Research article Special Issues

Cytomegalovirus dynamics model with random behavior

  • In view of the particularity of cytomegalovirus infection in infants and considering the uncertainty of infection mode and treatment, a dynamic model of cytomegalovirus with random behavior is established in this paper. The existence and uniqueness of the solution of the model are proved. Sufficient conditions for the existence of asymptotic, ergodic and extinctive solutions are provided. By using numerical simulation, the influence of uncertainty in breast milk handling and treatment on the variation of cytomegalovirus (CMV) are analyzed, which provides theoretical support for the strategy of preventing infant infection and the basis treatment.

    Citation: Dong-Mei Li, Bing Chai, Yu-Li Fu, Qi Wang. Cytomegalovirus dynamics model with random behavior[J]. AIMS Mathematics, 2020, 5(6): 6373-6394. doi: 10.3934/math.2020410

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  • In view of the particularity of cytomegalovirus infection in infants and considering the uncertainty of infection mode and treatment, a dynamic model of cytomegalovirus with random behavior is established in this paper. The existence and uniqueness of the solution of the model are proved. Sufficient conditions for the existence of asymptotic, ergodic and extinctive solutions are provided. By using numerical simulation, the influence of uncertainty in breast milk handling and treatment on the variation of cytomegalovirus (CMV) are analyzed, which provides theoretical support for the strategy of preventing infant infection and the basis treatment.


    The presence of singularities and degeneracies in elliptic equations introduces significant challenges in analyzing the behavior of solutions. These singularities, especially near the origin or boundary, can profoundly affect the properties of the operator, making solutions more sensitive to changes in the domain. For instance, when 1<p<N, it is known that ˜u/|y|Lp(RN) if ˜uW1,p(RN), or ˜u/|y|Lp(Ω) when ˜uW1,p(Ω), where Ω is a bounded domain (see Lemma 2.1 in [12] for further details). In this context, the solution under consideration is ˜u, and such behavior leads to the development of Hardy-type inequalities, which are crucial for controlling the singularities of solutions near critical points, particularly when the equation includes singular potential terms (see, e.g., [1,12,17,18,20]).

    Furthermore, the presence of an indefinite weight in the source term creates several challenges, mainly because it can change sign or behave irregularly. This complicates the application of standard methods for proving the existence of solutions, such as ensuring the necessary properties of the energy functional. The irregular behavior of the weight also makes it difficult to use common mathematical tools like Sobolev embeddings and variational methods. To overcome these difficulties, this manuscript employs a more flexible approach based on critical point theory [4], which allows establishing the existence of solutions despite the complexities introduced by the indefinite weight.

    Finally, the degeneracy of differential operators, such as p-Laplacian or p(x)-Laplacian, when coupled with a weight function ω(x) inside the divergence, introduces additional complexity to the problem. The presence of ω(x), whether it is singular or merely bounded, requires a shift in the selection of appropriate functional spaces. Traditional Sobolev spaces like W1,p(Ω) or W1,p(x)(Ω) may no longer be adequate in such cases. To properly handle the singularities or degeneracies, it becomes necessary to consider alternative Sobolev spaces, such as W1,p(x)(ω,Ω) (see section 2 for the definition of W1,p(ω,Ω)), which are specifically designed to accommodate the weight function (see [6] for further details). The most recent contribution to the study of the p Laplacian in a bounded domain and in the whole space can be found in respectively in [5] and [3], furthermore, the degenerate p-Laplacian operator combined with a Hardy potential can be found in [16].

    This paper tackles the challenges posed by degeneracy, Hardy-type singularities, and sign-changing source terms, which are common in applied mathematical models, by examining a class of weighted quasilinear elliptic Dirichlet problem involving a variable exponent p(x) and an indefinite source term. The main objective is to prove the existence of three weak solutions, using a critical point theorem introduced by Bonanno and Moranno in [4] while accounting for the complexities introduced by the operator's degeneracy and the singularities in the equation.

    This manuscript explores the multiplicity of weak solutions to a weighted elliptic equations of the form:

    {Δp(x),a(x,u)u+b(x)|u|q2u|x|q=λk(x)|u|s(x)2uin Ω,u=0on Ω, (1.1)

    where λ is a positive parameter, 1<q<N, and ΩRN (with N2) is a bounded open subset with smooth boundary Ω. The function u is a solution to a weighted quasilinear elliptic equation involving a variable exponent p(x)C+(¯Ω)(see, the beginning of Section 2) and the nonlinear source term of the form k(x)|u|s(x)2u which involves a weight function k(x) and may exhibit singularities on Ω and can change sign, belongs to a nonstandard Lebesgue space Lγ(x)(Ω).

