci.2021005

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  • Alkaptonuria (AKU) is a rare metabolic disease which is inherited as an autosomal recessive trait. It is characterized by the accumulation of homogentisic acid over time in various tissues of the body particularly connective tissues. This genetic disease is caused by mutation of the Homogentisate 1,2-dioxygenase (HGD) gene which encodes for enzyme essential for the catabolism of phenylalanine and tyrosine. The aim of the present study is to investigate variant types in Jordanian patients with alkaptonuria. Genomic DNA was extracted from whole blood samples of the participated AKU family members (n = 23). The 14 exons of HGD gene for the proband were amplified using specific PCR primers. The sequenced data were analysed and the pathogenicity of the identified variants were predicted using the online bioinformatics programs: PolyPhen2, SIFT and Mutation taster. The analysis showed that the proband was compound heterozygous for the missense mutations A122V and R225C found within E6 and E10, respectively. R225C variant is novel and the genotyping of the family members indicated that HGDA122V and HGDR225C alleles were fully segregated. Moreover, the cousins of the proband who are AKU patients inherited the homozygous pattern of the novel mutation. This study extends the pathogenic mutations spectrum of the HGD gene. It identified the novel mutation R225C and at the same time confirmed the high prevalence of the founder mutation A122V in Jordanian AKU patients.


    Abbreviations

    AKU:

    Alkaptonuria; 

    GC-MS:

    Gas Chromatography-Mass Spectrometry analysis; 

    HGD:

    Homogentisate 1,2-dioxygenase

    MLPA:

    multiplex ligation-dependent probe amplification

    In this paper, we consider the 3D nonlinear damped micropolar equation

    {ut+(u)u(ν+κ)Δu+σ|u|β1u+p=2κ×ω+f1(x,t),ωt+(u)ω+4κωγΔωμω=2κ×u+f2(x,t),u=0,u(x,t)|t=τ=uτ(x),   ω(x,t)|t=τ=ωτ(x), (1.1)

    where (x,t)Ω×[τ,+), τR, ΩR3 is a bounded domain, u=u(x,t) is the fluid velocity, ω=ω(x,t) is the angular velocity, σ is the damping coefficient, which is a positive constant, f1=f1(x,t) and f2=f2(x,t) represent external forces, ν, κ, γ, μ are all positive constants, γ and μ represent the angular viscosities.

    Micropolar flow can describe a fluid with microstructure, that is, a fluid composed of randomly oriented particles suspended in a viscous medium without considering the deformation of fluid particles. Since Eringen first published his paper on the model equation of micropolar fluids in 1966 [5], the formation of modern theory of micropolar fluid dynamics has experienced more than 40 years of development. For the 2D case, many researchers have discussed the long time behavior of micropolar equations (such as [2,4,10,24]). It should be mentioned that some conclusions in the 2D case no longer hold for the 3D case due to different structures of the system. In the 3D case, the work of micropolar equations (1.1) with σ=0, f1=0, and f2=0 has attracted a lot of attention (see [6,14,19]). Galdi and Rionero [6] proved the existence and uniqueness of solutions of 3D incompressible micropolar equations. In a 3D bounded domain, for small initial data Yamaguchi [19] investigated the existence of a global solution to the initial boundary problem for the micropolar system. In [14], Silva and Cruz et al. studied the L2-decay of weak solutions for 3D micropolar equations in the whole space R3. When f1=f2=0, for the Cauchy problem of the 3D incompressible nonlinear damped micropolar equations, Ye [22] discussed the existence and uniqueness of global strong solutions when β=3 and 4σ(ν+κ)>1 or β>3. In [18], Wang and Long showed that strong solutions exist globally for any 1β3 when initial data satisfies some certain conditions. Based on [22], Yang and Liu [20] obtained uniform estimates of the solutions for 3D incompressible micropolar equations with damping, and then they proved the existence of global attractors for 3<β<5. In [7], Li and Xiao investigated the large time decay of the L2-norm of weak solutions when β>145, and considered the upper bounds of the derivatives of the strong solution when β>3. In [21], for 1β<73, Yang, Liu, and Sun proved the existence of trajectory attractors for 3D nonlinear damped micropolar fluids.

    To the best of our knowledge, there are few results on uniform attractors for the three-dimensional micropolar equation with nonlinear damping term. The purpose of this paper is to consider the existence of uniform attractors of system (1.1). When ω=0,κ=0, system (1.1) is reduced to the Navier-Stokes equations with damping. In recent years, some scholars have studied the three-dimensional nonlinear damped Navier-Stokes equations (see [1,13,15,16,23,25]). In order to obtain the desired conclusion, we will use some proof techniques which have been used in the 3D nonlinear damped Navier Stokes equations. Note that, in [20], for the convenience of discussion the authors choose κ,μ=12,γ=1, and ν=32. In this work, we do not specify these parameters, but only require them to be positive real numbers. More importantly, we obtain the existence of uniform attractors in the case of β>3, which undoubtedly expands the range of β when the global attractor exists in [20], i.e., 3<β<5. For the convenience of discussion, similar to [3,8,9,11,16], we make some translational compactness assumption on the external forces term in this paper.

    The organizational structure of this article is as follows: In Section 2, we give some basic definitions and properties of function spaces and process theory which will be used in this paper. In Section 3, using various Sobolev inequalities and Gronwall inequalities, we make some uniform estimates from the space with low regularity to high regularity on the solution of the equation. Based on these uniform estimates, in Section 4 we prove that the family of processes {U(f1,f2)(t,τ)}tτ corresponding to (1.1) has uniform attractors A1 in V1×V2 and A2 in H2(Ω)×H2(Ω), respectively. Furthermore, we prove A1=A2.

    We define the usual functional spaces as follows:

    V1={u(C0(Ω))3:divu=0,Ωudx=0},V2={ω(C0(Ω))3:Ωωdx=0},H1=the closure of V1 in (L2(Ω))3,H2=the closure of V2 in (L2(Ω))3,V1=the closure of V1 in (H1(Ω))3,V2=the closure of V2 in (H1(Ω))3.

    For H1 and H2 we have the inner product

    (u,υ)=Ωuυdx,   u,vH1,or u,vH2,

    and norm 2=22=(,). In this paper, Lp(Ω)=(Lp(Ω))3, and p represents the norm in Lp(Ω).

