The value of urinary soluble urokinase plasminogen activator receptor (suPAR) in children with nephrotic syndrome

Phuong Anh Le Thy; Kiem Hao Tran; Thuy Yen Hoang Thi; Minh Phuong Phan Thi; Huu Son Nguyen; Phuong Anh Le Thy; Kiem Hao Tran; Thuy Yen Hoang Thi; Minh Phuong Phan Thi; Huu Son Nguyen

doi:10.3934/medsci.2021015

AIMS Medical Science

2021, Volume 8, Issue 2: 163-174. doi: 10.3934/medsci.2021015

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Research article

The value of urinary soluble urokinase plasminogen activator receptor (suPAR) in children with nephrotic syndrome

1.
Pediatric Department, Hue University of Medicine and Pharmacy, Hue University, Hue city, Vietnam
2.
Pediatric Center, Hue Central hospital, 16 Le Loi street, Hue city, Vietnam

Received: 19 April 2021 Accepted: 14 June 2021 Published: 17 June 2021

Objectives
To investigate the value of urinary suPAR with steroid responsiveness in childhood nephrotic syndrome (NS).

Methods
A longitudinal follow-up study was carried out in 92 children diagnosed with nephrotic syndrome (49 initial NS and 43 relapsed NS).

Results
The urinary suPAR/creatinine ratio was significantly high in the relapsed NS group (with a mean = 628 (386–1015) pg/µmol) compared with the initial NS group (mean = 509 (237–840) pg/µmol) and the control group (mean = 248 (88–609) pg/µmol) (p = 0.001). In the initial group, the concentration of urinary suPAR/creatinine ratio was higher in steroid-resistant NS (SRNS) than in steroid-sensitive NS (SSNS) after 6 weeks and 6 months of treatment, but the difference was not significant (p > 0.05). In the relapsed NS group, the concentration of urinary suPAR/creatinine ratio was higher in SRNS than that in SSNS (p = 0.02). The urinary suPAR/creatinine ratio had sensitivity (73.9%) and specificity (89.5%) at the cut-off point of 950 pg/µmol to predict SRNS (p < 0.001).

Conclusions
Urinary suPAR could help distinguish the steroid responsiveness between SRNS and SSNS in children.
- soluble urokinase plasminogen activator (suPAR),
- nephrotic syndrome,
- urinary suPAR/creatinine ratio
Citation: Phuong Anh Le Thy, Kiem Hao Tran, Thuy Yen Hoang Thi, Minh Phuong Phan Thi, Huu Son Nguyen. The value of urinary soluble urokinase plasminogen activator receptor (suPAR) in children with nephrotic syndrome[J]. AIMS Medical Science, 2021, 8(2): 163-174. doi: 10.3934/medsci.2021015

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Abstract

Objectives

To investigate the value of urinary suPAR with steroid responsiveness in childhood nephrotic syndrome (NS).

Methods

A longitudinal follow-up study was carried out in 92 children diagnosed with nephrotic syndrome (49 initial NS and 43 relapsed NS).

Results

The urinary suPAR/creatinine ratio was significantly high in the relapsed NS group (with a mean = 628 (386–1015) pg/µmol) compared with the initial NS group (mean = 509 (237–840) pg/µmol) and the control group (mean = 248 (88–609) pg/µmol) (p = 0.001). In the initial group, the concentration of urinary suPAR/creatinine ratio was higher in steroid-resistant NS (SRNS) than in steroid-sensitive NS (SSNS) after 6 weeks and 6 months of treatment, but the difference was not significant (p > 0.05). In the relapsed NS group, the concentration of urinary suPAR/creatinine ratio was higher in SRNS than that in SSNS (p = 0.02). The urinary suPAR/creatinine ratio had sensitivity (73.9%) and specificity (89.5%) at the cut-off point of 950 pg/µmol to predict SRNS (p < 0.001).

Conclusions

Urinary suPAR could help distinguish the steroid responsiveness between SRNS and SSNS in children.

Authors' contributions

P.A.L.T., K.H.T. and T.Y.H.T. conceptualized and designed the study. P.A.L.T. and M.P.P.T. analysed the data. K.H.T. and H.S.N. drafted the manuscript. K.H.T. and H.S.N revised the article. P.A.L.T. and K.H.T. provided intellectual content of critical importance to the work described. All authors gave final approval of the version to be published.

Conflicts of interest

The authors declare no conflicts of interest.

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