Gut neurotoxin p-cresol induces differential expression of GLUN2B and GLUN2A subunits of the NMDA receptor in the hippocampus and nucleus accumbens in healthy and audiogenic seizure-prone rats

Tevzadze Gigi; Zhuravliova Elene; Barbakadze Tamar; Shanshiashvili Lali; Dzneladze Davit; Nanobashvili Zaqaria; Lordkipanidze Tamar; Mikeladze David; Tevzadze Gigi; Zhuravliova Elene; Barbakadze Tamar; Shanshiashvili Lali; Dzneladze Davit; Nanobashvili Zaqaria; Lordkipanidze Tamar; Mikeladze David

doi:10.3934/Neuroscience.2020003

AIMS Neuroscience

2020, Volume 7, Issue 1: 30-42. doi: 10.3934/Neuroscience.2020003

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Research article

Gut neurotoxin p-cresol induces differential expression of GLUN2B and GLUN2A subunits of the NMDA receptor in the hippocampus and nucleus accumbens in healthy and audiogenic seizure-prone rats

1.
4-D Research Institute, Ilia State University, 3/5 Cholokashvili av, Tbilisi, 0162, Georgia
2.
Institute of Chemical Biology, Ilia State University, 3/5 Cholokashvili av, Tbilisi, 0162, Georgia
3.
I. Beritashvili Center of Experimental Biomedicine 14, Gotua Str., Tbilisi 0160, Georgia

Received: 30 October 2019 Accepted: 17 February 2020 Published: 10 March 2020

Mislocalization and abnormal expression of N-methyl-D-aspartate glutamate receptor (NMDAR) subunits is observed in several brain disorders and pathological conditions. Recently, we have shown that intraperitoneal injection of the gut neurotoxin p-cresol induces autism-like behavior and accelerates seizure reactions in healthy and epilepsy-prone rats, respectively. In this study, we evaluated the expression of GLUN2B and GLUN2A NMDAR subunits, and assessed the activity of cAMP-response element binding protein (CREB) and Rac1 in the hippocampi and nucleus accumbens of healthy and epilepsy-prone rats following p-cresol administration. We have found that subchronic intraperitoneal injection of p-cresol induced differential expression of GLUN2B and GLUN2A between the two brain regions, and altered the GLUN2B/GLUN2A ratio, in rats in both groups. Moreover, p-cresol impaired CREB phosphorylation in both brain structures and stimulated Rac activity in the hippocampus. These data indicate that p-cresol differently modulates the expression of NMDAR subunits in the nucleus accumbens and hippocampi of healthy and epilepsy-prone rats. We propose that these differences are due to the specificity of interactions between dopaminergic and glutamatergic pathways in these structures.

Keywords:

Citation: Tevzadze Gigi, Zhuravliova Elene, Barbakadze Tamar, Shanshiashvili Lali, Dzneladze Davit, Nanobashvili Zaqaria, Lordkipanidze Tamar, Mikeladze David. Gut neurotoxin p-cresol induces differential expression of GLUN2B and GLUN2A subunits of the NMDA receptor in the hippocampus and nucleus accumbens in healthy and audiogenic seizure-prone rats[J]. AIMS Neuroscience, 2020, 7(1): 30-42. doi: 10.3934/Neuroscience.2020003

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Abstract

1. Introduction

For a convex function $\sigma:\mathrm{I}\subseteq \bf{R}\to \bf{R}$ on $\mathrm{I}$ with $\nu_{1}, \nu_{2}\in \mathrm{I}$ and $\nu_{1} < \nu_{2}$ , the Hermite-Hadamard inequality is defined by ^[1]:

$\begin{equation} \sigma\left(\frac{\nu_{1}+\nu_{2}}{2}\right) \leq \frac{1}{\nu_{2}-\nu_{1}}\int_{\nu_{1}}^{\nu_{2}}\sigma(\eta)d\eta \leq \frac{\sigma(\nu_{1})+\sigma(\nu_{2})}{2}. \end{equation}$

(1.1)

The Hermite-Hadamard integral inequality (1.1) is one of the most famous and commonly used inequalities. The recently published papers ^[2,3,4] are focused on extending and generalizing the convexity and Hermite-Hadamard inequality.

The situation of the fractional calculus (integrals and derivatives) has won vast popularity and significance throughout the previous five decades or so, due generally to its demonstrated applications in numerous seemingly numerous and great fields of science and engineering ^[5,6,7].

Now, we recall the definitions of Riemann-Liouville fractional integrals.

Definition 1.1 (^[5,6,7]). Let $\sigma\in L_{1}[\nu_{1}, \nu_{2}].$ The Riemann-Liouville integrals $J_{\nu_{1}+}^{\vartheta }\sigma$ and $J_{\nu_{2}-}^{\vartheta }\sigma$ of order $\vartheta > 0$ with $\nu_{1}\geq 0$ are defined by

$\begin{equation} J_{\nu_{1}+}^{\vartheta }\sigma(x) = \frac{1}{\Gamma (\vartheta )}\int_{\nu_{1}}^{x}(x-\eta)^{\vartheta -1}\sigma(\eta)d\eta,\; \ \ \ \nu_{1} < x \end{equation}$

(1.2)

and

$\begin{equation} J_{\nu_{2}-}^{\vartheta }\sigma(x) = \frac{1}{\Gamma (\vartheta )}\int_{x}^{\nu_{2}}(\eta-x)^{\vartheta -1}\sigma(\eta)d\eta,\; \ \ x < \nu_{2}, \end{equation}$

(1.3)

respectively. Here $\Gamma (\vartheta)$ is the well-known Gamma function and $J_{\nu_{1}+}^{0}\sigma(x) = J_{\nu_{2}-}^{0}\sigma(x) = \sigma(x).$

With a huge application of fractional integration and Hermite-Hadamard inequality, many researchers in the field of fractional calculus extended their research to the Hermite-Hadamard inequality, including fractional integration rather than ordinary integration; for example see ^{[8,9,10,11,12,13,14,15,16,17,18,19,20,21]}.

In this paper, we consider the integral inequality of Hermite-Hadamard-Mercer type that relies on the Hermite-Hadamard and Jensen-Mercer inequalities. For this purpose, we recall the Jensen-Mercer inequality: Let $0 < x_{1}\leq x_{2}\leq \cdots\leq x_{n}$ and $\mu = (\mu _{1}, \mu_{2}, \ldots, \mu _{n})$ nonnegative weights such that $\sum_{i = 1}^{n}\mu_{i} = 1$ . Then, the Jensen inequality ^[22,23] is as follows, for a convex function $\sigma$ on the interval $[\nu_{1}, \nu_{2}]$ , we have

$\begin{equation} \sigma\Bigg(\sum\limits_{i = 1}^{n}\mu _{i}x_{i}\Bigg)\leq \sum\limits_{i = 1}^{n}\mu _{i}\sigma(x_{i}), \end{equation}$

(1.4)

where for all $x_{i}\in \lbrack \nu_{1}, \nu_{2}]$ and $\mu_{i}\in \lbrack 0, 1]$ , $(i = \overline{1, n})$ .