    We define operators

    Au=PΔu=Δu,   Aω=Δω,  (u,ω)H2×H2,B(u)=B(u,u)=P((u)u),   B(u,ω)=(u)ω,  (u,ω)V1×V2,b(u,υ,ω)=B(u,υ),ω=3i,j=1Ωui(Diυj)ωjdx,  uV1,υ,ωV2,

    where P is the orthogonal projection from L2(Ω) onto H1. Hs(Ω)=(Hs(Ω))3 is the usual Sobolev space, and its norm is defined by Hs=∥As2; as s=2, H2=∥A.

    Let us rewrite system (1.1) as

    {ut+B(u)+(ν+κ)Au+G(u)=2κ×ω+f1(x,t),ωt+B(u,ω)+4κω+γAωμω=2κ×u+f2(x,t),u=0,u(x,t)|t=τ=uτ(x),  ω(x,t)|t=τ=ωτ(x), (2.1)

    where we let G(u)=P(σ|u|β1u).

    The Poincarˊe inequality [17] gives

    λ1uu,λ2ωω,(u,ω)V1×V2, (2.2)
    λ1u∥≤∥Au, λ2ω∥≤∥Aω,(u,ω)H2(Ω)×H2(Ω), (2.3)

    where λ1 is the first eigenvalue of Au, and λ2 is the first eigenvalue of Aω. Let λ=min{λ1,λ2}. Then, we have

    λ(u2+ω2)u2+ω2, (u,ω)V1×V2,λ(u2+ω2)Au2+Aω2,(u,ω)H2(Ω)×H2(Ω).

    Agmon's inequality [17] gives

    ud1u12Δu12, uH2(Ω).

    The trilinear inequalities [12] give

    |b(u,v,w)|≤∥uv∥∥w,uL(Ω),vV1 or V2,wH1 or H2, (2.4)
    |b(u,v,w)|ku14u34v∥∥w14w34,u,v,wV1 or V2, (2.5)
    |b(u,v,w)|ku∥∥v12Av12w,uV1 or V2,vH2,wH1 or H2. (2.6)

    Recall that a function f(t) is translation bounded (tr.b.) in L2loc(R;L2(Ω)) if

    f2L2b=∥f2L2b(R;L2(Ω))=suptRt+1tf(t)2dt<,

    where L2b(R;L2(Ω)) represents the collection of functions that are tr.b. in L2loc(R;L2(Ω)). We say that H(f0)=¯{f0(+t):tR} is the shell of f0 in L2loc(R;L2(Ω)). If H(f0) is compact in L2loc(R;L2(Ω)), then we say that f0(x,t)L2loc(R;L2(Ω)) is translation compact (tr.c.). We use L2c(R;L2(Ω)) to express the collection of all translation compact functions in L2loc(R;L2(Ω)).

    Next, we will provide the existence and uniqueness theorems of the solution of Eq (2.1).

    Definition 2.1. A function pair (u,ω) is said to be a global strong solution to system (2.1) if it satisfies

    (u,ω)L(τ,T;V1×V2)L2(τ,T;H2(Ω)×H2(Ω)),
    |u|β12uL2(τ,T;L2(Ω)), |u|β+12L2(τ,T;L2(Ω)),

    for any given T>τ.

    Theorem 2.1. Suppose (uτ,ωτ)V1×V2 with uτ=0,f1,f2L2b(R;L2(Ω)). If β=3 and 4σ(ν+κ)>1 or β>3, then there exists a unique global strong solution of (2.1).

    Proof. Since the proof method is similar to that of Theorem 1.2 in [22], we omit it here.

    Let Σ be a metric space. X, Y are two Banach spaces, and YX is continuous. {Uσ(t,τ)}tτ, σΣ is a family of processes in Banach space X, i.e., u(t)=Uσ(t,τ)uτ, Uσ(t,s)Uσ(s,τ)=Uσ(t,τ),tsτ,τR,Uσ(τ,τ)=I, where σΣ is a time symbol space. B(X) is the set of all bounded subsets of X. Rτ=[τ,+).

    For the basic concepts of bi-space uniform absorbing set, uniform attracting set, uniform attractor, uniform compact, and uniform asymptotically compact of the family of processed {Uσ(t,τ)}tτ,σΣ, one can refer to [9,16].

    Let T(h) be a family of operators acting on Σ, satisfying: T(h)σ(s)=σ(s+h),sR. In this paper, we assume that Σ satisfies

    (C1) T(h)Σ=Σ, hR+;

    (C2) translation identity:

    Uσ(t+h,τ+h)=UT(h)σ(t,τ),   σΣ,tτ,τR,h0.

    Theorem 2.2. [3] If the family of processes {Uσ(t,τ)}tτ,σΣ is (X,Y)-uniformly (w.r.t. σΣ) asymptotically compact, then it has a (X,Y)-uniform (w.r.t. σΣ) attractor AΣ, AΣ is compact in Y, and it attracts all bounded subsets of X in the topology of Y.

    In this paper, the letter C represents a positive constant. It may represent different values in different lines, or even in the same line.

    In this paper, we chose H(f01)×H(f02) as the symbol space. Obviously, T(t)(H((f01)×H(f02))=H(f01)×H(f02), for all t0. {T(t)}t0 is defined by

    T(h)(f1(),f2())=(f1(+h),f2(+h)),   h0,(f1,f2)H(f01)×H(f02),

    which is a translation semigroup and is continuous on H(f01)×H(f02).

    Thanks to Theorem 2.1, when (uτ,ωτ)V1×V2, f1,f2L2loc(R;L2(Ω)), and β>3, we can define a process {U(f1,f2)(t,τ)}tτ in V1×V2 by

    U(f1,f2)(t,τ)(uτ,ωτ)=(u(t),ω(t)), tτ,

    where (u(t),ω(t)) is the solution of Eq (1.1) with external forces f1,f2 and initial data (uτ,ωτ).

    Next, let us assume that the external forces f01(x,t),f02(x,t) are tr.c. in L2loc(R;L2(Ω)). Then, f01,f02 are tr.b. in L2loc(R;L2(Ω)), and

    f12L2b=∥f12L2b(R;L2(Ω))=suptRt+1tf1(s)2ds≤∥f012L2b<+,f1H(f01),
    f22L2b=∥f22L2b(R;L2(Ω))=suptRt+1tf2(s)2ds≤∥f022L2b<+,f2H(f02).

