Research article Special Issues

A computational study on the influence of aortic valve disease on hemodynamics in dilated aorta

  • Received: 13 August 2019 Accepted: 16 October 2019 Published: 21 October 2019
  • A computational hemodynamics method was employed to investigate how the morphotype and functional state of aortic valve would affect the characteristics of blood flow in aortas with pathological dilation, especially the intensity and distribution of flow turbulence. Two patient-specific aortas diagnosed to have pathological dilation of the ascending segment while differential aortic valve conditions (i.e., one with a stenotic and regurgitant RL bicuspid aortic valve (RL-BAV), whereas the other with a quasi-normal tricuspid aortic valve (TAV)) were studied. When building the computational models, in addition to in vivo data-based reconstruction of geometrical model and boundary condition setting, the large eddy simulation method was adopted to quantify potential flow turbulence in the aortas. Obtained results revealed the presence of complex flow patterns (denoted by time-varying changes in vortex structure), flow turbulence (indicated by high turbulent eddy viscosity (TEV)), and regional high wall shear stress (WSS) in the ascending segment of both aortas. Such hemodynamic characteristics were significantly augmented in the aorta with RL-BAV. For instance, the space-averaged TEV in late systole and the wall area exposed to high time-averaged WSS (judged by WSS> two times of the mean WSS in the entire aorta) in the ascending aortic segment were increased by 176% and 465%, respectively. Relatively, flow patterns in the descending aortic segment were less influenced by the aortic valve disease. These results indicate that aortic valve disease has profound impacts on flow characteristics in the ascending aorta, especially the distribution and degree of high WSS and flow turbulence.

    Citation: Lijian Xu, Lekang Yin, Youjun Liu, Fuyou Liang. A computational study on the influence of aortic valve disease on hemodynamics in dilated aorta[J]. Mathematical Biosciences and Engineering, 2020, 17(1): 606-626. doi: 10.3934/mbe.2020031

    Related Papers:

  • A computational hemodynamics method was employed to investigate how the morphotype and functional state of aortic valve would affect the characteristics of blood flow in aortas with pathological dilation, especially the intensity and distribution of flow turbulence. Two patient-specific aortas diagnosed to have pathological dilation of the ascending segment while differential aortic valve conditions (i.e., one with a stenotic and regurgitant RL bicuspid aortic valve (RL-BAV), whereas the other with a quasi-normal tricuspid aortic valve (TAV)) were studied. When building the computational models, in addition to in vivo data-based reconstruction of geometrical model and boundary condition setting, the large eddy simulation method was adopted to quantify potential flow turbulence in the aortas. Obtained results revealed the presence of complex flow patterns (denoted by time-varying changes in vortex structure), flow turbulence (indicated by high turbulent eddy viscosity (TEV)), and regional high wall shear stress (WSS) in the ascending segment of both aortas. Such hemodynamic characteristics were significantly augmented in the aorta with RL-BAV. For instance, the space-averaged TEV in late systole and the wall area exposed to high time-averaged WSS (judged by WSS> two times of the mean WSS in the entire aorta) in the ascending aortic segment were increased by 176% and 465%, respectively. Relatively, flow patterns in the descending aortic segment were less influenced by the aortic valve disease. These results indicate that aortic valve disease has profound impacts on flow characteristics in the ascending aorta, especially the distribution and degree of high WSS and flow turbulence.


