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The modulatory role of gut microbiota on host behavior: exploring the interaction between the brain-gut axis and the neuroendocrine system

  • Received: 05 December 2023 Revised: 26 March 2024 Accepted: 28 March 2024 Published: 31 March 2024
  • The brain-gut axis refers to the communication between the central nervous system and the gastrointestinal tract, with the gut microbiome playing a crucial role. While our understanding of the interaction between the gut microbiome and the host's physiology is still in its nascent stage, evidence suggests that the gut microbiota can indeed modulate host behavior. Understanding the specific mechanisms by which the gut microbiota community modulates the host's behavior remains the focus of present and future neuro-gastroenterology studies. This paper reviews several pieces of evidence from the literature on the impact of gut microbiota on host behavior across animal taxa. We explore the different pathways through which this modulation occurs, with the aim of deepening our understanding of the fascinating relationship between the gut microbiome and the central nervous system.

    Citation: Temitope Awe, Ayoola Fasawe, Caleb Sawe, Adedayo Ogunware, Abdullahi Temitope Jamiu, Michael Allen. The modulatory role of gut microbiota on host behavior: exploring the interaction between the brain-gut axis and the neuroendocrine system[J]. AIMS Neuroscience, 2024, 11(1): 49-62. doi: 10.3934/Neuroscience.2024004

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  • The brain-gut axis refers to the communication between the central nervous system and the gastrointestinal tract, with the gut microbiome playing a crucial role. While our understanding of the interaction between the gut microbiome and the host's physiology is still in its nascent stage, evidence suggests that the gut microbiota can indeed modulate host behavior. Understanding the specific mechanisms by which the gut microbiota community modulates the host's behavior remains the focus of present and future neuro-gastroenterology studies. This paper reviews several pieces of evidence from the literature on the impact of gut microbiota on host behavior across animal taxa. We explore the different pathways through which this modulation occurs, with the aim of deepening our understanding of the fascinating relationship between the gut microbiome and the central nervous system.



    Ricci solitons as a generalization of Einstein manifolds introduced by Hamilton in mid 1980s [7,8]. In the last two decades, a lot of researchers have been done on Ricci solitons. Currently, Ricci solitons have became a crucial tool in studding Riemannian manifolds, especially for manifolds with positive curvature. Chen and Deshmukh in [3] classified the Ricci solitons with concurrent vector fields and introduced a condition for a submanifold to be a Ricci soliton in a Riemannian manifold equipped with a concurrent vector field. Pigola and others have introduced a natural deployment of the concept of gradient Ricci soliton, namely, the Ricci almost soliton [10]. The notion of h-almost Ricci soliton which develops naturally the notion of almost Ricci soliton has been introduced in [6]. It is shown that a compact non-trivial h-almost Ricci soliton of dimension no less than three with having defined signal and constant scalar curvature is isometric to a standard sphere with the potential function well assigned. Ghahremani-Gol showed that a compact non-trivial h-almost Ricci soliton is isometric to an Euclidean sphere with some conditions using the Hodge-de Rham decomposition theorem [5].

    In this paper, we will generalize results of [3] for h-almost Ricci solitons. A complete classification of h-almost Ricci soliton with concurrent potential field will be given. When h=1 our results coincide with Chen and Deshmukh results in [3].

    This paper is organized as follows: In section 2, we remind definitions of objects and some basic notions which we need throughout the paper. In section 3, we study the structure of h-almost Ricci solitons and classify h-almost Ricci solitons with concurrent vector fields. Moreover, we provide conditions on a submanifold of a Riemannian h-almost Ricci soliton to be an h-almost Ricci soliton. Finally, we study h-almost Ricci soliton on Euclidean hypersurfaces. In the last section, we present proofs of some of the identities provied throughout section 3.

    In this section, we shall present some preliminaries which will be needed for the establishment of our desired results.

