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Research article

Data-driven assessment of immune evasion and dynamic Zero-COVID policy on fast-spreading Omicron in Changchun

  • Due to its immune evasion capability, the SARS-CoV-2 Omicron variant was declared a variant of concern by the World Health Organization. The spread of Omicron in Changchun (i.e., the capital of Jilin province in northeast of China) during the spring of 2022 was successfully curbed under the strategy of a dynamic Zero-COVID policy. To evaluate the impact of immune evasion on vaccination and other measures, and to understand how the dynamic Zero-COVID measure stopped the epidemics in Changchun, we establish a compartmental model over different stages and parameterized the model with actual reported data. The model simulation firstly shows a reasonably good fit between our model prediction and the data. Second, we estimate the testing rate in the early stage of the outbreak to reveal the real infection size. Third, numerical simulations show that the coverage of vaccine immunization in Changchun and the regular nucleic acid testing could not stop the epidemic, while the 'non-pharmaceutical' intervention measures utilized in the dynamic Zero-COVID policy could play significant roles in the containment of Omicron. Based on the parameterized model, numerical analysis demonstrates that if one wants to achieve epidemic control by fully utilizing the effect of 'dynamic Zero-COVID' measures, therefore social activities are restricted to the minimum level, and then the economic development may come to a halt. The insight analysis in this work could provide reference for infectious disease prevention and control measures in the future.

    Citation: Kun Wang, Peng Wang, Zhengang Jiang, Lu Wang, Linhua Zhou, Dequan Qi, Weishi Yin, Pinchao Meng. Data-driven assessment of immune evasion and dynamic Zero-COVID policy on fast-spreading Omicron in Changchun[J]. Mathematical Biosciences and Engineering, 2023, 20(12): 21692-21716. doi: 10.3934/mbe.2023960

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  • Due to its immune evasion capability, the SARS-CoV-2 Omicron variant was declared a variant of concern by the World Health Organization. The spread of Omicron in Changchun (i.e., the capital of Jilin province in northeast of China) during the spring of 2022 was successfully curbed under the strategy of a dynamic Zero-COVID policy. To evaluate the impact of immune evasion on vaccination and other measures, and to understand how the dynamic Zero-COVID measure stopped the epidemics in Changchun, we establish a compartmental model over different stages and parameterized the model with actual reported data. The model simulation firstly shows a reasonably good fit between our model prediction and the data. Second, we estimate the testing rate in the early stage of the outbreak to reveal the real infection size. Third, numerical simulations show that the coverage of vaccine immunization in Changchun and the regular nucleic acid testing could not stop the epidemic, while the 'non-pharmaceutical' intervention measures utilized in the dynamic Zero-COVID policy could play significant roles in the containment of Omicron. Based on the parameterized model, numerical analysis demonstrates that if one wants to achieve epidemic control by fully utilizing the effect of 'dynamic Zero-COVID' measures, therefore social activities are restricted to the minimum level, and then the economic development may come to a halt. The insight analysis in this work could provide reference for infectious disease prevention and control measures in the future.



    Recently, fractional calculus methods became of great interest, because it is a powerful tool for calculating the derivation of multiples systems. These methods study real world phenomena in many areas of natural sciences including biomedical, radiography, biology, chemistry, and physics [1,2,3,4,5,6,7]. Abundant publications focus on the Caputo fractional derivative (CFD) and the Caputo-Hadamard derivative. Additionally, other generalization of the previous derivatives, such as Ψ-Caputo, study the existence of solutions to some FDEs (see [8,9,10,11,12,13,14]).

    In general, an m-point fractional boundary problem involves a fractional differential equation with fractional boundary conditions that are specified at m different points on the boundary of a domain. The fractional derivative is defined using the Riemann-Liouville fractional derivative or the Caputo fractional derivative. Solving these types of problems can be challenging due to the non-local nature of fractional derivatives. However, there are various numerical and analytical methods available for solving such problems, including the spectral method, the finite difference method, the finite element method, and the homotopy analysis method. The applications of m-point fractional boundary problems can be found in various fields, including physics, engineering, finance, and biology. These problems are useful in modeling and analyzing phenomena that exhibit non-local behavior or involve memory effects (see [15,16,17,18]).

    Pantograph equations are a set of differential equations that describe the motion of a pantograph, which is a mechanism used for copying and scaling drawings or diagrams. The equations are based on the assumption that the pantograph arms are rigid and do not deform during operation, we can simply say that see [19]. One important application of the pantograph equations is in the field of drafting and technical drawing. Before the advent of computer-aided design (CAD) software, pantographs were commonly used to produce scaled copies of drawings and diagrams. By adjusting the lengths of the arms and the position of the stylus, a pantograph can produce copies that are larger or smaller than the original [20], electrodynamics [21] and electrical pantograph of locomotive [22].