    The operator Δp(x),a(x,u)u represents a nonlinear generalization of the classical Laplacian, defined by:

    Δp(x),a(x,u)u=div(a(x,u)|u|p(x)2u),

    here a(x,u) denotes a Carathéodory function satisfying the inequality:

    a1ω(x)a(x,u)a2ω(x),

    with a1,a2 are two positive constants, the function ω(x) is assumed to belongs to the local Lebesgue space L1loc(Ω), and it satisfies additional growth conditions, such as ωh(x)L1(Ω), where h(x) satisfies certain bounds related to the variable exponent p(x). Specifically, we assume that

    (ω)ωh(x)L1(Ω),forh(x)C(¯Ω)andh(x)(Np(x),+)[1p(x)1,+).

    The nonlinearity in the equation involves the functions k(x) and s(x), which are assumed to satisfy the following inequality for almost every xΩ

    (k)1<s(x)<ph(x)<N<γ(x),

    where ph(x)=h(x)p(x)h(x)+1.

    Set, S(Ω), the space that contains all measurable functions in Ω and

    C+(¯Ω)={p(x)|p(x)C(¯Ω), p(x)>1, x¯Ω},
    p+=maxx¯Ωp(x),p=minx¯Ωp(x).

    For τ>0, and p(x)C+(¯Ω), we use the following notations

    τˆp=max{τp, τp+},  τˇp=min{τp, τp+}.

    In the sequel, we define the space Lp(x)(ω,Ω) as follows

    Lp(x)(ω,Ω)={uS(Ω)Ωω(x)|u(x)|p(x)dx<},

    where p(x) is a variable exponent, and ω(x) is a weight function. The space is endowed with a Luxemburg-type norm, given by:

    uLp(x)(ω,Ω)=inf{ν>0Ωω(x)|u(x)ν|p(x)dx1}.

    Next, we define the corresponding variable exponent Sobolev space, which incorporates the variable exponent p(x) in the functional setting.

    W1,p(x)(Ω)={uLp(x)(Ω): |u|Lp(x)(Ω)},

    with the norm

    uW1,p(x)(Ω)=up(x)+up(x),

    where up(x)=|u|p(x),|u|=(Ni=1|uxi|2)12,u=(ux1,ux2,...,uxN) is the gradient of u at (x1,x2,...,xN).

    Denote, by

    W1,p(x)(ω,Ω)={uLp(x)(Ω):ω1p(x)|u|Lp(x)(Ω)}

    the weighted Sobolev space and by W1,p(x)0(ω,Ω) as the closure of C0(Ω) in the space W1,p(x)(ω,Ω) endowed with the norm

    u=inf{ν>0:Ωω(x)|u(x)ν|p(x)dx1}.

    Lemma 2.1. [8] If p1(x),p2(x)C+(¯Ω) such that p1(x)p2(x) a.e. xΩ, then there exists the continuous embedding W1,p2(x)(Ω)W1,p1(x)(Ω).

    Proposition 2.1 ([9]) For p(x)C+(¯Ω),u,unLp(x)(Ω), one has

    min{upp(x),up+p(x)}Ω|u(x)|p(x)dxmax{upp(x),up+p(x) }.

    Let 0<d(x)S(Ω), and define the space

    Lp(x)(d,Ω):=Lp(x)d(x)(Ω)={uS(Ω)Ωd(x)|u(x)|p(x)dx<},

    where p(x) is a variable exponent, and d(x) is a weight function. The space is equipped with a Luxemburg-type norm, defined by

    uLp(x)d(x)(Ω)=u(p(x),d(x)):=inf{ν>0Ωd(x)|u(x)ν|p(x)dx1}.

    Proposition 2.2 ([10]) If pC+(¯Ω). Then

    min{up(p(x),d(x)),up+(p(x),d(x))}Ωd(x)|u(x)|p(x)dxmax{up(p(x),d(x)),up+(p(x),d(x))}

    for every uLp(x)d(x)(Ω) and for a.e. xΩ.

