Research article Special Issues

Encapsulation of flavours into Yarrowia lipolytica active yeast cells. Fluorescence study of the lipid droplets morphology and steryl/sterol balance during the shock

  • Yeast are a powerful material for the encapsulation of compounds. Usually, yeast used as capsules are inactivated by the encapsulation treatment, which is stressful to cells. However, if kept active, cells can bring their own activity in addition to the encapsulated compound. We have observed previously that lipid-grown Yarrowia lipolytica were more resistant to encapsulation. The objective of the present study was to identify physiological markers involved in this resistance. Cells were cultured in the presence of glucose or methyl-oleate as the sole carbon source and submitted to a γ-dodecalactone stress. This paper focuses on the role of intracellular lipid droplets (LDs) and of the ergosteryl content to protect cells during the lactone treatment. Lipid-grown cells were more resistant to lactone and the presence of LDs before the shock increased significantly the resistance. The ergosteryl esters from the LD pool were hydrolysed to release ergosterol able to strenghten the plasma membrane during the shock. For cells devoid of LDs, membrane ergosterols were esterified concomitantly with LDs growth, resulting in a membrane weakening. By using pox3-mutant strains, which possesse numerous and small-sized LDs, we observed the original behaviour: these mutants showed no increased resistance and their LDs exploded in the cytoplasma during the shock. These results point out the role of LDs in cell resistance to amphiphilic stresses as a storage compartment as well as in ergosterol homeostasis.

    Citation: Thi Minh Ngoc Ta, Cynthia Romero-Guido, Thi Hanh Phan, Hai Dang Tran, Hanh Tam Dinh, Yves Waché. Encapsulation of flavours into Yarrowia lipolytica active yeast cells. Fluorescence study of the lipid droplets morphology and steryl/sterol balance during the shock[J]. AIMS Biophysics, 2022, 9(3): 257-270. doi: 10.3934/biophy.2022022

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  • Yeast are a powerful material for the encapsulation of compounds. Usually, yeast used as capsules are inactivated by the encapsulation treatment, which is stressful to cells. However, if kept active, cells can bring their own activity in addition to the encapsulated compound. We have observed previously that lipid-grown Yarrowia lipolytica were more resistant to encapsulation. The objective of the present study was to identify physiological markers involved in this resistance. Cells were cultured in the presence of glucose or methyl-oleate as the sole carbon source and submitted to a γ-dodecalactone stress. This paper focuses on the role of intracellular lipid droplets (LDs) and of the ergosteryl content to protect cells during the lactone treatment. Lipid-grown cells were more resistant to lactone and the presence of LDs before the shock increased significantly the resistance. The ergosteryl esters from the LD pool were hydrolysed to release ergosterol able to strenghten the plasma membrane during the shock. For cells devoid of LDs, membrane ergosterols were esterified concomitantly with LDs growth, resulting in a membrane weakening. By using pox3-mutant strains, which possesse numerous and small-sized LDs, we observed the original behaviour: these mutants showed no increased resistance and their LDs exploded in the cytoplasma during the shock. These results point out the role of LDs in cell resistance to amphiphilic stresses as a storage compartment as well as in ergosterol homeostasis.



    To Sandro, with friendship, admiration and much more.

    Let z=(x,y)Rn+1, with xRn and yR, n1, aR. Our aim is to study the boundary behaviour of solutions to a class of problems involving singular/degenerate operators in divergence form including

    Lau:=div(|y|aA(x,y)u),

    and their regularizations. The boundary here coincides with Σ:={y=0} the characteristic manifold, where the weight becomes degenerate or singular, and this happens respectively when a>0 and a<0. Accordingly, this class of operators is called degenerate elliptic.

    The first motivation for this work is to complete the study started in [21] on local regularity for solutions to degenerate/singular problems including the following

    div(|y|au)=|y|af+div(|y|aF)in B1. (1.1)

    In [21], we treated the regularity of even-in-y solutions (corresponding to Neumann boundary conditions), including the case of variable coefficients. We provided local C0,α and C1,α estimates, which are uniform as the parameter ε0+, for even solutions of regularized uniformly elliptic problems of the form

    div(ρaε(y)A(x,y)uε)=ρaε(y)fε+div(ρaε(y)Fε)in B1, (1.2)

    where the regularized family of weights ρaε is defined as:

    ρaε(y):={(ε2+y2)a/2min{εa,1}if a0,(ε2+y2)a/2max{εa,1}if a0. (1.3)

    A further motivation comes from a remarkable link between our operators and fractional powers of the Laplacian, from a Dirichlet-to-Neumann point of view, as highlighted in [4], when our weights belong to the A2-class; i.e., a(1,1).

    Goal of this paper is to deal with odd-in-y solutions to (1.1) (corresponding to Dirichlet boundary conditions), providing local regularity, when possible in the ε-stable sense, by proving uniform bounds for solutions to (1.2). Odd solutions make sense as energy solutions in the natural weighted Sobolev spaces whenever a(,1) (in the sense of ยง2). At first, we notice that can not expect, for the odd solutions, the same estimates as for the even ones, where the regularity results from the combined effect of the ellipticity and the boundary condition. In fact, the function y|y|a is La-harmonic with finite energy when a<1 (in case of A=I), and for a(0,1) is no more than Hölder continuous. We will refer to this special solution as the characteristic odd comparison solution. Similar, yet smoother, characteristic odd comparison solutions exist for the full regularized family of ε-problems (in a rather general setting). Nonetheless, one major obstruction in the study of regularity is the fact that our weights need not to be locally integrable when a1, preventing the application of classical regularity theory such as that developed for degenerate weights of the A2-Muckenhoupt class, starting from the seminal papers [8,9,10]. We point out that our singular/degenerate operators fall within the class of edge operators whose calculus was developed by Mazzeo and his collaborators (see in particular [7,15,16] and references therein). We shall adopt here a different perspective, exploiting suitably tailored Liouville type theorems as main tools (similarly to [20]). To this aim, a major hindrance is that the measure |y|adz is not absolutely continuous with respect to the Lebesgue measure. In order to overcome this difficulty, one can be guided by the following insight:

    Proposition 1.1. Let a(,1) and uH1,a(B1) be an odd energy solution to (1.1) in B1 (for simplicity with F=0). Then for any r<1 the ratio w=u/y|y|aH1,2a(Br) and it is an even energy solution to

    div(|y|2aw)=|y|2aˉf=|y|2afy|y|ain Br. (1.4)

    Proposition 1.1 allows the application of the results for even solutions already proved in [21], providing regularity up to the multiplicative factor y|y|a. Thanks to this observation it is natural to shift the study of regularity for odd solutions to that of even solutions of the auxiliary problem above. A similar perspective has been adopted in [19] for the obstacle problem in the same singular/degenerate setting.

    As an example, by the Schauder estimates in [21], when the forcing ˉf=:f/y|y|a in (1.4) is Ck,α, then the ratio w=u/y|y|a is locally Ck+2,α. Thus, we understand that the correct way to face the regularity of odd solutions consists in seeking C0,α and C1,α bounds for the ratio between the solution and the characteristic odd one, depending on the regularity of the same ratio of the right hand side. This point of view corresponds to (possibly higher order and/or non homogeneous) boundary Harnack principle at Σ in the sense of [3,6,10,13,14]. It is worthwhile noticing that, when a(,1), then the exponent 2a belongs to (1,+), placing Eq (1.4) in the so called super degenerate case, again outside the land of A2-Muckenhoupt weights theory, and which has been treated in [21] when associated with Neumann boundary conditions. Furthermore, looking at the right hand side of (1.4), we realize that the transition from the odd to the even case requires to pay a cost in terms of more stringent conditions on the forcing term f, in the sense that the ratio fy|y|a must possess some regularity (integrability at least); in other words, when a<0, it means that the forcing term is vanishing with a certain rate at Σ. In this regard, our results are connected with the recent paper [1], where a boundary Harnack principle with right hand side is established in the uniformly elliptic case.

    As already pointed out, our results are not limited to the A2-Muckenhoupt class of weights, which restricts a in the interval (1,1). Nonetheless, we wish to state the following corollary, which joins the results contained in this paper with the Schauder theory for even solutions developed in [21], concerning full regularity for energy solutions of degenerate or singular problems when the weight is A2-Muckenhoupt and A=I.

    Corollary 1.2. Let a(1,1), kN{0}, α(0,1) and consider uH1,a(B1) an energy solution to

    div(|y|au)=|y|afin B1.

    Let us consider the even and odd parts* (with respect to y) of the forcing term f. Let

    *Even and odd parts (in y) of a function are defined as usual as

    fe(x,y)=f(x,y)+f(x,y)2,fo(x,y)=f(x,y)f(x,y)2.
    f=fe+fo=fe+y|y|a˜fewith fe,˜feCk,α(B1).

    Then

    u=ue+uo=ue+y|y|a˜ue,with ue,˜ueCk+2,αloc(B1).

    As a next step, we aim at deepening the ε-stability of these estimates with respect to the family of regularized weights (1.3) (also including the variable coefficient case). In other words, we deal with odd-in-y solutions to the family of Eq (1.2). We will provide local uniform-in-ε regularity estimates, enlightening their delicate link with curvature issues related with the matrix A. As we shall see, also the notion of characteristic solution must be suitably adjusted in order to deal with the variable coefficient cases. Finally, we will apply our results to a family of degenerate/singular equations naturally associated with the euclidean Laplacian expressed in Fermi coordinates in the neighbourhood of an embedded hypersurface.

    Below we set the minimal assumptions on the matrix A that we need throughout the paper:

    Assumption 1.3 (HA). The matrix A=(aij) is (n+1,n+1)-dimensional and symmetric A=AT, has the following symmetry with respect to Σ: we have

    A(x,y)=JA(x,y)J,withJ=(In001).

    Moreover, A is continuous and satisfies the uniform ellipticity condition λ1|ξ|2A(x,y)ξξλ2|ξ|2, for all ξRn+1, for every (x,y) and some ellipticity constants 0<λ1λ2. Therefore, the characteristic manifold Σ is assumed to be invariant with respect to A when y=0; that is, there exists a suitable scalar function μ such that

    A(x,0)ey=μ(x,0)ey.

    Whenever the hypothesis on A are not specified, we always imply Assumption (HA). From now on, through out the paper, whenever not otherwise specified, in order to simplify the notations, we will work with A=I every time this condition is not playing a role in the proofs. In the perspective of Proposition 1.1, but considering odd solutions for the family of regularized problems in (1.2), it will be convenient to adopt the following notation on the matrix A.

    Notation 1.4 (HA+). The matrix A is written as:

    A(x,y)=μ(x,y)B(x,y),

    with

    1Cμ(x,y)C, (1.5)
    B(x,y)=(˜B(x,y)T(x,y)T(x,y)1),

    where ˜B is a (n,n)-dimensional matrix and T:Rn+1Rn (we denote by ˜A=μ˜B). We remark here that under our hypothesis on the symmetries of coefficients; one has, for y<0

    A(x,y)=μ(x,y)(˜B(x,y)T(x,y)T(x,y)1).

    The structural assumption on the matrix A is consistent with [5]. Moreover, it fits also with the metric induced by Fermi's coordinates, which allow to study phenomena of singularity or degeneration on a characteristic manifold Σ which is a generic (regular enough) n-dimensional hypersurface embedded in Rn+1. Hence, the objective will be to consider the ratio wε between odd solutions uε to (1.2) and functions of the form

    vaε(x,y)=(1a)y0ρaε(s)μ(x,s)1ds, (1.6)

    which play now the role of the characteristic odd solution for the regularized family of weights in the variable coefficients case. It is worthwhile stressing that the characteristic solutions vaε do not longer solve the homogenous problem, as a dependence on the curvature appears.