    Many authors studied a huge number of positive solutions for nonlinear fractional BVP using fixed point theorems (FPTs) such as SFPT, Leggett-Williams and Guo-Krasnosel'skii (see [23,24]). Some studies addressed the sign-changing of solution of BVPs [25,26,27,28,29].

    In this work, we use Schauder's fixed point theorem (SFPT) to solve the semipostone multipoint Ψ-Caputo fractional pantograph problem

    Dν;ψrϰ(ς)+F(ς,ϰ(ς),ϰ(r+λς))=0, ς in (r,) (1.1)
    ϰ(r)=ϑ1, ϰ()=m2i=1ζiϰ(ηi)+ϑ2, ϑiR, i{1,2}, (1.2)

    where λ(0,r),Dν;ψr is Ψ-Caputo fractional derivative (Ψ-CFD) of order ν, 1<ν2, ζiR+(1im2) such that 0<Σm2i=1ζi<1, ηi(r,), and F:[r,]×R×RR.

    The most important aspect of this research is to prove the existence of a positive solution of the above m-point FBVP. Note that in [30], the author considered a two-point BVP using Liouville-Caputo derivative.

    The article is organized as follows. In the next section, we provide some basic definitions and arguments pertinent to fractional calculus (FC). Section 3 is devoted to proving the the main result and an illustrative example is given in Section 4.

    In the sequel, Ψ denotes an increasing map Ψ:[r1,r2]R via Ψ(ς)0, ς, and [α] indicates the integer part of the real number α.

    Definition 2.1. [4,5] Suppose the continuous function ϰ:(0,)R. We define (RLFD) the Riemann-Liouville fractional derivative of order α>0,n=[α]+1 by

    RLDα0+ϰ(ς)=1Γ(nα)(ddς)nς0(ςτ)nα1ϰ(τ)dτ,

    where n1<α<n.

    Definition 2.2. [4,5] The Ψ-Riemann-Liouville fractional integral (Ψ-RLFI) of order α>0 of a continuous function ϰ:[r,]R is defined by

    Iα;Ψrϰ(ς)=ςr(Ψ(ς)Ψ(τ))α1Γ(α)Ψ(τ)ϰ(τ)dτ.

    Definition 2.3. [4,5] The CFD of order α>0 of a function ϰ:[0,+)R is defined by

    Dαϰ(ς)=1Γ(nα)ς0(ςτ)nα1ϰ(n)(τ)dτ, α(n1,n),nN.

    Definition 2.4. [4,5] We define the Ψ-CFD of order α>0 of a continuous function ϰ:[r,]R by

    Dα;Ψrϰ(ς)=ςr(Ψ(ς)Ψ(τ))nα1Γ(nα)Ψ(τ)nΨϰ(τ)dτ, ς>r, α(n1,n),

    where nΨ=(1Ψ(ς)ddς)n,nN.

    Lemma 2.1. [4,5] Suppose q,>0, and ϰinC([r,],R). Then ς[r,] and by assuming Fr(ς)=Ψ(ς)Ψ(r), we have

    1) Iq;ΨrI;Ψrϰ(ς)=Iq+;Ψrϰ(ς),

    2) Dq;ΨrIq;Ψrϰ(ς)=ϰ(ς),

    3) Iq;Ψr(Fr(ς))1=Γ()Γ(+q)(Fr(ς))+q1,

    4) Dq;Ψr(Fr(ς))1=Γ()Γ(q)(Fr(ς))q1,

    5) Dq;Ψr(Fr(ς))k=0, k=0,,n1, nN, qin(n1,n].

    Lemma 2.2. [4,5] Let n1<α1n,α2>0, r>0, ϰL(r,), Dα1;ΨrϰL(r,). Then the differential equation

    Dα1;Ψrϰ=0

    has the unique solution

    ϰ(ς)=W0+W1(Ψ(ς)Ψ(r))+W2(Ψ(ς)Ψ(r))2++Wn1(Ψ(ς)Ψ(r))n1,

    and

    Iα1;ΨrDα1;Ψrϰ(ς)=ϰ(ς)+W0+W1(Ψ(ς)Ψ(r))+W2(Ψ(ς)Ψ(r))2++Wn1(Ψ(ς)Ψ(r))n1,

    with WR, {0,1,,n1}.

    Furthermore,

    Dα1;ΨrIα1;Ψrϰ(ς)=ϰ(ς),

    and

    Iα1;ΨrIα2;Ψrϰ(ς)=Iα2;ΨrIα1;Ψrϰ(ς)=Iα1+α2;Ψrϰ(ς).

    Here we will deal with the FDE solution of (1.1) and (1.2), by considering the solution of

    Dν;ψrϰ(ς)=h(ς), (2.1)

    bounded by the condition (1.2). We set

    Δ:=Ψ()Ψ(r)Σm2i=1ζi(Ψ(ηi)Ψ(r)).

