Research article Special Issues

Long non-coding RNA XIST is down-regulated and correlated to better prognosis in ovarian cancer

  • Received: 26 May 2019 Accepted: 08 December 2019 Published: 02 January 2020
  • Ovarian cancer (OC) is one of the most common gynecological malignant tumors. Understanding the molecular mechanisms involved in the development of ovarian cancer is helpful for the diagnosis and treatment of OC. In this study, we found that lncRNA XIST was significantly overexpressed in normal ovarian tissues and down-regulated in OC. Moreover, we showed XIST was associated with the development of OC and down-regulated in advanced stage OC compared to early-stage OC samples. Overexpression of XIST was significantly associated with longer survival in patients with OC. Also, our analysis also showed that lncRNA XIST was closely related to biological processes such as transcription, protein phosphorylation, transport, protein ubiquitination, and DNA repair. To further reveal the function and role of XIST in OC, we constructed a protein-protein interaction network and an endogenous competitive RNA network. The present study provided a theoretical basis for the diagnosis and treatment of OC.

    Citation: Yue Hu, Xiaoqin Mei, Dong Tang. Long non-coding RNA XIST is down-regulated and correlated to better prognosis in ovarian cancer[J]. Mathematical Biosciences and Engineering, 2020, 17(3): 2070-2081. doi: 10.3934/mbe.2020110

    Related Papers:

  • Ovarian cancer (OC) is one of the most common gynecological malignant tumors. Understanding the molecular mechanisms involved in the development of ovarian cancer is helpful for the diagnosis and treatment of OC. In this study, we found that lncRNA XIST was significantly overexpressed in normal ovarian tissues and down-regulated in OC. Moreover, we showed XIST was associated with the development of OC and down-regulated in advanced stage OC compared to early-stage OC samples. Overexpression of XIST was significantly associated with longer survival in patients with OC. Also, our analysis also showed that lncRNA XIST was closely related to biological processes such as transcription, protein phosphorylation, transport, protein ubiquitination, and DNA repair. To further reveal the function and role of XIST in OC, we constructed a protein-protein interaction network and an endogenous competitive RNA network. The present study provided a theoretical basis for the diagnosis and treatment of OC.