    As said, we wish to obtain uniform local regularity estimates for wε which will be even solutions to an auxiliary weighted problems having the following structure

    div(ρaε(vaε)2Awε)=ρaε(vaε)2fε+div(ρaε(vaε)2Fε)+ρaε(vaε)2bεwε. (1.7)

    The new weights appearing in the auxiliary equation are equivalent, though not equal, (using (1.5)) to

    ωaε(y)=ρaε(y)(1a)2(χaε(y))2 (1.8)

    where we have defined

    χaε(y):=y0ρaε(s)ds. (1.9)

    We remark that, as a(,1), such a class of weights is always super degenerate; indeed, at Σ, they behave like

    ωaε(y){y2if ε>0|y|2aif ε=0,

    with 2a(1,+).

    Our first main result concerns in fact the even solutions to the auxiliary family of Eq (1.7). It essentially consists in extending (in a non trivial way) the analogous result already obtained in [21] to the new family of weights ρaε(vaε)2.

    Theorem 1.5. Let a(,1) and, as ε0, let {wε} be a family of solutions in B+1 of (1.7) which are even-in-y; that is, satisfying the boundary condition

    ρaε(vaε)2ywε=0on 0B+1.

    1) Let r(0,1), β>1, p1>n+3+(a)+2, p2,p3>n+3+(a)+, and α(0,2n+3+(a)+p1](0,1n+3+(a)+p2](0,1n+3+(a)+p3]. Let's moreover take A with continuous coefficients and bεLp3(B+1,ωaε(y)dz)b. There is a positive constant c depending on a, b, n, β, p1, p2, p3, α and r only such that functions wε satisfy

    wεC0,α(B+r)c(wεLβ(B+1,ωaε(y)dz)+fεLp1(B+1,ωaε(y)dz)+FεLp2(B+1,ωaε(y)dz)).

    2) Let r(0,1), β>1, p1,p2>n+3+(a)+, and α(0,1n+3+(a)+p1](0,1n+3+(a)+p2]. Let Fε=(F1ε,...,Fn+1ε) with the y-component vanishing on Σ: Fn+1ε(x,0)=Fyε(x,0)=0 in 0B+1. Let's moreover take A with α-Hölder continuous coefficients and bεL2p2(B+1,ωaε(y)dz)b. There is a positive constant c depending on a, b, n, β, p1, p2, α and r only such that functions wε satisfy

    wεC1,α(B+r)c(wεLβ(B+1,ωaε(y)dz)+fεLp1(B+1,ωaε(y)dz)+FεC0,α(B+1)).

    We would like to remark here that local C2,α uniform estimates (up to Σ) with respect to the regularization can not be proven (for a counterexample we refer to [21, Remark 5.4]).

    When applying Theorem 1.5 to the quotient

    wε=uvaε (1.10)

    of a solution of (1.2) and the characteristic solution (1.6), we realise that the actual terms appearing in right hand side of (1.7) depend on the original forcings f,F jointly with the parameters μ,T,B of the matrix A written as in Notation (HA+). In particular, as shown in (2.8), we see the appearance of a drift term involving the x-derivatives of μ which, consequently, need to satisfy a C0,α condition. Our main result is Theorem 4.4. We give here below a simplified statement, suitable to be applied to the case of Laplacians in Fermi coordinates treated in subsection ยง1.1.

    Theorem 1.6. Let a(,1), the matrix A written as in Notation (HA+) with T0. As ε0 let {uε} be a family of solutions in B+1 of

    {div(ρaεAuε)=ρaεfε+div(ρaεFε)in B+1uε=0on 0B+1.

    Let also {vaε} be the family of solutions defined in (1.6) in B+1. Denote

    wε=uεvaε.

    1) Assume μ be Lipschitz continuous, r(0,1), β>1, p1>n+3+(a)+2, p2>n+3+(a)+, and α(0,2n+3+(a)+p1](0,1n+3+(a)+p2]. Let's moreover take A with continuous coefficients. There is a positive constant c depending on a, n, β, p1, p2, α and r only such that the wε satisfy

    wεC0,α(B+r)c(wεLβ(B+1,ωaε(y)dz)+fε/vaεLp1(B+1,ωaε(y)dz)+Fyε/(yvaε)Lp1(B+1,ωaε(y)dz)+Fε/vaεLp2(B+1,ωaε(y)dz)).

    2) Assume μC1,α(B+1), and let r(0,1), β>1, p1>n+3+(a)+, and α(0,1n+3+(a)+p1]. Let Fε=(F1ε,...,Fn+1ε) with the α-Hölder continuous ratio between the y-component and vaε vanishing on Σ: Fn+1ε(x,0)/vaε=Fyε(x,0)/vaε=0 in 0B+1. Let's moreover take A with α-Hölder continuous coefficients. There is a positive constant c depending on a, n, β, p1, α and r only such that

    wεC1,α(B+r)c(wεLβ(B+1,ωaε(y)dz)+fε/vaεLp1(B+1,ωaε(y)dz)+Fyε/(yvaε)Lp1(B+1,ωaε(y)dz)+Fε/vaεC0,α(B+1)).

    It is worthwhile noticing here that any energy odd solution to (1.2) for ε=0 (under suitable conditions on the matrix and the right hand side) can be approximated by a ε-sequence of solutions to (1.2) satisfying the hypothesis in our regularity results. The same happens for the auxiliary weighed problems solved by the even functions w=u/y|y|a. This is done in details in [21, Section 2 and 6].

    Remark 1.7. A special, yet fundamental, case is when we take A=I, so that μ1 and the family of fundamental comparison odd solutions vaε's are in fact the χaε's. Nevertheless, it has to be noticed that, in the presence of non trivial curvature, the ratio vaε/χaε may not be uniformly (in ε) bounded in C1,α(B+1). Furthermore, in the variable coefficient case, the χaε's are not in the kernel of the corresponding operators, as a (possibly weird) right hand side appears.

    Theorem 1.6 finds a natural application to the study of the boundary behaviour of solutions of operators degenerate/singular at embedded manifolds, as shown by the following result.

    Corollary 1.8. Let Σ be an n-dimensional hypersurface embedded in Rn+1, of class C3,α and let dΣ(X) denote the signed distance of X to Σ. Let a(,1), R>0 sufficiently small, and consider, as ε0, a family of solutions to

    {div(ρaεdΣuε)=ρaεdΣfε+div(ρaεdΣFε)in BR{dΣ(X)>0}uε=0on BRΣ.

    Let also {χaε} be the family of functions defined in (1.9) in BR. Denote

    wε=uεχaεdΣ,

    1) The same conclusion of point 1) of Theorem 1.6 holds with vaε replaced by χaε, y by dΣ(X) and en+1 by the normal ν at Σ.

    2) The same conclusion of point 2) of Theorem 1.6 holds in C1,α(Br{yε}) where c is independent of ε, and, again, vaε replaced by χaε, y by dΣ(X) and en+1 by the normal ν at Σ.

    Remark 1.9. In particular, letting ε0 we find C1,α(B+r) estimates in the degenerate/singular case, though not in the full ε-stable sense. The reason is the possible lack of uniform-in-ε smoothness of the ratio vaε/χaε.

    As already mentioned, the structural assumption on the matrix A done in Assumption (HA) with Notation (HA+) fits also with the metric induced by Fermi's coordinates around the characteristic manifold Σ (see [18]). Let Σ be an oriented regular enough hypersurface embedded in Rn+1. We are concerned with operators associated with Dirichlet energies of the form

    {dΣ(X)>0}(ρaεdΣ)(X)|u|2,

    with aR, XRn+1 and dΣ() the signed distance function to Σ. Let ge be the Euclidean metric on Rn+1 and denote by ν the unit normal vector field on Σ. We define Fermi coordinates in a tubular neighborhood of Σ as follows: let zΣ and yR, and define

    Z(z,y):=z+yν(z).

    Points z and yν(z) belong to Rn+1. Given yR, we define

    Σy:={Z(z,y)Rn+1 : zΣ}.

    Following Lemma 6.1 in [18], one has that the induced metric on Σy is given by

    gy=g02yh0+y2h0h0,

    where g0 is the induced metric on Σ, h0 is the second fundamental form on Σ and h0h0 its square; namely we have

    h0(t1,t2)=g0(t1ν,t2)

    for all t1,t2 on the tangent bundle of Σ. Notice in particular that, in local coordinates, the terms g0,h0,h0h0 depend only on z. Therefore, invoking Lemma 6.3 in [18], one finally has

    Zge=gy+dy2

    where gy is considered as a family of metrics on the tangent bundle of Σ, depending smoothly on y in a neighborhood of 0 in R.

    In other words, we are obtaining a quadratic form for v(z,y)=u(Z(z,y)) of the form

    y00ρaε(y)Σy(|gyv|2+|yv|2)detgy.

    Recall that the variation with respect to y of of the volume form of the parallel hypersurfaces Σy satisfy the equation:

    Hy=1detgyddydetgy. (1.11)

    Hence, by considering a parametrization of Σ of the form z=ψ(x) with xRn, then one obtains for w(x,y)=v(ψ(x),y)

    ρaε(y)Aww,

    where

    A(x,y)=(˜A(x,y)001)detgy.

    We remark that the matrix A satisfies Assumption (HA), and can be expressed as in Notation (HA+) with μ(x,y)=detgy. As ΣC3,α, we have μC1,α(B+r0) for r0 small enough. Hence we are in the position to apply Theorem 1.6. Next we have to compare the two families vaε and χaε. At first, in order to prove point 1) we remark that Proposition A.3 ensures uniform-in-ε C0,α estimates for the ratio vaε/χaε. Using (1.11), we infer that yμ(,0)C1,α(B+r0) and finally, by virtue of Proposition A.4, we obtain that also the ratio vaε/χaε satisfies the desired uniform bounds in C1,α(Br{yε}), for r<r0.

    Below is the list of symbols we shall use throughout this paper.

    Rn+1+=Rn×(0,+) z=(x,y) with xRn, y>0
    Σ={y=0} characteristic manifold
    B+r=Br{y>0} half ball
    +B+r=Sn+(r)=Br{y>0} upper boundary of the half ball
    0B+r=Br{y=0} flat boundary of the half ball
    ρaε(y)=(ε2+y2)a/2 regularized weight
    ωaε(y)=ρaε(y)πaε(y) regularized auxiliary weight
    Lρaεu=div(ρaε(y)A(x,y)u) regularized operator
    H1(Ω,ρaε(y)dz) weighted Sobolev space given by the completion of C(¯Ω)
    H10(Ω,ρaε(y)dz) weighted Sobolev space given by the completion of Cc(Ω)
    ˜H1(Ω,ρaε(y)dz) weighted Sobolev space given by the completion of Cc(¯ΩΣ)
    H1,a(Ω)=H1(Ω,|y|adz) weighted Sobolev space for ε=0
    ayu=|y|ayu "weighted" derivative
    y|y|a characteristic odd solution
    vaε characteristic odd solution in presence of A and ε>0
    a+=max{a,0}

    In this section we collect the natural notions of Sobolev spaces, and their main properties, needed to work in our degenerate or singular context (for further details see [21, Section 2]). Let ΩRn+1 be non empty, open and bounded. Denoting by C(¯Ω) the set of real functions u defined on ¯Ω such that the derivatives Dαu can be continuously extended to ¯Ω for all multiindices α, then for any aR, ε0 we define the weighted Sobolev space H1(Ω,ρaε(y)dz) as the closure of C(¯Ω) with respect to the norm

    uH1(Ω,ρaε(y)dz)=(Ωρaεu2+Ωρaε|u|2)1/2.

    To simplify the notation we will denote

    H1,a(Ω)=H1(Ω,|y|adz)=H1(Ω,ρa0(y)dz).

    In the same way, we define H10(Ω,ρaε(y)dz) as the closure of Cc(Ω) with respect to the norm

    uH10(Ω,ρaε(y)dz)=(Ωρaε|u|2)1/2.

