Discussion regarding hybrid manufacturing has dominated research in recent years. By synergistically integrating additive and subtractive manufacturing within a single workstation, the relative benefits of each manufacturing strategy are leveraged. The ability to add, remove feature flexibly enables remanufacturing end-of-life components into a "new" part with new features and functionalities. However, in the remanufacturing context, the process planning for hybrid additive-subtractive manufacturing is still an unsolved research topic. In general, a hybrid remanufacturing process is signified by an alternating sequence of additive and subtractive operations that alternatively add and remove materials on a used part, which results in a non-unique process planning. For determining an optimal sequence for hybrid remanufacturing, a quantitative evolution mechanism is demanded. Moreover, the constraints in process planning are required to be considered. For example, the collision avoidance between the workpiece and the material-dispensing nozzle is one of the most critical limitations that affect the alternating sequence. To fill the gap, automated feature extraction and cost-driven process planning method for hybrid remanufacturing are proposed in this paper. The feature extraction, developed under the level set framework, can extract optimal and collision-free additive-subtractive features. Then, the hybrid process planning task is formulated into an integer programming model with cost estimations. A case study is conducted, and the results confirm the correctness and effectiveness of the proposed method.
1.
Introduction
Dietary supplements (DS) have earned a place in the basket of consumers during the last decades [1]–[10]; fish oils (FO) have not been an exception [2]–[6],[8],[10]. Generally, multivitamins seem to dominate [1]–[3],[6],[7],[9],[11]. However, even if FO are not as not as widely used in Greece [9],[12], they have been shown to be, if not the most consumed DS [4],[5],[10], one of the most consumed DS [2],[3],[6],[11], especially in countries like England [6],[8],[10] and Norway [8]. In fact, in the US, the use of FO saw an increase from 1.3% to 12.0% during 1999–2012 [13], and they have been characterized to be among the most used non-vitamin, non-mineral DS [14].
FO have been around for centuries. Hippocrates (400 BC) mentioned their medicinal use [15], Vikings (700–1000AD) consumed them during wintertime when sunlight was not sufficient [16], and fishermen of northern coastal Europe consumed them for many years [15]. Indeed, Norwegians are known for traditional consumption of FO [8], with the latest Nordic Nutrition Recommendations (2012) recommending their consumption, considering FO not as DS but as food [17].
FO are essentially considered nutraceuticals and contain essential omega-3 polyunsaturated fatty acids (ω-3), like eicosapentaenoic (EPA) and docosahexaenoic acid (DHA), although vitamins might be added (e.g., vitamin E) or be included naturally e.g., vitamin A and D in cod liver oil [18]. Additionally, they seem to possess anti-inflammatory properties [19], beneficial to human health, such as their contribution towards endothelial function [20]. In fact, health claims such as the maintenance of normal blood pressure, heart function and triglyceride levels have been authorized by the European Health Authority (EFSA) to be used by DS manufacturers [21].
Given the popularity of DS, differences between DS users and non-users have been explored. Specifically, predictors of use, behaviors, attitudes and general stances have been examined. For example, being a woman [2],[9],[22]–[25], having a higher level of education [2],[9],[23],[25] and following certain dietary patterns [9],[24],[25] have been shown to predict DS use. Additionally, DS users seem to be more likely to hold positive views towards DS, compared to DS non-users [9],[26]. Differences between FO users and DS non-users have been examined in many countries such as New Zealand [3], Australia [27] and the UK [10]. Indeed, significant behavioral and other differences (e.g., sources of DS recommendation) and influences of factors were detected. However, no such study has yet been carried out in Greece. Therefore, we aimed to explore the aforementioned topics. Our research questions evolved around whether there are any differences between DS users who had used FO in the past (e.g., DS+FO), DS users who had never used FO (DS-FO) and DS non-users with regards to demographic characteristics, DS label comprehension and opinions about DS use and diet. Furthermore, we aimed to look into whether DS+FO differed with regards to the quantity and type of DS they consumed, sources of information or recommendations about DS, sources they consulted for DS approval and parameters they considered when buying DS.
2.
Material and methods
2.1. Study design
The current investigation was based on questionnaires that were distributed from 2018 to 2019 as part of the project titled “Creation of a database in the Department of Nutrition and Dietetics to investigate the nutrition habits of Greek consumers and their relationship with nutrition supplements and the nutrition label”, conducted at the Department of Nutrition and Dietetics of the International Hellenic University. The in-person surveys were carried out by the NUTSTUDY team, consisting of 90 trained senior students and their professors from the Department of Nutritional Sciences and Dietetics at the International Hellenic University (IHU). The research protocol was approved by the Committee for Research Ethics (IHU).