Theorem 1.1 (^[2,23]). If $\sigma$ is convex function on $[\nu_{1}, \nu_{2}]$ , then

$\begin{equation} \sigma\left(\nu_{1}+\nu_{2}-\sum\limits^{n}_{i = 1}\mu_{i}x_{i}\right)\leq \sigma(\nu_{1})+\sigma(\nu_{2})-\sum\limits^{n}_{i = 1}\mu_{i}\sigma(x_{i}), \end{equation}$

(1.5)

for each $x_{i}\in[\nu_{1}, \nu_{2}]$ and $\mu_{i}\in[0, 1]$ , $(i = \overline{1, n})$ with $\sum^{n}_{i = 1}\mu_{i} = 1$ . For some results related with Jensen-Mercer inequality, see ^[24,25,26].

In view of above indices, we establish new integral inequalities of Hermite-Hadamard-Mercer type for convex functions via the Riemann-Liouville fractional integrals in the current project. Particularly, we see that our results can cover the previous researches.

2. Main results

Theorem 2.1. For a convex function $\sigma:[\nu_{1}, \nu_{2}]\subseteq \bf{R} \to\bf{R}$ with $x, y\in[\nu_{1}, \nu_{2}]$ , we have:

$\begin{multline} \sigma\left(\nu_{1}+\nu_{2}-\frac{x+y}{2}\right)\leq \frac{2^{\vartheta -1} \Gamma\left(\vartheta +1\right)}{\left( y-x\right)^{\vartheta}} \Biggl[ J_{\left(\nu_{1}+\nu_{2}-y\right)+}^{\vartheta}\sigma\left(\nu_{1}+\nu_{2}-\frac{x+y}{2}\right) \\ +\; J_{\left(\nu_{1}+\nu_{2}-x\right)-}^{\vartheta}\sigma\left(\nu_{1}+\nu_{2}-\frac{x+y}{2}\right)\Biggr] \leq \sigma\left(\nu_{1}\right)+\sigma\left(\nu_{2}\right)-\frac{\sigma\left(x\right)+\sigma\left(y\right)}{2}. \end{multline}$

(2.1)

Proof. By using the convexity of $\sigma$ , we have

$\begin{equation} \sigma\left( \nu_{1}+\nu_{2}-\frac{u+v}{2}\right) \leq \frac{1}{2}\left[ \sigma\left( \nu_{1}+\nu_{2}-u\right) +\sigma\left( \nu_{1}+\nu_{2}-v\right) \right], \end{equation}$

(2.2)

and above with $u = \frac{1-\eta}{2}x+\frac{1+\eta}{2}y$ , $v = \frac{1+\eta}{2}x+\frac{1-\eta}{2}y$ , where $x, y\in[\nu_{1}, \nu_{2}]$ and $\eta\in [0, 1]$ , leads to

$\begin{multline} \sigma\left( \nu_{1}+\nu_{2}-\frac{x+y}{2}\right)\leq\frac{1}{2} \Biggl[\sigma\left(\nu_{1}+\nu_{2}-\left(\frac{1-\eta}{2}x+\frac{1+\eta}{2}y\right)\right) \\ +\sigma\left(\nu_{1}+\nu_{2}-\left(\frac{1+\eta}{2}x+\frac{1-\eta}{2}y\right)\right)\Biggr]. \end{multline}$

(2.3)

Multiplying both sides of (2.3) by $\eta^{\vartheta -1}$ and then integrating with respect to $\eta$ over $[0, 1]$ , we get

$\begin{align*} \frac{1}{\vartheta }\sigma\left( \nu_{1}+\nu_{2}-\frac{x+y}{2}\right) &\leq \frac{1}{2}\left[\int_{0}^{1}\eta^{\vartheta-1} \sigma\left(\nu_{1}+\nu_{2}-\left(\frac{1-\eta}{2}x+\frac{1+\eta}{2}y\right)\right)d\eta\right. \\ &+\left. \int_{0}^{1}\eta^{\vartheta -1}\sigma\left( \nu_{1}+\nu_{2}-\left( \frac{1+\eta}{2}x+\frac{1-\eta}{2}y\right)\right)d\eta\right] \\ & = \frac{1}{2}\left[ \frac{2^{\vartheta }}{\left( y-x\right) ^{\vartheta }}\int_{\nu_{1}+\nu_{2}-y}^{\nu_{1}+\nu_{2}-\frac{x+y}{2}} \left( \left( \nu_{1}+\nu_{2}-\frac{x+y}{2}\right)-w\right) ^{\vartheta -1}\sigma\left( w\right) dw\right. \\ &\left. +\frac{2^{\vartheta}}{\left(y-x\right)^{\vartheta}}\int_{\nu_{1}+\nu_{2}-\frac{x+y}{2}}^{\nu_{1}+\nu_{2}-x} \left( w-\left( \nu_{1}+\nu_{2}-\frac{x+y}{2}\right) \right) ^{\vartheta-1}\sigma\left( w\right) dw\right] \\ & = \frac{2^{\vartheta-1}\Gamma \left(\vartheta\right)}{\left(y-x\right)^{\vartheta}} \left[J_{\left(\nu_{1}+\nu_{2}-y\right)+}^{\vartheta}\sigma\left(\nu_{1}+\nu_{2}-\frac{x+y}{2}\right) +\; J_{\left(\nu_{1}+\nu_{2}-x\right)-}^{\vartheta}\sigma\left( \nu_{1}+\nu_{2}-\frac{x+y}{2}\right) \right], \end{align*}$

and thus the proof of first inequality in (2.1) is completed.

On the other hand, we have by using the Jensen-Mercer inequality:

$\begin{eqnarray} \sigma\left( \nu_{1}+\nu_{2}-\left( \frac{1-\eta}{2}x+\frac{1+\eta}{2}y\right) \right) &\leq &\sigma\left( \nu_{1}\right) +\sigma\left( \nu_{2}\right) -\left( \frac{1-\eta}{2}\sigma\left( x\right) +\frac{1+\eta}{2}\sigma\left( y\right) \right) \end{eqnarray}$

(2.4)

$\begin{eqnarray} \sigma\left( \nu_{1}+\nu_{2}-\left( \frac{1+\eta}{2}x+\frac{1-\eta}{2}y\right) \right) &\leq &\sigma\left( \nu_{1}\right) +\sigma\left( \nu_{2}\right) -\left( \frac{1+\eta}{2}\sigma\left( x\right) +\frac{1-\eta}{2}\sigma\left( y\right) \right). \end{eqnarray}$

(2.5)

Adding inequalities (2.4) and (2.5) to get

$\begin{multline} \sigma\left( \nu_{1}+\nu_{2}-\left( \frac{1-\eta}{2}x+\frac{1+\eta}{2}y\right) \right) +\sigma\left(\nu_{1}+\nu_{2}-\left( \frac{1+\eta}{2}x+\frac{1-\eta}{2}y\right) \right) \\ \leq 2\left[\sigma\left(\nu_{1}\right)+\sigma\left(\nu_{2}\right)\right]-\left[\sigma\left(x\right)+\sigma\left(y\right)\right]. \end{multline}$

(2.6)

Multiplying both sides of (2.6) by $\eta^{\vartheta -1}$ and then integrating with respect to $\eta$ over $[0, 1]$ to obtain

$\begin{multline*} \int_{0}^{1}\eta^{\vartheta -1}\sigma\left( \nu_{1}+\nu_{2}-\left( \frac{1-\eta}{2}x+\frac{1+\eta}{2}y\right) \right)d\eta +\int_{0}^{1}\eta^{\vartheta-1}\sigma\left(\nu_{1}+\nu_{2}-\left(\frac{1+\eta}{2}x+\frac{1-\eta}{2}y\right)\right)d\eta \\ \leq \frac{2}{\vartheta}\left[\sigma\left(\nu_{1}\right)+\sigma\left(\nu_{2}\right)\right] -\frac{1}{\vartheta }\left[ \sigma\left( x\right) +\sigma\left( y\right) \right]. \end{multline*}$

By making use of change of variables and then multiplying by $\frac{\vartheta }{2}$ , we get the second inequality in (2.1).

