Research article Special Issues

Quantitative analysis of body metabolism regulation model in the process of weight loss

  • Received: 09 December 2019 Accepted: 11 February 2020 Published: 09 March 2020
  • MSC : 34A34, 92B05

  • In this paper, the metabolic regulation model of the body during weight loss is established according to the numerical variation law of the three major nutrients and the biological principles. The changing trend of the solution of the model is qualitatively analyzed by using the theory of time-varying differential equation. According to the normal values of the three major nutrients and the ketone body, the sufficient conditions for safe weight loss under the three ways of weight loss during dieting, exercise and drug are provided respectively. Combining with the actual data, the model parameters are identified by the numerical analysis method. The feasible range and simulation curve of the three major nutrients and the ketone body under three weight loss modes are given as well. Finally, the unsafe factors in the process of weight loss are analyzed, and the weight loss suggestions beneficial to health are given.

    Citation: Dong-Mei Li, Ta-Na Guo, Qi Wang, Bing Chai, Rui-Xue Zhang. Quantitative analysis of body metabolism regulation model in the process of weight loss[J]. AIMS Mathematics, 2020, 5(3): 2500-2525. doi: 10.3934/math.2020165

    Related Papers:

  • In this paper, the metabolic regulation model of the body during weight loss is established according to the numerical variation law of the three major nutrients and the biological principles. The changing trend of the solution of the model is qualitatively analyzed by using the theory of time-varying differential equation. According to the normal values of the three major nutrients and the ketone body, the sufficient conditions for safe weight loss under the three ways of weight loss during dieting, exercise and drug are provided respectively. Combining with the actual data, the model parameters are identified by the numerical analysis method. The feasible range and simulation curve of the three major nutrients and the ketone body under three weight loss modes are given as well. Finally, the unsafe factors in the process of weight loss are analyzed, and the weight loss suggestions beneficial to health are given.