    We will denote by ˜H1(Ω,ρaε(y)dz) the closure of Cc(¯ΩΣ) with respect to the norm H1(Ω,ρaε(y)dz). In particular, when a<1, there is a natural isometry (on balls B centered in a point on Σ of any radius)

    Taε:˜H1(B,ρaε(y)dz)˜H1(B):uv=ρaεu,

    where ˜H1(B) is endowed with the equivalent norm with squared expression

    Qε(v)=B|v|2+[(yρaε2ρaε)2+y(yρaε2ρaε)]v2Byρaε2ρaεyv2,

    (this is detailed in the appendix B.5). We remark that both in the super singular and super degenerate cases, that is when a(,1][1,+) and ε=0, when the weight is taken outside the A2-Muckenhoupt class, one has

    H1,a(Ω)=˜H1,a(Ω). (2.1)

    This happens for very opposite reasons: roughly speaking, when a1 then the singularity is so strong to force the function to annihiliate on Σ (we will call this case the super singular case). Instead, when a1, then the strong degeneracy leaves enough freedom to the function to allow it to be very irregular through Σ (we will call this case the super degenerate case). In the latter case, Σ has vanishing capacity with respect to the energy |y|a|u|2.

    The Sobolev embedding theorems are stated in details in [21] as inequalities which are uniform in ε. This point is fundamental in order to develop a local regularity theory which is stable with respect to the regularization parameter ε. Hence, following some results contained in [12], the critical Sobolev exponents do depend on how the weighted measures dμ=ρaε(y)dz scale on balls of small radius r>0: one can check that there exists b,d>0 independent from ε0 (in the locally integrable case a>1) such that for small radii

    μ(Br(z))brd.

    So, we can define the effective dimension

    d=n+1+a+=n(a),

    and the Sobolev optimal exponent is

    2(a)=2dd2=2(n+1+a+)n+a+1.

    For details one can refer to Theorems 2.4 and 2.5 in [21].

    In the very same way one can define weighted Sobolev spaces for the class of weights ωaε; that is, the spaces H1(Ω,ωaε(y)dz)=˜H1(Ω,ωaε(y)dz) (the equality is due to the fact that ωaε is always a super degenerate weight as a<1) and H10(Ω,ωaε(y)dz).

    In this case one can check that there exist two positive constants ¯b,¯d>0 independent on ε0 such that d¯μ=ωaε(y)dz has the following growth condition on small balls of radius r>0

    ¯μ(Br(z))¯br¯d,

    and the effective dimension is given by ¯d=n+1+2+(a)+=n+3+(a)+=¯n(a). Hence one can state the following

    Theorem 2.1. Let a(,1), n1, ε0 and uC1c(Ω). Then there exists a constant which does not depend on ε0 such that

    (Ωωaε|u|¯2(a))2/¯2(a)c(¯d,¯b,Ω)Ωωaε|u|2,

    where the optimal embedding exponent is

    ¯2(a)=2¯d¯d2=2(n+3+(a)+)n+(a)++1.

    Throughout the paper, we are going to consider different elliptic equations depending on different families of weights. Nevertheless, we will deal with right hand sides having forcing terms, terms expressed by the divergence of a given field and drift terms (we will see that any other possible term that will appear can be translated in one of these). In order to give an unified definition of energy solutions to weighted problems, we will consider a generic measurable weight function w, and define an energy solution u in B1 to

    div(wAu)=wf+div(wF)+wbuin B1. (2.2)

    We say that uH1(B1,wdz) is an energy solution to (2.2) if

    B1wA(x,y)uϕ=B1wfϕB1wFϕ+B1w(bu)ϕ,ϕCc(B1)H1(B1,wdz), (2.3)

    any time the terms in the right hand side give sense to the previous integrals. We remark that we are not assuming local integrability of the weight, and this is the reason why we must consider test functions in the suitable weighted Sobolev space.

    Now, we recall the consequent definition of energy solutions in case the weight term is given by ρaε(y), with aR and ε0 (the following definition is contained in [21]). Let us consider the following problem

    div(ρaεAu)=ρaεf+div(ρaεF)in B1. (2.4)

    We say that uH1(B1,ρaε(y)dz) is an energy solution to (2.4) if

    B1ρaεA(x,y)uϕ=B1ρaεfϕB1ρaεFϕ,ϕCc(B1)H1(B1,ρaε(y)dz). (2.5)

    We remark that the condition in (2.5) can be equivalently expressed testing with any ϕCc(B1Σ) if a(,1][1,+) and ε=0. In order to give a sense to energy solutions to (2.4) we need the following minimal hypothesis on the right hand side.

    Assumption 2.2 (Hfρaε). Let a(1,+). Then if n2 or n=1 and a+>0, the forcing term f in (2.4) belongs to Lp(B1,ρaε(y)dz) with p(2(a)) the conjugate exponent of 2(a); that is,

    (2(a))=2(n+1+a+)n+a++3.

    If n=1 and a+=0 then fLp(B1,ρaε(y)dz) with p>1.

    Let a(,1]. Then if n2, the condition on the forcing term is (ρaε)1/2fLp(B1) with p(2(a))=(2). If n=1, then any p>1 is allowed.

    Assumption 2.3 (HFρaε). Let a(1,+). The condition on the field F=(F1,...,Fn+1) in (2.4) is FLp(B1,ρaε(y)dz) with p2. Let a(,1]. Then the condition is (ρaε)1/2FLp(B1) with p2.

    We are concerned with local regularity of energy odd solutions to (2.4) with a(,1) and ε0. Our analysis relies in the validity of suitable Liouville type theorems which hold true whenever a>1; that is, when the weight |y|a is locally integrable. In order to ensure regularity results also in the super singular case a1, we will consider the ratio w between the odd solution u and the function vaε defined in (1.6) which is odd and satisfies

    div(ρaεAvaε)=divx(ρaεμ˜Bxvaε)+divx(T)in B1, (2.6)

    whenever the right hand side in the equation satisfies suitable integrability assumptions and the matrix A is written as in Notation (HA+). As we have already remarked in the introduction, such a function vaε plays the role of the characteristic odd solution y|y|a in presence of a matrix and of regularization.

    The following Lemma is a formal computation

    Lemma 2.4. Let aR, ε>0 and let u,v be solutions to

    div(ρaεAu)=ρaεf,div(ρaεAv)=ρaεgin B1,

    with v>0 and A satisfying Assumption (HA). Then the function w=u/v is solution to

    div(ρaεv2Aw)=ρaεvfρaεugin B1.

    Proof. Let recall ρ=ρaε. Then

    div(ρv2Aw)=div(ρv2A(uvuvv2))=div(ρvAuρuAv)=vdiv(ρAu)ρv(Au)+udiv(ρAv)+ρu(Av)=vdiv(ρAu)ρv(Au)+udiv(ρAv)+ρv(ATu)=ρvfρug.

    The new class of weights appearing in the auxiliary equation for the ratio w=u/vaε is given by ρaε(vaε)2 and it will be equivalent (using (1.5)) to

    ωaε(y)=ρaε(y)πaε(y)=ρaε(y)(1a)2(χaε(y))2=ρaε(y)((1a)y0ρaε(s)ds)2.

    We remark that, considering a(,1), such a class of weights is always super degenerate; that is, at Σ

    ωaε(y){y2if ε>0|y|2aif ε=0,

    with 2a(1,+).

    Formal computations show that the auxiliary equation for w (which corresponds to Eq (1.4) in Proposition 1.1 for ε=0 and A=I) in Br for any r<1 is given by

    div(ρaε(vaε)2Aw)=ρaε(vaε)2(¯f+Vw¯Fvaεvaε)+div(ρaε(vaε)2¯F)in Br, (2.7)

    with

    ¯f:=fvaε,¯F:=Fvaε

    and

    V:=divx(μ˜Bxvaε)vaε+divx(T)ρaεvaε.

    Actually we can rewrite the 0-order term, obtaining that the auxiliary equation for w in Br is given by

    div(ρaε(vaε)2Aw)=ρaε(vaε)2(¯f¯Fvaεvaε)+div(ρaε(vaε)2¯F)+divx(ρaε(vaε)2b˜Aw)ρaε(vaε)2(b˜AbIw+b˜Axw)+divx(ρaε(vaε)2¯Tw)ρaε(vaε)2(¯TbIw+¯Txw), (2.8)

    where for a (n,n)-dimensional matrix M

    bM=Mxvaεvaε,and¯T=Tρaεvaε.

    Thus we can write the equation the following form:

    div(ρaε(vaε)2Aw)=ρaε(vaε)2f+div(ρaε(vaε)2F1)+divx(ρaε(vaε)2F2w)+ρaε(vaε)2Vw+ρaε(vaε)2bxw. (2.9)

    We would like to prove that w is an even energy solution to (2.9) in Br in the sense that wH1(Br,ωaε(y)dz) and satisfies

    Brρaε(vaε)2Awϕ=Brρaε(vaε)2fϕBrρaε(vaε)2F1ϕBrρaε(vaε)2F2wxϕ+Brρaε(vaε)2Vwϕ+Brρaε(vaε)2(bxw)ϕ,

    for any ϕCc(BrΣ) (as we have already remarked, super degeneracy allows us to take test functions compactly supported away from Σ). In order to give a sense to energy solutions to (2.9) we need the following minimal hypothesis on the right hand side.

    Assumption 2.5 (Hfωaε). Let a(,1). Then the forcing term f in (2.9) belongs to Lp(B1,ωaε(y)dz) with p(¯2(a)) the conjugate exponent of ¯2(a); that is,

    (¯2(a))=2(n+3+(a)+)n+(a)++5.

    Assumption 2.6 (HF1ωaε). Let a(,1). Then the field term F1 in (2.9) belongs to Lp(B1,ωaε(y)dz) with p2.

    Assumption 2.7 (HF2ωaε). Let a(,1). Then the field term F2 in (2.9) belongs to Lp(B1,ωaε(y)dz) with p¯d=n+3+(a)+.

    Assumption 2.8 (HVωaε). Let a(,1). Then the 0-order term V in (2.9) belongs to Lp(B1,ωaε(y)dz) with

    p¯d2=n+3+(a)+2.

    Assumption 2.9 (Hbωaε).Let a(,1). Then the field b the drift term in (2.9) belongs to Lp(B1,ωaε(y)dz) with p¯d=n+3+(a)+.

    We will need the following important result, which contains also Proposition 1.1 when ε=0 and A=I.

    Proposition 2.10. Let a(,1), ε0 and let uεH1(B1,ρaε(y)dz) be an odd energy solution to (2.4) in B1. Then, fixed 0<r<1, the function wε=uε/vaε is an even energy solution in H1(Br,ωaε(y)dz) to (2.8), provided that the right hand side satisfies the suitable integrability assumptions stated above.

    Proof. First, we want to show that wεH1(Br,ρaε(y)(vaε)2(x,y)dz). We remark that since 1CμC and since the weight is super degenerate, we have that at Σ

    ρaε(vaε)2ωaε{|y|2aif ε=0|y|2if ε>0,

    with 2a(1,+), then the (H = W)-property does not necessarily hold (due to the lack of a Poincaré inequality, see [21]). Nevertheless, we can argue as follows: let ηCc(B1) be a radial decreasing cut off function such that 0η1 and η1 in Br. Let also for δ>0

    fδ(y)={0in B1{|y|δ}logyδin B1{δ|y|δe}1in B1{δe|y|}.

    Let φδ=ηfδ, then |φδ|1 and |φδ|c/y uniformly in δ>0. We remark that one can replace fδ with a function with the same properties which is C(B1). So,

    B1ρaε(vaε)2|φδwε|2B1ρaεu2εc. (2.10)

    Obviously in B1Σ Eq (2.8) holds. It is an easy consequence of Lemma 2.4, using that vaε is an odd energy solution to (2.6) in B1 and that vaε>0 in B1Σ. Then, testing the equation with φ2δwε, we obtain

    B1ρaε(vaε)2A(φδwε)(φδwε)=B1ρaε(vaε)2(φ2δAwεwε+2φδwεAwεφδ+w2εAφδφδ)=B1(RHS)φ2δwε+B1ρaε(vaε)2w2εAφδφδB1(RHS)φ2δwε+cB1ρaεy2u2εc, (2.11)

    and this is true by the weighted Hardy inequality in (B.12), weighted Sobolev embeddings (Theorem 2.1) and Assumptions (Hfωaε), (HF1ωaε), (HF2ωaε), (HVωaε) and (Hbωaε) which give a bound on the term with (RHS) of Eq (2.8). We remark that, fixed δ>0, the boundedness in norm H1(B1,ρaε(y)(vaε)2(x,y)dz) is enough to ensure that φδwε belongs to the same space. In fact, they have compact support away from Σ, and hence these norms are equivalent to the usual H1-norm. Since the bounds in (2.10) and (2.11) are uniform in δ>0, this is enough to have weak convergence for the sequence φδwε in H1(Br,ρaε(y)(vaε)2(x,y)dz) as δ0 and of course the limit is wε (it is almost everywhere pointwise limit).