Remark 2.1. If we choose $\vartheta = 1$ , $x = \nu_{1}$ and $y = \nu_{2}$ in Theorem 2.1, then the inequality (2.1) reduces to (1.1).

Corollary 2.1. Theorem 2.1 with

● $\vartheta = 1$ becomes [24, Theorem 2.1].

● $x = \nu_{1}$ and $y = \nu_{2}$ becomes:

$\begin{align*} \sigma\left(\frac{\nu_{1}+\nu_{2}}{2}\right)\leq\frac{2^{\vartheta-1}\Gamma\left(\vartheta+1\right)}{\left(\nu_{2}-\nu_{1}\right)^{\vartheta}} \left[J_{\nu_{1}+}^{\vartheta }\sigma\left(\frac{\nu_{1}+\nu_{2}}{2}\right)+\; J_{\nu_{2}-}^{\vartheta }\sigma\left(\frac{\nu_{1}+\nu_{2}}{2}\right)\right] \leq \frac{\sigma\left(\nu_{1}\right)+\sigma\left(\nu_{2}\right) }{2}, \end{align*}$

which is obtained by Mohammed and Brevik in ^[10].

The following Lemma linked with the left inequality of (2.1) is useful to obtain our next results.

Lemma 2.1. Let $\sigma:[\nu_{1}, \nu_{2}]\subseteq\bf{R} \to\bf{R}$ be a differentiable function on $(\nu_{1}, \nu_{2})$ and $\sigma'\in L[\nu_{1}, \nu_{2}]$ with $\nu_{1}\leq \nu_{2}$ and $x, y\in[\nu_{1}, \nu_{2}]$ . Then, we have:

$\begin{multline} \frac{2^{\vartheta -1}\Gamma \left( \vartheta +1\right) }{\left( y-x\right)^{\vartheta}} \left[ J_{\left( \nu_{1}+\nu_{2}-y\right) +}^{\vartheta }\sigma\left(\nu_{1}+\nu_{2}-\frac{x+y}{2}\right) +\; J_{\left( \nu_{1}+\nu_{2}-x\right)-}^{\vartheta}\sigma\left(\nu_{1}+\nu_{2}-\frac{x+y}{2}\right)\right] \\ -\sigma\left(\nu_{1}+\nu_{2}-\frac{x+y}{2}\right) = \frac{\left(y-x\right)}{4}\int_{0}^{1}\eta^{\vartheta} \Bigl[\sigma'\left(\nu_{1}+\nu_{2}-\left(\frac{1-\eta}{2}x+\frac{1+\eta}{2}y\right)\right) \\ -\sigma'\left(\nu_{1}+\nu_{2}-\left(\frac{1+\eta}{2}x+\frac{1-\eta}{2}y\right)\right)\Bigr]d\eta. \end{multline}$

(2.7)

Proof. From right hand side of (2.7), we set

$\begin{align} \varpi_{1}-\varpi_{2}&:= \int_{0}^{1}\eta^{\vartheta}\left[\sigma'\left(\nu_{1}+\nu_{2} -\left(\frac{1-\eta}{2}x+\frac{1+\eta}{2}y\right)\right) -\sigma'\left( \nu_{1}+\nu_{2}-\left( \frac{1+\eta}{2}x+\frac{1-\eta}{2}y\right)\right)\right]d\eta \\ & = \int_{0}^{1}\eta^{\vartheta }\sigma'\left(\nu_{1}+\nu_{2}-\left(\frac{1-\eta}{2}x+\frac{1+\eta}{2}y\right)\right)d\eta \\ &-\int_{0}^{1}\eta^{\vartheta}\sigma'\left(\nu_{1}+\nu_{2}-\left(\frac{1+\eta}{2}x+\frac{1-\eta}{2}y\right)\right) d\eta. \end{align}$

(2.8)

By integrating by parts with $w = \nu_{1}+\nu_{2}-\left(\frac{1-\eta}{2}x+\frac{1+\eta}{2}y\right)$ , we can deduce:

$\begin{align*} \varpi_{1}& = -\frac{2}{\left( y-x\right) }\sigma\left(\nu_{1}+\nu_{2}-y\right)+\frac{2\vartheta }{\left(y-x\right)} \int_{0}^{1}\eta^{\vartheta -1}\sigma\left( \nu_{1}+\nu_{2}-\left( \frac{1-\eta}{2}x+\frac{1+\eta}{2}y\right) \right) d\eta \\ & = -\frac{2}{\left(y-x\right)}\sigma\left(\nu_{1}+\nu_{2}-y\right)+\frac{2^{\vartheta+1}\vartheta}{\left(y-x\right)^{\vartheta+1}} \int_{\nu_{1}+\nu_{2}-y}^{\nu_{1}+\nu_{2}-\frac{x+y}{2}}\sigma\left(\left( \nu_{1}+\nu_{2}-\frac{x+y}{2}\right)-w\right)^{\vartheta -1} \sigma\left(w\right) dw \\ & = -\frac{2}{\left(y-x\right)}\sigma\left( \nu_{1}+\nu_{2}-y\right) +\frac{2^{\vartheta+1}\Gamma\left(\vartheta+1\right)}{\left( y-x\right) ^{\vartheta +1}} J_{\left(\nu_{1}+\nu_{2}-y\right)+}^{\vartheta }\sigma\left( \nu_{1}+\nu_{2}-\frac{x+y}{2}\right). \end{align*}$

Similarly, we can deduce:

$\begin{equation*} \varpi_{2} = \frac{2}{y-x}\sigma\left(\nu_{1}+\nu_{2}-x\right) -\frac{2^{\vartheta+1}\Gamma\left(\vartheta+1\right)}{\left( y-x\right) ^{\vartheta +1}} J_{\left( \nu_{1}+\nu_{2}-x\right)-}^{\vartheta }\sigma\left(\nu_{1}+\nu_{2}-\frac{x+y}{2}\right). \end{equation*}$

By substituting $\varpi_{1}$ and $\varpi_{2}$ in (2.8) and then multiplying by $\frac{\left(y-x\right)}{4}$ , we obtain required identity (2.7).