    加载中


    [1] J. B. Kim, M. Spotnitz, M. E. Lindsay, et al., Risk of aortic dissection in the moderately dilated ascending aorta, J. Am. Coll. Cardiol., 68(2016), 1209-1219.
    [2] S. Verma and S. C. Siu, Aortic dilatation in patients with bicuspid aortic valve, N. Engl. J. Med., 370(2014), 1920-1929.
    [3] E. M. Isselbacher, Thoracic and abdominal aortic aneurysms, Circulation, 111(2005), 816-828.
    [4] P. W. Fedak, T. E. David, M. Borger, et al., Bicuspid aortic valve disease: recent insights in pathophysiology and treatment, Expert Rev. Cardiovasc. Ther.,3(2005), 295-308.
    [5] M. Ferencik and L. A. Pape, Changes in size of ascending aorta and aortic valve function with time in patients with congenitally bicuspid aortic valves, Am. J. Cardiol., 92(2003), 43-46.
    [6] R. S. Beroukhim, T. L. Kruzick, A. L. Taylor, et al., Progression of aortic dilation in children with a functionally normal bicuspid aortic valve, Am. J. Cardiol., 98(2006), 828-830. doi: 10.1016/j.amjcard.2006.04.022
    [7] T. A. Hope, M. Markl, L. Wigström, et al., Comparison of flow patterns in ascending aortic aneurysms and volunteers using four-dimensional magnetic resonance velocity mapping, J. Magn. Reson. Imag., 26(2007), 1471-1479.
    [8] A. J. Barker, P. Ooij, K. Bandi, et al., Viscous energy loss in the presence of abnormal aortic flow, Magn. Reson. Med., 72(2014), 620-628.
    [9] R. Mahadevia, A. J. Barker, S. Schnell, et al., Bicuspid aortic cusp fusion morphology alters aortic three-dimensional outflow patterns, wall shear stress, and expression of aortopathy, Circulation., 129(2014), 673-682.
    [10] N. Saikrishnan, L. Mirabella and A. P. Yoganathan, Bicuspid aortic valves are associated with increased wall and turbulence shear stress levels compared to trileaflet aortic valves, Biomech. Model. Mechanobiol., 14(2015), 577-588.
    [11] N. Saikrishnan, C. H. Yap, N. C. Milligan, et al., In vitro characterization of bicuspid aortic valve hemodynamics using particle image velocimetry, Ann. Biomed. Eng., 40(2012), 1760-1775.
    [12] A. McNally, A. Madan and P. Sucosky, Morphotype-dependent flow characteristics in bicuspid aortic valve ascending aortas: a benchtop particle image velocimetry study, Front Physiol., 8(2017), 1-11.
    [13] K. Cao, S. K. Atkins, A. McNally, et al., Simulations of morphotype-dependent hemodynamics in non-dilated bicuspid aortic valve aortas, J. Biomech., 50(2017), 63-70.
    [14] K. Cao and P. Sucosky, Effect of Bicuspid aortic valve cusp fusion on aorta wall shear stress: Preliminary computational assessment and implication for aortic dilation, World J. Cardiovasc. Dis., 5(2015), 129-140.
    [15] P. Youssefi, A. Gomez, T. He, et al., Patient-specific computational fluid dynamics-assessment of aortic hemodynamics in a spectrum of aortic valve pathologies, J. Thorac. Cardiovasc. Surg., 153(2017), 8-20.
    [16] F. Condemi, S. Campisi, M. Viallon, et al., Fluid- and biomechanical analysis of ascending thoracic aorta aneurysm with concomitant aortic insufficiency, Ann. Biomed. Eng., 45(2017), 1-12.
    [17] L. Goubergrits, R. Mevert, P. Yevtushenko, et al., The impact of mri-based inflow for the hemodynamic evaluation of aortic coarctation, Ann. Biomed. Eng., 41(2013), 2575-2587.
    [18] D. Gallo, F. Negri, D. Tresoldi, et al., On the use of in vivo measured flow rates as boundary conditions for image-based hemodynamic models of the human aorta: Implications for indicators of abnormal flow, Ann. Biomed. Eng., 40(2012), 729-741.
    [19] U. Morbiducci, R. Ponzini, D. Gallo, et al., Inflow boundary conditions for image-based computational hemodynamics: impact of idealized versus measured velocity profiles in the human aorta, J. Biomech., 46(2013), 102-109.
    [20] S. Pirola, B. Guo, C. Menichini, et al., 4D flow MRI-based computational analysis of blood flow in patient-specific aortic dissection,IEEE Trans. Biomed. Eng., (2019), in press.
    [21] S. Pirola, Z. Cheng, O. A. Jarral, et al., On the choice of outlet boundary conditions for patient-specific analysis of aortic flow using computational fluid dynamics, J. Biomech., 60(2017), 15-21.
    [22] P. D. Stein and H. N. Sabbah, Turbulent blood flow in the ascending aorta of humans with normal and diseased aortic valves, Circ. Res., 39(1976), 58-65.
    [23] A. F. Stalder, A. Frydrychowicz, M. F. Russe, et al., Assessment of flow instabilities in the healthy aorta using flow-sensitive MRI, J. Magn. Reson. Imag., 33(2011), 839-846.
    [24] R. Mittal, S. P. Simmons and F. Najjar, Numerical study of pulsatile flow in a constricted channel, J. Fluid Mech., 485(2003), 337-378.
    [25] C. Zhu, J. H. Seo and R. Mittal, Computational modelling and analysis of haemodynamics in a simple model of aortic stenosis, J. Fluid Mech., 851(2018), 23-49.