    Definition 2.1. A Riemannian manifold (Mm,g) is said to be a Ricci soliton if there exists a smooth vector field X on Mm such that

    LXg+2Ric=2λg, (2.1)

    where λ is a real constant, Ric and LX stand for the Ricci tensor and Lie derivative operator, respectively.

    We denote a Ricci soliton by (Mm,g,X,λ). The smooth vector field X mentioned above, is called a potential field for the Ricci soliton. A Ricci soliton (Mm,g,X,λ) is said to be steady, shrinking or expanding if λ=0, λ>0 or λ<0, respectively. Also, a Ricci soliton (Mm,g,X,λ) is said to be gradient soliton if there exists a smooth function f on M such that X=f. In this case, f is called a potential function for the Ricci soliton and the Eq (2.1) can be rewritten as follows

    Ric+2f=λg, (2.2)

    where 2 is the Hessian of f.

    Example 2.2. Einstein metrics are the most obvious examples of Ricci solitons.

    Definition 2.3. A Riemannian manifold (Mm,g) is said to be an h-almost Ricci soliton if there exists a smooth vector field X on Mm and a smooth function h:MmR, such that

    hLXg+2Ric=2λg, (2.3)

    where λ is a smooth function on M, Ric and LX stand for the Ricci tensor and Lie derivative, respectively.

    We will denote the h-almost Ricci soliton by (Mm,g,X,h,λ). All concepts related to Ricci soliton can be defined for h-almost Ricci soliton, accordingly. An h-almost Ricci soliton is said to be shirinking, steady or expanding if λ is positive, zero or negative, respectively.

    Also, if X=f for a smooth function f, then we say (Mm,g,f,h,λ) is a gradient h-almost Ricci soliton with potential function f. In such cases the Eq (2.3) can be rewritten as follows

    Ric+h2f=λg, (2.4)

    where 2f denotes the Hessian of f. Note that when the potential function f be a real constant then, the underlying Ricci soltion is simply Einstein metric.

    Yano has proved that if the holonomy group of a Riemannian m-manifold leaves a point invariant, then there exists a vector field X on M which satisfies

    YX=Y, (2.5)

    for any vector Y tangent to M [15]. We have the following definition.

    Definition 2.4. A vector field X on a Riemannian manifold is said to be concircular vector field if it satisfies an equation of the following form [14]

    YX=ρY, (2.6)

    for all smooth vector fields Y, where ρ is a scalar function. If ρ is constant, then X is called a concurrent vector field.

    Concurrent vector fields in Riemannian geometry and related topics have been studied by many researchers, for example see [12]. Also, concurrent vector fields have been studied in Finsler geometry [13].

    Let (M,g) be a Rimannian submanifold of (ˉM,ˉg) and ψ:MˉM be an isometric immersion from M into ˉM. The Levi-Civita connection of ˉM and the submanifold M will be denote by ˉ and , respectively.

    Proposition 2.5. (The Gauss Formula)[9] If X,Yχ(M) are extended arbitrarily to vector fields on ˉM, the following formula holds

    ˉXY=XY+II(X,Y), (2.7)

    where II is called the second fundamental form.

    Lemma 2.6. (The Weingarten Equation)[9] Suppose X,Yχ(M) and N is normal vector on M. If X,Y,N are extended arbitrarily to ˉM, the following equations hold at points of M.

    <ˉXN,Y>=<N,II(X,Y)>, (2.8)
    ˜XN=ANX+DXN, (2.9)

    where A and D denote the shape operator and normal connection of M, respectively.

    Recall that the equations of Gauss and Codazzi are given by the following equations

    g(R(X,Y)Z,W)=˜g(˜R(X,Y)Z,W)+˜g(II(X,Y),II(Y,Z))˜g(II(X,W),II(Y,Z)), (2.10)
    (˜R(X,Y)Z)=(ˉXII)(Y,Z)(ˉYII)(X,Z), (2.11)

    where X,Y,Z and W are tangent to M.