    Furthermore, we assume f01,f02 are uniformly bounded in L2(Ω), i.e., there exists a positive constant K, which satisfies

    suptRf01(x,t)∥≤K, suptRf02(x,t)∥≤K.

    Meanwhile, we suppose the derivatives df01dt, df02dt, labeled as h1,h2, also belong to L2c(R;L2(Ω)).

    Lemma 3.1. Suppose (uτ,ωτ)V1×V2 and (f1,f2)H(f01)×H(f02). If β>3 then there exists a time t0 and constants ρ1,I1 such that, for any tt0,

    u(t)2+ω(t)2ρ1, (3.1)
    t+1t[u(s)2+ω(s)2+u(s)β+1β+1+ω(s)2]dsI1. (3.2)

    Proof. Multiplying (1.1)1 and (1.1)2 with external forces f1H(f01), f2H(f02) by u and ω, respectively, and integrating the results equations on Ω, using H¨older's inequality, Young's inequality, and Poincarˊe's inequality, it yields

    12ddt(u(t)2+ω(t)2)+(ν+κ)u2+γω2+4κω(t)2+σu(t)β+1β+1+μω2=4κΩ×uωdx+(f1,u(t))+(f2,ω(t))κu2+4κω2+νλ2u2+γλ2ω2+12νλf12+12γλf22(ν2+κ)u2+γ2ω2+4κω(t)2+12νλf12+12γλf22. (3.3)

    So, we can obtain that

    ddt(u(t)2+ω(t)2)+νu2+γω2+2σu(t)β+1β+1+2μω21νλf1(t)2+1γλf2(t)2, (3.4)

    and by Poincarˊe's inequality, it yields

    ddt(u(t)2+ω(t)2)+λα(u(t)2+ω(t)2)1λα(f1(t)2+f2(t)2), (3.5)

    where α=min{ν,γ}. So, by Gronwall's inequality, we get

    u(t)2+ω(t)2(uτ2+ωτ2)eλα(tτ)+1λαtτeλα(ts)(f1(s)2+f2(s)2)ds(uτ2+ωτ2)eλα(tτ)+1λα[tt1eλα(ts)(f1(s)2+f2(s)2)ds+t1t2eλα(ts)(f1(s)2+f2(s)2)ds+...](uτ2+ωτ2)eλα(tτ)+1λα[1+eλα+e2λα+...](f12L2b+f22L2b)(uτ2+ωτ2)eλα(tτ)+1λα(1eλα)1(f12L2b+f22L2b)(uτ2+ωτ2)eλα(tτ)+1λα(1+1λα)(f12L2b+f22L2b),   tτ.

    Therefore, there must exists a time t0τ+1λαlnλ2α2(uτ2+ωτ2)(1+λα)(f12L2b+f22L2b), such that, tt0,

    u(t)2+ω(t)22λα(1+1λα)(f12L2b+f22L2b)ρ1. (3.6)

    Taking tt0, integrating (3.4) from t to t+1, and noticing (3.6), we get

    t+1t[νu(s)2+γω(s)2+2σu(s)β+1β+1+2μω(s)2]ds(u(t)2+ω(t)2)+1νλt+1tf1(s)2ds+1γλt+1tf2(s)2dsρ1+1λα(f12L2b+f22L2b),   tt0. (3.7)

    Letting δ1=min{ν,γ,2σ,2μ}, we have

    δ1t+1t[u(s)2+ω(s)2+u(s)β+1β+1+ω(s)2]dsρ1+1λα(f12L2b+f22L2b),   tt0.

    Letting I1=1δ1(ρ1+1λα(f12L2b+f22L2b)), we have

    t+1t[u(s)2+ω(s)2+u(s)β+1β+1+ω(s)2]dsI1,   tt0.

    This completes the proof of Lemma 3.1.

    Lemma 3.2. Assume β>3, (uτ,ωτ)V1×V2 and (f1,f2)H(f01)×H(f02). Then, there exists a time t2 and a constant ρ2 such that

    u(t)2+ω(t)2+t+1t(Au(s)2+Aω(s)2+|u|β12u2+|u|β+122)dsρ2, (3.8)

    for any tt2.

    Proof. Taking the inner product of Δu in H1 with the first equation of (1.1), we obtain

    12ddtu2+(ν+κ)Au2+σ|u|β12u2+4σ(β1)(β+1)2|u|β+122=b(u,u,Au)+2κΩ×ωAudx+(f1(t),Au). (3.9)

    In [18], we find that, when β>3,

    Ω(uu)Δudxν+κ4Δu2+σ2|u|β12u2+C1u2, (3.10)

    where C1=N2ν+κ+N2(ν+κ)(Nβ1+1), and N is sufficiently large such that

    N(2β3)1β1 and  N2(ν+κ)(Nβ1+1)σ2.

    And, because

    |2κΩ×ωAudx|ν+κ4Δu2+4κ2ν+κω2, (3.11)
    |(f1(t),Au)|ν+κ4Δu2+f1(t)2ν+κ, (3.12)

    so combining (3.10)–(3.12) with (3.9), we have

    ddtu2+ν+κ2Au2+σ|u|β12u2+8σ(β1)(β+1)2|u|β+1222C1u2+8κ2ν+κω2+2f1(t)2ν+κC2(u2+ω2+f1(t)2), (3.13)

    where C2=max{2C1,8κ2ν+κ,2ν+κ}.

    Applying uniform Gronwall's inequality to (3.13), we obtaint, tt0+1t1,

    u(t)2+t+1t(ν+κ2Au(s)2+σ|u(s)|β12u(s)2+8σ(β1)(β+1)2|u(s)|β+122)dsC3, (3.14)

    where C3 is a positive constant dependent on C2, I1, and f012L2b.

    Taking the inner product of Δω in H2 with the second equation of (1.1), we get

    12ddtω2+4κω2+γAω2+μω2=b(u,ω,Aω)+2κΩ×uAωdx+(f2(t),Aω)3γ4Aω2+d21γuAuω2+4κ2γu2+1γf2(t)2. (3.15)

    In the last inequality of (3.15), we used Agmon's inequality and the trilinear inequality. Then,

    ddtω2+γ2Aω2+2μω2C4(uAuω2+u2+f2(t)2), (3.16)

    where C4=max{2d21γ,8κ2γ,2γ}.