    Lemma 2.3. Let ν(1,2] and ς[r,]. Then, the FBVP (2.1) and (1.2) have a solution ϰ of the form

    ϰ(ς)=[1+Σm2i=1ζi1Δ(Ψ(ς)Ψ(r))]ϑ1+Ψ(ς)Ψ(r)Δϑ2+rϖ(ς,τ)h(τ)Ψ(τ)dτ,

    where

    ϖ(ς,τ)=1Γ(ν){[(Ψ()Ψ(r))ν1Σm2j=iζj(Ψ(ηj)Ψ(τ))ν1]Ψ(ς)Ψ(r)Δ(Ψ(ς)Ψ(τ))ν1,τς,ηi1<τηi,[(Ψ()Ψ(τ))ν1Σm2j=iζj(Ψ(ηj)Ψ(τ))ν1]Ψ()Ψ(r)Δ,ςτ,ηi1<τηi, (2.2)

    i=1,2,...,m2.

    Proof. According to the Lemma 2.2 the solution of Dν;ψrϰ(ς)=h(ς) is given by

    ϰ(ς)=1Γ(ν)ςr(Ψ(ς)Ψ(τ))ν1h(τ)Ψ(τ)dτ+c0+c1(Ψ(ς)Ψ(r)), (2.3)

    where c0,c1R. Since ϰ(r)=ϑ1 and ϰ()=m2i=1ζiϰ(ηi)+ϑ2, we get c0=ϑ1 and

    c1=1Δ(1Γ(ν)m2i=1ζiηjr(Ψ(ηi)Ψ(τ))ν1h(τ)Ψ(τ)dτ+1Γ(ν)r(Ψ()Ψ(τ))ν1h(τ)Ψ(τ)dτ+ϑ1[m2i=1ζi1]+ϑ2).

    By substituting c0,c1 into Eq (2.3) we find,

    ϰ(ς)=[1+Σm2i=1ζi1Δ(Ψ(ς)Ψ(r))]ϑ1+(Ψ(ς)Ψ(r))Δϑ21Γ(ν)(ςr(Ψ(ς)Ψ(τ))ν1h(τ)Ψ(τ)dτ+(Ψ(ς)Ψ(r))Δm2i=1ζiηjr(Ψ(ηi)Ψ(τ))ν1h(τ)Ψ(τ)dτΨ(ς)Ψ(r)Δr(Ψ()Ψ(τ))ν1h(τ)Ψ(τ)dτ)=[1+Σm2i=1ζi1Δ(Ψ(ς)Ψ(r))]ϑ1+(Ψ(ς)Ψ(r))Δϑ2+rϖ(ς,τ)h(τ)Ψ(τ)dτ,

    where ϖ(ς,τ) is given by (2.2). Hence the required result.

    Lemma 2.4. If 0<m2i=1ζi<1, then

    i) Δ>0,

    ii) (Ψ()Ψ(τ))ν1m2j=iζj(Ψ(ηj)Ψ(τ))ν1>0.

    Proof. i) Since ηi<, we have

    ζi(Ψ(ηi)Ψ(r))<ζi(Ψ()Ψ(r)),
    m2i=1ζi(Ψ(ηi)Ψ(r))>m2i=1ζi(Ψ()Ψ(r)),
    Ψ()Ψ(r)m2i=1ζi(Ψ(ηi)Ψ(r))>Ψ()Ψ(r)m2i=1ζi(Ψ()Ψ(r))=(Ψ()Ψ(r))[1m2i=1ζi].

    If 1Σm2i=1ζi>0, then (Ψ()Ψ(r))Σm2i=1ζi(Ψ(ηi)Ψ(r))>0. So we have Δ>0.

    ii) Since 0<ν11, we have (Ψ(ηi)Ψ(τ))ν1<(Ψ()Ψ(τ))ν1. Then we obtain

    m2j=iζj(Ψ(ηj)Ψ(τ))ν1<m2j=iζj(Ψ()Ψ(τ))ν1(Ψ()Ψ(τ))ν1m2i=1ζi<(Ψ()Ψ(τ))ν1,

    and so

    (Ψ()Ψ(τ))ν1m2j=iζj(Ψ(ηj)Ψ(τ))ν1>0.

    Remark 2.1. Note that rϖ(ς,τ)Ψ(τ)dτ is bounded ς[r,]. Indeed

    r|ϖ(ς,τ)|Ψ(τ)dτ1Γ(ν)ςr(Ψ(ς)Ψ(τ))ν1Ψ(τ)dτ+Ψ(ς)Ψ(r)Γ(ν)Δm2i=1ζiηir(Ψ(ηj)Ψ(τ))ν1Ψ(τ)dτ+Ψ(ς)Ψ(r)ΔΓ(ν)r(Ψ()Ψ(τ))ν1Ψ(τ)dτ=(Ψ(ς)Ψ(r))νΓ(ν+1)+Ψ(ς)Ψ(r)ΔΓ(ν+1)m2i=1ζi(Ψ(ηi)Ψ(r))ν+Ψ(ς)Ψ(r)ΔΓ(ν+1)(Ψ()Ψ(r))ν(Ψ()Ψ(r))νΓ(ν+1)+Ψ()Ψ(r)ΔΓ(ν+1)m2i=1ζi(Ψ(ηi)Ψ(r))ν+(Ψ()Ψ(r))ν+1ΔΓ(ν+1)=M. (2.4)

    Remark 2.2. Suppose Υ(ς)L1[r,], and w(ς) verify

    {Dν;ψrw(ς)+Υ(ς)=0,w(r)=0, w()=Σm2i=1ζiw(ηi), (2.5)

    then w(ς)=rϖ(ς,τ)Υ(τ)Ψ(τ)dτ.