Corollary 2.2. Lemma 2.1 with

● $\vartheta = 1$ becomes:

$\begin{multline*} \frac{1}{y-x}\int_{\nu_{1}+\nu_{2}-y}^{\nu_{1}+\nu_{2}-x}\sigma\left(w\right) dw-\sigma\left( \nu_{1}+\nu_{2}-\frac{x+y}{2}\right) = \frac{\left( y-x\right) }{4}\int_{0}^{1}\eta\left[ \sigma'\left( \nu_{1}+\nu_{2}-\left( \frac{1-\eta}{2}x+\frac{1+\eta}{2}y\right) \right) \right. \\ \left. -\sigma'\left( \nu_{1}+\nu_{2}-\left( \frac{1+\eta}{2}x+\frac{1-\eta}{2}y\right)\right) \right] d\eta. \end{multline*}$

● $\vartheta = 1$ , $x = \nu_{1}$ and $y = \nu_{2}$ becomes:

$\begin{multline*} \frac{1}{\nu_{2}-\nu_{1}}\int_{\nu_{1}}^{\nu_{2}}\sigma\left( w\right) dw-\sigma\left(\frac{\nu_{1}+\nu_{2}}{2}\right) = \frac{\left( \nu_{2}-\nu_{1}\right) }{4}\int_{0}^{1}\eta \left[ \sigma'\left(\nu_{1}+\nu_{2}-\left( \frac{1-\eta}{2}\nu_{1}+\frac{1+\eta}{2}\nu_{2}\right) \right) \right. \\ \left. -\sigma'\left( \nu_{1}+\nu_{2}-\left( \frac{1+\eta}{2}\nu_{1}+\frac{1-\eta}{2}\nu_{2}\right)\right) \right] d\eta. \end{multline*}$

● $x = \nu_{1}$ and $y = \nu_{2}$ becomes:

$\begin{multline*} \frac{2^{\vartheta -1}\Gamma \left( \vartheta +1\right) }{\left( \nu_{2}-\nu_{1}\right)^{\vartheta }} \left[ J_{\nu_{1}+}^{\vartheta }\sigma\left(\frac{\nu_{1}+\nu_{2}}{2}\right) +\; J_{\nu_{2}-}^{\vartheta }\sigma\left(\frac{\nu_{1}+\nu_{2}}{2}\right) \right]-\sigma\left(\frac{\nu_{1}+\nu_{2}}{2}\right) \\ = \frac{\left( \nu_{2}-\nu_{1}\right) }{4}\int_{0}^{1}\eta^{\vartheta } \left[\sigma'\left( \nu_{1}+\nu_{2}-\left( \frac{1-\eta}{2}\nu_{1}+\frac{1+\eta}{2}\nu_{2}\right) \right) \right. \left. -\sigma'\left( \nu_{1}+\nu_{2}-\left( \frac{1+\eta}{2}\nu_{1}+\frac{1-\eta}{2}\nu_{2}\right) \right) \right] d\eta. \end{multline*}$

Theorem 2.2. Let $\sigma:[\nu_{1}, \nu_{2}]\subseteq\bf{R}\to\bf{R}$ be a differentiable function on $(\nu_{1}, \nu_{2})$ and $|\sigma'|$ is convex on $[\nu_{1}, \nu_{2}]$ with $\nu_{1}\leq \nu_{2}$ and $x, y\in[\nu_{1}, \nu_{2}]$ . Then, we have:

$\begin{multline} \Biggl| \frac{2^{\vartheta -1}\Gamma \left( \vartheta +1\right) }{\left(y-x\right) ^{\vartheta }} \Biggl[ J_{\left( \nu_{1}+\nu_{2}-y\right) +}^{\vartheta }\sigma\left( \nu_{1}+\nu_{2}-\frac{x+y}{2}\right) +\; J_{\left( \nu_{1}+\nu_{2}-x\right) -}^{\vartheta }\sigma\left( \nu_{1}+\nu_{2}-\frac{x+y}{2}\right) \Biggr] \\ -\sigma\left( \nu_{1}+\nu_{2}-\frac{x+y}{2}\right)\Biggr| \leq \frac{\left( y-x\right) }{2\left( 1+\vartheta \right) }\left[ \left| \sigma'\left( \nu_{1}\right) \right| +\left| \sigma'\left(\nu_{2}\right) \right| -\frac{\left| \sigma'\left( x\right) \right| +\left| \sigma'\left( y\right) \right| }{2}\right]. \end{multline}$

(2.9)

Proof. By taking modulus of identity (2.7), we get

$\begin{multline*} \Biggl|\frac{2^{\vartheta-1}\Gamma\left(\vartheta+1\right)}{\left(y-x\right)^{\vartheta}} \left[J_{\left(\nu_{1}+\nu_{2}-y\right)+}^{\vartheta}\sigma\left(\nu_{1}+\nu_{2}-\frac{x+y}{2}\right) +\; J_{\left( \nu_{1}+\nu_{2}-x\right) -}^{\vartheta }\sigma\left( \nu_{1}+\nu_{2}-\frac{x+y}{2}\right) \right] \\ -\sigma\left( \nu_{1}+\nu_{2}-\frac{x+y}{2}\right) \Biggr|\leq \frac{\left( y-x\right) }{4} \left[\int_{0}^{1}\eta^{\vartheta }\left|\sigma'\left( \nu_{1}+\nu_{2}-\left( \frac{1-\eta}{2}x+\frac{1+\eta}{2}y\right) \right) \right| d\eta\right. \\ \left. +\int_{0}^{1}\eta^{\vartheta }\left| \sigma'\left( \nu_{1}+\nu_{2}-\left( \frac{1+\eta}{2}x+\frac{1-\eta}{2}y\right) \right) \right| d\eta\right]. \end{multline*}$

Then, by applying the convexity of $|\sigma'|$ and the Jensen-Mercer inequality on above inequality, we get

$\begin{align*} &\Biggl|\frac{2^{\vartheta-1}\Gamma\left(\vartheta+1\right)}{\left(y-x\right)^{\vartheta}} \left[J_{\left(\nu_{1}+\nu_{2}-y\right)+}^{\vartheta}\sigma\left(\nu_{1}+\nu_{2}-\frac{x+y}{2}\right) +\; J_{\left( \nu_{1}+\nu_{2}-x\right) -}^{\vartheta }\sigma\left( \nu_{1}+\nu_{2}-\frac{x+y}{2}\right) \right] \\ &-\sigma\left( \nu_{1}+\nu_{2}-\frac{x+y}{2}\right) \Biggr|\leq \frac{\left( y-x\right) }{4}\left[ \int_{0}^{1}\eta^{\vartheta }\left[ \left| \sigma'\left( \nu_{1}\right) \right| +\left| \sigma'\left( \nu_{2}\right) \right| -\left( \frac{1+\eta}{2}\left| \sigma^{\prime }\left( x\right) \right| +\frac{1-\eta}{2}\right) \left| \sigma'\left( y\right) \right| \right] d\eta\right. \\ &\left. +\int_{0}^{1}\eta^{\vartheta }\left[ \left| \sigma'\left(\nu_{1}\right) \right| +\left| \sigma'\left( \nu_{2}\right) \right| -\left(\frac{1-\eta}{2}\left|\sigma'\left(x\right) \right| +\frac{1+\eta}{2}\right)\left| \sigma'\left( y\right)\right| \right] d\eta\right] \\ & = \frac{\left(y-x\right)}{2\left(1+\vartheta \right)}\left[ \left|\sigma'\left( \nu_{1}\right)\right| +\left|\sigma'(\nu_{2})\right|-\frac{\left|\sigma'\left(x\right)\right|+\left|\sigma'\left(y\right)\right|}{2}\right], \end{align*}$

which completes the proof of Theorem 2.2.

Corollary 2.3. Theorem 2.2 with

● $\vartheta = 1$ becomes:

$\begin{align*} \left|\frac{1}{y-x}\int_{\nu_{1}+\nu_{2}-y}^{\nu_{1}+\nu_{2}-x}\sigma(w)dw-\sigma\left(\nu_{1}+\nu_{2}-\frac{x+y}{2}\right)\right| \leq \frac{\left(y-x\right)}{4}\left[\left| \sigma'\left(\nu_{1}\right)\right|+\left|\sigma'\left(\nu_{2}\right)\right| -\frac{\left|\sigma'\left(x\right)\right|+\left|\sigma'\left(y\right)\right|}{2}\right]. \end{align*}$

● $\vartheta = 1$ , $x = \nu_{1}$ and $y = \nu_{2}$ becomes [27, Theorem 2.2].