    By the uniform Gronwall's inequality, we easily obtain that, for tt1+1t2,

    ω(t)2+t+1t(γ2Aω(s)2+2μω(s)2)dsC5, for tt1+1t2, (3.17)

    where C5 is a positive constant dependent on C3,C4, and f022L2b.

    Adding (3.14) with (3.17) yields

    u(s)2+ω(s)2+t+1t(Au(s)2+Aω(s)2+|u(s)|β12u(s)2+|u(s)|β+122)dsC,

    for tt2. Hence, Lemma 3.2 is proved.

    Lemma 3.3. Suppose that (uτ,ωτ)V1×V2 and (f1,f2)H(f01)×H(f02). Then, for β>3, there exists a time t3 and a constant ρ3 such that

    u(t)β+1+ω(t)2ρ3, (3.18)

    for any tt3.

    Proof. Multiplying (1.1)1 by ut, then integrating the equation over Ω, we have

    ut2+ν+κ2ddtu2+σβ+1ddtu(t)β+1β+1=b(u,u,ut)+2κΩ×ωutdx+(f1(t),ut)12ut2+3d212λ1u2Au2+6κ2ω2+32f1(t)2. (3.19)

    The trilinear inequality (2.4), Agmon's inequality, and Poincarˊe's inequality are used in the last inequality of (3.19).

    Hence,

    (ν+κ)ddtu2+2σβ+1ddtu(t)β+1β+1C6(u2Au2+ω2+f1(t)2), (3.20)

    where C6=max{3d21λ1,12κ2,3}.

    By (3.20), using Lemmas 3.1 and 3.2 and the uniform Gronwall's inequality, we have

    u(t)β+1C,  tt2+1t3. (3.21)

    Similar to (3.19), multiplying (1.1)2 by ωt and integrating it over Ω, we get

    ωt2+2κddtω2+γ2ddtω2+μ2ddtω2=b(u,ω,ωt)+2κΩ×uωtdx+(f2(t),ωt)12ωt2+3d212λ1Au2ω2+6κ2u2+32f2(t)2. (3.22)

    Hence,

    4κddtω2+γddtω2+μddtω2C6(Au2ω2+u2+f2(t)2). (3.23)

    By (3.23), using Lemma 3.2 and the uniform Gronwall's inequality, we infer that

    ω(t)2C,  tt3. (3.24)

    The proof of Lemma 3.3 is finished.

    Lemma 3.4. Suppose (uτ,ωτ)V1×V2 and (f1,f2)H(f01)×H(f02). If β>3, then there exists a time t4 and a constant ρ5, such that

    ut(s)2+ωt(s)2ρ5, (3.25)

    for any st4.

    Proof. Taking the inner products of ut and ωt with the first and second equations of (1.1), respectively, and using (3.19) and (3.22), we find

    ut2+ωt2+ν+κ2ddtu2+γ2ddtω2+2κddtω(t)2+σβ+1ddtu(t)β+1β+1+μ2ddtω2=b(u,u,ut)b(u,ω,ωt)+2κΩ×ωutdx+2κΩ×uωtdx+(f1(t),ut)+(f2(t),ωt)12(ut2+ωt2)+C7(f1(t)2+f2(t)2+u2+ω2+u2Au2+ω2Au2), (3.26)

    where C7=max{3d212λ1,6κ2,32}. The trilinear inequality (2.4), Agmon's inequality, and Poincarˊe's inequality are used in the last inequality of (3.26).

    Integrating (3.26) over [t,t+1] and using Lemmas 3.1–3.3, we get

    t+1t(ut(s)2+ωt(s)2)dsρ4, tt3, (3.27)

    where ρ4 is a positive constant dependent on C7,ρ2,ρ3, f012L2b, and f022L2b.

    We now differentiate (2.1)1 with respect to t, then take the inner product of ut with the resulting equation to obtain

    12ddtut2+(ν+κ)ut2=b(ut,u,ut)ΩG(u)ututdx+2κΩ×ωtutdx+(f1t,ut). (3.28)

    Then, we differentiate (2.1)2 with respect to t and take the inner product with ωt to obtain

    12ddtωt2+4κωt2+γωt2+μωt2=b(ut,ω,ωt)+2κΩ×utωtdx+(f2t,ωt). (3.29)

    Adding (3.28) with (3.29), we have

    12ddt(ut2+ωt2)+(ν+κ)ut2+γωt2+4κωt2+μωt2|b(ut,u,ut)|+|b(ut,ω,ωt)|+2κΩ×ωtutdx+2κΩ×utωtdx+(f1t,ut)+(f2t,ωt)ΩG(u)ututdx:=7i=1Li. (3.30)

    From Lemma 2.4 in [15], we know that G(u) is positive definite, so

    L7=ΩG(u)ututdx0. (3.31)

    For L1, using the trilinear inequality (2.5) and Lemma 3.2, we have

    L1kut12ut32uν+κ4ut2+Cut2u4ν+κ4ut2+Cut2, for tt2. (3.32)

    For L2, by H¨older's inequality, Gagliardo-Nirenberg's inequality, and Young's inequality, we have

    L2Cut4ωt4ωCut14ut34ωt14ωt34ων+κ4ut2+γ4ωt2+C(ut2+ωt2), for tt2. (3.33)
    L3+L4ν+κ4ut2+γ2ωt2+C(ut2+ωt2). (3.34)

    By (3.30)–(3.34), we get

    ddt(ut2+ωt2)C(ut2+ωt2)+(f1t,ut)+(f2t,ωt)C(ut2+ωt2)+f1t2+f2t2. (3.35)

    Thanks to

    t+1tf1t(s)2ds≤∥f1t2L2b≤∥h12L2b,t+1tf2t(s)2ds≤∥f2t2L2b≤∥h22L2b,

    and applying uniform Gronwall's inequality to (3.35), we have for any st3+1t4,

    ut(s)2+ωt(s)2C. (3.36)

    Thus, Lemma 3.4 is proved.

    Lemma 3.5. Suppose (uτ,ωτ)V1×V2 and (f1,f2)H(f01)×H(f02). Then, for β>3, there exists a constant ρ6 such that

    Au(t)2+Aω(t)2ρ6, (3.37)

    for any tt4.