    Next we recall the Schauder fixed point theorem.

    Theorem 2.1. [23] [SFPT] Consider the Banach space Ω. Assume bounded, convex, closed subset in Ω. If ϝ: is compact, then it has a fixed point in .

    We start this section by listing two conditions which will be used in the sequel.

    (Σ1) There exists a nonnegative function ΥL1[r,] such that rΥ(ς)dς>0 and F(ς,ϰ,v)Υ(ς) for all (ς,ϰ,v)[r,]×R×R.

    (Σ2) G(ς,ϰ,v)0, for (ς,ϰ,v)[r,]×R×R.

    Let =C([r,],R) the Banach space of CFs (continuous functions) with the following norm

    ϰ=sup{|ϰ(ς)|:ς[r,]}.

    First of all, it seems that the FDE below is valid

    Dν;ψrϰ(ς)+G(ς,ϰ(ς),ϰ(r+λς))=0, ς[r,]. (3.1)

    Here the existence of solution satisfying the condition (1.2), such that G:[r,]×R×RR

    G(ς,z1,z2)={F(ς,z1,z2)+Υ(ς), z1,z20,F(ς,0,0)+Υ(ς), z10 or z20, (3.2)

    and ϰ(ς)=max{(ϰw)(ς),0}, hence the problem (2.5) has w as unique solution. The mapping Q: accompanied with the (3.1) and (1.2) defined as

    (Qϰ)(ς)=[1+Σm2i=1ζi1Δ(Ψ(ς)Ψ(r))]ϑ1+Ψ(ς)Ψ(r)Δϑ2+rϖ(ς,τ)G(ς,ϰ(τ),ϰ(r+λτ))Ψ(τ)dτ, (3.3)

    where the relation (2.2) define ϖ(ς,τ). The existence of solution of the problems (3.1) and (1.2) give the existence of a fixed point for Q.

    Theorem 3.1. Suppose the conditions (Σ1) and (Σ2) hold. If there exists ρ>0 such that

    [1+Σm2i=1ζi1Δ(Ψ()Ψ(r))]ϑ1+Ψ()Ψ(r)Δϑ2+LMρ,

    where Lmax{|G(ς,ϰ,v)|:ς[r,], |ϰ|,|v|ρ} and M is defined in (2.4), then, the problems (3.1) and (3.2) have a solution ϰ(ς).

    Proof. Since P:={ϰ:ϰρ} is a convex, closed and bounded subset of B described in the Eq (3.3), the SFPT is applicable to P. Define Q:P by (3.3). Clearly Q is continuous mapping. We claim that range of Q is subset of P. Suppose ϰP and let ϰ(ς)ϰ(ς)ρ, ς[r,]. So

    |Qϰ(ς)|=|[1+Σm2i=1ζi1Δ(Ψ(ς)Ψ(r))]ϑ1+Ψ(ς)Ψ(r)Δϑ2+rϖ(ς,τ)G(τ,ϰ(τ),ϰ(r+λτ))Ψ(τ)dτ|[1+Σm2i=1ζi1Δ(Ψ()Ψ(r))]ϑ1+Ψ()Ψ(r)Δϑ2+LMρ,

    for all ς[r,]. This indicates that Qϰρ, which proves our claim. Thus, by using the Arzela-Ascoli theorem, Q: is compact. As a result of SFPT, Q has a fixed point ϰ in P. Hence, the problems (3.1) and (1.2) has ϰ as solution.

    Lemma 3.1. ϰ(ς) is a solution of the FBVP (1.1), (1.2) and ϰ(ς)>w(ς) for every ς[r,] iff the positive solution of FBVP (3.1) and (1.2) is ϰ=ϰ+w.