    Combining Proposition 2.1 with Proposition 2.2, one has

    Lemma 2.2. Let

    ρω(u)=Ωω(x)|u(x)|p(x)dx.

    For pC+(¯Ω),uW1,p(x)(ω,Ω), we have

    min{up,up+}ρω(u)max{up,up+}.

    From Proposition 2.4 of [20], if (ω) holds, W1,p(x)(ω,Ω) is a reflexive separable Banach space.

    From Theorem 2.11 of [15], if (ω) holds, the following embedding

    W1,p(x)(ω,Ω)W1,ph(x)(Ω) (2.1)

    is continuous, where

    ph(x)=p(x)h(x)h(x)+1<p(x).

    Combining (2.1) with Proposition 2.7 and Proposition 2.8 in [11], we get the following embedding

    W1,p(x)(ω,Ω)Lr(x)(Ω)

    is continuous, where

     1r(x)ph(x)=Nph(x)Nph(x)=Np(x)h(x)Nh(x)+Np(x)h(x).

    Furthermore, the following embedding

    W1,p(x)(ω,Ω)↪↪Lt(x)(Ω)

    is compact, when 1t(x)<ph(x).

    In what follows, and for any p(x)C+(¯Ω), let us denote by p(x):=p(x)p(x)1, the conjugate exponent of p(x).

    Remark 2.1. Under Condition (k), one has

    1<β(x)<ph(x) for almost every xΩ, where β(x):=γ(x)s(x)γ(x)s(x), consequently

    W1,p(x)(ω,Ω)↪↪Lβ(x)(Ω)

    is compact.

    1<α(x)<ph(x) for almost every xΩ, where α(x)=γ(x)s(x), consequently

    W1,p(x)(ω,Ω)↪↪Lα(x)(Ω)

    is compact.

    Lemma 2.3 (Hölder type inequality [2,11]). Let p1,p2,t1 three functions that belong in S(Ω) such that

    1t(x)=1p1(x)+1p2(x),for almost every xΩ.

    If fLp1(x)(Ω) and gLp2(x)(Ω), then fgLt(x)(Ω), moreover

    fgt(x)2fp1(x)gp2(x).

    Similarly, if 1t(x)+1p1(x)+1p2(x)=1, for a.e. xΩ, then

    Ω|f(x)g(x)h(x)|dx3ft(x)gp1(x)hp2(x).

    Lemma 2.4 ([7]). Let r1(x) and r2(x) be measurable functions such that r1(x)L(Ω), and 1r1(x)r2(x), for a.e. xΩ. Let wLr2(x)(Ω), w0. Then

    wˇr1r1(x)r2(x)|w|p(x)r2(x)wˆpr1(x)r2(x).

    Let's define the functional Iλ:W1,p(x)0(ω,Ω)R as

    Iλ(u):=L(u)λM(u),

    where

    L(u):=Ωa(x,u)p(x)|u|p(x)dx+1qΩb(x)|u|q|x|qdx, (2.2)

    and

    M(u):=Ω1s(x)k(x)|u|s(x)dx. (2.3)

    It is noted that, based on Remark 2.1 and Lemma 2.4, the aforementioned functionals are both well-defined and continuously Gâteaux differentiable (see [14] for further details). The Gâteaux derivatives are as follows

    L(u),v=Ωa(x,u)|u|p(x)2uvdx+Ωb(x)|u|q2uv|x|qdx,

    and

    M(u),v=Ωk(x)|u|s(x)2uvdx.

    Furthermore, M(u) is compact in the dual space (W1,p(x)0(ω,Ω)) (see [14]).

    uW1,p(x)0(ω,Ω) is said to be a weak solution of the problem (1.1) if, the following holds for every vW1,p(x)0(ω,Ω).

    Iλ(u),v=L(u),vλM(u),v=0.

    Lemma 2.5. L is a strictly monotone coercive functional that belongs in (W1,p(x)0(ω,Ω)).

    Proof. For any uW1,p(x)0(ω,Ω){0}, by Lemma 2.2, one has

    L(u)(u)=Ωa(x,u)|u|p(x)2uudx+Ωb(x)|u|q2u2|x|qdxa1ρω(u)a1min{up+,up},

    thus

    limuL(u)(u)ua1limumin{up+,up}u=+,

    then L is coercive in view of p(x)C+(¯Ω).