    Proof. Taking the inner product of Δu in H1 with the first equation of (1.1), we have

    (ν+κ)Au2+σ|u|β12u2+4σ(β1)(β+1)2|u|β+122=(ut,Au)(B(u),Au)+2κΩ×ωAudx+(f1(t),Au)4(ν+κ)6Au2+32(ν+κ)ut2+32(ν+κ)B(u)2+6κ2ν+κω2+32(ν+κ)f1(t)2. (3.38)

    Because

    32(ν+κ)B(u)232(ν+κ)u2u23d212(ν+κ)u3Δuν+κ6Au2+Cu6, (3.39)

    combining (3.39) with (3.38), we obtain

    ν+κ6Au232(ν+κ)ut2+Cu6+6κ2ν+κω2+32(ν+κ)f1(t)2. (3.40)

    From the assumption of f01(t), we can easily get

    suptRf1(t)∥≤suptRf01(t)∥≤K,f1H(f01). (3.41)

    By Lemmas 3.2 and 3.4, we obtain

    Au(t)C, for any tt4. (3.42)

    Taking the inner product of Aω with (2.1)2, we get

    γAω2+4κω2+μω2=(ωt,Aω)(B(u,ω),Aω)+2κ(×u,Aω)+(f2(t),Aω)γ2Aω2+C(ωt2+B(u,ω)2+u2+f2(t)2). (3.43)

    And, by Agmon's inequality,

    B(u,ω)2Cu2ω2CuΔuω2Au2+Cu2ω4. (3.44)

    From the assumption on f02(t), we can easily obtain

    suptRf2(t)∥≤suptRf02(t)∥≤K,f2H(f02). (3.45)

    By Lemma 3.2, Lemma 3.4, (3.42), (3.43), (3.44), and (3.45), we get

    Aω(t)C, for any tt4. (3.46)

    By (3.42) and (3.46), Lemma 3.5 is proved for all tt4.

    Lemma 3.6. Suppose (uτ,ωτ)V1×V2 and (f1,f2)H(f01)×H(f02). Then, for β>3, there exists a time t5 and a constant ρ7 satisfying

    ut(t)2+ωt(t)2ρ7,tt5. (3.47)

    Proof. In the proof of Lemma 3.4, from (3.30)–(3.34) we can also get

    ddt(ut2+ωt2)+ν+κ2ut2+γ2ωt2+2μωt2C(ut2+ωt2)+f1(t)2+f2(t)2. (3.48)

    Integrating (3.48) from t to t+1, and according to Lemma 3.4, we have

    t+1t(ut(s)2+ωt(s)2+ωt(s)2)dsC(ut(t)2+ωt(t)2+t+1t(ut(s)2+ωt(s)2)ds+t+1tf1t(s)2ds+t+1tf2t(s)2ds)C+h12L2b+h22L2bC, tt4. (3.49)

    By Lemma 3.5, we get

    u(t)H2+ω(t)H2C,tt4. (3.50)

    So, by Lemma 3.2, applying Agmon's inequality, we get

    u(t)+ω(t)C,tt4. (3.51)

    Taking the derivative of (2.1)1 and (2.1)2 with respect to t, then multiplying by Aut and Aωt, respectively, and integrating the resulting equations over Ω, we then have

    12ddt(ut2+ωt2)+(ν+κ)Aut2+γAωt2+4κωt2+μωt2|b(ut,u,Aut)|+|b(u,ut,Aut)|+|b(u,ωt,Aωt)|+|b(ut,ω,Aωt)|    +2κΩ|×ωtAut|dx+2κΩ|×utAωt|dx+|ΩG(u)utAutdx|    +(f1t,Aut)+(f2t,Aωt):=9i=1Ji. (3.52)

    For J1, J2, using (2.6) and Lemmas 3.2 and 3.5, we have

    J1kutu12Au12Autν+κ5Aut2+Cut2, tt4, (3.53)

    and

    J2kuut12Aut12Autkuut12Aut32ν+κ5Aut2+Cut2, tt4. (3.54)

    For J3 and J4, similar to (3.53) and (3.54), we get

    J3kuωt12Aωt12Aωtγ4Aωt2+Cωt2, tt4, (3.55)
    J4kutω12Aω12Aωtγ4Aωt2+Cut2, tt4. (3.56)

    For J5, J6, and J7, applying Hölder's inequality and Young's inequality, we have

    J5+J6ν+κ5Aut2+γ4Aωt2+C(ut2+ωt2), (3.57)

    and thanks to (3.51),

    J7Cuβ1utAutν+κ5Aut2+Cut2, tt4. (3.58)

    For J8 and J9, we have

    J8ν+κ5Aut2+Cf1t2, (3.59)
    J9γ4Aωt2+Cf2t2. (3.60)

    By (3.52)–(3.60), we obtain

    ddt(ut2+ωt2)C(ut2+ωt2)+Cut2+C(f1t2+f2t2). (3.61)

    Then, by (3.27), (3.49), and using the uniform Gronwall's lemma, we get

    ut(s)2+ωt(s)2C, st4+1t5. (3.62)

    Thus, Lemma 3.6 is proved.

    In this section, we consider the existence of the (V1×V2,V1×V2)-uniform (w.r.t. (f1,f2)H(f01)×H(f02)) attractor and the (V1×V2,H2(Ω)×H2(Ω))-uniform attractor for {U(f1,f2)(t,τ)}tτ,f1×f2H(f01)×H(f02).

    Lemma 4.1. Suppose β>3. The family of processes {U(f1,f2)(t,τ)}tτ, f1×f2H(f01)×H(f02), corresponding to (2.1) is ((V1×V2)×(H(f01)×H(f02)),V1×V2)-continuous for τt5.

    Proof. Let τn[τ,+) be a time sequence, U(f(n)1,f(n)2)(t,τ)(uτn,ωτn)=(u(n)(t),ω(n)(t)), U(f1,f2)(t,τ)(uτ,ωτ)=(u(t),ω(t)) and

    (ˉu(n)(t),ˉω(n)(t))=(u(t)u(n)(t),ω(t)ω(n)(t))=U(f1,f2)(t,τ)(uτ,ωτ)U(f(n)1,f(n)2)(t,τ)(uτn,ωτn).