    Proof. Let ϰ(ς) be a solution of FBVP (3.1) and (1.2). Then

    ϰ(ς)=[1+Σm2i=1ζi1Δ(Ψ(ς)Ψ(r))]ϑ1+(Ψ(ς)Ψ(r))Δϑ2+1Γ(ν)rϖ(ς,τ)G(τ,ϰ(τ),ϰ(r+λτ))Ψ(τ)dτ=[1+Σm2i=1ζi1Δ(Ψ(ς)Ψ(r))]ϑ1+Ψ(ς)Ψ(r)Δϑ2+1Γ(ν)rϖ(ς,τ)(F(τ,ϰ(τ),ϰ(r+λτ))+p(τ))Ψ(τ)dτ=[1+Σm2i=1ζi1Δ(Ψ(ς)Ψ(r))]ϑ1+Ψ(ς)Ψ(r)Δϑ2+1Γ(ν)rϖ(ς,τ)F(τ,(ϰw)(τ),(ϰw)(r+λτ))Ψ(τ)dτ+1Γ(ν)rϖ(ς,τ)p(τ)Ψ(τ)dτ=[1+Σm2i=1ζi1Δ(Ψ(ς)Ψ(r))]ϑ1+Ψ(ς)Ψ(r)Δϑ2+1Γ(ν)rϖ(ς,τ)G(τ,(ϰw)(τ),(ϰw)(r+λτ))Ψ(τ)dτ+w(ς).

    So,

    ϰ(ς)w(ς)=[1+Σm2i=1ζi1Δ(Ψ(ς)Ψ(r))]ϑ1+Ψ(ς)Ψ(r)Δϑ2+1Γ(ν)rϖ(ς,τ)F(τ,(ϰw)(τ),(ϰw)(r+λτ))Ψ(τ)dτ.

    Then we get the existence of the solution with the condition

    ϰ(ς)=[1+Σm2i=1ζi1Δ(Ψ(ς)Ψ(r))]ϑ1+Ψ(ς)Ψ(r)Δϑ2+1Γ(ν)rϖ(ς,τ)F(τ,ϰ(τ),ϰ(r+λτ))Ψ(τ)dτ.

    For the converse, if ϰ is a solution of the FBVP (1.1) and (1.2), we get

    Dν;ψr(ϰ(ς)+w(ς))=Dν;ψrϰ(ς)+Dν;ψrw(ς)=F(ς,ϰ(ς),ϰ(r+λς))p(ς)=[F(ς,ϰ(ς),ϰ(r+λς))+p(ς)]=G(ς,ϰ(ς),ϰ(r+λς)),

    which leads to

    Dν;ψrϰ(ς)=G(ς,ϰ(ς),ϰ(r+λς)).

    We easily see that

    ϰ(r)=ϰ(r)w(r)=ϰ(r)0=ϑ1,

    i.e., ϰ(r)=ϑ1 and

    ϰ()=m2i=1ζiϰ(ηi)+ϑ2,
    ϰ()w()=m2i=1ζiϰ(ηi)m2i=1ζjw(ηi)+ϑ2=m2i=1ζi(ϰ(ηi)w(ηi))+ϑ2.

    So,

    ϰ()=m2i=1ζiϰ(ηi)+ϑ2.

    Thus ϰ(ς) is solution of the problem FBVP (3.1) and (3.2).

    We propose the given FBVP as follows

    D75ϰ(ς)+F(ς,ϰ(ς),ϰ(1+0.5ς))=0, ς(1,e), (4.1)
    ϰ(1)=1, ϰ(e)=17ϰ(52)+15ϰ(74)+19ϰ(115)1. (4.2)

    Let Ψ(ς)=logς, where F(ς,ϰ(ς),ϰ(1+12ς))=ς1+ςarctan(ϰ(ς)+ϰ(1+12ς)).

    Taking Υ(ς)=ς we get e1ςdς=e212>0, then the hypotheses (Σ1) and (Σ2) hold. Evaluate Δ0.366, M3.25 we also get |G(ς,ϰ,v)|<π+e=L such that |ϰ|ρ, ρ=17, we could just confirm that

    [1+Σm2i=1ζi1Δ(Ψ()Ψ(r))]ϑ1+Ψ()Ψ(r)Δϑ2+LM16.3517. (4.3)

    By applying the Theorem 3.1 there exit a solution ϰ(ς) of the problem (4.1) and (4.2).

    In this paper, we have provided the proof of BVP solutions to a nonlinear Ψ-Caputo fractional pantograph problem or for a semi-positone multi-point of (1.1) and(1.2). What's new here is that even using the generalized Ψ-Caputo fractional derivative, we were able to explicitly prove that there is one solution to this problem, and that in our findings, we utilize the SFPT. The results obtained in our work are significantly generalized and the exclusive result concern the semi-positone multi-point Ψ-Caputo fractional differential pantograph problem (1.1) and (1.2).

    The authors extend their appreciation to the Deanship of Scientific Research at King Khalid University for funding this work through Small Groups (RGP.1/350/43).

    The authors declare no conflict of interest.