● $x = \nu_{1}$ and $y = \nu_{2}$ becomes:

$\begin{align*} \left\vert \frac{1}{\nu_{2}-\nu_{1}}\int_{\nu_{1}}^{\nu_{2}}\sigma\left( w\right) dw-\sigma\left(\frac{\nu_{1}+\nu_{2}}{2}\right) \right\vert \leq \frac{\left( \nu_{2}-\nu_{1}\right) }{4}\left[ \frac{\left\vert \sigma^{\prime }\left( \nu_{1}\right) \right\vert +\left\vert \sigma^{\prime }\left( \nu_{2}\right) \right\vert }{2}\right] . \end{align*}$

Theorem 2.3. Let $\sigma:[\nu_{1}, \nu_{2}]\subseteq\bf{R}\to\bf{R}$ be a differentiable function on $(\nu_{1}, \nu_{2})$ and $\left| \sigma'\right|^{q}, q > 1$ is convex on $[\nu_{1}, \nu_{2}]$ with $\nu_{1}\leq \nu_{2}$ and $x, y\in[\nu_{1}, \nu_{2}]$ . Then, we have:

$\begin{multline} \left| \frac{2^{\vartheta -1}\Gamma \left( \vartheta +1\right) }{\left( y-x\right) ^{\vartheta }}\left[ J_{\left( \nu_{1}+\nu_{2}-y\right) +}^{\vartheta }\sigma\left( \nu_{1}+\nu_{2}- \frac{x+y}{2}\right) \right. \right. \\ \left. \left. +\; J_{\left( \nu_{1}+\nu_{2}-x\right) -}^{\vartheta }\sigma\left(\nu_{1}+\nu_{2}-\frac{x+y}{2}\right) \right] -\sigma\left( \nu_{1}+\nu_{2}-\frac{x+y}{2}\right) \right| \\ \leq \frac{\left( y-x\right) }{4\sqrt[p]{\vartheta p+1}} \left[ \left( \left| \sigma'\left( \nu_{1}\right) \right|^{q}+\left| \sigma'\left(\nu_{2}\right)\right| ^{q} -\left(\frac{\left|\sigma'(x) \right|^{q}+3\left|\sigma'(y)\right|^{q}}{4}\right)\right)^{\frac{1}{q}}\right. \\ \left. +\left( \left| \sigma'\left( \nu_{1}\right) \right|^{q}+\left|\sigma'\left(\nu_{2}\right)\right|^{q} -\left(\frac{3\left|\sigma'(x)\right|^{q}+\left|\sigma'(y)\right|^{q}}{4}\right)\right)^{\frac{1}{q}}\right], \end{multline}$

(2.10)

where $\frac{1}{p}+\frac{1}{q} = 1$ .

Proof. By taking modulus of identity (2.7) and using Hölder's inequality, we get

$\begin{multline*} \left| \frac{2^{\vartheta -1}\Gamma \left( \vartheta +1\right) }{\left(y-x\right)^{\vartheta }} \left[ J_{\left( \nu_{1}+\nu_{2}-y\right)+}^{\vartheta }\sigma\left( \nu_{1}+\nu_{2}-\frac{x+y}{2}\right) \right. \right. \\ \left. \left. +\; J_{\left(\nu_{1}+\nu_{2}-x\right)-}^{\vartheta }\sigma\left(\nu_{1}+\nu_{2}-\frac{x+y}{2}\right) \right] -\sigma\left( \nu_{1}+\nu_{2}-\frac{x+y}{2}\right) \right| \\ \leq \frac{\left( y-x\right) }{4}\left( \int_{0}^{1}\eta^{\vartheta p}\right)^{\frac{1}{p}} \left\{\left(\int_{0}^{1} \left|\sigma'\left(\nu_{1}+\nu_{2}-\left(\frac{1-\eta}{2}x+\frac{1+\eta}{2}y\right)\right)\right|^{q}d\eta\right) ^{\frac{1}{q}}\right. \\ \left. +\left(\int_{0}^{1} \left|\sigma'\left(\nu_{1}+\nu_{2}-\left(\frac{1+\eta}{2}x+\frac{1-\eta}{2}y\right)\right)\right|^{q}d\eta\right) ^{\frac{1}{q}}\right\}. \end{multline*}$

Then, by applying the Jensen-Mercer inequality with the convexity of $\left|\sigma'\right|^{q}$ , we can deduce

$\begin{align*} &\left| \frac{2^{\vartheta -1}\Gamma \left( \vartheta +1\right) }{\left(y-x\right) ^{\vartheta }} \left[J_{\left(\nu_{1}+\nu_{2}-y\right)+}^{\vartheta }\sigma\left( \nu_{1}+\nu_{2}-\frac{x+y}{2}\right) \right. \right. \\ &\left. \left. +\; J_{\left( \nu_{1}+\nu_{2}-x\right) -}^{\vartheta }\sigma\left( \nu_{1}+\nu_{2}-\frac{x+y}{2}\right) \right] -\sigma\left( \nu_{1}+\nu_{2}-\frac{x+y}{2}\right) \right| \\ &\leq \frac{\left( y-x\right) }{4}\left( \int_{0}^{1}\eta^{\vartheta p}\right)^{\frac{1}{p}} \left\{ \left( \int_{0}^{1}\left| \sigma'\left( \nu_{1}\right)\right| ^{q}+\left| \sigma'\left( \nu_{2}\right) \right|^{q} -\left(\frac{1-\eta}{2}\left|\sigma'(x)\right|^{q}+\frac{1+\eta}{2}\left|\sigma'(y)\right|^{q}\right)\right)^{\frac{1}{q}}\right. \\ &\left. +\left( \int_{0}^{1}\left| \sigma'\left( \nu_{1}\right)\right| ^{q}+\left| \sigma'\left( \nu_{2}\right) \right|^{q} -\left(\frac{1+\eta}{2}\left| \sigma'\left( x\right)\right|^{q}+\frac{1-\eta}{2}\left| \sigma'\left( y\right) \right|^{q} \right) \right)^{\frac{1}{q}}\right\} \\ & = \frac{\left(y-x\right)}{4\sqrt[p]{\vartheta p+1}}\left[\left( \left| \sigma'\left( \nu_{1}\right) \right| ^{q} +\left|\sigma'\left( \nu_{2}\right) \right| ^{q}-\left( \frac{\left|\sigma'\left( x\right) \right|^{q} +3\left| \sigma'\left(y\right) \right|^{q} }{4}\right) \right) ^{\frac{1}{q}}\right. \\ &\left. +\left( \left| \sigma'\left( \nu_{1}\right) \right|^{q}+\left| \sigma'\left( \nu_{2}\right) \right| ^{q} -\left(\frac{3\left|\sigma'(x)\right|^{q}+\left|\sigma'(y)\right|^{q}}{4}\right)\right)^{\frac{1}{q}}\right], \end{align*}$

which completes the proof of Theorem 2.3.