    Also, the mean curvature H of M in ˉM is give by

    H=(1n)trace(II). (2.12)

    We also need to know the warped product structure of Riemannian manifolds. Let B and E be two Riemannian manifolds equipped with Riemannian metrics gB and gE, respectively, and let f be a positive smooth function on B. Consider the product manifold B×E with its natural projection π:B×EB and η:B×EE.

    Definition 2.7. The warped product M=B×E is the manifold B×E equipped with the Riemannian metric structure given by

    <X,Y>=<π(X),π(Y)>+f2<η(X),η(Y)>, (2.13)

    for any tangent vector X,YTM. Thus we have

    g=πgB+(fπ)2ηgE. (2.14)

    The function f is called the warping function of the warped product.[4]

    In this section, we announce our main results and theorems which will be proven in the next section.

    Theorem 3.1. Let (Mm,g,X,h,λ) be a complete h-almost Ricci solition on a Riemannian manifold (Mm,g). Then X is a concurrent field if and only if the following conditions hold:

    1) The h-almost Ricci solition would be shrinking, steady or expanding.

    2) The m-dimensional complete manifold Mm is a warped manifold I×sE, where I is an open interval of arclength s and (E,gE) is an Einstein manifold with dimension (m1) whose RicE=(m2)gE, where gE is the metric tensor of E.

    From the above theorem, the following results are obtained immediately.

    Corollary 3.2. Any h-almost Ricci solition (Mm,g,X,h,λ) equipped with a concurrent vector field X would be a gradiant soliton.

    Corollary 3.3. There are three types of shrinking, steady or expanding h-almost Ricci solition (Mm,g,X,h,λ) equipped with a concurrent vector field X.

    In what follows, we present the existence conditions for a submanifold to be an h-almost Ricci soliton.

    In the rest of this paper, suppose that (Pp,˜g) is a Riemannian manifold equiped with a concurrent vector field X. Let ψ:MmPp is an isometric immersion of a Rimannian submanifold (Mm,g) into (Pp,˜g). We use notations XT and X to show the tangential and normal components of X. Also, suppose that A, D and II are the usual notation for the shape operator, normal connection and the second fundamental form of the submanifold M in P, respectively.

    Theorem 3.4. Let ψ:(Mm,g)(Pp,˜g) be a hypersurface immersed in (Pp,˜g). Then (Mm,g) has an h-almost Ricci solition structure with a concurrent vector field XT if only if the following equation holds

    Ric(Y,Z)=(λh)g(Y,Z)h˜g(II(Y,Z),X). (3.1)

    Using theorem 3.4, we obtain the following results.

    Theorem 3.5. Let ψ:(Mm,g)(Pp,˜g) be a minimal immersed in (Pp,˜g). If (M,g) admits a structure of h-almost Ricci soliton (Mm,g,X,h,λ), then Mm has the scaler curvature given by m(λh)/2.

    Also, we can conclude the following theorem.

    Theorem 3.6. Let ψ:MmRm+1 be a hypersurface immersed in Rm+1. If (M,g) admits an h-almost Ricci soliton structure (Mm,g,XT,h,λ), then two distinct principal curvatures of Mm are given by the following equation

    κ1,κ2=mβ+θ±(mβ+θ)2+4h4λ2, (3.2)

    where XT stands for the tangential component of the vector field X, β is the mean curvature and θ is the support function, that is H=βN and θ=<N,X>, where N is a unit normal vector.

    Next, using the distinct principal curvatures formula of Mm presented in Proposition (3.6), we classify h-almost Ricci solitons on hypersurface of Mm of Rm+1 with λ=h. In fact, we have the following theorem.

    Theorem 3.7. Let ψ:MmRm+1 be a hypersurface immersed in Rm+1. If (M,g) admits an h-almost Ricci soliton structure (Mm,g,XT,h,λ) with λ=h. Then Mm is an open portion of one of the following hypersurface of Rm+1:

    1) A totally umbilical hypersurface.

    2) A flat hypersurface generated by lines through the origin 0 of Rm+1.