    [1] S. He, Y. Peng, K. Sun, SEIR modeling of the COVID-19 and its dynamics, Nonlinear Dyn., 101 (2020), 1667–1680. https://doi.org/10.1007/s11071-020-05743-y doi: 10.1007/s11071-020-05743-y
    [2] R. Khandia, S. Singhal, T. Alqahtani, M. A. Kamal, N. A. El-Shall, F. Nainu, et al., Emergence of SARS-CoV-2 Omicron (B.1.1.529) variant, salient features, high global health concerns and strategies to counter it amid ongoing COVID-19 pandemic, Environ. Res., 209 (2022), 1–18. https://doi.org/10.1016/j.envres.2022.112816 doi: 10.1016/j.envres.2022.112816
    [3] M. Hoffmann, N. Krger, S. Schulz, A. Cossmann, C. Rocha, A. Kempf, et al., The Omicron variant is highly resistant against antibody-mediated neutralization: Implications for control of the COVID-19 pandemic, Cell, 185 (2022), 447–456. https://doi.org/10.1016/j.cell.2021.12.032 doi: 10.1016/j.cell.2021.12.032
    [4] L. Jansen, B. Tegomoh, K. Lange, K. Showalter, J. Figliomeni, B. Abdalhamid, et al., Investigation of a sars-cov-2 b. 1.1. 529 (omicron) variant cluster-nebraska, november-december 2021, Morb. Mortal. Wkly. Rep., 70 (2021), 1782–1784. https://doi.org/10.15585/mmwr.mm705152e3 doi: 10.15585/mmwr.mm705152e3
    [5] C. Reno, F. Sanmarchi, M. Stoto, M. P. Fantini, J. Lenzi, D. Golinelli, The impact of health policies and vaccine rollout on the COVID-19 pandemic waves in Italy, Health Policy Technol., 11 (2022), 100604. https://doi.org/10.1016/j.hlpt.2022.100604 doi: 10.1016/j.hlpt.2022.100604
    [6] L. Chen, K. Wang, Analysis of COVID-19 epidemic characteristics in Shanxi Province based on SEIR model, J. Shanxi Datong Univ., 37 (2021), 40–45.
    [7] D. Eyre, D. Taylor, M. Purver, D. Chapman, T. Fowler, K. B. Pouwels, et al., Effect of Covid-19 vaccination on transmission of alpha and delta variants, N. Engl. J. Med., 386 (2022), 744–756. https://doi.org/10.1056/NEJMoa2116597 doi: 10.1056/NEJMoa2116597
    [8] J. Bernal, N. Andrews, C. Gower, E. Gallagher, R. Simmons, S. Thelwall, et al., Effectiveness of Covid-19 vaccines against the B. 1.617.2 (Delta) variant, N. Engl. J. Med., 385 (2021), 585–594. https://doi.org/10.1056/NEJMc2113090 doi: 10.1056/NEJMc2113090
    [9] D. Planas, N. Saunders, P. Maes, F. Guivel-Benhassine, C. Planchais, J. Buchrieser, et al., Considerable escape of SARS-CoV-2 Omicron to antibody neutralization, Nature, 602 (2022), 671–675. https://doi.org/10.1038/s41586-021-04389-z doi: 10.1038/s41586-021-04389-z
    [10] S. Zhao, H. Chen, Modeling the epidemic dynamics and control of COVID-19 outbreak in China, Quant. Biol., 8 (2020), 11–19. https://doi.org/10.1007/s40484-020-0199-0 doi: 10.1007/s40484-020-0199-0
    [11] N. Andrews, J. Stowe, F. Kirsebom, S. Toffa, T. Rickeard, E. Gallagher, et al., COVID-19 vaccine effectiveness against the omicron (B.1.1.529) variant, N. Engl. J. Med., 386 (2022), 1532–1546. https://doi.org/10.1056/NEJMoa2119451 doi: 10.1056/NEJMoa2119451
    [12] K. Wang, Z. Jia, L. Bao, L. Wang, L. Cao, H. Chi, et al., Memory B cell repertoire from triple vaccinees against diverse SARS-CoV-2 variants, Nature, 603 (2022), 919–925. https://doi.org/10.1038/s41586-022-04466-x doi: 10.1038/s41586-022-04466-x
    [13] S. Tartof, J. Slezak, Effectiveness of mRNA BNT162b2 COVID-19 vaccine up to 6 months in a large integrated health system in the USA: a retrospective cohort study, Lancet, 398 (2021), 1407–1416. https://doi.org/10.1016/S0140-6736(21)02183-8 doi: 10.1016/S0140-6736(21)02183-8
    [14] H. Tseng, B. Ackerson, Y. Luo, L. S. Sy, C. A. Talarico, Y. Tian, et al., Effectiveness of mRNA-1273 against SARS-CoV-2 omicron and delta variants, Nat. Med., 28 (2022), 1063–1071. https://doi.org/10.1038/s41591-022-01753-y doi: 10.1038/s41591-022-01753-y
    [15] C. Baraniuk, COVID-19: How effective are vaccines against the delta variant?, BMJ, 374 (2021). https://doi.org/10.1136/bmj.n1960