    [26] N. H. Johari, N. B. Wood, Z. Cheng, et al., Disturbed flow in a stenosed carotid artery bifurcation: Comparison of RANS-based transitional model and LES with experimental measurements, Int. J. Appl. Mech., 11(2019), 4.
    [27] R. Agujetas, C. Ferrera, A. C. Marcos, et al., Numerical and experimental analysis of the transitional flow across a real stenosis, Biomech. Model. Mechanobiol.,16(2017), 1447-1458.
    [28] F. P. P. Tan, N. B. Wood, G. Tabor, et al., Comparison of LES of steady transitional flow in an idealized stenosed axisymmetric artery model with a RANS transitional model, ASME. J. Biomech. Eng., 133(2011), 051001.
    [29] M. Andersson, T. Ebbers and M. Karlsson, Characterization and estimation of turbulence-related wall shear stress in patient-specific pulsatile blood flow, J. Biomech., 85(2019), 108-117.
    [30] J. Lantz, T. Ebbers, J. Engvall, et al., Numerical and experimental assessment of turbulent kinetic energy in an aortic coarctation. J. Biomech., 46(2013), 1851-1858.
    [31] S. Karimi, M. Dabagh, P. Vasava, et al., Effect of rheological models on the hemodynamics within human aorta: CFD study on CT image-based geometry, J. Non-Newton. Fluid Mech., 207(2014), 42-52.
    [32] R. E. Collins, Flow of fluids through porous materials, (1976).
    [33] J. O. Hinze, Turbulence. McGraw-Hill Publishing Co, (1975).
    [34] F. Nicoud and F. Ducros, Subgrid-scale stress modelling based on the square of the velocity gradient tensor, Flow, Flow Turbul. Combust., 62(1999), 183-200.
    [35] P. Youssefi, A. Gomez, C. Arthurs, et al., Impact of patient-specific inflow velocity profile on hemodynamics of the thoracic aorta, J. Biomech. Eng. Trans. ASME, 140(2018), 011002.
    [36] L. Xu, F. Liang, L. Gu, et al., Flow instability detected in ruptured versus unruptured cerebral aneurysms at the internal carotid artery, J. Biomech., 72(2018), 187-199.
    [37] Z. Zhang, L. Xu, R. Liu, et al., Importance of incorporating systemic cerebroarterial hemodynamics into computational modeling of blood flow in intracranial aneurysm, J. Hydrodyn., (2019), 1-14.
    [38] J. Alastruey, J. H. Siggers, V. Peiffer, et al., Reducing the data: Analysis of the role of vascular geometry on blood flow patterns in curved vessels, Phys. Fluids, 24(2012), 031902.
    [39] J. M. Dolan, J. Kolega and H. Meng, High wall shear stress and spatial gradients in vascular pathology: a review, Ann. Biomed. Eng., 41(2013), 1411-1427.
    [40] D. Y. Lee, C. I. Lee, T. E. Lin, et al., Role of histone deacetylases in transcription factor regulation and cell cycle modulation in endothelial cells in response to disturbed flow, Proc. Natl. Acad. Sci. USA, 109(2012), 1967-1972.
    [41] M. Cotrufo, A. Della Corte, L. S. De Santo, et al., Different patterns of extracellular matrix protein expression in the convexity and the concavity of the dilated aorta with bicuspid aortic valve: preliminary results, J. Thorac. Cardiovasc. Surg.,130(2005), 504-e1.
    [42] M. Bauer, V. Gliech, H. Siniawski, et al., Configuration of the ascending aorta in patients with bicuspid and tricuspid aortic valve disease undergoing aortic valve replacement with or without reduction aortoplasty, J. Heart Valve Dis.,15(2006), 594-600.
    [43] S. K. Atkins, K. Cao, N. M. Rajamannan, et al., Bicuspid aortic valve hemodynamics induces abnormal medial remodeling in the convexity of porcine ascending aortas, Biomech. Model. Mechanobiol., 13(2014), 1209-1225.
    [44] F. Piatti, F. Sturla, M. M. Bissell, et al., 4D flow analysis of BAV-related fluid-dynamic alterations: Evidences of wall shear stress alterations in absence of clinically-relevant aortic anatomical remodeling, Front. Physiol., 8(2017), 441.
    [45] M. Bonfanti, S. Balabani, M. Alimohammadi, et al., A simplified method to account for wall motion in patient-specific blood flow simulations of aortic dissection: Comparison with fluid-structure interaction, Med. Eng. Phys.,58(2018), 72-79.
    [46] M. Alimohammadi, J. M. Sherwood, M. Karimpour, et al., Aortic dissection simulation models for clinical support: fluid-structure interaction vs. rigid wall models, Biomed. Eng. Online, 14(2015), 34.
    [47] F. Y. Liang, S. Takagi, R. Himeno, et al., Biomechanical characterization of ventricular-arterial coupling during aging: a multi-scale model study, J. Biomech., 42(2009), 692-704.
  • Reader Comments
  • © 2020 the Author(s), licensee AIMS Press. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0)
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索

Metrics

Article views(4297) PDF downloads(525) Cited by(4)

Article outline

Figures and Tables

Figures(11)  /  Tables(1)

Other Articles By Authors

/

DownLoad:  Full-Size Img  PowerPoint
Return
Return

Catalog