Corollary 2.4. Theorem 2.3 with

● $\vartheta = 1$ becomes:

$\begin{multline*} \left|\frac{1}{y-x}\int_{\nu_{1}+\nu_{2}-y}^{\nu_{1}+\nu_{2}-x}\sigma\left(w\right)dw -\sigma\left(\nu_{1}+\nu_{2}-\frac{x+y}{2}\right)\right| \\ \leq \frac{\left( y-x\right)}{4\sqrt[p]{p+1}}\left[\left( \left| \sigma'\left( \nu_{1}\right) \right|^{q} +\left|\sigma'\left( \nu_{2}\right) \right| ^{q}-\left( \frac{\left|\sigma'\left( x\right) \right|^{q} +3\left|\sigma'\left(y\right) \right|^{q}}{4}\right)\right)^{\frac{1}{q}}\right. \\ \left. +\left(\left|\sigma'\left( \nu_{1}\right)\right|^{q}+\left| \sigma'\left( \nu_{2}\right)\right|^{q} -\left(\frac{3\left|\sigma'(x)\right|^{q}+\left|\sigma'(y)\right|^{q} }{4}\right)\right)^{\frac{1}{q}}\right]. \end{multline*}$

● $\vartheta = 1$ , $x = \nu_{1}$ and $y = \nu_{2}$ becomes:

$\begin{align*} &&\left\vert \frac{1}{\nu_{2}-\nu_{1}}\int_{\nu_{1}}^{\nu_{2}}\sigma\left( w\right) dw-\sigma\left(\frac{\nu_{1}+\nu_{2}}{2}\right) \right\vert \leq \frac{\left( \nu_{2}-\nu_{1}\right) }{2^{\frac{2}{p}}}\left(\frac{1}{p+1}\right)^{\frac{1}{p}}\left[ \left\vert \sigma^{\prime }\left( \nu_{1}\right) \right\vert +\left\vert \sigma^{\prime }\left( \nu_{2}\right) \right\vert \right] . \end{align*}$

● $x = \nu_{1}$ and $y = \nu_{2}$ becomes:

$\begin{align*} &\left\vert \frac{2^{\vartheta-1}\Gamma\left(\vartheta+1\right)}{\left(\nu_{2}-\nu_{1}\right)^{\vartheta}} \left[ J_{\nu_{1}+}^{\vartheta }\sigma\left(\frac{\nu_{1}+\nu_{2}}{2}\right) \right. \right. \left. \left. +\; J_{\nu_{2}-}^{\vartheta }\sigma\left(\frac{\nu_{1}+\nu_{2}}{2}\right) \right] -\sigma\left(\frac{\nu_{1}+\nu_{2}}{2}\right) \right\vert \\ &\leq \frac{2^{\vartheta-1-\frac{2}{q}}}{\nu_{2}-\nu_{1}}\left(\frac{1}{p+1}\right)^{\frac{1}{p}}\left[ \left\vert \sigma'\left( \nu_{1}\right) \right\vert +\left\vert \sigma'\left( \nu_{2}\right) \right\vert \right]. \end{align*}$

Theorem 2.4. Let $\sigma:[\nu_{1}, \nu_{2}]\subseteq\bf{R}\to\bf{R}$ be a differentiable function on $(\nu_{1}, \nu_{2})$ and $\left|\sigma'\right|^{q}, q\geq 1$ is convex on $[\nu_{1}, \nu_{2}]$ with $\nu_{1}\leq \nu_{2}$ and $x, y\in[\nu_{1}, \nu_{2}]$ . Then, we have:

$\begin{multline} \left| \frac{2^{\vartheta -1}\Gamma \left( \vartheta +1\right) }{\left(y-x\right) ^{\vartheta }} \left[ J_{\left( \nu_{1}+\nu_{2}-y\right) +}^{\vartheta }\sigma\left( \nu_{1}+\nu_{2}-\frac{x+y}{2}\right)\right.\right. \\ \left. \left. +\; J_{\left( \nu_{1}+\nu_{2}-x\right) -}^{\vartheta }\sigma\left( \nu_{1}+\nu_{2}-\frac{x+y}{2}\right) \right] -\sigma\left( \nu_{1}+\nu_{2}-\frac{x+y}{2}\right) \right| \\ \leq \frac{\left(y-x\right)}{4\left(\vartheta+1\right)}\left[\left(\left|\sigma'(\nu_{1})\right|^{q} +\left|\sigma'\left(\nu_{2}\right)\right|^{q}-\left( \frac{\left| \sigma'\left(x\right)\right|^{q} +\left( 2\vartheta+3\right)\left|\sigma'(y)\right|^{q}}{2\left(\vartheta+2\right) }\right)\right)^{\frac{1}{q}}\right. \\ \left. +\left( \left|\sigma'\left(\nu_{1}\right)\right|^{q}+\left| \sigma'\left( \nu_{2}\right)\right|^{q} -\left(\frac{\left(2\vartheta+3\right)\left|\sigma'(x)\right|^{q}+\left|\sigma'(y)\right|^{q}}{2\left( \vartheta+2\right) }\right) \right) ^{\frac{1}{q}}\right]. \end{multline}$

(2.11)

Proof. By taking modulus of identity (2.7) with the well-known power mean inequality, we can deduce

$\begin{multline*} \left| \frac{2^{\vartheta -1}\Gamma \left( \vartheta +1\right) }{\left(y-x\right) ^{\vartheta }} \left[ J_{\left( \nu_{1}+\nu_{2}-y\right) +}^{\vartheta }\sigma\left( \nu_{1}+\nu_{2}-\frac{x+y}{2}\right) \right. \right. \\ \left. \left. +\; J_{\left( \nu_{1}+\nu_{2}-x\right) -}^{\vartheta }\sigma\left( \nu_{1}+\nu_{2}-\frac{x+y}{2}\right) \right] -\sigma\left( \nu_{1}+\nu_{2}-\frac{x+y}{2}\right) \right| \\ \leq \frac{\left( y-x\right) }{4}\left( \int_{0}^{1}\eta^{\vartheta }\right) ^{1-\frac{1}{q}} \left\{\left(\int_{0}^{1}\eta^{\vartheta} \left|\sigma'\left(\nu_{1}+\nu_{2}-\left(\frac{1-\eta}{2}x+\frac{1+\eta}{2}y\right)\right)\right|^{q}d\eta\right)^{\frac{1}{q}}\right. \\ \left. +\left( \int_{0}^{1}\eta^{\vartheta } \left|\sigma'\left(\nu_{1}+\nu_{2}-\left(\frac{1+\eta}{2}x+\frac{1-\eta}{2}y\right)\right)\right|^{q}d\eta\right)^{\frac{1}{q}}\right\} . \end{multline*}$

By applying the Jensen-Mercer inequality with the convexity of $\left|\sigma'\right|^{q}$ , we can deduce

