Electromagnetic radiation and electrical stimulation controls of absence seizures in a coupled reduced corticothalamic model

Xiaolong Tan; Hudong Zhang; Yan Xie; Yuan Chai; Xiaolong Tan; Hudong Zhang; Yan Xie; Yuan Chai

doi:10.3934/era.2023004

Electronic Research Archive

2023, Volume 31, Issue 1: 58-74. doi: 10.3934/era.2023004

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Research article

Electromagnetic radiation and electrical stimulation controls of absence seizures in a coupled reduced corticothalamic model

School of Mathematics and Physics, Shanghai University of Electric Power, Shanghai 201306, China

Received: 23 July 2022 Revised: 27 September 2022 Accepted: 09 October 2022 Published: 21 October 2022

The important role of basal ganglia in corticothalamic loops has received widespread attention. However, its connection between coupled reduced corticothalamic networks is rarely researched, particularly the regulatory mechanism about electromagnetic radiation and electrical stimulation has not been comprehensively investigated. In this paper, we establish a model simplified the basal-ganglia as a connector connecting two corticothalamic loops. Four kinds of treatment methods are applied to the coupled reduced corticothalamic model, for instance deep brain stimulation (DBS), 1:0 coordinate reset stimulation (CRS) and 3:2 CRS to stimulate thalamic reticular nucleus (TRN) and electromagnetic radiation to stimulate the pyramidal neuronal population (PY). One of the important results is that the epileptic area can be significantly reduced in varying degrees by changing the strength of the basal-ganglia connector. Another one is that electromagnetic radiation, DBS and CRS have preferable inhibitory effects on absence seizure. The results show that DBS has a more significant inhibitory effect than 1:0 CRS and 3:2 CRS. The results might contribute to understanding the role of basal ganglia in coupled model and providing a reference for inhibiting epileptic seizures.
- absence seizures,
- corticothalamic model,
- memristor,
- deep brain stimulation,
- coordinated reset stimulation
Citation: Xiaolong Tan, Hudong Zhang, Yan Xie, Yuan Chai. Electromagnetic radiation and electrical stimulation controls of absence seizures in a coupled reduced corticothalamic model[J]. Electronic Research Archive, 2023, 31(1): 58-74. doi: 10.3934/era.2023004

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Abstract

The important role of basal ganglia in corticothalamic loops has received widespread attention. However, its connection between coupled reduced corticothalamic networks is rarely researched, particularly the regulatory mechanism about electromagnetic radiation and electrical stimulation has not been comprehensively investigated. In this paper, we establish a model simplified the basal-ganglia as a connector connecting two corticothalamic loops. Four kinds of treatment methods are applied to the coupled reduced corticothalamic model, for instance deep brain stimulation (DBS), 1:0 coordinate reset stimulation (CRS) and 3:2 CRS to stimulate thalamic reticular nucleus (TRN) and electromagnetic radiation to stimulate the pyramidal neuronal population (PY). One of the important results is that the epileptic area can be significantly reduced in varying degrees by changing the strength of the basal-ganglia connector. Another one is that electromagnetic radiation, DBS and CRS have preferable inhibitory effects on absence seizure. The results show that DBS has a more significant inhibitory effect than 1:0 CRS and 3:2 CRS. The results might contribute to understanding the role of basal ganglia in coupled model and providing a reference for inhibiting epileptic seizures.

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