Evaluation of the relationship between the prealbumin/fibrinogen ratio and diabetic nephropathy in patients with type 2 diabetes mellitus

Burcin Meryem Atak Tel; Ramiz Tel; Tuba Duman; Satilmis Bilgin; Hamza Kaya; Halil Bardak; Gulali Aktas; Burcin Meryem Atak Tel; Ramiz Tel; Tuba Duman; Satilmis Bilgin; Hamza Kaya; Halil Bardak; Gulali Aktas

doi:10.3934/medsci.2024008

AIMS Medical Science

2024, Volume 11, Issue 2: 90-98. doi: 10.3934/medsci.2024008

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Research article

Evaluation of the relationship between the prealbumin/fibrinogen ratio and diabetic nephropathy in patients with type 2 diabetes mellitus

1.
Department of Internal Medicine, Abant Izzet Baysal University Hospital, Golkoy, Bolu, Turkey
2.
Department of Emergency Medicine, Izzet Baysal State Hospital, Bolu, Turkey

Received: 27 December 2023 Revised: 17 April 2024 Accepted: 11 May 2024 Published: 17 May 2024

Introduction
Our aim was to compare the prealbumin/fibrinogen ratio (PFR) of diabetic patient populations with or without diabetic nephropathy.

Materials and methods
People with type 2 diabetes who attended the internal medicine outpatient clinic were enrolled in the study. Two groups were formed according to the proteinuria of the patients: Diabetic nephropathy and non-nephropathy group. Diabetic nephropathy was calculated using the mathematical formula of spot urine albumin/spot urine creatinine x100. Patients with proteinuria above 200 mg/g were considered to have nephropathy. PFR was simply calculated by dividing prealbumin by fibrinogen.

Results
A total of 152 patients who attended our outpatient clinic were enrolled in the study. There were 68 patients in the diabetic nephropathy group and 84 in the non-nephropathy group. The prealbumin/fibrinogen ratios (PFR) were significantly lower in the nephropathic group [0.061 (0.02–0.16)] than the non-nephropathic group [0.0779 (0.01–0.75)] (p = 0.002).

Conclusions
We suggest that decreased levels of PFR can indicate diabetic nephropathy in subjects with type 2 diabetes mellitus.
- diabetic nephropathy,
- inflammation,
- prealbumin to fibrinogen ratio
Citation: Burcin Meryem Atak Tel, Ramiz Tel, Tuba Duman, Satilmis Bilgin, Hamza Kaya, Halil Bardak, Gulali Aktas. Evaluation of the relationship between the prealbumin/fibrinogen ratio and diabetic nephropathy in patients with type 2 diabetes mellitus[J]. AIMS Medical Science, 2024, 11(2): 90-98. doi: 10.3934/medsci.2024008

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Abstract

Introduction

Our aim was to compare the prealbumin/fibrinogen ratio (PFR) of diabetic patient populations with or without diabetic nephropathy.

Materials and methods

People with type 2 diabetes who attended the internal medicine outpatient clinic were enrolled in the study. Two groups were formed according to the proteinuria of the patients: Diabetic nephropathy and non-nephropathy group. Diabetic nephropathy was calculated using the mathematical formula of spot urine albumin/spot urine creatinine x100. Patients with proteinuria above 200 mg/g were considered to have nephropathy. PFR was simply calculated by dividing prealbumin by fibrinogen.

Results

A total of 152 patients who attended our outpatient clinic were enrolled in the study. There were 68 patients in the diabetic nephropathy group and 84 in the non-nephropathy group. The prealbumin/fibrinogen ratios (PFR) were significantly lower in the nephropathic group [0.061 (0.02–0.16)] than the non-nephropathic group [0.0779 (0.01–0.75)] (p = 0.002).

Conclusions

We suggest that decreased levels of PFR can indicate diabetic nephropathy in subjects with type 2 diabetes mellitus.

Author contributions

Burcin Meryem Atak Tel: study design, data curation, data interpretation, statistical analyses, critical review and writing; Ramiz Tel: study design, statistical analyses, writing; Tuba Duman: formal analysis; Satilmis Bilgin: formal analysis; Hamza Kaya: data curation, writing; Halil Bardak: data curation, data interpretation; Gulali Aktas: study design, formal analysis, critical review and writing. All authors have read and approved the final version of the manuscript for publication.

Data availability

Data will be shared by corresponding author on reasonable request.

Ethics approval of research and informed consent

This work has been approved by Abant Izzet Baysal University ethics committee (approval number: 2022/205). All subjects have consent to participate to the study.

Conflict of interest

The authors declare no conflicts of interest.

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