$\begin{align*} &\left| \frac{2^{\vartheta -1}\Gamma \left( \vartheta +1\right) }{\left(y-x\right)^{\vartheta}} \left[ J_{\left( \nu_{1}+\nu_{2}-y\right)+}^{\vartheta}\sigma\left(\nu_{1}+\nu_{2}-\frac{x+y}{2}\right) \right. \right. \\ &\left. \left. +\; J_{\left( \nu_{1}+\nu_{2}-x\right) -}^{\vartheta }\sigma\left( \nu_{1}+\nu_{2}-\frac{x+y}{2}\right)\right] -\sigma\left( \nu_{1}+\nu_{2}-\frac{x+y}{2}\right) \right| \\ &\leq \frac{\left( y-x\right)}{4}\left(\int_{0}^{1}\eta^{\vartheta }\right)^{1-\frac{1}{q}} \left\{ \left( \int_{0}^{1}\eta^{\vartheta }\left[ \left|\sigma'\left( \nu_{1}\right) \right|^{q} +\left| \sigma'\left(\nu_{2}\right) \right| ^{q}-\left( \frac{1-\eta}{2}\left| \sigma'\left(x\right)\right|^{q} +\frac{1+\eta}{2}\left| \sigma'\left( y\right)\right| ^{q}\right) \right] \right) ^{\frac{1}{q}}\right. \\ &\left. +\left( \int_{0}^{1}\eta^{\vartheta }\left[ \left| \sigma'\left(\nu_{1}\right)\right|^{q} +\left| \sigma'\left( \nu_{2}\right) \right|^{q}-\left( \frac{1+\eta}{2}\left| \sigma'\left( x\right) \right|^{q} +\frac{1-\eta}{2}\left| \sigma'\left( y\right) \right|^{q}\right) \right] \right) ^{\frac{1}{q}}\right\} \\ & = \frac{\left( y-x\right) }{4\left( \vartheta +1\right) }\left[\left(\left|\sigma'\left(\nu_{1}\right)\right|^{q} +\left|\sigma'\left( \nu_{2}\right) \right| ^{q}-\left( \frac{\left| \sigma'\left(x\right) \right|^{q} +\left(2\vartheta +3\right)\left|\sigma'(y)\right|^{q}}{2\left(\vartheta+2\right)}\right)\right)^{\frac{1}{q}}\right. \\ &\left. +\left( \left| \sigma'\left( \nu_{1}\right) \right|^{q}+\left|\sigma'\left( \nu_{2}\right)\right|^{q} -\left( \frac{\left( 2\vartheta +3\right) \left| \sigma'\left( x\right) \right|^{q} +\left|\sigma'\left( y\right)\right|^{q}}{2\left(\vartheta+2\right)}\right)\right)^{\frac{1}{q}}\right], \end{align*}$

which completes the proof of Theorem 2.4.

Corollary 5. Theorem 2.4 with

● $q = 1$ becomes Theorem 2.2.

● $\vartheta = 1$ becomes:

$\begin{multline*} \left| \frac{1}{y-x}\int_{\nu_{1}+\nu_{2}-y}^{\nu_{1}+\nu_{2}-x}\sigma\left(w\right) dw -\sigma\left( \nu_{1}+\nu_{2}-\frac{x+y}{2}\right) \right| \\ \leq \frac{\left( y-x\right) }{8}\left[ \left( \left|\sigma'\left( \nu_{1}\right)\right|^{q} +\left| \sigma'\left( \nu_{2}\right)\right|^{q}-\left( \frac{\left| \sigma'\left( x\right)\right|^{q} +5\left|\sigma'\left(y\right)\right|^{q}}{6}\right)\right)^{\frac{1}{q}}\right. \\ \left. +\left( \left| \sigma'\left( \nu_{1}\right) \right|^{q}+\left|\sigma'\left(\nu_{2}\right)\right|^{q} -\left(\frac{5\left|\sigma'(x)\right|^{q}+\left|\sigma'(y)\right|^{q}}{6}\right)\right)^{\frac{1}{q}}\right]. \end{multline*}$

● $\vartheta = 1$ , $x = \nu_{1}$ and $y = \nu_{2}$ becomes:

$\begin{multline*} \left| \frac{1}{\nu_{2}-\nu_{1}}\int_{\nu_{1}}^{\nu_{2}}\sigma\left( w\right) dw -\sigma\left(\frac{\nu_{1}+\nu_{2}}{2}\right)\right| \\ \leq \frac{\left(y-x\right)}{8}\left[\left(\frac{5\left|\sigma'\left(\nu_{1}\right)\right|^{q} +\left| \sigma'\left( \nu_{2}\right)\right| ^{q}}{6}\right)^{\frac{1}{q}} +\left(\frac{\left|\sigma'(\nu_{1})\right|^{q}+5\left| \sigma'(\nu_{2})\right|^{q}}{6}\right)^{\frac{1}{q}}\right]. \end{multline*}$

● $x = \nu_{1}$ and $y = \nu_{2}$ becomes:

$\begin{multline*} \left| \frac{2^{\vartheta-1}\Gamma\left(\vartheta+1\right)}{\left(\nu_{2}-\nu_{1}\right)^{\vartheta}} \left[J_{\nu_{1} +}^{\vartheta}\sigma\left(\frac{\nu_{1}+\nu_{2}}{2}\right)+\; J_{\nu_{2} -}^{\vartheta }\sigma\left( \frac{\nu_{1}+\nu_{2}}{2}\right)\right] -\sigma\left( \frac{\nu_{1}+\nu_{2}}{2}\right)\right| \\ \leq \frac{\left(\nu_{2}-\nu_{1}\right)}{4\left(\vartheta+1\right)} \left[\left(\frac{\left(2\vartheta+3\right)\left|\sigma'(\nu_{1})\right|^{q}+\left|\sigma'(\nu_{2})\right|^{q}}{2\left(\vartheta+2\right)}\right)^{\frac{1}{q}} +\left(\frac{\left|\sigma'(\nu_{1})\right|^{q}+\left(2\vartheta+3\right)\left|\sigma'(\nu_{2})\right|^{q}}{2\left(\vartheta+2\right)}\right) ^{\frac{1}{q}}\right]. \end{multline*}$

3. Applications to special means

Here, we consider the following special means:

● The arithmetic mean:

$\mathcal{A}(\nu_{1},\nu_{2}) = \frac{\nu_{1}+\nu_{2}}{2}, \quad \nu_{1}, \nu_{2}\geq 0.$

● The harmonic mean:

$\mathcal{H}(\nu_{1},\nu_{2}) = \frac{2\nu_{1}\nu_{2}}{\nu_{1}+\nu_{2}}, \quad \nu_{1}, \nu_{2} > 0.$

● The logarithmic mean:

$\begin{equation*} \mathcal{L}(\nu_{1},\nu_{2}) = \begin{cases} \frac{\nu_{2}-\nu_{1}}{\ln \nu_{2}-\ln \nu_{1}}, & \text{if}\; \nu_{1}\neq \nu_{2}, \\ \nu_{1}, & \text{if}\; \nu_{1} = \nu_{2}, \end{cases} \quad \nu_{1}, \nu_{2} > 0. \end{equation*}$

● The generalized logarithmic mean:

$\begin{equation*} \mathcal{L}_{n}(\nu_{1},\nu_{2}) = \begin{cases} \left[\frac{\nu_{2}^{n+1}-\nu_{1}^{n+1}}{\left(n+1\right)(\nu_{2}-\nu_{1})}\right]^{\frac{1}{n}}, & \text{if}\; \nu_{1}\neq \nu_{2} \\ \nu_{1}, & \text{if}\; \nu_{1} = \nu_{2}, \end{cases} \quad \nu_{1},\nu_{2} > 0;\; n\in\bf{Z}\setminus \{-1,0\}. \end{equation*}$

Proposition 3.1. Let $0 < \nu_{1} < \nu_{2}$ and $n\in\bf{N}$ , $n \geq 2$ . Then, for all $x, y\in[\nu_{1}, \nu_{2}]$ , we have:

(3.1)

Proof. By applying Corollary 2.3 (first item) for the convex function $\sigma(x) = x^{n}, \, x > 0$ , one can obtain the result directly.

Proposition 3.2. Let $0 < \nu_{1} < \nu_{2}$ . Then, for all $x, y\in[\nu_{1}, \nu_{2}]$ , we have:

(3.2)

Proof. By applying Corollary 2.3 (first item) for the convex function $\sigma(x) = \frac{1}{x}, \, x > 0$ , one can obtain the result directly.