The questionnaire consisted of closed-ended questions, divided into different sections. The first was about the demographic characteristics of respondents [i.e. sex, age, BMI (calculated according to the declared weight and height), income, educational level, employment status, exercise (exercisers: exercise was reportedly performed at least once per week; and, non-exercisers: exercise was reported as “rarely” or “never”), type of diet], the second was about the comprehension of DS labels and views about DS and diet, and the third was about the sources of DS approval, information and recommendation, the types of DS used and the DS purchasing parameters.
The verbal consent of participants was obtained following the provision of a research information sheet and a detailed explanation of the project's objectives. Subsequently, participants were instructed on the completion of the questionnaire. The target group was the Greek population and the sample collection method was proportional stratified random sampling. The Greek population was categorized into 74 regional units (strata), which align with the 13 administrative regions of Greece. The students visited various places within each regional unit (i.e., food stores, supermarkets, gyms and pharmacies) and they distributed the questionnaire to individuals aged at least 15 years old, randomly, without considering socio-economic status, educational level or any other inclusion criteria.
The collected sample was representative of the general population in terms of sex. Specifically, according to the 2011 census, the Greek population consisted of 51% women and 49% men. Accordingly, our sample consisted of 53% women and 47% men. The initial sample consisted of 31824 Greek citizens. The questionnaires that were incomplete were removed, leaving 28491 respondents. Those that had used a DS at least once in their lifetime were defined as DS users (15608; 54.8%) and those that had never used DS as DS non-users (12494; 43.8%). The remaining 389 (1.4%) respondents could not remember whether they had used a DS or not and were not considered when analyzing the outcome variables, leading to a final sample size of 28102. Among DS users, if FO were among their reported DS, they were defined as DS+FO (1001; 6.5%); otherwise, they were defined as DS-FO (14607; 93.5%).
The assumed definition of DS was as follows: “foodstuffs the purpose of which is to supplement the normal diet and which are concentrated sources of nutrients or other substances with a nutritional or physio-logical effect, alone or in combination, marketed in dose form, namely forms such as capsules, pastilles, tablets, pills and other similar forms, sachets of powder, ampoules of liquids, drop dispensing bottles, and other similar forms of liquids and powders de-signed to be taken in measured small unit quantities” (Directive 2002/46/EC, European Parliament and Council, 2002) [28].
2.2. Statistical analysis
For all of the variables, the frequencies and percentages were presented overall and according to sex, age, body mass index (BMI), monthly income, education level, employment status, exercise, type of adhered diet and DS use. Pearson's chi-square (χ2) test was used to detect for independence or significant association between subgroups of the categorical variables [29] and column proportions were compared using z test.
Additionally, multinomial logistic regression (MLR) was performed [30], while all of the analysis' conditions were examined, in order to create a general predictive profile of a DS+FO. The dependent variable was the status of DS use, having three mutually exclusive and exhaustive categories (“DS non-users”, “DS-FO” and “DS+FO”). The reference category of the dependent variable was the DS+FO. The independent variables were the nominal variables of the demographic characteristics of respondents (i.e., sex, age, BMI, etc.). All of the assumptions of the MLR were examined and were valid. Additionally, in the MLR analysis, there were two types of models. The first model was the null one because it includes only the intercept variable. The second model was the final (or the full) one, which includes all the independent variables. The Akaike and the Bayesian information criteria (AIC and BIC) showed that the final model had better fit than the null (AICnull = 20114.9 > AICfinal = 18801.2 and BICnull = 20131.4 > BICfinal = 19295.8). Also, the fit of the final model was significant (χ2 of Pearson = 1429.7, p < 0.001) and correctly predicted 57.4% of the cases. Furthermore, all the independent variables were significant for the final model (χ2 test of Pearson, p < 0.05).
The original SPSS output of the MLR analysis with regards to the calculation of the OR of one being a DS non-user or a DS-FO compared to being a DS+FO (reference category) can be found on Supplementary Table S7. However, we assumed that showing the odds of the opposite, i.e., being a DS+FO compared to being a DS non-user or DS-FO, would lead to more comprehensive results (transformed results). Therefore, Supplementary Table S7 was modified, i.e., all the originally generated OR values were modified using Formula 1.
