Quantitative generation of microfluidic flow by using optically driven microspheres

Songyu Hu; Ruifeng Hu; Liping Tang; Weiwei Jiang; Banglin Deng; Songyu Hu; Ruifeng Hu; Liping Tang; Weiwei Jiang; Banglin Deng

doi:10.3934/mbe.2019334

Mathematical Biosciences and Engineering

2019, Volume 16, Issue 6: 6696-6707. doi: 10.3934/mbe.2019334

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Quantitative generation of microfluidic flow by using optically driven microspheres

1.
College of Mechatronics and Control Engineering, Shenzhen University, Shenzhen 518060, China
2.
Department of Mechanical Engineering and Materials Science, University of Pittsburgh, Pittsburgh, PA 15260, USA
3.
College of Computer Science & Technology, Zhejiang University of Technology, Hangzhou 310023, China

Received: 29 April 2019 Accepted: 09 July 2019 Published: 24 July 2019

Microfluidic flow generation plays a fundamental role in microfluidic systems and shows potential for applications in basic biology and clinical medicine. In this study, an enabling technology is proposed to quantitatively generate microfluid flow through the automatic movement of a microsphere in liquid by using optical tweezers. A closed-loop control strategy with visual servoing feedback is introduced to achieve high precision and robustness. The theoretical solution of the generated microfluid is obtained on the basis of Stokes equations. An experimental method is proposed, and experiments are performed to verify the effectiveness of our approach. This method does not impose any dedicated fabrication of microtool, and the microfluidic flow can be dexterously adjusted by controlling the direction, speed, and distance of the microsphere from a target location. To the best of our knowledge, this is the first demonstration of optically actuating liquids through the translational movement of microspheres with closed-loop control. The proposed method will be useful in various biomedical applications needing quantitative, precise and controllable localized microfluid.
- microfluidic flow,
- microfluidic system,
- theoretical solution,
- optical tweezers,
- optical trap,
- microsphere
Citation: Songyu Hu, Ruifeng Hu, Liping Tang, Weiwei Jiang, Banglin Deng. Quantitative generation of microfluidic flow by using optically driven microspheres[J]. Mathematical Biosciences and Engineering, 2019, 16(6): 6696-6707. doi: 10.3934/mbe.2019334

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Abstract

Microfluidic flow generation plays a fundamental role in microfluidic systems and shows potential for applications in basic biology and clinical medicine. In this study, an enabling technology is proposed to quantitatively generate microfluid flow through the automatic movement of a microsphere in liquid by using optical tweezers. A closed-loop control strategy with visual servoing feedback is introduced to achieve high precision and robustness. The theoretical solution of the generated microfluid is obtained on the basis of Stokes equations. An experimental method is proposed, and experiments are performed to verify the effectiveness of our approach. This method does not impose any dedicated fabrication of microtool, and the microfluidic flow can be dexterously adjusted by controlling the direction, speed, and distance of the microsphere from a target location. To the best of our knowledge, this is the first demonstration of optically actuating liquids through the translational movement of microspheres with closed-loop control. The proposed method will be useful in various biomedical applications needing quantitative, precise and controllable localized microfluid.

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