Expression and clinical significance of p75NTR in esophageal squamous cell carcinoma

Dijian Shen; Youhua Jiang; Kaiyi Tao; Dijian Shen; Youhua Jiang; Kaiyi Tao

doi:10.3934/mbe.2019405

Mathematical Biosciences and Engineering

2019, Volume 16, Issue 6: 8060-8068. doi: 10.3934/mbe.2019405

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Research article Special Issues

Expression and clinical significance of p75NTR in esophageal squamous cell carcinoma

Department of thoracic surgery, Institute of Cancer Research and Basic Medical Sciences of Chinese Academy of Sciences, Cancer Hospital of University of Chinese Academy of Sciences, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China

Received: 20 February 2019 Accepted: 10 July 2019 Published: 05 September 2019

Objectives To analyze the expression and clinical significance of p75NTR in esophageal squamous cell carcinoma.

Methods Sixty patients with esophageal squamous cell carcinoma who underwent surgical resection in our hospital between January 2017 and January 2018 were selected as the study subjects. The content of the study was in accordance with medical ethics and approved by the medical ethics committee, and patients understood and signed an informed consent form. The clinical data of all patients were analyzed retrospectively. The positive rate of p75NTR in lymph node metastasis-positive patients, lymph node metastasis-negative patients and patients with invasion of the muscle layer was detected and statistically analyzed.

Results Lymph node metastasis-positive patients had a p75NTR-positive rate of 100.00% (30/30), which was significantly higher than that of lymph node metastasis-negative patients (20.00% (6/30)) (P < 0.05) The p75NTR-positive rate in patients with infiltration of the muscular layer was 73.33% (20/30), which was significantly higher than that of patients with infiltration of the whole layer (43.33% (13/30) (P < 0.05).

Conclusions The high expression of p75NTR in esophageal squamous cell carcinoma tissue can indicate the invasion depth of the cancerous tissue and lymph node metastasis, and the clinical introduction of the p75NTR index can be the basis for an effective prognosis prediction in patients with esophageal squamous cell carcinoma.
- esophageal squamous cell carcinoma,
- p75NTR,
- expression,
- clinical significance
Citation: Dijian Shen, Youhua Jiang, Kaiyi Tao. Expression and clinical significance of p75NTR in esophageal squamous cell carcinoma[J]. Mathematical Biosciences and Engineering, 2019, 16(6): 8060-8068. doi: 10.3934/mbe.2019405

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Abstract

Objectives To analyze the expression and clinical significance of p75NTR in esophageal squamous cell carcinoma.

Methods Sixty patients with esophageal squamous cell carcinoma who underwent surgical resection in our hospital between January 2017 and January 2018 were selected as the study subjects. The content of the study was in accordance with medical ethics and approved by the medical ethics committee, and patients understood and signed an informed consent form. The clinical data of all patients were analyzed retrospectively. The positive rate of p75NTR in lymph node metastasis-positive patients, lymph node metastasis-negative patients and patients with invasion of the muscle layer was detected and statistically analyzed.

Results Lymph node metastasis-positive patients had a p75NTR-positive rate of 100.00% (30/30), which was significantly higher than that of lymph node metastasis-negative patients (20.00% (6/30)) (P < 0.05) The p75NTR-positive rate in patients with infiltration of the muscular layer was 73.33% (20/30), which was significantly higher than that of patients with infiltration of the whole layer (43.33% (13/30) (P < 0.05).

Conclusions The high expression of p75NTR in esophageal squamous cell carcinoma tissue can indicate the invasion depth of the cancerous tissue and lymph node metastasis, and the clinical introduction of the p75NTR index can be the basis for an effective prognosis prediction in patients with esophageal squamous cell carcinoma.

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