    加载中


    [1] R. L. Siegel, K. D. Miller, A. Jemal, Cancer statistics, 2016, CA Cancer J. Clin., 66 (2016), 7-30.
    [2] R. L. Siegel, K. D. Miller, S. A. Fedewa, D. J. Ahnen, R. G. S. Meester, A. Barzi, et al., Colorectal Cancer Statistics, 2017, CA Cancer J. Clin., 67 (2017), 177-193.
    [3] N. Lalwani, S. R. Prasad, R. Vikram, A. K. Shanbhogue, P. C. Huettner, N. Fasih, Histologic, molecular, and cytogenetic features of ovarian cancers: Implications for diagnosis and treatment, Radiographics, 31 (2011), 625-646.
    [4] R. J. Bast, B. Hennessy, G. B. Mills, The biology of ovarian cancer: New opportunities for translation, Nat. Rev. Cancer, 9 (2009), 415-428.
    [5] D. D. L. Bowtell, The genesis and evolution of high-grade serous ovarian cancer, Nat. Rev. Cancer, 10 (2010), 803-808.
    [6] G. Yang, X. Lu, L. Yuan, LncRNA: A link between RNA and cancer, Biochim. Biophys. Acta Gene Regul. Mech., 1839 (2014), 1097-1109.
    [7] L. Li, T. Feng, Y. Lian, G. Zhang, A. Garen, X. Song, Role of human noncoding RNAs in the control of tumorigenesis, Proc. Natl. Acad. Sci., 106 (2009), 12956-12961.
    [8] R. Li, J. Qian, Y. Y. Wang, J. X. Zhang, Y. P. You, Long noncoding RNA profiles reveal three molecular subtypes in glioma, CNS Neurosci. Ther., 20 (2014), 339-343.
    [9] P. Grote, L. Wittler, D. Hendrix, F. Koch, S. Wahrisch, A. Beisaw, et al., The tissue-specific lncRNA Fendrr is an essential regulator of heart and body wall development in the mouse, Dev. Cell, 24 (2013), 206-214. doi: 10.1016/j.devcel.2012.12.012
    [10] N. A. Rapicavoli, K. Qu, J. Zhang, M. Mikhail, R. M. Laberge, H. Y. Chang, A mammalian pseudogene lncRNA at the interface of inflammation and anti-inflammatory therapeutics, eLife, 2 (2013), e00762.
    [11] H. Li, B. Yu, J. Li, L. Su, M. Yan, Z. Zhu, et al., Overexpression of lncRNA H19 enhances carcinogenesis and metastasis of gastric cancer, Oncotarget, 5 (2014), 2318-2329.
    [12] Y. Gao, H. Meng, S. Liu, J. Hu, Y. Zhang, T. Jiao, et al., LncRNA-HOST2 regulates cell biological behaviors in epithelial ovarian cancer through a mechanism involving microRNA let-7b, Hum. Mol. Genet., 24 (2015), 841-852.
    [13] J. M. Silva, N. J. Boczek, M. W. Berres, X. Ma, D. I. Smith, LSINCT5 is over expressed in breast and ovarian cancer and affects cellular proliferation, RNA Biol., 8 (2011), 496-505.
    [14] J. J. Qiu, Y. Wang, J. X. Ding, H. Y. Jin, G. Yang, K. Q. Hua, The long non-coding RNA HOTAIR promotes the proliferation of serous ovarian cancer cells through the regulation of cell cycle arrest and apoptosis, Exp. Cell Res., 333 (2015), 238-248.
    [15] Y. Chai, J. Liu, Z. Zhang, L. Liu, HuR-regulated lncRNA NEAT1 stability in tumorigenesis and progression of ovarian cancer, Cancer Med., 5 (2016), 1588-1598.
    [16] H. Zhu, T. Zheng, J. Yu, L. Zhou, L. Wang, LncRNA XIST accelerates cervical cancer progression via upregulating Fus through competitively binding with miR-200a, Biomed. Pharmacother., 105 (2018), 789-797.
    [17] X. Wang, G. Zhang, Z. Cheng, L. Dai, L. Jia, X. Jing, et al., Knockdown of LncRNA-XIST Suppresses Proliferation and TGF-beta1-Induced EMT in NSCLC Through the Notch-1 Pathway by Regulation of miR-137, Genet. Test. Mol. Biomarkers, 22 (2018), 333-342.
    [18] D. W. Huang, B. T. Sherman, R. A. Lempicki, Bioinformatics enrichment tools: Paths toward the comprehensive functional analysis of large gene lists, Nucleic Acids Res., 37 (2009), 1-13.
    [19] D. W. Huang, B. T. Sherman, R. A. Lempicki, Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources, Nat. Protoc., 4 (2009), 44-57.
    [20] Q. Liu, J. Huang, N. Zhou, Z. Zhang, A. Zhang, Z. Lu, et al., LncRNA loc285194 is a p53-regulated tumor suppressor, Nucleic Acids Res., 41 (2013), 4976-4987.
    [21] D. Chakravarty, A. Sboner, S. S. Nair, E. Giannopoulou, R. Li, S. Hennig, et al., The oestrogen receptor alpha-regulated lncRNA NEAT1 is a critical modulator of prostate cancer, Nat. Commun., 5 (2014), 5383.
    [22] J. Y. Liu, J. Yao, X. M. Li, Y. C. Song, X. Q. Wang, Y. J. Li, et al., Pathogenic role of lncRNA-MALAT1 in endothelial cell dysfunction in diabetes mellitus, Cell Death Dis., 5 (2014), e1506.
    [23] J. Li, H. Huang, Y. Li, L. Li, W. Hou, Z. You, Decreased expression of long non-coding RNA GAS5 promotes cell proliferation, migration and invasion, and indicates a poor prognosis in ovarian cancer, Oncol. Rep., 36 (2016), 3241-3250.
    [24] M. Zhou, X. Wang, H. Shi, L. Cheng, Z. Wang, H. Zhao, et al., Characterization of long non-coding RNA-associated ceRNA network to reveal potential prognostic lncRNA biomarkers in human ovarian cancer, Oncotarget, 7 (2016), 12598-12611.
    [25] S. P. Liu, J. X. Yang, D. Y. Cao, K. Shen, Identification of differentially expressed long non-coding RNAs in human ovarian cancer cells with different metastatic potentials, Cancer Biol. Med., 10 (2013), 138-141.
    [26] F. Tao, X. Tian, M. Lu, Z. Zhang, A novel lncRNA, Lnc-OC1, promotes ovarian cancer cell proliferation and migration by sponging miR-34a and miR-34c, J. Genet. Genomics, 45 (2018), 137-145.
    [27] L. Zhu, Q. Guo, X. Lu, J. Zhao, J. Shi, Z. Wang, et al., CTD-2020K17.1, a Novel Long Non-Coding RNA, Promotes Migration, Invasion, and Proliferation of Serous Ovarian Cancer Cells in vitro, Med. Sci. Monit., 24 (2018), 1329-1339.
    [28] Z. Wang, J. Yuan, L. Li, Y. Yang, X. Xu, Y. Wang, Long non-coding RNA XIST exerts oncogenic functions in human glioma by targeting miR-137, Am. J. Transl. Res., 9 (2017), 1845-1855.
    [29] X. Xu, C. Ma, C. Liu, Z. Duan, L. Zhang, Knockdown of long noncoding RNA XIST alleviates oxidative low-density lipoprotein-mediated endothelial cells injury through modulation of miR-320/NOD2 axis, Biochem. Biophys. Res. Commun., 503 (2018), 586-592.
    [30] P. Song, L. F. Ye, C. Zhang, T. Peng, X. H. Zhou, Long non-coding RNA XIST exerts oncogenic functions in human nasopharyngeal carcinoma by targeting miR-34a-5p, Gene, 592 (2016), 8-14.
  • Reader Comments
  • © 2020 the Author(s), licensee AIMS Press. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0)
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索

Metrics

Article views(4596) PDF downloads(448) Cited by(6)

Article outline

Figures and Tables

Figures(5)

Other Articles By Authors

/

DownLoad:  Full-Size Img  PowerPoint
Return
Return

Catalog