    It is evident that ˉu(n)(t) is the solution of

    ˉu(n)(t)t+B(u)B(u(n)(t))+(ν+κ)Aˉu(n)+G(u)G(u(n))=2κ×ˉω(n)+(f1f(n)1), (4.1)

    and ˉω(n)(t) is the solution of the following system

    ˉω(n)(t)t+B(u,ω)B(u(n),ω(n))+4κˉω(n)+γAˉω(n)μˉω(n)=2κ×ˉu(n)+(f2f(n)2), (4.2)

    for each n.

    Taking the inner product of (4.1) with Aˉu(n) in H1, we get

    12ddtˉu(n)2+b(u,u,Aˉu(n))b(u(n),u(n),Aˉu(n))+(ν+κ)Aˉu(n)2+(G(u)G(u(n)),Aˉu(n))=2κ(×ˉω(n),Aˉu(n))+(f1f(n)1,Aˉu(n)). (4.3)

    Taking the inner product of (4.2) with Aˉω(n) in H2, we have

    12ddtˉω(n)2+b(u,ω,Aˉω(n))b(u(n),ω(n),Aˉω(n))+4κˉω(n)2+γAˉω(n)2+μˉω(n)2=2κ(×ˉu(n),Aˉω(n))+(f2f(n)2,Aˉω(n)). (4.4)

    Combining (4.3) with (4.4), we get

    12ddt(ˉu(n)2+ˉω(n)2)+b(u,u,Aˉu(n))b(u(n),u(n),Aˉu(n))+(ν+κ)Aˉu(n)2+(G(u)G(u(n)),Aˉu(n))+b(u,ω,Aˉω(n))b(u(n),ω(n),Aˉω(n))+4κˉω(n)2+γAˉω(n)2+μˉω(n)2=2κ(×ˉω(n),Aˉu(n))+2κ(×ˉu(n),Aˉω(n))+(f1f(n)1,Aˉu(n))+(f2f(n)2,Aˉω(n)). (4.5)

    Due to

    b(u,u,Aˉu(n))b(u(n),u(n),Aˉu(n))=b(ˉu(n),u,Aˉu(n))+b(u(n),ˉu(n),Aˉu(n)), (4.6)
    b(u,ω,Aˉω(n))b(u(n),ω(n),Aˉω(n))=b(ˉu(n),ω,Aˉω(n))+b(u(n),ˉω(n),Aˉω(n)), (4.7)

    and

    |b(ˉu(n),u,Aˉu(n))|kˉu(n)u12Au12Aˉu(n)ν+k5Aˉu(n)2+Cˉu(n)2uAu, (4.8)
    |b(u(n),ˉu(n),Aˉu(n))|ku(n)ˉu(n)12Aˉu(n)12Aˉu(n)ν+k5Aˉu(n)2+Cu(n)4ˉu(n)2, (4.9)
    b(ˉu(n),ω,Aˉω(n))kˉu(n)ω12Aω12Aˉω(n)γ4Aˉω(n)2+Cˉu(n)2ωAω, (4.10)
    b(u(n),ˉω(n),Aˉω(n))ku(n)ˉω(n)12Aˉω(n)12Aˉω(n)γ4Aˉω(n)2+Cu(n)4ˉω(n)2, (4.11)
    2κ|(×ˉω(n),Aˉu(n))|2κAˉu(n)ˉω(n)ν+k5Aˉu(n)2+Cˉω(n)2, (4.12)
    2κ|(×ˉu(n),Aˉω(n))2κAˉω(n)ˉu(n)γ4Aˉω(n)2+Cˉu(n)2, (4.13)
    |(f1f(n)1,Aˉu(n))|ν+k5Aˉu(n)2+54(ν+κ)f1f(n)12, (4.14)
    |(f2f(n)2,Aˉω(n))|γ4Aˉω(n)2+1γf2f(n)22, (4.15)
    G(u)G(u(n))2=Ω|σ|u|β1uσ|u(n)|β1u(n)|2dxCΩ[|u|β1|ˉu(n)|+||u|β1|u(n)|β1||u(n)|]2dxCΩ|u|2(β1)|ˉu(n)|2dx+CΩ[|u|β2+|u(n)|β2]2|u(n)|2|ˉu(n)|2dxC[u2(β1)+(u2(β2)+u(n)2(β2))u(n)2]ˉu(n)2, (4.16)

    where ˉu(n)(t)=u(t)un(t). In the above inequality, we used the fact that

    |xpyp|cp(|x|p1+|y|p1)|xy|

    for any x,y0, where c is an absolute constant.

    Therefore,

    (G(u)G(u(n)),Aˉu(n))ν+κ5Aˉu(n)2+54(ν+κ)G(u)G(u(n))2C[u2(β1)+(u2(β2)+u(n)2(β2))u(n)2]ˉu(n)2+ν+k5Aˉu(n)2. (4.17)

    By (4.5)–(4.15) and (4.17), we obtain

    ddt(ˉu(n)2+ˉω(n)2)C[u2(β1)+(u2(β2)+u(n)2(β2))u(n)2+uAu+u(n)4+ωAω+1](ˉu(n)2+ˉω(n)2)+52(ν+κ)f1f(n)12+2γf2f(n)22. (4.18)

    Using Gronwall's inequality in (4.18) yields

    ˉu(n)2+ˉω(n)2(ˉu(n)τ2+ˉω(n)τ2+52(ν+κ)tτf1f(n)12ds    +2γtτf2f(n)22ds)    exp{Ctτ[u2(β1)+(u2(β2)+u(n)2(β2))u(n)2    +uAu+u(n)4+ωAω+1]ds}. (4.19)

    From Lemmas 3.2 and 3.5, and using Agmon's inequality, we know that

    u<C,u(n)<C,tt5.

    So, from Lemmas 3.2–3.5, we have

    exp{Ctτ[u2(β1)+(u2(β2)+u(n)2(β2))u(n)2+uAu+u(n)4+ωAω+1]ds}<+,

    for any given t and τ, tτ, τt5.

    Thus, from (4.19), we have that {U(f1,f2)(t,τ)}tτ, f1×f2H(f01)×H(f02) is ((V1×V2)×(H(f01)×H(f02)),V1×V2)-continuous, for τt5.