    We have already remarked that in BrΣ Eq (2.8) holds. Then, one can conclude since the weighted Sobolev space H1(Br,ρaε(y)(vaε)2(x,y)dz) is super degenerate, and consequently test functions can be taken in Cc(BrΣ).

    In this section we present two important results which will be our main tool in order to prove regularity local estimates which are uniform with respect to ε0.

    Theorem 3.1. Let a(1,1), ε0 and w be a solution to

    {div(ρaε(y)w)=0in Rn+1+w(x,0)=0,

    and let us suppose that for some γ[0,1a), C>0 it holds

    |w(z)|C(1+|z|γ) (3.1)

    for every z. Then w is identically zero.

    Proof It is enough to prove the result only for ε{0,1}. In fact for any other value of ε>0 we can normalize the problem falling in the case ε=1.

    Case 1: ε=0.

    Let us consider wH1,aloc(Rn+1+) satisfying the conditions of the statement, that is, solution in the following sense

    Rn+1+yawϕ=0ϕCc(Rn+1+).

    Let us define

    E(r)=1rn+a1B+rya|w|2,H(r)=1rn+a+B+ryaw2.

    Note that, as the weight ya is locally integrable, (3.1) implies

    H(r)C(1+r2γ),r>0. (3.2)

    Now, defining wr(x)=w(rx), we have

    E(r)=B+1ya|wr|2andH(r)=Sn+ya(wr)2,

    and hence

    H(r)=2rE(r).

    We are looking for the best constant in the following trace Poincaré inequality

    B+1ya|u|2λ(a)Sn+yau2,u˜H1,a(B+1). (3.3)

    Actually we are able to provide the best constant λ(a) in (3.3), since it is given by the homogeneity of the unique (up to multiplicative constants) solution in ˜H1,a(B+1) to

    {Lau=0in B+1u>0in B+1u(x,0)=0uν=λ(a)uin Sn+,

    which is u(x,y)=y1a with λ(a)=1a. However λ(a) is the same as (B.9). Hence H(r)2λ(a)rH(r), and integrating, then we infer

    H(r)r2(1a)H(1).

    We obtain that if w is not trivial, the growth of H at infinity is at least r2(1a), in contradiction with (3.2) taking r large.

    Case 2: ε=1.

    Let us define

    E(r)=1rn+a1B+r(1+y2)a/2|w|2,H(r)=1rn+a+B+r(1+y2)a/2w2.

    Note that, as a>1, the ρaε's are uniformly locally integrable and thus (3.1) implies again

    H(r)C(1+r2γ),r>0,with γ<1a. (3.4)

    Hence,

    H(r)=2rE(r)arn+a+1+B+r(1+y2)a/21w2. (3.5)

    Moreover, defining wr(x)=w(rx) one has

    E(r)=B+1(1r2+y2)a/2|wr|2andH(r)=Sn+(1r2+y2)a/2(wr)2.

    By Lemma B.4 and Remark B.5, one can find for any radius r>0 the best constant λr(a) such that

    B+1(1r2+y2)a/2|u|2λr(a)Sn+(1r2+y2)a/2u2. (3.6)

    Defining ρk(y)=(1r2k+y2)a/2 with rk+ as k+, one can see

    λ(a)=minv˜H1(B+1){0}Qa(v)Sn+v2andλk(a)=minv˜H1(B+1){0}Qρk(v)Sn+v2.

    By Lemma B.4, λk(a)λ(a)=1a as k+.

    Now we want to prove that the correction term in (3.5) is of lower order as r+. By (B.13), we have that in ˜Cc(B+1)

    B+1ρr|u|2c0B+1ρryu2.

    Hence

    |arn+a+1+B+r(1+y2)a/21w2||a|rn+a+1+B+r(1+y2)a/21/2w2=|a|r2Sn+(1r2+y2)a/21/2(wr)2|a|r2Sn+(1r2+y2)a/2y1(wr)2|a|c0r2B+1(1r2+y2)a/2|wr|2=|a|c0r2E(r).

    Hence for r large enough

    H(r)2λr(a)rH(r),

    and since λr(a)λ(a)=1a, by integrating the above expression we deduce that, for all small δ, there exists r0>0 such that, for every r>r0

    H(r)r2(1aδ)H(r0),

    which says that if w is not trivial, the growth of H at infinity is at least r2(1aδ). Taking δ>0 so small that 1aδ>γ we find a contradiction with (3.4).

    Theorem 3.2. Let a(,1), ε0 and w be a solution to

    {div((ωaε(y))1w)=0in Rn+1+w=0in Rn×{0},

    and let us suppose that for some γ[0,1), C>0 it holds

    |w(z)|Cωaε(y)(1+|z|γ) (3.7)

    for every z=(x,y). Then w is identically zero.

    Proof. By a simple normalization argument, it is enough to prove the result only for ε{0,1}. We start with

    Case 1: ε=0.

    The case falls into the proof of Case 1 in [21, Theorem 3.4] replacing a(,1) with (a2)(,1).

    Case 2: ε=1.

    Let us now define

    E(r)=1rn+(a2)1B+r(ωa1(y))1|w|2,andH(r)=1rn+(a2)+B+r(ωa1(y))1w2.

    Note that, defining wr(x)=w(rx) one has

    E(r)=B+1(ωa1/r(y))1|wr|2,andH(r)=Sn+(ωa1/r(y))1(wr)2.

    First we remark that the growth condition (3.7) implies the following upper bound

    H(r)Cr2(a2)(1+r2γ),r>0, (3.8)

    (due to the local integrability of y2a) and heence

    Sn+ωa1/r(y)c

    uniformly in r>0. Therefore,

    H(r)=2rE(r)+Sn+ddr[(ωa1/r(y))1](wr)2. (3.9)

    By Lemma B.7 and Lemma B.8, one can find for any radius r>0 the best constant μr(a) such that

    B+1(ωa1/r(y))1|u|2μr(a)Sn+(ωa1/r(y))1|u|2. (3.10)

    Defining (ωak(y))1=(ωa1/rk(y))1 and μk=μrk with rk+ as k+, by Lemma B.8, μk(a)μ(a)=1(a2)=3a as k+.

    Now we want to prove that the correction term in (3.9) is of lower order as r+. By (B.27), we have that

    B+1(ωa1/r(y))1|u|2c0Sn+(ωa1/r(y))1yu2.

    Using

    Sn+ddr[(ωa1/r(y))1](wr)2=ar3Sn+1(1r2+y2)(ωa1/r(y))1(wr)22ar3Sn+y0(1r2+s2)a/21y0(1r2+s2)a/2(ωa1/r(y))1(wr)2,

    we can estimate the first term of the rest as follows

    |ar3Sn+1(1r2+y2)(ωa1/r(y))1(wr)2||a|r2Sn+1(1r2+y2)1/2(ωa1/r(y))1(wr)2|a|r2Sn+(ωa1/r(y))1y(wr)2cr2E(r).

    Moreover, when a0 the second term of the rest can be estimated as

    |2ar3Sn+y0(1r2+s2)a/21y0(1r2+s2)a/2(ωa1/r(y))1(wr)2|2|a|r2Sn+ryry0(1+s2)a/21ry0(1+s2)a/2(ωa1/r(y))1y(wr)22|a|r2Sn+(ωa1/r(y))1y(wr)2cr2E(r),

    and this is due to the fact that, calling z=ry[0,+), by the fact that

    f(z)=zz0(1+s2)a/21z0(1+s2)a/2

    is continuous and such that f(0)=0 and

    f(z)z+{czaif a(1,0]logzzif a=11zif a<1

    and hence f(z)c in [0,+). Instead, when a(0,1) the second term of the rest can be estimated as

    |2ar3Sn+y0(1r2+s2)a/21y0(1r2+s2)a/2(ωa1/r(y))1(wr)2|2|a|r2aSn+(ry)1ary0(1+s2)a/21ry0(1+s2)a/2(ωa1/r(y))1y1a(wr)22|a|r2aSn+(ωa1/r(y))1y1a(wr)22|a|r2aSn+(ωa1/r(y))1y(wr)2cr2aE(r),

    using the fact that 0y1 and by the fact that

    f(z)=z1az0(1+s2)a/21z0(1+s2)a/2

    is continuous and such that f(0)=0 and

    f(z)z+c

    and hence f(z)c in [0,+). Hence for r large enough

    H(r)2μr(a)rH(r),

    and since μr(a)μ(a)=1(a2), we can choose a small δ>0 such that 1(a2)δ>γ(a2). Hence, by integrating the above expression we deduce that there exists r0>0 such that, for every r>r0, we have μr(a)>1(a2)δ>γ(a2) and

    H(r)r2(1(a2)δ)H(r0), (3.11)

    which is in contradiction with (3.8) for r large if w is not trivial.

    Corollary 3.3. Let a(,1), ε0 and w be a solution to

    {div(ωaε(y)w)=0in Rn+1+ωaεyw=0in Rn×{0},

    and let us suppose that for some γ[0,1), C>0 it holds

    |w(z)|C(1+|z|γ) (3.12)

    for every z. Then w is constant.

    Proof. Again, it is enough to treat the cases ε{0,1}. Let us assume ε=1, the case ε=0 coincides with the case ε=0 in [21, Corollary 3.5], by replacing in the proof a(1,+) by (2a)(1,+). Then we have (by an even reflection across Σ) an even solution w to

    div(ωa1(y)w)=0in Rn+1.

    Such a solution is wH1,2loc(Rn+1)=H1loc(Rn+1,|y|2dz), with the growth condition (3.12). Now we observe that, as w is not constant with a sublinear growth at infinity, v=ωa1(y)yw can not be trivial, otherwise w would be globally harmonic and sublinear, in contradiction with the Liouville theorem in [17]. Hence, if w is not constant, v must be an odd and nontrivial solution to

    {div((ωa1(y))1v)=0in Rn+1+v=0in {y=0}.

    By (3.11), we know that the weighted average of v2 must satisfy a minimal growth rate as

    H(r)=1rn+(a2)+B+r(ωa1(y))1v2cr2(1(a2)δ),1δ>γ,

    for rr0 depending on δ>0 chosen. Therefore, by integrating, we obtain

    B+rωa1(y)(yw)2=r0dt+B+t(ωa1(y))1v2crn(a2)+22δ.

    On the other hand, we have, by (3.12)

    B+rωa1(y)(yw)2B+rωa1(y)|w|2cB+2rωa1(y)|w|2c(1+rn(a2)+2γ)

    in contradiction with the previous inequality when r is large, since 1δ>γ.

    As a first step in our regularity theory for odd solutions, we state some results on local uniform estimates for solutions to (1.7); that is,

    div(ρaε(vaε)2Auε)=ρaε(vaε)2fε+div(ρaε(vaε)2Fε)+ρaε(vaε)2bεuεin B1.

    Using a Moser iteration argument (see also [11, Section 8.4]), one can prove the following nowadays standard result.

    Proposition 4.1. Let a(,1) and ε0. Let uH1(B1,ωaε(y)dz) be an energy solution to (1.7). Let β>1,

    p1>¯d2=n+3+(a)+2,p2,p3>¯d.

    Let moreover bLp3(B1,ωaε(y)dz)b. Then, for any 0<r<1 there exists a positive constant independent of ε (depending on n, a, p1, p2, p3, β, b, r and α) such that

    uL(Br)c(uLβ(B1,ωaε(y)dz)+fLp1(B1,ωaε(y)dz)+FLp2(B1,ωaε(y)dz)).