Afterwards, the modified OR values were expressed as percentages using Formula 2.
Thus, percentages with a negative sign indicate fewer odds of being a DS+FO compared to being a DS non-user or a DS-FO, while those with a positive sign indicate higher odds. Henceforth, the following references to OR refer exclusively on their calculated form (Table 6) and not in the original form presented in Supplementary Table S7.
All analyses were performed using IBM SPSS Statistics version 29.0. In order to mitigate the risk of a type I error, which entails an increased probability of obtaining a significant result purely by chance, a Bonferroni correction was applied to adjust p-values in all multiple analyses performed. The significance level was set at α = 0.05.
3.
Results
The analyzed sample consisted of 28102 respondents, consisting of 12494 (44.5%) DS non-users, 1001 (3.6%) DS+FO and 14607 (52.0%) DS-FO.
3.1. Demographic characteristics
Overall, our sample consisted of slightly more women (53.0% vs. 47.0%), 21–50 years olds (72.9%), those with normal BMI (54.5%), monthly income up to 1000 € (81.0%), secondary education (41.4%), tertiary education (45.0%), students (25.8%), private employees (25.2%), public employees (13.7%), freelancers (16.8%), farmers (4.7%), unemployed individuals (13.8%), exercisers (56.7%) and followers of a mixed unrestricted diet (animal and plant foods) (67.0%).
Regarding DS+FO users, 50.6% were men and consisted mainly by those between 21–40 years old (58.4%), respondents with normal BMI (51.3%) or overweight (34.8%), monthly income up to 1000 € (73.3%), secondary education (35.7%), tertiary education (48.2%), private employees (27.8%), public employees (17.9%), students (20.4%), freelancers (19.4%), farmers (2.8%), unemployed individuals (11.8%), exercisers (67.6%) and followers of mixed unrestricted diets (60.4%).
There was a significant association of the demographic characteristics and the DS use categories (i.e., DS+FO, DS-FO and DS non-users, p = 0.000, Table 1). Significantly different percentages of DS+FO compared to DS-FO were observed in some variables which were found to be strongly associated with the DS use category. For example, significantly different percentages were found in sex (among DS+FO: higher percentage of men, i.e. 50.6% vs. 43.8%, Table 1), age (among DS+FO: higher percentages of older respondents), BMI (among DS+FO: slightly higher percentages of underweight and overweight respondents, but also lower percentages of respondents with normal weight), income (among DS+FO: higher percentages of respondents with high income), education (among DS+FO: slightly higher prevalence of postgraduate education but a lower one regarding secondary education) and exercise (among DS+FO: higher prevalence of exercisers, i.e. 67.6% vs. 61.2%). However, DS+FO and DS-FO, with regards to their employment status or type of adhered diet, were similar or, at most, slightly different from each other.
Significantly different percentages of DS non-users compared to DS users overall (i.e. DS+FO, DS-FO) were found regarding age (among DS non-users: slightly higher percentages of young but lower percentages of old age respondents, Table 1), income (among DS non-users: significantly higher percentage of the <500 € group, Table 1), education (among DS non-users: higher percentages of primary and secondary educated respondents but lower of tertiary and postgraduate educated ones), employment (among DS non-users: higher percentages of the unemployed, student and farmer groups but lower of private/public employees and freelancers), exercise (lower percentage of exercised respondents, i.e. 50.5% in the DS non-users group vs. 67.6% & 61.2% for the DS+FO and DS-FO groups respectively, Table 1) and diet (among DS non-users: higher percentage, i.e., 71.7%, of mixed unrestricted diet but lower in the case of specific/restricted diets, i.e. fat, starch/carbohydrate, vegan, etc.).
3.2. DS label comprehension and views about DS and diet
The comparison between the three DS-use groups (DS+FO vs. DS-FO vs. DS non-users), regarding views about DS and DS label comprehension revealed certain differences (Table 2). Specifically, DS non-users were the most likely to firmly believe that nutrients from foods are enough to ensure good health, while DS+FO displayed the lowest level of agreement (25.6% vs. 27.9% vs. 44.5%, respectively). Conversely, DS non-users were approximately twice as likely to not know, by reading DS's labels, whether DS are of personal importance (15.0% vs. 15.7% vs. 31.4%) and whether DS or their ingredients are approved (34.0% vs. 37.1% vs. 72.7%), while DS+FO had the highest percentage of respondents who confidently reported comprehension for both of these matters (55.2% vs. 45.8% vs. 29.1% and 33.7% vs. 27.6% vs. 18.0%, respectively).