    By Lemma 3.5, the fact of compact imbedding H2×H2V1×V2, and Theorem 3.1 in [16], we have the following theorems.

    Theorem 4.1. Suppose β>3. The family of processes {U(f1,f2)(t,τ)}tτ, f1×f2H(f01)×H(f02) with respect to problem (1.1) has a (V1×V2,V1×V2) uniform attractor A1. Moreover,

    A1=(f1,f2)H(f01)×H(f02)K(f1,f2)(0), (4.20)

    where K(f1,f2)(0) is the section at t=0 of kernel K(f1,f2) of the processes {U(f1,f2)(t,τ)}tτ.

    Theorem 4.2. Suppose β>3. The family of processes {U(f1,f2)(t,τ)}tτ, f1×f2H(f01)×H(f02) with respect to problem (1.1) has a (V1×V2,H2(Ω)×H2(Ω))-uniform attractor A2. A2 is compact in H2(Ω)×H2(Ω), and it attracts every bounded subset of V1×V2 in the topology of H2(Ω)×H2(Ω).

    Proof. By Theorem 2.2, we only need to prove that {U(f1,f2)(t,τ)}tτ, f1×f2H(f01)×H(f02) acting on V1×V2 is (V1×V2,H2(Ω)×H2(Ω))-uniform (w.r.t.  f1×f2H(f01)×H(f02)) asymptotically compact.

    Thanks to Lemma 3.5, we know that B={(u×ω)H2×H2:Au2+Aω2C} is a bounded (V1×V2,H2(Ω)×H2(Ω))-uniform absorbing set of {U(f1,f2)(t,τ)}tτ. Then, we just need to prove that, for any τnR, any t+, and (uτn,ωτn)B, {(un(t),ωn(t))}n=0 is precompact in H2(Ω)×H2(Ω), where(un(t),ωn(t))=U(f1,f2)(t,τn)(uτn,ωτn).

    Because V1H1,V2H2 are compact, from Lemma 3.6 we obtain that {ddtun(t)}n=0, {ddtωn(t)}n=0 are precompact in H1 and H2, respectively.

    Next, we will prove {un(t)}n=0, {ωn(t)}n=0 are Cauchy sequences in H2(Ω). From (2.1), we have

    (ν+κ)(Aunk(t)Aunj(t))=ddtunk(t)+ddtunj(t)B(unk(t))+B(unj(t))G(unk(t))+G(unj(t))+2κ×ωnk(t)2κ×ωnj(t). (4.21)
    γ(Aωnk(t)Aωnj(t))μωnk(t)+μωnj(t)=ddtωnk(t)+ddtωnj(t)B(unk(t),ωnk(t))+B(unj(t),ωnj(t))4κωnk(t)+4κωnj(t)+2κ×unk(t)2κ×unj(t). (4.22)

    Multiplying (4.21) by Aunk(t)Aunj(t), we obtain

    (ν+κ)Aunk(t)Aunj(t)2≤∥ddtunk(t)ddtunj(t)Aunk(t)Aunj(t)+B(unk(t))B(unj(t))Aunk(t)Aunj(t)+G(unk(t))G(unj(t))Aunk(t)Aunj(t)   +2κωnk(t)ωnj(t)Aunk(t)Aunj(t)4(ν+κ)5Aunk(t)Aunj(t)2+54(ν+κ)ddtunk(t)ddtunj(t)2   +54(ν+κ)B(unk(t))B(unj(t))2+54(ν+κ)G(unk(t))G(unj(t))2   +5κ2ν+κωnk(t)ωnj(t)2,

    so we have

    ν+κ5Aunk(t)Aunj(t)254(ν+κ)ddtunk(t)ddtunj(t)2   +54(ν+κ)B(unk(t))B(unj(t))2   +54(ν+κ)G(unk(t))G(unj(t))2   +5κ2ν+κωnk(t)ωnj(t)2. (4.23)

    Multiplying (4.22) by Aωnk(t)Aωnj(t) we obtain

    γAωnk(t)Aωnj(t)2+μ(ωnk(t)ωnj(t))2≤∥ddtωnk(t)ddtωnj(t)Aωnk(t)Aωnj(t)+B(unk(t),ωnk(t))B(unj(t),ωnj(t))   Aωnk(t)Aωnj(t)+4κωnk(t)ωnj(t)Aωnk(t)Aωnj(t)   +2κunk(t)unj(t)Aωnk(t)Aωnj(t)4γ5Aωnk(t)Aωnj(t)2+54γddtωnk(t)ddtωnj(t)2   +54γB(unk(t),ωnk(t))B(unj(t),ωnj(t))2+20κ2γωnk(t)ωnj(t))2   +5κ2γunk(t)unj(t)2,

    so we get

       γ5Aωnk(t)Aωnj(t)2+μ(ωnk(t)ωnj(t))254γddtωnk(t)ddtωnj(t)2+54γB(unk(t),ωnk(t))B(unj(t),ωnj(t))2   +20κ2γωnk(t)ωnj(t)2+5κ2γunk(t)unj(t)2. (4.24)

    Combining (4.23) with (4.24), we have

       ν+κ5Aunk(t)Aunj(t)2+γ5Aωnk(t)Aωnj(t)254(ν+κ)ddtunk(t)ddtunj(t)2+54(ν+κ)B(unk(t))B(unj(t))2   +54(ν+κ)G(unk(t))G(unj(t))2+5κ2ν+κωnk(t)ωnj(t)2   +54γddtωnk(t)ddtωnj(t)2+54γB(unk(t),ωnk(t))B(unj(t),ωnj(t))2   +20κ2γωnk(t)ωnj(t)2+5κ2γunk(t)unj(t)2. (4.25)

    Because V2H2 is compact, from Lemma 3.2 we know that {ωn(t)}n=0 is precompact in H2. And, using the compactness of embedding H2(Ω)V1,H2(Ω)V2 and Lemma 3.5, we have that {un(t)}n=0,{ωn(t)}n=0 are precompact in V1 and V2, respectively. Considering V1H1,V2H2 are compact, from Lemma 3.6 we know that {ddtun(t)}n=0, {ddtωn(t)}n=0 are precompact in H1 and H2, respectively.