    Proof. The proof follows the same steps as in [21, Proposition 2.17], but iterating the Sobolev embedding in Theorem 2.1.

    Now we show how the uniform local boundedness of solutions to (1.7) yields also local uniform bounds in Hölder spaces.

    Theorem 4.2. Let a(,1). As ε0, let {uε} be a family of solutions in B+1 of (1.7) satisfying boundary conditions (evenness)

    ρaε(vaε)2yuε=0on 0B+1.

    Let r(0,1), β>1, p1>¯d2=n+3+(a)+2, p2,p3>¯d, and α(0,1)(0,2n+3+(a)+p1](0,1n+3+(a)+p2](0,1n+3+(a)+p3]. Let bLp3(B1,ωaε(y)dz)b. Let moreover A satisfy assumption (HA) with continuous coefficients. Then, there is a positive constant depending on a, n, β, p1, p2, p3, b, α and r only such that

    uεC0,α(B+r)c(uεLβ(B+1,ωaε(y)dz)+fεLp1(B+1,ωaε(y)dz)+FεLp2(B1,ωaε(y)dz)).

    Proof. The proof follows the very same steps as in the proof of [21, Theorem 4.1]. First, one has to remark that the suitable Hölder continuity for ε0 fixed is given by the theory developed for even solutions to degenerate problems in [21]. Then, one can argue by contradiction with the usual blow up argument considering two blow up sequences

    vk(z)=(ηuk)(zk+rkz)(ηuk)(zk)Lkrαk,wk(z)=η(zk)(uk(zk+rkz)uk(zk))Lkrαk,

    (with the same asymptotic behaviour on compact sets) defined in the rescaled domains B(k)=Bzkrk (where B=B1+r2 and {zk} is one of the two sequences of points where Hölder seminorms blow up), the first possessing some uniform Hölder continuity, and the second one satisfying suitable problems on rescaled domains which blow up. In order to complete the proof we prove some steps.

    Step 1: blow-ups. The first thing to do is to characterize the possible asymptotic behaviours of the weights ρaε(vaε)2 in the rescaled points: that is,

    pk(z):=ρaε(yk+rky)(vaε(zk+rkz))2=(ε2k+(yk+rky)2)a/2(yk+rky0(ε2k+s2)a/2μ(xk+rkx,s)1ds)2.

    To this end, let us define by Γk=(εk,yk,rk) and denote νk=|Γk|. The latter is a bounded sequence and, up to subsequences, has finite limit ν=|(0,y,0)|0 (where we have assumed zkz=(x,y)). Taking possibly another subsequence, we may assume that the normalized sequence

    ˜Γk=Γkνk=(˜εk,˜yk,˜rk)=(εkνk,ykνk,rkνk)

    has a limit

    ˜Γk˜Γ=(˜ε,˜y,˜r)S2,

    and moreover that

    limk+˜yk˜rk=˜l[0,+].

    Thus we can consider ˜Σ=limΣk; that is,

    ˜Σ={{(x,y)Rn+1 : y=˜l}if˜l<+,if˜l=+.

    After rescaling the independent variables, we find new weights having the form:

    pk(z)=ν2ak(˜ε2k+(˜yk+˜rky)2)a/2(˜yk+˜rky0(˜ε2k+t2)a/2μ(xk+rkx,νkt)1dt)2,

    and, in order to study their asymptotics, we have to distinguish between different cases:

    Case 1. ν>0. Then, ˜r=˜ε=0 and ˜y=1. Moreover, it is easy to see, using that 1/μ is continuous, that pk(z)=c+o(1).

    Case 2. ν=0 and ˜ε=0 (˜y0˜r0). Using the continuity of 1/μ, up to a vertical translation of ˜l, one obtains

    pk(z)=ν2ak˜p(y)(1+o(1))

    where

    ˜p(y)={cif ˜r=0,c|y|2aif ˜r0.

    Case 3. ν=0 and ˜ε(0,1). Using again the continuity of 1/μ, , up to a vertical translation of ˜l, we obtain

    pk(z)=ν2ak˜p(y)(1+o(1))

    where

    ˜p(y)={cif ˜r=0,c ωa1(y)if ˜r0.

    in the second case up to a dilation of ˜ε˜r.

    Case 4. ν=0 and ˜ε=1 (˜y=0˜r=0). As usual, by the continuity of 1/μ, , up to a vertical translation of ˜l, one obtains, if ˜rk=o(˜yk)

    pk(z)=ν2ak˜y2kc(1+o(1)),

    and otherwise

    pk(z)=ν2ak˜r2kc|y|2(1+o(1)).

    Let us define

    hk={ν2akin Cases 1,2,3,ν2ak˜y2kin Case 4, and ˜rk=o(˜yk)ν2ak˜r2kin Case 4, otherwise,

    and ˜pk=pkhk. We have shown that, up to the suitable normalization, the rescaled weights ˜pk do converge uniformly to ˜p on compact sets of Rn+1˜Σ (or the whole Rn+1 whenever ˜Σ=). Note that this latter case is equivalent to the limiting weight ˜p be constant.

    Step 2: the limiting equation and uniform-in-k energy estimates. The equation for the rescaled variable wk becomes:

    div(˜pkA(zk+rk)wk)(z)=η(zk)Lkr2αk˜pk(z)fk(zk+rkz)+div(η(zk)Lkr1αk˜pk()Fk(zk+rk))(z)+rk˜pk(z)bk(zk+rkz)wk(z). (4.1)

    By a Caccioppoli type inequality, easily obtained by multiplying (4.1) by ¯η2wk, being ¯η a cut-off function, taking into account that the wk are uniformly bounded and that

    ● the first term in the right hand side of (4.1) is bounded in L1loc;

    ● the field η(zk)Lkr1αkFk(zk+rk) in the second term in the right hand side of (4.1) is bounded in L2loc(˜p(z)dz);

    rkbk(zk+rk) is bounded in L2loc(˜pk(z)dz);

    then we obtain uniform-in-k energy bounds holding on compact subsets of Rn+1:

    R>0,c>0,k,BR˜pkA(zk+rkz)wkwkc.

    The computations are very similar to the ones done in the following step.

    Step 3: the right hand side vanishes as k+. Next we wixh to check that the right hand sides in the rescaled equations vanish in L1loc(Rn+1˜Σ) (or L1loc(Rn+1) whenever ˜Σ=), and that consequently the limit w is an energy solution of

    div(˜pA(z)w)=0in Rn+1˜Σ, (4.2)

    even with respect to ˜Σ (when not empty). We use the continuity of the matrix A in order to obtain a constant coefficients matrix in the limit Eq (4.2) together with the fact that ˜Σ is invariant with respect to the limit matrix to have evenness across the characteristic hyperplane.

    Let us show that the right hand sides vanish in L1loc at least for one of the cases (the other cases are very similar), for instance when hk=ν2ak˜y2k; that is, Case 4, when ˜rk=o(˜yk). Indeed, let ϕCc(Rn+1): using the fact that for k large enough supp(ϕ)BRB(k), using Hölder inequality, we have

    |BR˜pk(z)fεk(zk+rkz)ϕ(z)dz|ϕL(BR)(1rn+1khkBrkR(zk)ρaεk(ζn+1)(vaεk(ζ))2|fεk(ζ)|p1dζ)1/p1(BR˜pk(z)dz)1/p1crn+1p1kν2ap1k˜y2p1k,

    and hence the first term in the right hand side converges to zero since α2n+3+(a)+p1, ˜rk=rkνk, the fact that 0rkνk and having

    η(zk)Lkr2αn+3+(a)+p1k(r(a)+kνak)1/p1(˜rk˜yk)2/p10.

    With analogous computations one can check that also the second term in the right hand side vanishes.

    Concerning the third term, one can estimate the integral as follows

    rk|BR˜pk(z)bk(zk+rkz)wk(z)ϕ(z)|rkϕL(BR)(BR˜pk|wk|2)12(BR˜pk)p322p3(1hkrn+1kBrkR(zk)ρaεk(ζn+1)(vaεk(ζ))2|bεk(ζ)|p3)1p3cb1p3r1n+3+(a)+p3k(r(a)+kνak)1/p3(˜rk˜yk)2/p3(BR˜pk|wk|2)1/2=tk(BR˜pk|wk|2)1/2. (4.3)

    The sequence tk converges to zero, having p3>n+3+(a)+. Moreover, the full term vanishes using the uniform energy bound obtained in the previous step.

    Step 4: the limit belongs to H1loc(Rn+1,˜pdz). At this point, always up to subsequences, we know that the (pointwise) convergence to w holds also in the weak H1loc(Rn+1˜Σ) topology. Now we wish to infer that the limit w belongs to the space H1loc(Rn+1,˜pdz) as the closure of C with respect to the weighted norm (as defined in ยง2). Let us start with the easiest case when ˜Σ= and the limiting weight ˜p is constant. Moreover, we know tha ˜pk converge uniformly to ˜p on compact sets. Thus the sequence wk converges weakly H1 to w on each compact subset. The convergence to the case when ˜Σ requires a more thorough analysis. In order to ensure that wH1loc(Rn+1,˜p(y)dz) also when ˜Σ, one can argue as follows: using the fact that μ is continuous with 1C<μ<C, then fixed a compact set of Rn+1, we can find positive constants ck,Ck (which are uniformly bounded from above and below by two constants respectively 0<c1<c2<+) such that

    ck˜ωεk(yk+rky)˜pk(x,y)Ck˜ωεk(yk+rky)andCkck1.

    where we have denoted

    ˜ωk=ωεkhk. (4.4)

    Now, reabsorbing the weights as in (B.30) and using the family of isometries given by

    ¯Tk(wk)=(˜ωk(yk+rky))1/2wk=Wk,

    one obtains uniform boundedness of the Wk's in H1loc(Rn+1), and hence they weakly converge in the same space to W. Coming back with the inverse isometry associated with the limit weight

    ¯T(w)=(˜p(y))1/2w=W,

    we obtain wH1loc(Rn+1,˜p(y)dz).

    Step 5: end of the proof. Next we wish to show that w solves the equation in (4.2) also across the limiting characteristic hyperplane ˜Σ. Indeed, using wH1loc(Rn+1,˜p(y)dz) jointly with Eq (4.2) holding in Rn+1Σ, using that Cc(¯BRΣ) is actually dense in H1(BR,˜p(y)dz) (all the weights here, including the limit one, are super degenerate), as we have already remarked in (2.1). Eventually, one can reach a contradiction by applying the suitable Liouville theorems in [17,21] and Corollary 3.3 for the case ˜p(y)=ωa1(y).

    As a further step we now provide C1,α uniform estimates.

    Theorem 4.3. Let a(,1). As ε0, let {uε} be a family of solutions in B+1 of (1.7) satisfying boundary conditions (evenness)

    ρaε(vaε)2yuε=0on 0B+1.

    Let r(0,1), β>1, p1,p2>¯d=n+3+(a)+. Let bL2p2(B1,ωaε(y)dz)b. Let Fε=(F1ε,...,Fn+1ε) with the y-component vanishing on Σ: Fn+1ε(x,0)=Fyε(x,0)=0 in 0B+1. Let moreover A satisfy assumption (HA) with α-Hölder continuous coefficients and α(0,1n+3+(a)+p1](0,1n+3+(a)+p2]. Then, there is a positive constant depending on a, n, β, p1, p2, b, α and r only such that

    uεC1,α(B+r)c(uεLβ(B+1,ωaε(y)dz)+fεLp1(B+1,ωaε(y)dz)+FεC0,α(B+1)).

    Proof. We wish to follow the same steps of proof of [21, Theorems 5.1 and 5.2]. Among others, we have to deal with an additional difficulty; that is, our weights here do depend on the full variable z=(x,y) and not on y only. For our purposes, we can take advantage of the fact that the ratio

    γaε(x,y)=:vaε(x,y)χaε(y)=y0ρaε(s)μ1(x,s)dsy0ρaε(s)ds (4.5)

    is uniformly bounded in C0,α with respect to ε (just apply Lemma A.3, using the fact that μ1C0,α since the matrix A possesses α-Hölder continuous coefficients). Hence, one can rewrite our operator as

    div(ρaε(y)(vaε(x,y))2A(x,y)uε)=div(ωaε(y)Aε(x,y)uε), (4.6)

    where, up to constants, the new family of matrices is defined as

    Aε(x,y)=(γaε(x,y))2A(x,y), (4.7)

    with coefficients which are uniformly bounded in C0,α with respect to ε.

