TRPV1 is a potential biomarker for the prediction and treatment of multiple cancers based on a pan-cancer analysis

Tao Huang; Tao Huang

doi:10.3934/mbe.2022389

Mathematical Biosciences and Engineering

2022, Volume 19, Issue 8: 8361-8379. doi: 10.3934/mbe.2022389

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Research article

TRPV1 is a potential biomarker for the prediction and treatment of multiple cancers based on a pan-cancer analysis

Tao Huang ^,

Department of Cardiothoracic Vascular Surgery, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, China

Received: 21 March 2022 Revised: 06 May 2022 Accepted: 19 May 2022 Published: 09 June 2022

Background
Transient receptor potential cation channel subfamily V member 1 (TRPV1) was considered to play pivotal roles in multiple cancers; however, the expression and clinical significance of the TRPV1 remain unclear, which were explored in this study.

Results
The pan-cancer analysis was performed based on 10,236 samples in 32 cancers. Differential TRPV1 expression levels were detected in 12 cancers (p < 0.05). TRPV1 demonstrated its conspicuous prognosis significance and prediction effects for some cancers (e.g., lung adenocarcinoma), indicating its potential as a valuable and novel biomarker in treating and predicting cancers. TRPV1 expression was relevant to DNA methyltransferases, mismatch repair genes, tumor mutational burden, and microsatellite instability. TRPV1 expression was associated with the immune microenvironment of some cancers, and its roles in different cancers may be mediated by affecting various immune cells. Gene set enrichment analysis discloses the significant relevance of TRPV1 expression with a series of metabolic and immunoregulatory-related pathways.

Conclusions
This study provided a comprehensive workflow of the expression, clinical significance, and underlying mechanisms of TRPV1 in pan-cancer. TRPV1 may be an underlying biomarker for predicting and treating multiple cancer.
- cancer biology,
- cancer genetics,
- prognosis,
- immunology,
- biomarkers
Citation: Tao Huang. TRPV1 is a potential biomarker for the prediction and treatment of multiple cancers based on a pan-cancer analysis[J]. Mathematical Biosciences and Engineering, 2022, 19(8): 8361-8379. doi: 10.3934/mbe.2022389

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Abstract

Background

Transient receptor potential cation channel subfamily V member 1 (TRPV1) was considered to play pivotal roles in multiple cancers; however, the expression and clinical significance of the TRPV1 remain unclear, which were explored in this study.

Results

The pan-cancer analysis was performed based on 10,236 samples in 32 cancers. Differential TRPV1 expression levels were detected in 12 cancers (p < 0.05). TRPV1 demonstrated its conspicuous prognosis significance and prediction effects for some cancers (e.g., lung adenocarcinoma), indicating its potential as a valuable and novel biomarker in treating and predicting cancers. TRPV1 expression was relevant to DNA methyltransferases, mismatch repair genes, tumor mutational burden, and microsatellite instability. TRPV1 expression was associated with the immune microenvironment of some cancers, and its roles in different cancers may be mediated by affecting various immune cells. Gene set enrichment analysis discloses the significant relevance of TRPV1 expression with a series of metabolic and immunoregulatory-related pathways.

Conclusions

This study provided a comprehensive workflow of the expression, clinical significance, and underlying mechanisms of TRPV1 in pan-cancer. TRPV1 may be an underlying biomarker for predicting and treating multiple cancer.

References

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