    Using (2.6), we have

       B(unk(t))B(unj(t))2C(B(unk(t),unk(t)unj(t))2+B(unk(t)unj(t),unj(t))2)C(unk(t)2(unk(t)unj(t))∥∥A(unk(t)unj(t))    +(unk(t)unj(t))2unj(t)∥∥Aunj(t))0,as k,j+, (4.26)

    and

        B(unk(t),ωnk(t))B(unj(t),ωnj(t))2C(B(unk(t),ωnk(t)ωnj(t))2+B(unk(t)unj(t),ωnj(t))2)C(unk(t)2(ωnk(t)ωnj(t))∥∥A(ωnk(t)ωnj(t))    +(unk(t)unj(t))2ωnj(t)∥∥Aωnj(t))0, as k,j+. (4.27)

    From the proof of Lemma 4.2 in [15], we have

    G(unk(t))G(unj(t))2Cunk(t)unj(t)20, as k,j+. (4.28)

    Taking into account (4.25)–(4.28), we have

    ν+κ5Aunk(t)Aunj(t)2+γ5Aωnk(t)Aωnj(t)20, as k,j+. (4.29)

    (4.29) indicates that the processes {U(f1,f2)(t,τ)}tτ are uniformly asymptotically compact in H2(Ω)×H2(Ω). So, by Theorem 2.2, it has a (V1×V2,H2(Ω)×H2(Ω))-uniform attractor A2.

    Theorem 4.3. Suppose β>3. The (V1×V2,V1×V2)-uniform attractor A1 of the family of processes {U(f1,f2)(t,τ)}tτ, f1×f2H(f01)×H(f02) is actually the (V1×V2,H2(Ω)×H2(Ω))-uniform attractor A2, i.e., A1=A2.

    Proof. First, we will prove A1A2. Because A2 is bounded in H2(Ω)×H2(Ω), and the embedding H2(Ω)×H2(Ω)V1×V2 is continuous, A2 is bounded in V1×V2. From Theorem 4.2, we know that A2 attracts uniformly all bounded subsets of V1×V2, so A2 is a bounded uniform attracting set of {U(f1,f2)(t,τ)}tτ, f1×f2H(f01)×H(f02) in V1×V2. By the minimality of A1, we have A1A2.

    Now, we will prove A2A1. First, we will prove A1 is a (V1×V2,H2(Ω)×H2(Ω))-uniformly attracting set of {U(f1,f2)(t,τ)}tτ, f1×f2H(f01)×H(f02). That is to say, we will prove

    limt+(sup(f1,f2)H(f01)×H(f02)distH2(Ω)×H2(Ω)(U(f1,f2)(t,τ)B,A1))=0, (4.30)

    for any τR and BB(V1×V2).

    If we suppose (4.30) is not valid, then there must exist some τR, BB(V1×V2), ε0>0, (f(n)1,f(n)2)H(f01)×H(f02), and tn+, when n+, such that, for all n1,

    distH2(Ω)×H2(Ω)(U(f(n)1,f(n)2)(tn,τ)B,A1)2ε0. (4.31)

    This shows that there exists (un,ωn)B such that

    distH2(Ω)×H2(Ω)(U(f(n)1,f(n)2)(tn,τ)(un,ωn),A1)ε0. (4.32)

    In the light of Theorem 4.2, {U(f1,f2)(t,τ)}tτ, f1×f2H(f01)×H(f02) has a (V1×V2,H2(Ω)×H2(Ω))-uniform attractor A2 which attracts any bounded subset of V1×V2 in the topology of H2(Ω)×H2(Ω). Therefore, there exists (ζ,η)H2(Ω)×H2(Ω) and a subsequence of U(f(n)1,f(n)2)(tn,τ)(un,ωn) such that

    U(f(n)1,f(n)2)(tn,τ)(un,ωn)(ζ,η)strongly in H2(Ω)×H2(Ω). (4.33)

    On the other side, the processes {U(f1,f2)(t,τ)}tτ, f1×f2H(f01)×H(f02) have a (V1×V2,V1×V2)-uniform attractor A1, which attracts uniformly any bounded subsets of V1×V2 in the topology of V1×V2. So, there exists (u,ω)V1×V2 and a subsequence of U(f(n)1,f(n)2)(tn,τ)(un,ωn) such that

    U(f(n)1,f(n)2)(tn,τ)(un,ωn)(u,ω) strongly in V1×V2. (4.34)

    From (4.33) and (4.34), we have (u,ω)=(ζ,η), so (4.33) can also be written as

    U(f(n)1,f(n)2)(tn,τ)(un,ωn)(u,ω) strongly in H2(Ω)×H2(Ω). (4.35)

    And, from Theorem 4.1, we know that A1 attracts B, so

    limn+distV1×V2(U(f(n)1,f(n)2)(tn,τ)(un,ωn),A1)=0. (4.36)

    By (4.34), (4.36), and the compactness of A1 in V1×V2, we have (u,ω)A1. Considering (4.35), we have

    limn+distH2(Ω)×H2(Ω)(U(f(n)1,f(n)2)(tn,τ)(un,ωn),A1)limn+distH2(Ω)×H2(Ω)(U(f(n)1,f(n)2)(tn,τ)(un,ωn),(u,ω))=0,

    which contradicts (4.32). Therefore, A1 is a (V1×V2,H2(Ω)×H2(Ω))-uniform attractor of {U(f1,f2)(t,τ)}tτ, f1×f2H(f01)×H(f02), and by the minimality of A2, we have A2A1.

    In this paper, we discussed the existence of uniform attractors of strong solutions for 3D incompressible micropolar equations with nonlinear damping. Based on some translation-compactness assumption on the external forces, and when β>3, we made a series of uniform estimates on the solutions in various functional spaces. According to these uniform estimates, we proved the existence of uniform attractors for the process operators corresponding to the solution of the equation in V1×V2 and H2×H2, and verified that the uniform attractors in V1×V2 and H2×H2 are actually the same.

    The authors declare they have not used Artificial Intelligence (AI) tools in the creation of this article.

    The authors are thankful to the editors and the anonymous reviewers for their valuable suggestions and comments on the manuscript. This work is supported by National Natural Science Foundation of China (Nos. 11601417, 12001420).

    The authors declare no conflict of interest in this paper.


    Acknowledgments



    This study was funded by the Deanship of Scientific research and graduate studies at Philadelphia University in Jordan.

    Conflict of interest



    All authors declare no conflicts of interest in this paper.

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