    With these premises, we are now able to follow the construction made in [21, Theorems 5.1 and 5.2]. Just to give the idea, the contradiction argument uses two blow-up sequences

    vk(z)=η(ˆzk+rkz)Lkr1+αk(uk(ˆzk+rkz)uk(ˆzk)),wk(z)=η(ˆzk)Lkr1+αk(uk(ˆzk+rkz)uk(ˆzk)),

    for zB(k):=Bˆzkrk. Hence, one has to work with

    ¯vk(z)=vk(z)vk(0)z,¯wk(z)=wk(z)wk(0)z,

    or

    ¯vk(z)=vk(z)xvk(0)x,¯wk(z)=wk(z)xwk(0)x,

    respectively when d(zk,Σ)rk+ (in this case we choose ˆzk=zk), or d(zk,Σ)rkc uniformly in k (in this case we choose ˆzk=(xk,0) to be the projection on Σ of zk, where zk=(xk,yk)).

    Hence, reasoning as in the previous Theorem 4.2, one can characterize all possible rescalings of the weights (in facts the possible scalings of weights pk and ωk are the same), and prove that the limit w is an energy entire solution to the suitable limiting problem.

    We remark that in order to show that the limit equation has a constant coefficient matrix one has to reason as in [21, Remark 5.3], using the α-Hölder continuity of coefficients of the matrix (in this case we will invoke the uniform bounds with respect to ε in C0,α for the coefficients of Aεk).

    Nevertheless, we need also to deal with drift terms in the rescaled equations, and we wish to show that they vanish once testing with the suitable test function ϕ supported in BR. We assume here that hk=ν2ak (one of the possible cases). Hence, also in this case we use the fact that we know a priori that the sequence {uk} is uniformly locally bounded in C0,β spaces, for any choice of β(0,1) (follows from Theorem 4.2). Reasoning as in [21, Remark 5.3], this gives the following energy estimate

    Brpk(z)|uk|2cr2(1β)B2rpk(z). (4.8)

    Hence, we can estimate

    rk|BR˜pk(z)bk(ˆzk+rkz)wk(z)ϕ(z)|r1αkη(ˆzk)LkϕL(BR)BR˜pk(z)|bk(ˆzk+rkz)||uk(ˆzk+rkz)|cr1αkLk(BR˜pk(z)|bk(ˆzk+rkz)|2)1/2(BR˜pk(z)|uk(ˆzk+rkz)|2)1/2cr1αkLk(BR˜pk(z))1/2p2(1rn+1khkBrkR(ˆzk)ρaεk(ζn+1)(vaεk(ζ))2|bk(ζ)|2p2)1/2p2cr1βk(2BR˜pk(z))1/2cLk(rkνk)1/p2(r(a)+kνak)1/2p2r12(1αn+3+(a)+p2)krβ1+α2k0

    since Lk+, νkrk, p2>n+3+(a)+, α1n+3+(a)+p2 and choosing β>1+α2.

    The following is the main result of the paper (we have already stated it in a simplified version in Theorem 1.6 in the introduction). Let a(,1), the matrix A written as in Notation (HA+) and let uε be an odd energy solution to (1.2) in B+1; that is,

    {div(ρaεAuε)=ρaεfε+div(ρaεFε)in B+1uε=0on 0B+1. (4.9)

    Let also vaε be defined as in (1.6) in B+1. Then, we have already showed (in Proposition 2.10) that under suitable integrability assumptions on the terms in the right hand side and on coefficients of the matrix A, then functions

    wε=uεvaε

    are even energy solutions (for any R<1) to Eq (2.8); that is,

    div(ρaε(vaε)2Awε)=ρaε(vaε)2(¯fε¯Fεvaεvaε)+div(ρaε(vaε)2¯Fε)+divx(ρaε(vaε)2(b˜Aε+¯Tε)wε)ρaε(vaε)2((b˜Aε+¯Tε)bIεwε+(b˜Aε+¯Tε)xwε),

    with boundary condition

    ρaε(vaε)2ywε=0on 0B+R,

    and where we denote by

    ¯fε=fεvaε,¯Fε=Fεvaε,bMε=Mxvaεvaε,and¯Tε=Tρaεvaε,

    (M is a general (n,n)-dimensional matrix).

    Theorem 4.4. Let a(,1), the matrix A written as in Notation (HA+) and as ε0 let {uε} be a family of solutions in B+1 of (4.9).

    1) Let r(0,1), β>1, p1,p2>n+3+(a)+2, p3,p4>n+3+(a)+, and α(0,2n+3+(a)+p1](0,2n+3+(a)+p2](0,1n+3+(a)+p3](0,1n+3+(a)+p4]. Let also

    (b˜Aε+¯Tε)bIεLp2(B+1,ωaε(y)dz)b1,b˜Aε+¯TεLp4(B+1,ωaε(y)dz)b2.

    Let us moreover take A with continuous coefficients. There is a positive constant depending on a, n, β, p1, p2, p3, p4, b1, b2, α and r only such that functions

    wε=uεvaε

    satisfy

    wεC0,α(B+r)c(wεLβ(B+1,ωaε(y)dz)+¯fε¯FεvaεvaεLp1(B+1,ωaε(y)dz)+¯FεLp3(B+1,ωaε(y)dz)).

    2) Let r(0,1), β>1, p1,p2>n+3+(a)+, and α(0,1n+3+(a)+p1](0,1n+3+(a)+p2]. Let ¯Fε=(¯F1ε,...,¯Fn+1ε) with the y-component vanishing on Σ: ¯Fn+1ε(x,0)=¯Fyε(x,0)=0 in 0B+1. Let also

    (b˜Aε+¯Tε)bIεLp2(B+1,ωaε(y)dz)b1,b˜Aε+¯TεC0,α(B+1)b2.

    Let's moreover take A with α-Hölder continuous coefficients. There is a positive constant depending on a, n, β, p1, p2, b1, b2, α and r only such that functions

    wε=uεvaε

    satisfy

    wεC1,α(B+r)c(wεLβ(B+1,ωaε(y)dz)+¯fε¯FεvaεvaεLp1(B+1,ωaε(y)dz)+¯FεC0,α(B+1)).

    We remark that uniform estimates with respect to the regularization are optimal in C1,α-spaces (in [21, Remark 5.4] we provided a counterexample which show that C2,α estimates could not be uniform up to Σ as ε0).

    In order to prove our main result we have the following useful preliminary result on equations of the form

    div(ρaε(vaε)2Auε)=ρaε(vaε)2Vuε+div(ρaε(vaε)2Fuε)in B1. (4.10)

    Lemma 4.5. Let a(,1) and ε0. Let uH1(B1,ωaε(y)dz) be an energy solution to (4.10), where VLp1(B1,ωaε(y)dz) with p1>¯d2=n+3+(a)+2 and FLp2(B1,ωaε(y)dz) with p2>¯d=n+3+(a)+. Let

    VLp1(B1,ωaε(y)dz)b1,FLp2(B1,ωaε(y)dz)b2.

    1) Then, for any 0<r<1 and β>1 there exists a positive constant independent of ε (depending on n, a, r, β, p1, p2, b1, b2), m1>¯d2 and m2>¯d such that

    VuLm1(Br,ωaε(y)dz)+FuLm2(Br,ωaε(y)dz)cuLβ(B1,ωaε(y)dz).

    2) If moreover p1>¯d=n+3+(a)+ and FC0,α(B1) for some α(0,1),

    VLp1(B1,ωaε(y)dz)b1,FC0,α(B1)b2,

    then for any 0<r<1 and β>1 there exists a positive constant independent of ε (depending on n, a, r, β, p1, α, b1, b2), and m1>¯d such that

    VuLm1(Br,ωaε(y)dz)+FuC0,α(Br)cuLβ(B1,ωaε(y)dz).

    Proof. The proof is done applying Moser iterations on a finite number of small enough balls which cover Br. The radius of such balls is chosen in order to ensure coercivity of the quadratic forms. Hence, using the fact that the weighted integrability of V and F is suitably large, by a finite number of Moser iterations one can promote the integrability of u itself, up to guarantee that the products Vu and Fu have the desired integrability (this type of argument is classic, see for instance [11, Section 8.4]). Since the number of iterations is finite, one can control uniformly the constants in the iterative process, proving point 1). At to point 2), thanks to point 1) we can apply Theorem 4.2 in order to obtain that the solution is C0,α with a bound which is independent from ε. Hence, we obtain the second inequality taking into account the Hölder continuity of F.

    A relevant consequence of this result is that, under suitable conditions on the 0-order terms and divergence terms with the solution itself inside (the conditions stated in Theorem 4.4), we can treat Vw and div(ρv2Fw) respectively as a fixed forcing term and a divergence term with a given field. As a consequence, we obtain uniform local regularity estimates in Theorem 4.4 for solutions wε to (2.7) by simply applying Theorems 4.2 and 4.3.

    We would like to show an example of a set of hypothesis for which part 2) of our main Theorem 4.4 holds true; that is, local uniform C1,α estimates for the ratio of odd solutions and the fundamental ones.

    We remark that, as a, the decay of the data on Σ becomes stronger and stronger.

    Assumption 4.6 (C1,α). Let fε:=ymax{1,1a}gε with gε uniformly bounded in Lp(B+1,ωaε(y)dz) as ε0 and

    p>n+3+(a)+.

    Let Fε:=ymax{1,1a}Gε with Gε uniformly bounded in C0,α(B+1) as ε0 and

    α>11+min{2,2a}n+3+(a)+.

    Nevertheless, the matrix A, which satisfies Assumption (HA+), must also satisfy some regularity assumptions: AC0,α(B+1) with xμC0,α(B+1) and T=y˜T with ˜TC0,α(B+1).

    Moreover, when the weight is locally integrable; that is, a(1,1), we obtain local estimates for odd solutions working directly on the equation.

    Theorem 4.7. Let a(1,1) and as ε0 let {uε} be a family of solutions in B+1 of either

    div(ρaεAuε)=ρaεfε+div(ρaεFε) (4.11)

    satisfying the Dirichlet boundary condition

    uε=0on 0B+1.

    Let r(0,1), β>1, p1>n+1+a+2, p2>n+1+a+ and α(0,1)(0,1a)(0,2n+1+a+p1](0,1n+1+a+p2]. Let moreover A satisfy assumption (HA) with continuous coefficients. There are constants depending on a, n, β, p1, p2, α and r only such that

    uεC0,α(B+r)c(uεLβ(B+1,ρaε(y)dz)+fεLp1(B+1,ρaε(y)dz)+FεLp2(B+1,ρaε(y)dz)).

    Proof. The proof is obtained by contradiction following the very same passages of [21, Theorem 4.1], observing that in presence of the zero Dirichlet boundary condition at Σ we obtain a contradiction by applying the Liouville Theorem 3.1. The blow-up sequences invoked are centered in points ˆzkB+=B1+r2{y0}; that is,

    vk(z)=(ηuk)(ˆzk+rkz)(ηuk)(ˆzk)Lkrαk,wk(z)=η(ˆzk)(uk(ˆzk+rkz)uk(ˆzk))Lkrαk,

    with

    zB(k):=Bˆzkrk.

    Moreover, if yk/rk+ (where zk=(xk,yk)), then we choose ˆzk=zk, while if yk/rkc uniformly, then we choose ˆzk=(xk,0). In this second case, we remark that vk and wk are antisymmetric with respect to {y=0} so that the limit w will be odd in y.

    Work partially supported by the ERC Advanced Grant 2013 n. 339958 Complex Patterns for Strongly Interacting Dynamical Systems - COMPAT. Y. S. was partially supported by the Simons foundation.

