Autophagy is a normal cellular physiological process. As one of the cell degradation systems, it participates in the lysosomal pathway process of degrading damaged proteins and subcellular organelles to maintain cell metabolism and energy states. Moreover, autophagy is essential for regulating organelle quality control and cell homeostasis. In recent decades, a large number of studies have demonstrated that autophagy abnormalities are present in a variety of human malignancies and that autophagy plays a crucial role in all stages of tumor development. Multiple tumors interfere with autophagy's normal regulation and use autophagy's essential properties to restructure their proteome, reprogram their metabolism, and adapt to stress. This article primarily discusses how autophagy either promotes or inhibits cancer development, the significance of autophagy in maintaining cell genome stability, and the role of selective autophagy in the reshaping and quality control of tumor cells.
Citation: Chunzheng Li, Chenyu Wei, Gongke Zhao, Xianguang Yang. Cancer cells remodeling and quality control are inextricably linked to autophagy[J]. AIMS Molecular Science, 2023, 10(2): 109-126. doi: 10.3934/molsci.2023009
Autophagy is a normal cellular physiological process. As one of the cell degradation systems, it participates in the lysosomal pathway process of degrading damaged proteins and subcellular organelles to maintain cell metabolism and energy states. Moreover, autophagy is essential for regulating organelle quality control and cell homeostasis. In recent decades, a large number of studies have demonstrated that autophagy abnormalities are present in a variety of human malignancies and that autophagy plays a crucial role in all stages of tumor development. Multiple tumors interfere with autophagy's normal regulation and use autophagy's essential properties to restructure their proteome, reprogram their metabolism, and adapt to stress. This article primarily discusses how autophagy either promotes or inhibits cancer development, the significance of autophagy in maintaining cell genome stability, and the role of selective autophagy in the reshaping and quality control of tumor cells.
phosphatidylinositol-3-phosphate
WD-repeat protein interacting with phosphoinositides
double FYVE-containing protein 1
genetically engineered mouse models
reactive oxygen species
damage-regulated autophagy modulator 1
cancer stem cell
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Chunzheng Li, Chenyu Wei, Gongke Zhao, Xianguang Yang. Cancer cells remodeling and quality control are inextricably linked to autophagy[J]. AIMS Molecular Science, 2023, 10(2): 109-126. doi: 10.3934/molsci.2023009
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