    According to (2.2) of [13], for all x,yRN, there is a positive constant Cp such that

    |x|p2x|y|p2y,xyCp|xy|p, if p2,

    and

    |x|p2x|y|p2y,xyCp|xy|2(|x|+|y|)2p, if 1<p<2, and (x,y)(0,0),

    where .,. is the usual inner product in RN. Thus, for any u,vX satisfying uv, by standard arguments we can obtain

    L(u)L(v),uv=Ωa(x,u)(|u|p(x)2u|v|p(x)2v)(uv)dx      +Ωb(x)|x|q(|u|q2u|v|q2v)(uv))dx>0,

    hence, one has L is strictly monotone in W1,p(x)0(ω,Ω).

    Lemma 2.6. The functional L is a mapping of (S+)-type, i.e. if unu in W1,p(x)0(ω,Ω), and ¯limnL(un)L(u),unu)0, then unu in W1,p(x)0(ω,Ω).

    Proof. Let unu in W1,p(x)0(ω,Ω), and ¯limnL(un)L(u),unu0.

    Noting that L is strictly monotone in W1,p(x)0(ω,Ω), we have

    limnL(un)L(u),unu=0,

    while

    L(un)L(u),unu=Ωa(x,u)(|un|p(x)2un|u|p(x)2u)(unu)dx   +Ω(b(x)|un|q2|x|qun(unu)b(x)|u|q2|x|qu(unu))dx,

    thus we get

    ¯limnΩa(x,u)(|un|p(x)2un|u|p(x)2u)(unu)dx0.

    Further, by (1.2) one has

    ¯limnΩω(x)(|un|p(x)2un|u|p(x)2u)(unu)dx0,

    then unu in W1,p(x)0(ω,Ω) via Lemma 3.2 in [19].

    Lemma 2.7. L is an homeomorphism.

    Proof. The strict monotonicity of L implies that it is injective. Since L is coercive, it is also surjective, and hence L has an inverse mapping.

    Next, we show that the inverse mapping (L)1 is continuous.

    Let ˜fn,˜f(W1,p(x)0(ω,Ω)) such that ˜fn˜f. We aim to prove that (L)1(˜fn)(L)1(˜f).

    Indeed, let (L)1(˜fn)=un and (L)1(˜f)=u, so that L(un)=˜fn and L(u)=˜f. By the coercivity of L, the sequence un is bounded. Without loss of generality, assume unu0, which implies

    limn(L(un)L(u),unu0)=limn(˜fn˜f,unu0)=0.

    Thus, unu0 because L is of (S+)-type, which ensures that L(un)L(u0). Combining this with L(un)L(u), we deduce that L(u)=L(u0). Since L is injective, it follows that u=u0, and hence unu. Therefore, we have (L)1(˜fn)(L)1(˜f), proving that (L)1 is continuous.

    The following critical point theorems constitute the principal tools used to obtain our result.

    Theorem 2.1. ([4, Theorem 3.6]). Let X be a reflexive real Banach space and assume the following

    L:XR be a coercive functional that is continuously Gateaux differentiable and weakly lower semicontinuous in the sequential sense

    The Gateaux derivative of L has a continuous inverse on the dual space X.

    M:XR is a continuously Gateaux differentiable functional whith a compact Gateaux derivative.

    Furthermore, suppose that

    (a0)infXL=L(0)=0 and M(0)=0.

    There exist a positive constant d and a point ¯vX such that d06L(¯v), and the following conditions are satisfied:

    (a1)supL(x)<dM(x)d<M(¯v)L(¯v),
    (a2)For each λΛd:=(L(¯v)M(¯v),dsupL(x)dM(x)),the functional Iλ:=LλM is coercive.

    Then, for any λΛd, LλM has at least three distinct critical points in X.

    In this section, a theorem about the existence of at least three weak solutions to the problem (1.1) is obtained.

    Recall the Hardy inequality (refer to Lemma 2.1 in [12] for more details), which asserts that for 1<t<N, the following inequality holds:

    Ω|u(x)|t|x|tdx1HΩ|u|tdx,uW1,t0(Ω),

    where the optimal constant H is given by:

    H=(Ntt)t.