    The authors declare no conflict of interest.

    In this appendix we are going to state and prove some technical results which will allow us to compare, from the regularity point of view, the variable coefficient case with the constant one.

    Remark A.1. Let a(,1), ε0. Then the family of functions

    ψaε(y):=yρaε(y)y0ρaε(s)ds (A.1)

    are monotone in y and uniformly bounded in L(B+1) by a constant which does not depend on ε. In fact, denoting t=y/ε, we have

    ψaε(y)=ψa1(yε)=ψa1(t)=t(1+t2)a/2t0(1+s2)a/2ds.

    The latter function is continuous and monotone nondecreasing if a<0 and nonincreasing if a(0,1). Since ψa1 has limit 1 as t0 and limit 1a as t+, then

    supt>0ψa1(t)=max{1,1a}andinft>0ψa1(t)=min{1,1a}.

    Finally, note that the family ψaε can not be equicontinuous, nor uniformly bounded in C0,α(B+1), while it enjoys the following property:

    c>0:ε[0,ε0),ψaεLip(B1{y>ε})<c, (A.2)

    due to the fact that ψa1 is bounded, has a finite limit as t+ and its derivative vanishes as 1/t2.

    Lemma A.2. Let a(,1), ε0, α(0,1) and let g(x,y,s)C0,αx,y(B+1) uniformly in s[0,y], such that |g(x,y,s)|c|y|α for uniformly in . Then the family of functions

    is uniformly bounded in by a constant which does not depend on .

    Proof. We remark that the proof follows some ideas of the proof in [21, Lemma 7.5], where the case is done. The uniform Hölder continuity in the -variable is trivial. Hence, fixed , let us consider the following two sets

    and

    If we consider , using that for , in the interval it holds and thanks to the inequalities , then

    If we consider , then

    Hence, can be bounded using the fact that . Working on , there exists such that

    using the fact that , the inequalities

    and the fact that (easy to check). Eventually, recalling , we have already remarked that the function defined in (1.1) is bounded uniformly in

    With analogous computations we can bound also .

    Proposition A.3. Let , , and let . Then the family of functions

    is uniformly bounded in by a constant which does not depend on .

    Proof Just notice that, since for , satisfies conditions of the previous Lemma A.2. Indeed is -Hölder continuous in uniformly in and

    Proposition A.4. Let , , and let with . Consider the family of functions

    Then there exists such that, for every , is uniformly bounded in by .

    Proof. One can rewrite our function as

    First we show that the second term has the desired property uniformly in . At first we remark that . Now consider that the family of functions

    is uniformly bounded in . In fact, denoting ,

    is bounded in (uniformly with respect to ). In fact, the first factor is obviously bounded in and the second one is bounded for . Now, let us consider the derivative in ,

    We claim that enjoys the property stated in (A.2), being the product of two functions, both bounded, having a finite limit as and derivatives vanishing as ..

    Eventually we consider . Computing the gradient , we obtain

    where

    and satisfies the assumptions in Proposition A.3.

    It remains to consider the partial derivative in of ; that is,

    By Remark A.1, the family of functions enjoy the desired propery (A.2). Now we wish to conclude that is uniformly bounded in . To this aim, it is enough to prove that the function

    satisfies conditions in Lemma A.2. Using the Hölder continuity of , obviously

    The Hölder continuity of in the -variable is trivial. Nevertheless, following the reasonings in the proof of Lemma A.2, fixed , let us consider the following two sets

    and

    If we consider , using that for it holds and thanks to the inequalities , then

    If we consider , then, using the fact that

    In this appendix we are going to prove some useful inequalities, needed when working in weighted Sobolev spaces, specially whenever the weight does not belong to the class. These results will be the key of the validity of Liouville type theorems in Section 3.

    B.1. Hardy type inequalities

    At first, we deal with the validity of Hardy (trace) type inequalities and their spectral stability. These results will be the key tools in order to establish a class of Liouville theorems contained in this section. Let , and . We define the space as the closure of with respect to the norm

    Then, we remark that the following trace Poincaré inequality holds

    (B.1)

    We first state the following Hardy inequality.

    Lemma B.1 (Hardy inequality). Let . Then

    (B.2)

    Proof. The proof is an easy exercise based on the well known Hardy inequality on the half space

    and using the Kelvin transform.

    Next, we will need a boundary version of the Hardy inequality

    Lemma B.2 (Boundary Hardy inequality). There exists such that, for every , there holds

    (B.3)

    Proof. By taking the harmonic replacement of on , we may assume without loss of generality that in . Now we consider the following inversion (stereographic projection) such that

    with

    This map is conformal and such that and . Hence, the Kelvin transform

    is harmonic in and such that

    Using a fractional Hardy inequality (see [2]) on the -dimensional half space , up to extending the function in , we have

    Finally we compute

    B.2. A stability result

    The following Lemma is a stability result for quadratic forms which is usueful for our Liouville theorems.

    Lemma B.3. Let be a family of quadratic forms defined by

    Assume that the family satisfies the following conditions:

    i) on and in uniformly on ;

    ii) there exists a constant which does not depend on such that for any

    (B.4)

    iii) in and on pointwisely as , where

    with satisfying on , in and

    Let

    Then, .

    Proof. Let be a sequence of minimizers for ; that is, such that

    and . Since by compact embedding the minimum

    is achieved by and it is strictly positive by the trace Poincaré inequality, then there exists a positive constant independent from such that

    Moreover, we have that

    and so there exists such that in and, up to passing to a subsequence, in . Moreover, the limit is non trivial by the condition .

    We want to prove that the convergence is strong in . Testing the eigenvalue equation solved by with , we have

    Using the fact that uniformly in , the strong convergence and the normalization in , by the Hölder inequality the terms over the half sphere go to 0 in the limit. So

    (B.5)

    Hence,

    (B.6)

    In fact, the sum of the first two terms goes to 0 by (B.5), the sum of the second two by weak convergence in . The third term is such that

    We used that , the fact that and the Hardy inequality to ensure the dominated convergence theorem. Eventually the last term in (B.6) goes to 0 by the strong convergence in . Hence we obtain the strong convergence by (B.4).

    It is easy to see that . This is enough to conclude because if we consider the normalized in minimizer of , since it is competitor for the minimization of any , then

    and since and , then by , and by the minimality of , we finally obtain that with .

    B.3. Quadratic forms for the odd case

    Let , and consider a function and define . Let us define the quadratic form

    (B.7)

    where

    and

    Let

    with and . Eventually consider a sequence as and define . Let us recall and .

    Lemma B.4. Under the previous hypothesis, the family defined in (B.7) and its limit satisfy the conditions in Lemma B.3.

    Proof. Condition is trivially satisfied. Moreover, combining , the trace Poincaré and the Hardy inequalities, we easily obtain the upper bound in for any with a constant independent on ; that is,

    Let us consider and let us define .

    (B.8)

    First of all we notice that if the lower bound follows trivially. So we can suppose that . Since for , , hence by the Hardy inequality in (B.2), the quantity

    defines an equivalent norm in . Hence by the compact embedding we have that the minimum in

    is achieved. In fact, considering a minimizing sequence, we can take it such that and also such that . So it is uniformly bounded in and with . Moreover the convergence is strong in by compact embedding. Since , we also obtain convergence of the -norms of the to that of the limit, yielding strong convergence in . In fact, by the lower semicontinuity of the norm

    Obviously by the condition the limit is not trivial. This proves that achieves the minimum. Moreover, defining

    (B.9)

    we want to prove that actually . First of all, such a minimum is nonnegative since the minimizing sequence can be taken in and so the equalities in (B.8) give this condition. By contradiction let . Hence the minimizing sequence is such that . Defining , one has . Moreover, the strong convergence in gives the almost everywhere convergence of which of course implies that almost everywhere in . Hence, since almost everywhere, , but does not belong to . This is a contradiction. So . So we have the inequality

    which says that

    and by the equivalence of the norms we obtain the result for a constant which depends on and . Eventually, we have proved that also is an equivalent norm on .

    In order to find a lower bound for which is uniform in , it is enough to remark that if , then . If , then one can check that

    with and hence by the Hardy inequality in (B.2) we have also in this case an equivalent norm.

    Let us recall the definition of as the closure of with respect to the norm

    Lemma B.5. Let , and . Then the following inequalities hold true for a positive constant independent of

    (B.10)
    (B.11)
    (B.12)
    (B.13)
    (B.14)

    which are respectively the Poincaré inequality, the trace Poincaré inequality, the Hardy inequality, the trace Hardy inequality and a Sobolev type inequality.

    Proof The proof is performed for functions and then extending the inqualities to by a density argument. By Lemma B.4 there exists a positive constant uniform in such that

    (B.15)

    then all the inequalities are obtained by the validity of them in .

    B.4. Quadratic forms for the auxiliary weights

    Consider now and define

    and

    We observe that this weight is super degenerate; that is, at

    with

    B.4.1. Super singular weights

    Let us consider and define . Then we consider the quadratic form

    (B.16)

    with

    and

    Hence

    Eventually consider a sequence as and define . Let us name and . In what follows it would be useful to consider for , the continuous function defined in (A.1); that is,

    which is monotone nondecreasing if and nonincreasing if . Since has limit as and limit as , then

    Let us finally define for any

    (B.17)

    First we need the following technical result.

    Lemma B.6. Let us define for and the function

    (B.18)

    Hence there exists a positive constant such that

    Proof Step 1: .

    Whenever , there holds

    Moreover, if ,

    Hence, whenever , then, the infimum remains strictly larger that .

    Moreover, for , then in . From now on we will consider and . Now, let us compute the square in (B.18), and add ; that is

    with

    It is easy to see that

    Nevertheless, since

    then has its global minimum in , and hence it is easy to see that

    surely if . Hence, when , we have the result since and . In the case one can see that

    using the explicit form

    Step 2: .

    We can express

    Hence

    and ; that is,

    (B.20)

    First need to highlight some fundamental properties of the functions

    As one has the pointwise convergence in (which is however uniform on compact subsets) with

    We wish to prove the following

    Claim: in . At first, elementary computations show that, in a neighbourhood of , the expansion

    holds, while in a neighbourhood of we have

    implying that near zero and at infinity. Thus, the claim is false if and only if there exists such that

    (B.21)

    Remark that, and solve respectively the following differential equations

    and

    Using these equations we obtain

    and (B.21) holds if and only if

    Now we are going to show that, on the contrary,

    (B.22)

    In we have and . Moreove the inequality (B.22) can be checked numerically (with error estimate) on , and is also valid in a neighbourhood of , by the exapnsion

    This was proved with the aid of the computing system Mathematica, by numerical computations with error estimates. So, the function is positive near and at , and hence denying (B.22) yields the existence of such that

    It is easy to see that at such a point one has if (using the fact that ). Finally, we observe that the function changes monotonicity only once on and its absolute minimum value is larger than .

    Now we can turn back to (B.20), obtaining that

    (B.23)

    In order to complete the proof, we need to prove positivity of the right hand side. To this end we take advantage once more of numerical computations with error estimates. At first, as and , since changes monotonicity only once, we infer positivity of the right hand side for all , for all . The remaining values lay in the compact rectangle and can be easily dealt numerically with error controlled minimization.

    Lemma B.7. Let . The family defined in (B.17) and its limit satisfy the conditions in Lemma B.3.

    Proof. First, we want to prove property ; that is, there exists a positive constant uniform in such that

    We remark that there exists a positive constant uniform in such that

    Moreover

    It remains to prove the following uniform bounds

    Then the result follows since we are considering the logarithm of a product by linearity of the derivative.

    Moreover,

    Eventually

    Obviously, point implies the uniform upper bound in (B.4) by trace Poincaré and the Hardy inequalities. In order to prove the uniform lower bound and eventually proving , we only have to prove that there exists a positive constant uniform in such that

    In fact,

    Let . Then

    with as in definition (B.18). We can conclude by applying Lemma B.6.

    Eventually we remark that also condition holds true.