Additionally, DS non-users were the least likely to agree with DS-friendly statements, while DS+FO were the most likely to do so. Agreement with the idea of the recommendation of DS by doctors was most prevalent among DS non-users and the least prevalent among DS+FO (48.1% vs. 52.3% vs. 71.1%; Supplementary Table S1 displays the above data but with the frequencies of DS+FO and DS-FO pooled together).
3.3. Sources of approval, information and recommendation regarding DS
The top sought approval sources of DS were the National Organization for Medicines (NOM; 58.0%) and the supplier or pharmacist (27.6%), while 9.8% did not pay any attention to this matter (Table 3). Additionally, the top sources of information and recommendations were doctors (46.7% and 42.4%, respectively) and pharmacists (42.1% and 29.3%, respectively). The comparison between DS+FO and DS-FO shows that more DS+FO check whether DS are approved by NOM (64.7% vs. 57.6%) but fewer seek approval from the supplier or pharmacist (21.3% vs. 28.0%). However, 90.0% of DS+FO and DS-FO seek approval from at least one of the three listed sources (Supplementary Table S2).
Additionally, DS+FO selected a higher number of information (Supplementary Table S3) and recommendation sources (Supplementary Table S4). Also, most of these sources, individually, were selected by more DS+FO (Table 3), even if in certain cases statistical significance was absent (e.g., doctors). In addition, doctors and pharmacists were the top two sources in both DS+FO and DS-FO; yet, hierarchical differences between DS+FO and DS-FO were detected for the 3rd from the top and below sources. For instance, the 3rd top source of information for both groups was the internet (41.3% vs. 28.9%). However, as a source of recommendation, the 3rd top source for DS+FO was, again, the internet (21.0%) but for DS-FO it was coaches (15.8%).
3.4. Prevalence of use of additional dietary supplements
Every DS type and every individual DS (except for iron) was selected by a significantly higher percentage of DS+FO compared to DS-FO (Table 4), while DS+FO seemed to have used a higher number of DS (Supplementary Table S5). Overall (DS+FO and DS-FO), the DS types selected in descending order were vitamins (77.3%; 82.2% vs. 76.9%), metals (54.4%; 64.5% vs. 53.7%) and herbs and extracts (50.3%; 68.4% vs. 49.1%), followed by “unclassified DS” (49.3%; 72.3% vs. 45.8%). Regarding individual DS, for both DS+FO and DS-FO, the 1st, 3rd and 4th most frequently chosen DS were multivitamins (54.7% vs. 46.1%), vitamin C (37.3% vs. 29.3%) and green/black tea (32.2% vs. 20.6%). However, the 2nd most common DS among DS+FO, was ω-3 fatty acids (41.0%), while for DS-FO it was iron (29.8%).
3.5. Dietary supplement purchasing parameters
The top parameters for buying DS were the popularity of the manufacturing company (48.8%), the certification of the product's effect via studies (38.7%), the provision of information regarding side effects (34.1%) and the product price-content relationship (31.2%, Table 5, overall). Almost every one of the listed parameters was chosen significantly more frequently by DS+FO, who also tended to consider a higher combination of parameters simultaneously (Supplementary Table S6). Also, while for both DS+FO and DS-FO, the two top considerations were the aforementioned popularity (61.6% vs 48.0%, respectively) and certifications (49.4% vs 37.9%, respectively), the 3rd most important parameter for DS+FO was the product/price relationship (41.2%) and for DS-FO, the provision of information regarding side effects (33.9%).
3.6. MLR analysis
The first two columns of Table 6 focus on the comparison between DS+FO and DS non-users and display the odds of one being a DS+FO compared to being a DS non-user, while the last two columns focus on the comparison between DS+FO and DS-FO by displaying the odds of one being a DS+FO compared to being a DS-FO. Regarding the first comparison, based on Wald's test, it seems that sex was not a predictor of DS use (p = 0.578). However, in the second comparison, i.e., being a DS+FO vs. a DS-FO, men had 35.5% higher odds of being a DS+FO compared to women.
Regarding age, compared to those >60, those in the age groups 15–20 and 21–30 years old, had lower odds of being a DS+FO compared to being a DS non-user (-65.3% and -36.7%, respectively) or a DS-FO (-59.7% and -50.4%, respectively). Additionally, those between 31–40 years old had lower odds of being DS+FO but only when compared to being DS-FO (-35.7%).
