Short-term outcome of laparoscopic surgery versus open surgery on colon carcinoma: A meta-analysis

Jin-Li Sun; Su-Yan Xing; Jin-Li Sun; Su-Yan Xing

doi:10.3934/mbe.2019233

Mathematical Biosciences and Engineering

2019, Volume 16, Issue 5: 4645-4659. doi: 10.3934/mbe.2019233

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Short-term outcome of laparoscopic surgery versus open surgery on colon carcinoma: A meta-analysis

Jin-Li Sun ¹,
Su-Yan Xing ^{2
,
,}

1.
Department of Thyroid and Gastrointestinal Surgical Oncology, Shenyang Fifth People Hospital, Shenyang 110023, China
2.
Department of Obstetrics and Gynecology, Shenyang Yuhong District People’s Hospital, Shenyang 110141, China

Received: 13 February 2019 Accepted: 23 April 2019 Published: 23 May 2019

ObjectiveThe aim of this article is to compare the oncological outcomes of laparoscopic and open resection for colon cancer.

MethodSearch the publications on comparison the efficacy of laparoscopic surgery comparison with open surgery in treatment outcomes of colon cancer to May, 2018. After rigorous reviewing on quality, the data was extracted from eligible trials. All trials analyzed the summary hazard ratios (HRs) of the endpoints of interest, including intraoperative and postoperative outcomes.

Results A total of 13 trials were met our inclusion criteria. With the pooled result of duration of surgery indicate that laparoscopic surgery was associated with a trend longer operate time (SMD = 0.58, 95% CI 0.17-0.99; P＝0.005), shorter length of hospital stay (SMD = -0.57, 95% CI -1.00--0.15; P = 0.008) and postoperative hospital stay (SMD = -0.66, 95% CI -0.99--0.33; P = 0.0001), less blood loss (SMD = -0.68, 95% CI -1.12--0.24; P = 0.002), shorter incision length (SMD = -4.61, 95% CI -5.79--3.43; P < ＝0.00001 and less wound infection (OR = 0.30, 95% CI 0.13-0.67; P = 0.004). However, there were no differences in the number of lymph nodes harvested (P = 0.17), ileus (P = 0.91), pulmonary infection (P = 0.22) and postoperative complications (P = 0.24) between the 2 groups.

ConclusionLaparoscopic surgery had similar intraoperative and postoperative recovery parameters to those of the patients in the open group. The patients treated with laparoscopic had a trend longer operate time, shorter hospital stays, less intra-operative blood loss, faster recovery and lower incidence of wound infection. Whether it can be expected to be a standardization operation method for colon carcinoma still need more random clinical trials to be verified.
- colon carcinoma,
- laparoscopic surgery,
- open surgery,
- clinical outcomes,
- meta-analysis
Citation: Jin-Li Sun, Su-Yan Xing. Short-term outcome of laparoscopic surgery versus open surgery on colon carcinoma: A meta-analysis[J]. Mathematical Biosciences and Engineering, 2019, 16(5): 4645-4659. doi: 10.3934/mbe.2019233

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Abstract

ObjectiveThe aim of this article is to compare the oncological outcomes of laparoscopic and open resection for colon cancer.

MethodSearch the publications on comparison the efficacy of laparoscopic surgery comparison with open surgery in treatment outcomes of colon cancer to May, 2018. After rigorous reviewing on quality, the data was extracted from eligible trials. All trials analyzed the summary hazard ratios (HRs) of the endpoints of interest, including intraoperative and postoperative outcomes.

Results A total of 13 trials were met our inclusion criteria. With the pooled result of duration of surgery indicate that laparoscopic surgery was associated with a trend longer operate time (SMD = 0.58, 95% CI 0.17-0.99; P＝0.005), shorter length of hospital stay (SMD = -0.57, 95% CI -1.00--0.15; P = 0.008) and postoperative hospital stay (SMD = -0.66, 95% CI -0.99--0.33; P = 0.0001), less blood loss (SMD = -0.68, 95% CI -1.12--0.24; P = 0.002), shorter incision length (SMD = -4.61, 95% CI -5.79--3.43; P < ＝0.00001 and less wound infection (OR = 0.30, 95% CI 0.13-0.67; P = 0.004). However, there were no differences in the number of lymph nodes harvested (P = 0.17), ileus (P = 0.91), pulmonary infection (P = 0.22) and postoperative complications (P = 0.24) between the 2 groups.

ConclusionLaparoscopic surgery had similar intraoperative and postoperative recovery parameters to those of the patients in the open group. The patients treated with laparoscopic had a trend longer operate time, shorter hospital stays, less intra-operative blood loss, faster recovery and lower incidence of wound infection. Whether it can be expected to be a standardization operation method for colon carcinoma still need more random clinical trials to be verified.

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