Innovative strategies for Lassa fever epidemic control: a groundbreaking study

Yasir Ramzan; Aziz Ullah Awan; Muhammad Ozair; Takasar Hussain; Rahimah Mahat; Yasir Ramzan; Aziz Ullah Awan; Muhammad Ozair; Takasar Hussain; Rahimah Mahat

doi:10.3934/math.20231574

AIMS Mathematics

2023, Volume 8, Issue 12: 30790-30812. doi: 10.3934/math.20231574

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Research article

Innovative strategies for Lassa fever epidemic control: a groundbreaking study

1.
Department of Mathematics, University of the Punjab, Lahore 54590, Pakistan
2.
Department of Mathematics, COMSATS University Islamabad, Attock Campus, Attock, Pakistan
3.
Universiti Kuala Lumpur Malaysian Institute of Industrial Technology, Persiaran Sinaran Ilmu Bandar Seri Alam, 81750 Masai, Johor Bahru, Johor, Malaysia

Received: 02 August 2023 Revised: 21 September 2023 Accepted: 26 September 2023 Published: 15 November 2023
MSC : 34D23, 34H05

This study aims to develop a mathematical model for analyzing Lassa fever transmission dynamics and proposing effective control measures. The stability of the Lassa fever-free equilibrium point is examined and the model's accuracy is assessed using real-world data. Additionally, the parameter values and the basic reproduction number are estimated. A sensitivity analysis is also conducted, which identifies the key drivers influencing transmission dynamics. Moreover, the impact of model parameters on basic reproduction numbers is investigated. Multiple control methodologies including use of Ribavirin, implementing mobile health technology and incorporating natural predators are devised and analyzed using optimal control theory to curtail virus transmission.
- Lassa fever,
- mathematical model,
- parameter estimation,
- sensitivity analysis,
- optimal control theory,
- mobile health technology
Citation: Yasir Ramzan, Aziz Ullah Awan, Muhammad Ozair, Takasar Hussain, Rahimah Mahat. Innovative strategies for Lassa fever epidemic control: a groundbreaking study[J]. AIMS Mathematics, 2023, 8(12): 30790-30812. doi: 10.3934/math.20231574

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Abstract

This study aims to develop a mathematical model for analyzing Lassa fever transmission dynamics and proposing effective control measures. The stability of the Lassa fever-free equilibrium point is examined and the model's accuracy is assessed using real-world data. Additionally, the parameter values and the basic reproduction number are estimated. A sensitivity analysis is also conducted, which identifies the key drivers influencing transmission dynamics. Moreover, the impact of model parameters on basic reproduction numbers is investigated. Multiple control methodologies including use of Ribavirin, implementing mobile health technology and incorporating natural predators are devised and analyzed using optimal control theory to curtail virus transmission.

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