    3) A spherical hypercylinder Sk(k1)×Rmk,2km1.

    In this section, we will prove our results which are established in the previous section.

    Proof of Theorem 3.1 Suppose that (Mm,g,X,h,λ) is a h-almost Ricci solition on a Riemannian manifold and X is a concurrent vector field on (Mm,g), then we have

    YX=Y,YTM. (4.1)

    From Eq (4.1) and definition of the Lie derivative operator, we can write

    (LXg)(Y,Z)=g(YX,Z)+g(ZX,Y)=2g(Y,Z), (4.2)

    for any X,Y tangent to M. Considering h-almost Ricci soliton equation (2.3) and Eq (4.2) we have

    Ric(Y,Z)=(λh)g(Y,Z), (4.3)

    which shows that Mm is an Einstein manifold. An straightforward calculation shows that the sectional curvature of (Mn,g) satisfies

    K(X,Y)=0, (4.4)

    for each unit vector Y orthogonal to X. Hence, the Ricci tensor of M satisfies the following equation

    Ric(X,X)=0. (4.5)

    By comparing Eqs (4.3) and (4.5) we can deduce that Mm is a Ricci flat Riemannian manifold. Therefore, we get λ=h. Since h is an arbitrary real function, so the h-almost Ricci soliton (Mm,g,X,h,λ) would be a shrinking, steady or expanding.

    Let v1 be a unit vector field tangent to Mm and suppose {v1,...vm} is a local orthonormal frame of Mm extended by v1. We denote the spaces produced by span{v1} and span{v2,,vm} with Π1 and Π2, respectively. i.e, Π1=span{v1} and Π2=span{v2,,vm}.

    In [3], it is shown that Π1 is a totally geodesic distribution. Therefore, the leaves of Π1 are geodesics of Mm.

    Furthermore, a logical argument concludes that the second fundamental form H for each leaf K of Π2 in Mm is given as follows.

    H(vi,vj)=δijμv1,2i,jm. (4.6)

    Therefore, the mean curvature of each leaf of K is μ1. In addition, we deduce from the above equation that each leaf of Π2 is a totally umbilical hypersurface of Mm. Setting X=μv1, then with an easy calculation we have

    μv2=....=μvm=0. (4.7)

    Using the above equations we deduce that Π2 is a spherical distribution. Since, the mean curvature vector of each totally umbilical leaf is parallel to the normal bundle, we conclude from Pong-Reckziegal (see [11]) that (Mm,g) is locally isometric to a warped product I×f(s)E equipped with the following warp metric.

    g=ds2+f2gE, (4.8)

    where v1=/s.

    From definition of above warped metric, the sectional curvature M is obtained as follows

    K(Y,X)=f(s)f(s), (4.9)

    for any unit vector Y orthonormal to X. From Eq (4.4) and the above equation, we obtain f=0. So we have

    f(s)=cs+d, (4.10)

    for some c,d in R.

    The quantity c cannot be equal to zero because if c=0, then I×f(s)E is a Riemannian product and as a result every leaf Π2 is totally geodesic in Mm. Hence μ=0. which is the opposite of the Eq (4.6). Due to the reasons provided, we have c0. With a transfer we can assume f(s)=s. That is, f is the identity function. Therefore Mm is locally isometric with a warped product I×sE.

    On the other hand, since Mm is a Ricci flat manifold, the Corollary 4.1 of [2], follows that E is an Einstein manifold with RicE=(n2)gE. An straightforward computation shows the converse of the theorem (see Example 1.1 of [4,page 20]).

    Proof of Corollary 3.2. Using Eq (4.2) we get (12LXg)=g. It follows from the Eq (2.3) and λ=h that Ric=0. Setting f:=12g(X,X), we obtain Hess(f)=g.

    By Eq (2.3), Hess(f)=g and (12LXg)=g, we have Ric+hHess(f)=λg. So the h-almost Ricci solition is gradient.