    [16] P. Sah, S. Moghadas, T. Vilches, A. Shoukat, B. H. Singer, P. J. Hotez, et al., Implications of suboptimal COVID-19 vaccination coverage in Florida and Texas, Lancet Infect. Dis., 21 (2021), 1493–1494. https://doi.org/10.1016/S1473-3099(21)00620-4 doi: 10.1016/S1473-3099(21)00620-4
    [17] C. Banho, L. Sacchetto, G. Campos, C. Bittar, F. S. Possebon, L. S. Ullmann, et al., Impact of SARS-CoV-2 Gamma lineage introduction and COVID-19 vaccination on the epidemiological landscape of a Brazilian city, Nat. Commun. Med., 2 (2022), 41. https://doi.org/10.1038/s43856-022-00108-5 doi: 10.1038/s43856-022-00108-5
    [18] E. Chen, COVID-19 prevention and control strategies in the era of vaccines, Preventive Med., 33 (2021), 221–225. https://doi.org/10.19485/j.cnki.issn2096-5087.2021.03.002 doi: 10.19485/j.cnki.issn2096-5087.2021.03.002
    [19] Number of people vaccinated against COVID-19 nationwide as of February 25, 2022. Available from: http://www.nhc.gov.cn/xcs/fkdt/202202/8f49f6627a6540ce87511ac708ea7ad9.shtml.
    [20] C. Kuhlmann, C. Mayer, M. Claassen, T. Maponga, W. A. Burgers, R. Keeton, et al., Breakthrough infections with SARS-CoV-2 omicron despite mRNA vaccine booster dose, Lancet, 625 (2022), 625–626. https://doi.org/10.1016/S0140-6736(22)00090-3 doi: 10.1016/S0140-6736(22)00090-3
    [21] K. Liu, S. Ai, S. Song, G. Zhu, F. Tian, H. Li, et al., Population movement, city closure in Wuhan, and geographical expansion of the COVID-19 infection in China in January 2020, Clin. Infect. Dis., 71 (2020), 2045–2051. https://doi.org/10.1093/cid/ciaa422 doi: 10.1093/cid/ciaa422
    [22] L. Zhou, X. Rong, M. Fan, L. Yang, H. Chu, L. Xue, et al., Modeling and evaluation of the joint prevention and control mechanism for curbing COVID-19 in Wuhan, Bull. Math. Biol., 84 (2022), 28. https://doi.org/10.1007/s11538-021-00983-4 doi: 10.1007/s11538-021-00983-4
    [23] S. Wang, Y. Ye, K. Hu, H. Lei, C. Chen, X. Xu, et al., To study the impact of Wuhan city lockdown on COVID-19 epidemic situation in China based on population mobility data, J. ZheJiang Univ., 50 (2021), 61–67. https://doi.org/10.3724/zdxbyxb-2021-0021 doi: 10.3724/zdxbyxb-2021-0021
    [24] M. Chinazzi, J. Davis, M. Ajelli, C. Gioannini, M. Litvinova, S. Merler, et al., The effect of travel restrictions on the spread of the 2019 novel coronavirus (COVID-19) outbreak, Science, 368 (2020), 395–400. https://doi.org/10.1101/2020.02.09.20021261 doi: 10.1101/2020.02.09.20021261
    [25] H. Lau, V. Khosrawipour, P. Kocbach, A. Mikolajczyk, J. Schubert, J. Bania, et al., The positive impact of lockdown in Wuhan on containing the COVID-19 outbreak in China, J. Travel Med., 27 (2020). https://doi.org/10.1093/jtm/taaa037
    [26] Y. Chen, Y. Wang, H. Wang, Z. Hu, L. Hua, Controlling urban traffic-one of the useful methods to ensure safety in Wuhan based on COVID-19 outbreak, Saf. Sci., 131 (2020), 104938. https://doi.org/10.1016/j.ssci.2020.104938 doi: 10.1016/j.ssci.2020.104938
    [27] K. Yu, X. Bai, Y. Guo, Analysis and prediction of COVID-19 epidemic and prevention and control strategies based on delay effect SAIR2D model, J. Qiqihar Univ., 37 (2021), 89–94.
    [28] H. Tian, Y. Liu, Y. Li, C. H. Wu, B. Chen, M. U. G. Kraemer, et al., An investigation of transmission control measures during the first 50 days of the COVID-19 epidemic in China, Science, 368 (2020), 638–642. https://doi.org/10.1126/science.abb6105 doi: 10.1126/science.abb6105
    [29] General Office of National Health Commission, Diagnosis and treatment plan for patients with COVID-19, 2022. Available from: http://www.gov.cn/zhengce/zhengceku/2022-03/15/content_5679257.htm.
    [30] Z. Zhang, Y. Ma, T. Dong, Y. Wang, Z. Qu, Effect of novel Coronavirus Variants on the immunity efficacy of novel coronavirus vaccine, Int. J. Immunol., 44 (2021), 487–492. https://doi.org/10.3760/cma.j.issn.1673-4394.2021.05.001 doi: 10.3760/cma.j.issn.1673-4394.2021.05.001
    [31] Changchun Municipal Health Commission, Available from: http://wjw.changchun.gov.cn/.