As for BMI, in comparison with those of a normal BMI, those who were underweight had higher odds of being a DS+FO compared to being a DS non-user (123.2%) or a DS-FO (89.0%).
For income, compared with those with a monthly income of >2000 €, those in the 500–1000 € group had fewer odds of being a DS+FO compared to being a DS non-user (-37.5%) or a DS-FO (-34.0%), while the other income groups could not significantly predict DS+FO usage in either way (p > 0.050).
Regarding educational attainment, compared with those with postgraduate education, those with primary and secondary education had lower odds of being a DS+FO compared to being a DS non-user (-56.2% and -35.3%, respectively). However, when comparing the odds of being a DS+FO with being a DS-FO, significantly lower odds were observed only for those with secondary education (-22.8%).
As for employment status, compared with unemployed respondents, private employees had 37.7% higher odds of being a DS+FO compared to being a DS non-user. However, none of the employment categories could significantly predict being a DS+FO when compared to being a DS-FO (p > 0.050). With regards to exercise, compared with exercisers, non-exercisers had lower odds of being a DS+FO compared to being a DS non-user or a DS-FO (-51.8% and -28.2%).
Last but not least, regarding the type of diet followed, in comparison with those who follow a “mixed-unrestricted diet”, higher odds of being a DS+FO compared to being a DS non-user were observed (in a descending order) for those who follow “other diets” (i.e., other than the ones listed in the questionnaire) (332.9%), vegan/vegetarian (148.8%), starch/carbohydrate restricted (137.5%), lacto-ovo-vegetarian (72.7%) and fat restricted (35.9%) diets. However, when comparing the odds of being a DS+FO compared to being a DS-FO, only those who followed a starch/carbohydrate restricted diet had higher odds towards being a DS+FO (51.5%).
4.
Discussion
4.1. Prevalence of FO usage
Based on data collected during 2018 to 2019, we found that 6.5% of DS users (or 3.5% of the overall sample) had used or are currently using FO. Similarly, both the European Prospective Investigation into Cancer and Nutrition (EPIC) study (1995–2000 data) [8] and a more recent study by Kanellou et al. (2013–2014 data) [12] on a representative Greek sample found a usage rate of less than 5.0% (according to 24-hour dietary recalls for both and, additionally for the second study, food propensity questionnaires). Similarly, an Australian study found that 6.0% of its participants were using FO [27], while a more recent one found that 9.2% of its respondents had used FO preparations (without added nutrients; 2nd most used DS) [2]. However, the percentages of FO users in other countries (including those in EPIC) have been shown to be considerably higher in certain cases. For instance, regarding “current or regular use”, the percentage of FO users was 21.9% in New Zealand (2015 data) [3], 31.6% in the United Kingdom (2006–2010 data) [31] and 44.7% in Norway (1998 data; women only) [4]. In fact, a UK study (2018 data) found that of those who were current DS users, 35.0% were currently using FO and 58.0% had taken them in the past [6]. Last but not least, Asian studies have also shown high usage rates in both adults and children. Specifically, Parmenter et al. sampled China, Thailand and Vietnam throughout 2019 and found that 23.0% of their adult respondents had used a specific FO product during the last year [32]. Similarly, they found that 35.0% of children (<18 years old) had been given that FO product by their parents [33]. However, an earlier 2010 Chinese study found that 69.0% of the participating parents gave their kindergarten-aged children cod FO in the last three months [5].
4.2. Additional DS use, label comprehension and opinions about the adequacy of diet
Our analysis showed that DS users are more likely to think that nutrient intake from a diet without DS is inadequate, while DS non-users think the opposite. Indeed, in our previous study we found that following a proper diet was the 3rd top reason for not using DS (selected by 33.2% of DS non-users), while “nutrient deficiencies” was the 2nd top reason for using DS (selected by 35.9% of DS users) [9]. Furthermore, DS users, compared to DS non-users, were significantly more likely to declare that they can draw certain conclusions about DS just by reading their labels (i.e., about the relative importance of DS for them and detection of approved or prohibited ingredients or DS).
Now, the above results were even more prevalent among DS+FO, compared to DS-FO. In fact, most DS+FO think that the nutrient intake from foods is definitely inadequate (36.6% vs. 30.7% of DS-FO and 9.5% of DS non-users). At the same time, every DS (except for iron) was used by a significantly higher percentage of DS+FO, when compared to DS-FO. Moreover, 91.9% of DS+FO have used three or more DS in their lifetime, compared to only 62.7% of DS-FO.