    In the following, we prove Theorem 3.4.

    Proof of Theorem 3.4. Let ψ:MmPp be an isometric immersion from M into P. We write X based on its tangential and normal components as follows,

    X=XT+X. (4.11)

    Since X is a concurrent vector field on P, applying Eq (4.11) and the Gauss and Wiengarten equations we have

    Y=˜YXT+˜YXYXT+h(Y,XT)AXY+DYX, (4.12)

    for any Y tangent to M. The following equations are established by comparing the tangential and normal components of two sides of the Eq (4.12).

    YXT=AXY+X, (4.13)
    II(Y,XT)=DYX, (4.14)

    hence,

    (LXTg)(Y,Z)=g(YXT,Z)+g(ZXT,Z)=2g(Y,Z)+2g(AXY,Z)=2g(Y,Z)+2˜g(II(Y,Z),X), (4.15)

    for Y,Z tangent to M. Equation (2.3) and above equation show that M is an h-almost Ricci soliton if and only if we have

    Ric(Y,Z)+h2LXTg(Y,Z)=λg(Y,Z), (4.16)
    Ric(Y,Z)+g(Y,Z)+˜g(II(Y,Z),X)=λg(Y,Z),
    Ric(Y,Z)+h(g(Y,Z)+˜g(II(Y,Z),X))=λg(Y,Z),
    Ric(Y,Z)=(λh)g(Y,Z)h˜g(II(Y,Z),X),

    as required.

    Proof of Theorem 3.5. By Theorem 3.4 we can obtain the following equation.

    Ric(Y,Z)=(λh)g(Y,Z)h˜g(II(Y,Z),X), (4.17)

    for Y,Z tangent to Mm. Since Mm is a minimal submanifold of Pp, then H=0. Specially, we have ˜g(H,X)=0. So, in the ray of Eq (4.17) we can write

    mi=1Ric(ei,ei)=m(λh). (4.18)

    Hence, the scalar curvature given by m(λh)/2.

    Proof of Theorem 3.6. Let Mm a hypersurface of Rm+1 be an h-almost Ricci soliton. We choose a local orthonormal frame {vi}mi=1 on Mm such that vi are eigenvectors of the shape operator AN, then we have

    ANvi=κivi. (4.19)

    From the Gauss formula (2.10), we obtain

    Ric(Y, Z)=n˜g(II(Y,Z),H)mi=1˜g(II(Y,ei),II(Z,ei)), (4.20)

    where ˜g is the Euclidean metric of Rm+1. By an straightforward calculation, using Theorem 3.4, Eq (4.19) and formula (4.20) we deduce that (Mm,g,XT,h,λ) is an h-almost Ricci soliton if and only if we have

    (mβκj)κiδij=(λh)δijθκiδij. (4.21)

    By simplifying two sides of the Eq (4.21), we obtain the following quadratic equation with respect to κi

    κ2i(mβ+θ)κi+(λh)=0,i=1,...m. (4.22)

    Solving the above equation, completes the proof.

    Now we are ready to prove Theorem 3.7.

    Proof of Theorem 3.7. Suppose the given condition holds and Let (Mm,g,XT,h,λ) be an h-almost Ricci soliton on hypersurface of MmRm+1 with λ=h. using relation (3.2) from Theorem (3.6), Mm has two distinct principal curvatures give by

    κ1=mβ+θ+(mβ+θ)2+4h4λ2,κ2=mβ+θ(mβ+θ)2+4h4λ2. (4.23)

    By combining λ=h and (4.23), we obtain κ1=mβ+θ and κ2=0, respectively. The rest of the proof is similar to the proof of Theorem 6.1 of [3], therefore we omit it.

    The authors declare no conflict of interest in this paper.



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    This review article does not contain original data. The data sources used in this review are publicly available and referenced accordingly in the article. Any additional information or data used in this review can be obtained by contacting the corresponding author.

    Conflict of interest



    The authors declare that there are no conflicts of interest.

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