    [32] P. Driessche, J. Watmough, Reproduction numbers and sub-threshold endemic equilibria for compartmental models of disease transmission, Math. Biosci., 180 (2002), 29–48. https://doi.org/10.1016/S0025-5564(02)00108-6 doi: 10.1016/S0025-5564(02)00108-6
    [33] The total population of Changchun as of March 1, 2022. Available from: http://tjj.changchun.gov.cn/tjgb/202106/t20210602_2830531.html.
    [34] Health Commission of Jinlin Province, Changchun City's COVID-19 Epidemic Report of March 4, 2022. Available from: http://wsjkw.jl.gov.cn/xwzx/xwzx/202203/t20220305_8406908.html.
    [35] K. Prem, A. R. Cook, M. Jit, Projecting social contact matrices in 152 countries using contact surveys and demographic data, PLoS Comput. Biol., 13 (2017), e1005697. https://doi.org/10.1371/journal.pcbi.1005697 doi: 10.1371/journal.pcbi.1005697
    [36] National Health Commission of the People's Republic of China, Quarantine period, Available from: http://www.nhc.gov.cn/xcs/xxgzbd/gzbd_index.shtml.
    [37] G. Milne, J. Carrivick, SARS-CoV-2 Omicron disease burden in Australia following border reopening: a modelling analysis, MedRxiv, (2022). https://doi.org/10.1101/2022.03.09.22272170
    [38] A. Cjlm, COVID-19 will continue but the end of the pandemic is near, Lancet, 399 (2022), 261–270. https://doi.org/10.1016/S0140-6736(22)00100-3 doi: 10.1016/S0140-6736(22)00100-3
    [39] A. Aleta, D. Martn-Corral, A. P. Piontti, M. Ajelli, M. Litvinova, M. Chinazzi, et al., Modelling the impact of testing, contact tracing and household quarantine on second waves of COVID-19, Nat. Hum. Behav., 4 (2020), 964–971. https://doi.org/10.1038/s41562-020-0931-9 doi: 10.1038/s41562-020-0931-9
    [40] Y. Li, S. Hou, Y. Zhang, J. Liu, H. Fan, C. Cao, The effect of travel restrictions of Wuhan city against the COVID-19: A modified SEIR model analysis, Disaster Med. Public Health Prep., 16 (2022), 1431–1437. https://doi.org/10.1017/dmp.2021.5 doi: 10.1017/dmp.2021.5
    [41] The basic reproduction number of Omicron, in MedSci, Availiable from: https://www.medsci.cn/article/show_article.do?id = 517c30214eaa.
    [42] G. Giordano, M. Colaneri, A. Filippo, F. Blanchini, P. Bolzern, G. De Nicolao, et al., Modeling vaccination rollouts, SARS-COV-2 variants and the requirement for non-pharmaceutical interventions in Italy, Nat. Med., 27 (2021), 993–998. https://doi.org/10.1038/s41591-021-01334-5 doi: 10.1038/s41591-021-01334-5
    [43] K. Reddy, K. Fitzmaurice, J. Scott, G. Harling, R. J. Lessells, C. Panella, et al., Clinical outcomes and cost-effectiveness of COVID-19 vaccination in South Africa, Nat. Commun., 12 (2021). https://doi.org/10.1101/2021.05.07.21256852
    [44] L. Zhang, Q. Li, Z. Liang, T. Li, S. Liu, Q. Cui, et al., The significant immune escape of pseudotyped SARS-COV-2 variant Omicron, Emerging Microbes Infect., 11 (2022). https://doi.org/10.1080/22221751.2021.2017757
    [45] H. Tseng, B. Ackerson, Y. Luo, L. S. Sy, C. A. Talarico, Y. Tian, et al., Effectiveness of mRNA-1273 against SARS-CoV-2 Omicron and Delta variants, Nat. Med., 28 (2022), 1063–1071. https://doi.org/10.1038/s41591-022-01753-y doi: 10.1038/s41591-022-01753-y
    [46] On March 9, 2022, Changchun City held the 1st press conference on the prevention and control of COVOD-19, Available from: https://mp.weixin.qq.com/s/pMjNA8nlJLWicEjUKlZXLQ.
    [47] On April 4, 2022, Changchun City held the 46th press conference on the prevention and control of COVOD-19, Available from: https://mp.weixin.qq.com/s/kJUqvzp37eEQWelNOjVBhg.
    [48] On April 6, 2022, Changchun City held the 48th press conference on the prevention and control of COVOD-19, Available from: https://mp.weixin.qq.com/s/LBLRq-Z_jdLIKhBEJAfMJg.
    [49] On April 10, 2022, Changchun City held the 52nd press conference on the prevention and control of COVOD-19, Available from: https://mp.weixin.qq.com/s/h5cbszBPisak5SLqLIYGTw.
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