On a related note, a 2014 review by Dickinson and MacKay showed that it was more probable for DS users to have a healthier dietary pattern, when compared to DS non-users [34]. Similarly, certain studies have pointed out differences in dietary patterns between FO users and FO non-users. For example, FO consumption was positively associated with consumption of fish [3],[4],[33], fruits and vegetables [4] and a higher intake of red and processed meat [10]. However, a negative association was noted between FO and nut consumption [3]. Furthermore, history of FO use has been positively associated with use of additional DS in other studies as well [4],[31],[33].
4.3. Views about DS
Studies, including our previous work, have showed that DS users were more likely to have positive views towards DS compared to DS non-users [9]. For instance, in a national study in the UK, a general consideration of DS as risk-free was observed [6], while in a Dutch one, DS non-users had a more risk-averse stance [26]. Similarly, we found that such favorable beliefs were reported significantly more often by DS+FO. For example, more DS+FO believed that DS are generally harmless and that they were necessary for all ages. Other studies have revealed a positive relationship between FO usage and belief in their safety, efficacy and its scientific proof etc. [32],[33] or even a generally more positive attitude [35].
4.4. DS purchasing parameters and sources of information and recommendation
Overall, the two most commonly considered DS purchasing parameters were the manufacturer's popularity (48.8%) and the existence of certifications of the effects of said DS (38.7%). However, a significantly higher percentage of DS+FO seemed to take into consideration almost every listed parameter. Moreover, ≅65.0% of DS+FO considered two or more parameters, compared to ≅45.0% of DS-FO. Characteristically, a significantly higher percentage of DS+FO cares about the popularity, the certifications and the price/content relationship. In fact, this last parameter was the 3rd most commonly cited parameter among DS+FO, while for DS-FO it was the provision of information regarding side-effects. The above results suggest that DS+FO are more likely to be subjectively knowledgeable and engaged in the world of DS, to be advocates of DS and show trust in them as seen by the top selected considerations during DS shopping, i.e., popularity, proof of efficacy and affordability, compared to safety precautions. Interpretively, however, popularity might represent a seal of approval towards DS, stemming from the healthcare professional or consumer community, ensuring their safety, efficacy and quality. It is underlined that a higher percentage of DS+FO comes in contact with almost every source of DS information/recommendation (e.g., pharmacists and the internet). Also, around 48.0% and 65.0% of DS+FO–vs. 33.0% and 55.0% of DS-FO–are receivers of two or more recommendation and information sources respectively. This further reinforces the previous observations.
In a recent New Zealand study, brand, price and quality were reported to affect the decisions of around 20.0%–35.0% of their respondents [3]. A review by Teoh et al. showed that fundamental factors, with regards to the consumption of nutraceuticals, are the belief in their safety and efficacy, health professional's guidance and the family/friend cycle with cost being a barrier [36]. However, a study pointed out that cost was not significantly associated with lower FO consumption [32]. Α UK study showed that consumers enjoy DS without much concern, given that they shop from well reputed retailers and consume DS responsibly. Also, it was revealed that recommendations and online reviews from professionals (healthcare/fitness), DS users or family/friend cycle are of cardinal importance for the decisions of DS interested individuals [6]. Indeed, while healthcare professionals as sources are reported at considerable rates in certain studies, it seems that they closely contend with the influence of non-healthcare sources (e.g., friends, internet, TV, etc.) [37],[38]. The same goes for FO users specifically [3], although studies have shown healthcare professionals to either have a small effect [39] or no significant effect altogether [32],[33], unlike the social [32],[33] or familial cycle [32].
4.5. Sources of DS approval
Despite the apparently more active interest of DS+FO, both DS+FO and DS-FO seem to not be aware of the legislative background of DS. Specifically, ≅90.0% of each group reported checking whether DS are approved by at least one of the listed sources, i.e., the National Organization of Medicines (NOM; 58.0%), the supplier or pharmacist (27.6%) and the Supreme Chemical Council (5.8%). The importance of this result lies within the fact that DS are not approved by a government authority in Greece before being marketed. Indeed, DS are under the competent authority of NOM. However, before a DS is released into the market, NOM must receive a notification letter by their manufacturer, which states specific information, e.g., quantitative and qualitative data about said DS. Henceforth, a notification number, instead of approval indicative items (e.g., “approved by NOM”), is assigned to the DS before it enters the market. In fact, such approval indications regarding their safety, efficacy or quality are considered illegal and misleading [40]. Therefore, even if our DS users had in mind the notification number instead of approval with its strict definition, it is questionable whether they are aware of the relative legislative background.