Proposition 3.3. Let $0 < \nu_{1} < \nu_{2}$ and $n\in\bf{N}$ , $n \geq 2$ . Then, we have:

$\begin{equation} \left| \mathcal{L}_{n}^{n}(\nu_{1},\nu_{2}) -\mathcal{A}^{n}(\nu_{1},\nu_{2}) \right| \leq \frac{n(\nu_{2}-\nu_{1})}{4} \left[ \mathcal{A}\left(\nu_{1}^{n-1}, \nu_{2}^{n-1}\right) \right], \end{equation}$

(3.3)

and

$\begin{equation} \left| \mathcal{L}^{-1}(\nu_{1},\nu_{2}) -\mathcal{A}^{-1}(\nu_{1},\nu_{2}) \right| \leq \frac{(\nu_{2}-\nu_{1})}{4}\mathcal{H}^{-1}\left( \nu_{1}^{2},\nu_{2}^{2}\right) . \end{equation}$

(3.4)

Proof. By setting $x = \nu_{1}$ and $y = \nu_{2}$ in results of Proposition 3.1 and Proposition 3.2, one can obtain the Proposition 3.3.

Proposition 3.4. Let $0 < \nu_{1} < \nu_{2}$ and $n\in\bf{N}$ , $n \geq 2$ . Then, for $q > 1, \, \frac{1}{p}+\frac{1}{q} = 1$ and for all $x, y\in[\nu_{1}, \nu_{2}],$ we have:

$\begin{multline} \left| \mathcal{L}_{n}^{n}\left( \nu_{1}+\nu_{2}-y,\nu_{1}+\nu_{2}-x\right) -\left( 2\mathcal{A}(\nu_{1},\nu_{2}) -\mathcal{A}\left( x,y\right) \right) ^{n}\right| \\ \leq \frac{n(y-x)}{4\sqrt[p]{p+1}}\Bigg\{\left[ 2\mathcal{A}\left( \nu_{1}^{q(n-1)}, \nu_{2}^{q(n-1)}\right) -\frac{1}{2}\mathcal{A}\left(x^{q(n-1)}, 3y^{q(n-1)}\right) \right]^{\frac{1}{q}} \\ +\left[ 2\mathcal{A}\left( \nu_{1}^{q(n-1)}, \nu_{2}^{q(n-1)}\right) -\frac{1}{2}\mathcal{A}\left(3x^{q(n-1)}, y^{q(n-1)}\right) \right]^{\frac{1}{q}}\Bigg\}. \end{multline}$

(3.5)

Proof. By applying Corollary 2.4 (first item) for convex function $\sigma\left(x\right) = x^{n}, \, x > 0$ , one can obtain the result directly.

Proposition 3.5. Let $0 < \nu_{1} < \nu_{2}$ . Then, for $q > 1, \, \frac{1}{p}+\frac{1}{q} = 1$ and for all $x, y\in[\nu_{1}, \nu_{2}]$ , we have:

$\begin{multline} \left| \mathcal{L}^{-1}\left( \nu_{1}+\nu_{2}-y,\nu_{1}+\nu_{2}-x\right) -\left( 2\mathcal{A}(\nu_{1},\nu_{2}) -\mathcal{A}\left(x,y\right)\right)^{-1}\right| \\ \leq \frac{\sqrt[q]{2}(y-x)}{4\sqrt[p]{p+1}}\Bigg\{\left[ \mathcal{H}^{-1}\left(\nu_{1}^{2q},\nu_{2}^{2q}\right) -\frac{3}{4}\mathcal{H}^{-1}\left(x^{2q}, 3y^{2q}\right) \right]^{\frac{1}{q}} \\ +\left[\mathcal{H}^{-1}\left(\nu_{1}^{2q},\nu_{2}^{2q}\right) -\frac{3}{4}\mathcal{H}^{-1}\left(3x^{2q}, y^{2q}\right) \right]^{\frac{1}{q}}\Bigg\}. \end{multline}$

(3.6)

Proof. By applying Corollary 2.4 (first item) for the convex function $\sigma\left(x\right) = \frac{1}{x}, \, x > 0$ , one can obtain the result directly.

Proposition 3.6. Let $0 < \nu_{1} < \nu_{2}$ and $n\in\bf{N}$ , $n \geq 2$ . Then, for $q > 1$ and $\frac{1}{p}+\frac{1}{q} = 1$ , we have:

$\begin{multline} \left| \mathcal{L}_{n}^{n}(\nu_{1},\nu_{2}) -\mathcal{A}^{n}(\nu_{1},\nu_{2}) \right| \leq \frac{n(\nu_{2}-\nu_{1})}{4\sqrt[p]{p+1}} \Bigg\{\left[ 2\mathcal{A}\left( \nu_{1}^{q(n-1)}, \nu_{2}^{q(n-1)}\right) -\frac{1}{2}\mathcal{A}\left( \nu_{1}^{q(n-1)}, 3\nu_{2}^{q(n-1)}\right) \right]^{\frac{1}{q}} \\ +\left[ 2\mathcal{A}\left( \nu_{1}^{q(n-1)}, \nu_{2}^{q(n-1)}\right) -\frac{1}{2}\mathcal{A}\left(3\nu_{1}^{q(n-1)}, \nu_{2}^{q(n-1)}\right) \right]^{\frac{1}{q}}\Bigg\}, \end{multline}$

(3.7)

and

$\begin{multline} \left| \mathcal{L}^{-1}(\nu_{1},\nu_{2}) -\mathcal{A}^{-1}(\nu_{1},\nu_{2}) \right| \leq \frac{\sqrt[q]{2}(\nu_{2}-\nu_{1})}{4\sqrt[p]{p+1}} \Bigg\{\left[ \mathcal{H}^{-1}\left( \nu_{1}^{2q}, \nu_{2}^{2q}\right) -\frac{3}{4}\mathcal{H}^{-1}\left(\nu_{1}^{2q}, 3\nu_{2}^{2q}\right) \right]^{\frac{1}{q}} \\ +\left[ \mathcal{H}^{-1}\left( \nu_{1}^{2q}, \nu_{2}^{2q}\right) -\frac{3}{4}\mathcal{H}^{-1}\left(3\nu_{1}^{2q}, \nu_{2}^{2q}\right) \right]^{\frac{1}{q}}\Bigg\}. \end{multline}$

(3.8)

Proof. By setting $x = \nu_{1}$ and $y = \nu_{2}$ in results of Proposition 3.4 and Proposition 3.5, one can obtain the Proposition 3.6.

4. Conclusions

As we emphasized in the introduction, integral inequality is the most important field of mathematical analysis and fractional calculus. By using the well-known Jensen-Mercer and power mean inequalities, we have proved new inequalities of Hermite-Hadamard-Mercer type involving Riemann-Liouville fractional operators. In the last section, we have considered some propositions in the context of special functions; these confirm the efficiency of our results.

Acknowledgements

We would like to express our special thanks to the editor and referees. Also, the first author would like to thank Prince Sultan University for funding this work through research group Nonlinear Analysis Methods in Applied Mathematics (NAMAM) group number RG-DES-2017-01-17.

Conflict of interest

The authors declare no conflict of interest.

Acknowledgments

This research was supported by the Basic Science Research Program of Ilia State University.

Conflict of interest

The authors declare no conflict of interest.

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