    By combining this with Lemma 2.1 and using the fact that 1<q<ph(x)<N, we deduce the continuous embeddings

    W1,p(x)0(ω,Ω)W1,ph(x)0(Ω)W1,q0(Ω),

    which leads to the inequality

    Ω|u(x)|q|x|qdx1HΩ|u|qdx,uW1,p(x)0(ω,Ω),

    where H=(Nqq)q.

    We are now ready to present our primary result. To this end, we define

    ˜D(x):=sup{˜D>0B(x,˜D)Ω}

    for each xΩ, here B(x,˜D) denotes a ball centered at x with radius ˜D. It is clear that there exists a point x0Ω such that B(x0,R)Ω, where

    R=supxΩ˜D(x).

    In the remainder, assume that k(x), fulfill this requirement

    k(x):={0, forxΩB(x0,R),k0, forxB(x0,R2),>0, for xB(x0,R)B(x0,R2),

    where k0 is a positive constant, the symbol ˜m will represent the constant

    ˜m=πN2N2Γ(N2),

    with Γ denoting the Gamma function.

    Theorem 3.1. Assume that p>s+, and, there exist two positive constants d and δ>0, such that

    1p+(2δR)ˇpwL1(B)=d,

    and

    Aδ:=1p(2δR)ˆpωL1(B)+(2δR)qbqH˜m(RN(R2)N)1s+k0δˇs˜m(R2)N<Bd:=dcˆsγskγ(x)s[(p+d)1ˇp]ˆs,

    then for any λ]Aδ,Bd[, problem (1.1) has at least three weak solutions.

    Proof. It is worth noting that the functional L and M associated with problem (1.1) and defined in (2.2) and (2.3), satisfy the regularity assumptions outlined in Theorem 2.1. We will now establish the fulfillment of conditions (a1) and (a2). To this end, let's consider

    1p+(2δR)ˇpωL1(B)=d

    and consider vdX such that

    vδ(x):={0xΩB(x0,R)2δR(R|xx0|)xB:=¯B(x0,R)B(x0,R2),δx¯B(x0,R2).

    Then, by the definition of L, we have

    1p+(2δR)ˇpωL1(B)<L(vδ)1p(2δR)ˆpωL1(B)+(2δR)qbqH˜m(RN(R2)N)

    Therefore, L(vδ)>d. However, it is important to consider the following

    M(vδ)B(x0,R2)k(x)s(x)|vδ|γ(x)dx1s+k0δˇs˜m(R2)N (3.1)

    In addition, for each uL1(],d]), we have

    1p+uˇpd. (3.2)

    therefore,

    u(p+L(u))1ˇp<(p+d)1ˇp.

    Furthermore, we can deduce using Lemmas 2.3, 2.4 and Remark 2.1 the following

    M(u)1skγ(x)|u|s(x)γ(x)1sks(x)(cγsu)ˆs, (3.3)

    where cγs is the constant from the continuous embedding of W1,p(x)0(ω,Ω) into W1,γ(x)s(x)(Ω).

    This leads to the following result

    supL(u)<dM(u)cˆsγskγ(x)s[(p+d)1ˇp]ˆs,

    and

    1dsupL(u)<dM(u)<1λ.

    Furthermore, we can establish the coerciveness of Iλ for any positive value of λ by employing inequality (3.1) once more. This yields the following result

    M(u)cˆsγskγ(x)suˆs.

    When u is great enough, the following can be inferred

    L(u)λM(u)1p+upλcˆsγskγ(x)suˆs.

    By considering the fact that p>s+, we can reach the desired conclusion. In conclusion, considering the aforementioned fact that

    ˉΛd:=(Aδ,Bd)(L(vδ)M(vδ),dsupL(u)<dM(u)),

    since all assumptions of Theorem 2.1 are fulfilled, it can be deduced that for any λˉΛd, the function LλM possesses at least three critical points that belong in X:=W1,p0(ω,Ω). Consequently these critical points are exactly weak solutions of problem (1.1).

    Khaled Kefi: Conceptualization, Methodology, Writing–original draft, Supervision; Nasser S. Albalawi: Conceptualization, Methodology, Writing–original draft, Supervision. All authors have read and agreed to the published version of the manuscript.

    The authors declare they have not used Artificial Intelligence (AI) tools in the creation of this article.

    The authors extend their appreciation to the Deanship of Scientific Research at Northern Border University, Arar, KSA for funding this research work through the project number NBU-FPEJ-2025-1706-01.

    The authors declare that they have no conflicts of interest.



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