4.6. Profile of DS+FO
Previously, we found certain characteristics to be significant determinants of DS use, i.e., being a woman, a middle aged-man, an older woman, having a higher income as a man, an abnormal BMI as a woman, having higher education, exercising, being employed (with a few job exceptions) and following a special diet (e.g., vegan/vegetarian) [9]. In the current study, we found that being a DS+FO instead of a DS-FO was more likely for men. Also, higher likelihood for one being a DS+FO compared to being a DS-FO or a DS non-user was detected for those who were older, underweight, outside of the 500–1000 € monthly income range, with higher education and exercisers, with employment status not playing such a significant role.
Below, findings of similar studies are discussed. However, their interpretation requires caution as most of these studies have compared FO users with FO non-users, regardless of whether these FO non-users were DS-FO or DS non-users [3],[27],[31]–[33], while we made that distinction. Contrary to our results, the majority of studies have found FO usage to be more likely among women [3],[13],[27],[31], while less studies pointed at men [10],[35] or to an insignificant influence of sex [32],[33]. However, our results regarding the influence of age, income, education and exercise seem to agree with the existing literature, except for BMI–for which mixed results were detected–and the type of diet, as it was examined by a different perspective. Specifically, increasing age has been associated with FO use [4],[10],[13],[27],[31],[32],[35], while few studies have found an insignificant association [3],[33]. Regarding income, the majority of studies are roughly aligned with our results, by pointing out to a positive association between income and FO consumption [3],[27],[32],[33]. Similarly, some studies have used the Townsend Index, a material deprivation index, for which lower values indicate higher material possessions and vice versa. Hence, one study has linked high material possession with FO usage [31], while another did not reveal a significant association [10]. However, employment status, in general terms, did not play a significant role in predicting FO usage in our study. Studies do not report homogenous results regarding the influence of BMI. A study has showed FO users to have slightly higher BMI than FO non-users [10]. Meanwhile, studies have either not found a significant association [3] or have linked FO usage with lower [31] or normal BMI [4]. In agreement with our results, most studies reveal that FO usage is positively associated with the education level [4],[13],[32],[33], as one found a more or less negative association [3], while some studies did not reveal a significant influence [10],[27]. Moreover, previous studies have noted a significantly positive association between physical activity and FO use [4],[10], rather than an insignificant one [3]. Finally, regarding the followed type of diet, dietary patterns have been associated with FO usage in the past. For example, studies have shown FO users to be more likely to consume fish [3],[32],[33], while others have shown that FO users follow healthier diets overall [4],[28].
A fundamental limitation of our study is that we defined a respondent as a DS user if they had used a DS at least once during their entire lifetime and not in a specific timeframe (e.g., last week). In contrast, demographic and behavioral information (e.g., attitude) reflected data at the time of questionnaire completion. Therefore, a cross-tabulation between DS use, as we defined it, and demographic and behavioral data could not necessarily produce realistic results for a number of reasons. For example, a currently habitual user of DS differs from a respondent who had used DS only once in his lifetime. However, they would both be considered DS users, while the second one is practically not. This affects the division of DS users between DS+FO and DS-FO in a similar manner, since even the slightest use of FO would label a respondent as a DS+FO, even if they were currently not using them, leading to biased results.
5.
Conclusions
Several predictors of FO use and behavioral patterns were identified. Compared to DS non-users, more DS users, especially DS+FO, believe that a diet without DS is inadequate, have beliefs favorable towards DS and are subjectively knowledgeable regarding DS label comprehension. Among DS users, almost every DS purchasing parameter and source of information/recommendation was selected by a higher percentage of DS+FO. Meanwhile, DS+FO are more likely to consider a higher number of purchasing parameters and be receivers of more sources of information/recommendations, making them more involved in DS. However, knowledge gaps regarding the legislative background of DS were revealed, regardless of DS use. At the same time, many respondents, overall, seem to seek professional involvement regarding the recommendation of DS.
Use of AI tools declaration
The authors declare they have not used Artificial Intelligence (AI) tools in the creation of this article.
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