    Let us define as the closure of with respect to the norm

    Lemma B.8. Let and . Then the following inequalities hold true for a positive constant independent of

    (B.24)
    (B.25)
    (B.26)
    (B.27)
    (B.28)

    which are respectively the Poincaré inequality, the trace Poincaré inequality, the Hardy inequality, the trace Hardy inequality and a Sobolev type inequality.

    Proof. First, we prove (B.25). Thanks to Lemma B.7 we can define for a sequence

    and

    Actually, we are able to provide the value of since is the unique function in which solves

    with . Hence, by Lemma B.3, since , then and one can find such that for one has . Hence one has (B.25) with a constant uniform in . For the other inequalities, the proof is done taking functions and then passing to functions by density. By Lemma B.7 there exists a positive constant uniform in such that

    (B.29)

    then all the inequalities are obtained by the validity of them in and using the trace Poincaré inequality (B.25).

    B.4.2. Super degenerate weights

    Let and let us consider and define . Then we consider the quadratic form

    (B.30)

    with

    and

    We remark that in (B.7). It is easy to check that the family of quadratic forms are equivalent norms in with constants which are uniform in ; i.e., the following holds

    Lemma B.9. Let . The family defined in (B.30) and its limit satisfy the conditions in Lemma B.3.

    B.5. Isometries

    In this last section, we express a fundamental consequence of the previous estimate on uniform-in- equivalence of norms. Indeed, for all exponents , the nature of the weighted Sobolev spaces changes drastically when switching between and . For this reason, we need to embed them isometrically in the common space uniformly as . To this aim, we can take advantage of some fundamental isometries between weighted spaces to , which allow, by reabsorbing the weight, to obtain uniform estimates in a common space to any element in the approximating sequence. Fixed and , then the map

    is an isometry when we endow the space with the squared norm . Indeed we have:

    Is is worthwhile noticing that the family of quadratic forms is uniformly bounded (above and below) with respect to .

    Eventually, we remark that, similarily, fixed and , then the map

    (B.31)

    is also an isometry when the latter space is endowed with the squared norm as we have

    Again, is uniformly bounded (above and below) with respect to . Once again, we remark that for these super degenerate weights Poincaré type inequalities do not hold true (see [21]) and hence we can not consider only the weighted -norm of the gradient in the equation above.


    Acknowledgments



    The authors are thankful to Hélène Licandro for helpful discussions and suggestions and to Christine Rojas for technical help.
    Funding: Ta Thi Minh Ngoc was granted by the French Ministry for Science and Technology and Cynthia Romero Guido by the Alβan Fellows Program of High Level for Latinamerica (Alβan, No. E07D404079MX) and the Mexican CONACyT (No.188320). The project was granted by ANR (programme Transaronat).

    Conflict of interest



    All the authors declare that they have no conflict of interest.

    Author contributions



    TMNT, CRG and YW conceived and designed research. TMNT, CRG, HPT, HDT and HTD conducted experiments. TMNT, CRG and YW analysed data and wrote the manuscript. All authors read and approved the manuscript.

    [1] Pham-Hoang BN, Romero-Guido C, Phan-Thi H, et al. (2013) Encapsulation in a natural, preformed, multi-component and complex capsule: yeast cells. Appl Microbiol Biotechnol 97: 6635-6645. https://doi.org/10.1007/s00253-013-5044-1
    [2] Pham-Hoang BN, Phan-Thi H, Waché Y (2015) Can biological structures be natural and sustainable capsules?. Front Chem 3: 36. https://doi.org/10.3389/fchem.2015.00036
    [3] Weber FJ, de Bont JAM (1996) Adaptation mechanisms of microorganisms to the toxic effects of organic solvents on membranes. BBA-Rev Biomembranes 1286: 225-245. https://doi.org/10.1016/S0304-4157(96)00010-X
    [4] Sikkema JAN, de Bont JA, Poolman B (1995) Mechanisms of membrane toxicity of hydrocarbons. Microbiol Rev 59: 201-222. https://doi.org/10.1128/mr.59.2.201-222.1995
    [5] Ta TMN, Cao-Hoang L, Phan-Thi H, et al. (2010) New insights into the effect of medium-chain-length lactones on yeast membranes. Importance of the culture medium. Appl Microbiol Biotechnol 87: 1089-1099. https://doi.org/10.1007/s00253-010-2560-0
    [6] Aguedo M, Beney L, Waché Y, et al. (2003) Interaction of an odorant lactone with model phospholipid bilayers and its strong fluidizing action in yeast membrane. Int J Food Microbiol 80: 211-215. https://doi.org/10.1016/S0168-1605(02)00150-2
    [7] Aguedo M, Beney L, Waché Y, et al. (2002) Interaction of odorous lactones with phospholipids: implications in toxicity towards producing yeast cells. Biotechnol Lett 24: 1975-1979. https://doi.org/10.1023/A:1021129800080
    [8] Aguedo M, Beney L, Waché Y, et al. (2003) Mechanisms underlying the toxicity of lactone aroma compounds towards the producing yeast cells. J Appl Microbiol 94: 258-265. https://doi.org/10.1046/j.1365-2672.2003.01828.x
    [9] Zweytick D, Athenstaedt K, Daum G (2000) Intracellular lipid particles of eukaryotic cells. BBA-Rev Biomembranes 1469: 101-120. https://doi.org/10.1016/S0005-2736(00)00294-7
    [10] Clausen MK, Christiansen K, Jensen PK, et al. (1974) Isolation of lipid particles from baker's yeast. FEBS Lett 43: 176-179. https://doi.org/10.1016/0014-5793(74)80994-4
    [11] Czabany T, Athenstaedt K, Daum G (2007) Synthesis, storage and degradation of neutral lipids in yeast. BBA-Mol Cell Biol L 1771: 299-309. https://doi.org/10.1016/j.bbalip.2006.07.001
    [12] Czabany T, Wagner A, Zweytick D, et al. (2008) Structural and biochemical properties of lipid particles from the yeast Saccharomyces cerevisiae. J Biol Chem 283: 17065-17074. https://doi.org/10.1074/jbc.M800401200
    [13] Mlícková K, Roux E, Athenstaedt K, et al. (2004) Lipid accumulation, lipid body formation, and acyl coenzyme a oxidases of the yeast Yarrowia lipolytica. Appl Environ Microbiol 70: 3918-3924. https://doi.org/10.1128/AEM.70.7.3918-3924.2004
    [14] Robichon C, Dugail I (2007) De novo cholesterol synthesis at the crossroads of adaptive response to extracellular stress through SREBP. Biochimie 89: 260-264. https://doi.org/10.1016/j.biochi.2006.09.015
    [15] Thati B, Noble A, Rowan R, et al. (2007) Mechanism of action of coumarin and silver(I)-coumarin complexes against the pathogenic yeast Candida albicans. Toxicol In Vitro 21: 801-808. https://doi.org/10.1016/j.tiv.2007.01.022
    [16] Zweytick D, Hrastnik C, Kohlwein SD, et al. (2000) Biochemical characterization and subcellular localization of the sterol C-24(28) reductase, erg4p, from the yeast Saccharomyces cerevisiae. FEBS Lett 470: 83-87. https://doi.org/10.1016/S0014-5793(00)01290-4
    [17] Bagnat M, Keränen S, Shevchenko A, et al. (2000) Lipid rafts function in biosynthetic delivery of proteins to the cell surface in yeast. Proc Natl Acad Sci USA 97: 3254-3259. https://doi.org/10.1073/pnas.97.7.3254
    [18] Taylor FR, Parks LW (1978) Metabolic interconversion of free sterols and steryl esters in Saccharomyces cerevisiae. J Bacteriol 136: 531-537. https://doi.org/10.1128/jb.136.2.531-537.1978
    [19] Zweytick D, Leitner E, Kohlwein SD, et al. (2000) Contribution of Are1p and Are2p to steryl ester synthesis in the yeast Saccharomyces cerevisiae. Eur J Biochem 267: 1075-1082. https://doi.org/10.1046/j.1432-1327.2000.01103.x
    [20] Leber R, Zinser E, Hrastnik C, et al. (1995) Export of steryl esters from lipid particles and release of free sterols in the yeast, Saccharomyces cerevisiae. BBA-Biomembranes 1234: 119-126. https://doi.org/10.1016/0005-2736(94)00270-Y
    [21] Beopoulos A, Haddouche R, Kabran P, et al. (2012) Identification and characterization of DGA2, an acyltransferase of the DGAT1 acyl-CoA: diacylglycerol acyltransferase family in the oleaginous yeast Yarrowia lipolytica. New insights into the storage lipid metabolism of oleaginous yeasts. Appl Microbiol Biotechnol 93: 1523-1537. https://doi.org/10.1007/s00253-011-3506-x
    [22] Ta TMN, Cao-Hoang L, Romero-Guido C, et al. (2012) A shift to 50 degrees C provokes death in distinct ways for glucose- and oleate-grown cells of Yarrowia lipolytica. Appl Microbiol Biotechnol 93: 2125-2134. https://doi.org/10.1007/s00253-011-3537-3
    [23] Arthington-Skaggs BA, Jradi H, Desai T, et al. (1999) Quantitation of ergosterol content: novel method for determination of fluconazole susceptibility of Candida albicans. J Clin Microbiol 37: 3332-3337. https://doi.org/10.1128/JCM.37.10.3332-3337.1999
    [24] Shobayashi M, Mitsueda S, Ago M, et al. (2005) Effects of culture conditions on ergosterol biosynthesis by Saccharomyces cerevisiae. Biosci Biotechnol Biochem 69: 2381-2388. https://doi.org/10.1271/bbb.69.2381
    [25] Pham-Hoang BN, Voilley A, Waché Y (2016) Molecule structural factors influencing the loading of flavoring compounds in a natural-preformed capsule: Yeast cells. Colloid Surface B 148: 220-228. https://doi.org/10.1016/j.colsurfb.2016.08.045
    [26] Fukui S, Kawamoto S, Yasuhara S, et al. (1975) Microbody of methanol-grown yeasts. Localization of catalase and flavin-dependent alcohol oxidase in the isolated microbody. Eur J Biochem 59: 561-566. https://doi.org/10.1111/j.1432-1033.1975.tb02482.x
    [27] Wagner A, Grillitsch K, Leitner E, et al. (2009) Mobilization of steryl esters from lipid particles of the yeast Saccharomyces cerevisiae. BBA-Mol Cell Biol L 1791: 118-124. https://doi.org/10.1016/j.bbalip.2008.11.004
    [28] Athenstaedt K, Zweytick D, Jandrositz A, et al. (1999) Identification and characterization of major lipid particle proteins of the yeast Saccharomyces cerevisiae. J Bacteriol 181: 6441-6448. https://doi.org/10.1128/JB.181.20.6441-6448.1999
    [29] Ploier B, Korber M, Schmidt C, et al. (2015) Regulatory link between steryl ester formation and hydrolysis in the yeast Saccharomyces cerevisiae. BBA-Mol Cell Biol L 1851: 977-986. https://doi.org/10.1016/j.bbalip.2015.02.011
    [30] Gao Q, Binns D, Kinch L, et al. (2017) Pet10p is a yeast perilipin that stabilizes lipid droplets and promotes their assembly. J Cell Biol 216: 3199-3217. https://doi.org/10.1083/jcb.201610013
    [31] Moldavski O, Amen T, Levin-Zaidman S, et al. (2015) Lipid droplets are essential for efficient clearance of cytosolic inclusion bodies. Dev Cell 33: 603-610. https://doi.org/10.1016/j.devcel.2015.04.015
    [32] Mlícková K, Roux E, Athenstaedt K, et al. (2004) Lipid accumulation, the formation of lipid bodies, and acyl-CoA oxidases of the yeast Yarrowia lipolytica. Appl Environ Microbiol 70: 3918-3924. https://doi.org/10.1128/AEM.70.7.3918-3924.2004
    [33] Binns D, Januszewski T, Chen Y, et al. (173) An intimate collaboration between peroxisomes and lipid bodies. J Cell Biol 173: 719-731. https://doi.org/10.1083/jcb.200511125
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