    加载中


    [1] R. Eckel, S. Grundy, P. Zimmet, The metabolic syndrome, The Lancet, 365 (2005), 1415-1428. doi: 10.1016/S0140-6736(05)66378-7
    [2] S. Baldassarre, S. Fragapani, A. Panero, et al. NTproBNP in insulin-resistance mediated conditions: overweight/obesity, metabolic syndrome and diabetes. the population-based casale monferrato study, Cardiovasc. Diabetol., 16 (2017), 119.
    [3] S. Obesity, Preventing and managing the global epidemic. report of a who consultation, WHO Technical Report Series, 1 (2000), 18-30.
    [4] T. O. Cheng, Childhood obesity in China, Health & Place, 4 (2004), 395-396.
    [5] O. Fiala, Natural disasters in developing countries: natural disasters and individual behaviour in developing countries, Germany: Springer International Publishing, 2017.
    [6] X. Li, W. Huang, L. J. Ming, et al. Effects of a multivitamin/multimineral supplement on young males with physical over training: a placebo-controlled, randomized, double-blinded cross-over trial, Biomed. Environ. Sci., 26 (2013), 599-604.
    [7] S. M. Pasiakos, L. M. Margolis, N. E. Murphy, et al. Effects of exercise mode, energy, and macronutrient interventions on inflammation during military training, Physiological Reports, 4 (2016), 678.
    [8] K. R. Westerterp, Exercise for weight loss, The American Journal of Clinical Nutrition, 3 (2019), 540-541.
    [9] J. Obert, M. Pearlman, L. Obert, et al. Popular weight loss strategies: a review of four weight loss techniques, Current Gastroenterology Reports, 12 (2017), 61.
    [10] K. A. Varady, S. Bhutani, E. C. Church, et al. Short-term modified alternate-day fasting: a novel dietary strategy for weight loss and cardioprotection in obese adults, The American Journal of Clinical Nutrition, 90 (2009), 1138-1143. doi: 10.3945/ajcn.2009.28380
    [11] C. N. Ochner, A. G. Tsai, R. F. Kushner, et al. Treating obesity seriously: when recommendations for lifestyle change confront biological adaptations, The Lancet Diabetes & Endocrinology, 3 (2015), 232-234.
    [12] J. R. Speakman, K. R. Westerterp, A mathematical model of weight loss under total starvation: evidence against the thrifty-gene hypothesis, Disease Models and Mechanisms, 6 (2013), 236-251. doi: 10.1242/dmm.010009
    [13] F. P. Kozusko, Body weight setpoint, metabolic adaption and human starvation, B. Math. Biol., 63 (2001), 393-403. doi: 10.1006/bulm.2001.0229
    [14] Z. Xie, A mathematical mode of the relation between men is weight and intake of heat, Journal of Wuhan Food Industry College, 4 (1998), 46-48.
    [15] L. Dang, Mathematical model for influence of being on diet and exercises on weight loss, Journal of Qujing Normal University, 3 (2013), 68-72.
    [16] T. L. Saaty, J. M. Alexander, Thinking with models: mathematical models in the physical, biological, and social sciences, America: RWS Publications, 1981.
    [17] Y. Zhong, The modeling of markov skeleton process on the mathematical model of reduce weight, Journal of Anyang Normal University, 2 (2008), 20-22.
    [18] K. M. Hvizdos, A. Markham, Orlistat, Drugs, 4 (1999), 743-760.
    [19] K. Nakai, R. Wada, S. Iida, et al. Modeling and simulation of orlistat to predict weight loss and weight maintenance in obesity patients, Drug Metab. Pharmacok., 29 (2014), 278-282. doi: 10.2133/dmpk.DMPK-13-RG-100
    [20] W. Lei, K. LIu, K. Zhang, Y. Li, Relations between body mass index and the biochemical indexes of blood glucose, fat and protein metabolisms, Chinese J. Clin. Rehab., 9 (2005), 64-65.
    [21] K. T. Borer, How effective is exercise in producing fat loss?, International journal of fundamental and applied kinesiology, 40 (2008), 127-138.
    [22] Y. Guo, W. Chen, Influencing factors over obesity and exercise induced weight loss, Journal of Shanghai University of Sport, 3 (2010), 64-66.
    [23] Y. Zhang, C. Zhang, Y. Tang, et al. Effect of exercise interventions on blood lipid in patients with hypertension: meta-analysis, Journal of Community Medicine, 4 (2018), 1-6.
    [24] F. A. Maruf, A. O. Akinpelu, B. L. Salako, A randomized controlled trial of the effects of aerobic dance training on blood lipids among individuals with hypertension on a thiazide, High Blood Pressure & Cardiovascular Prevention, 4 (2014), 275-283.
    [25] Y. Bai, J. Zhang, S. Jiang, Effects of the body fat mass and blood sugar and plasma resistin to slim exercise prescription for overweight and obesity students, Journal Of Hygiene Research, 42 (2013), 538-542.
    [26] Mathematics Modeling and Cross Technology, the Question C of the "Shenzhen Cup" Mathematical Modeling Challenge Competition in China: Study on the Regulation Model and Health Utility of Human Weight Reduction Mechanism.iCarbonX-Israel, 2018. Available from: http://www.m2ct.org/modular-list.jsp?pageType=smxly&menuType=flowUp.
    [27] H. Nagao, H. Nishizawa, T. Bamba, et al. Increased dynamics of tricarboxylic acid cycle and glutamate synthesis in obese adipose tissue, J. Biol. Chem., 292 (2017), 4469-4483. doi: 10.1074/jbc.M116.770172
    [28] D. A. Bender, Tricarboxylic acid cycle, Encyclopedia of Food Sciences & Nutrition, 6 (2003), 5851-5856.
    [29] J. Ge, Y. Xu, Internal medicine, Peking: People's Medical Publishing House(PMPH), 2013.
    [30] R. K. Murray, D. K. Granner, P. A. Mayes, et al. Harper's biochemistry, Norwalk (Conn): Appleton & Lange, 1988.
    [31] X. Liao, Theory methods and application of stability, 2 Eds., Huhan: Huazhong University of Science and Technology Press, 2010.
    [32] G. Derosa, P. Maffioli, A. Sahebkar, Improvement of plasma adiponectin, leptin and C-reactive protein concentrations by orlistat: a systematic review and meta analysis, Brit. J. Clin. Pharmaco., 81 (2016), 819-834. doi: 10.1111/bcp.12874
    [33] S. Qi, J. Yuan, A new antiobesity drugorlistat, Chinese New Drugs Journal, 10 (2001), 423-425.
    [34] S. S. Ray, Numerical analysis with algorithms and programming, New York: Chapman and Hall/CRC, 2016.
    [35] R. H. Johnson, J. L. Walton, Fitness, fatness, and post-exercise ketosis, The Lancet, 297 (1971), 566-568.
    [36] R. J. Jarrett, R. H. Johnson, J. Walton, et al. Post-exercise ketosis, The Lancet, 294 (1969), 1383-1385. doi: 10.1016/S0140-6736(69)90931-3
    [37] J. M. D. Smith, J. A. Maas, P. C. Garnsworthy, et al. Mathematical modeling of glucose homeostasis and its relationship with energy balance and body fat, Obesity, 17 (2009), 632-639. doi: 10.1038/oby.2008.604
    [38] Z. Fang, Influence of carbohydrate loading with different glycemic index on metabolic and immune response of endurance exercise, Beijing: Beijing Sport University, 2007.
    [39] H. P. Bian, Q. Ning, H. Y. Zhou, Graphical synthetic routes of orlistat, Chinese Journal of Pharmaceuticals, 37 (2006), 716.
    [40] M. Kristensen, S. R. Juul, K. V. Srensen, et al. Supplementation with dairy calcium and/or flaxseed fibers in conjunction with orlistat augments fecal fat excretion without altering ratings of gastrointestinal comfort, Nutr. Metab., 14 (2017), 13.
  • Reader Comments
  • © 2020 the Author(s), licensee AIMS Press. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0)
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索

Metrics

Article views(3648) PDF downloads(342) Cited by(0)

Article outline

Figures and Tables

Figures(11)  /  Tables(7)

/

DownLoad:  Full-Size Img  PowerPoint
Return
Return

Catalog