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AIMS Neuroscience

2022, Volume 9, Issue 4: 519-535. doi: 10.3934/Neuroscience.2022030
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Chronic traumatic encephalopathy: Diagnostic updates and advances

  • 1.
    University of Florida Department of Radiology, Gainesville 32603, Florida, USA
  • 2.
    Sam Houston State University of Osteopathic Medicine, Conroe 77304, Texas, USA
  • 3.
    University of Florida Department of Neurosurgery, Gainesville 32603, Florida, USA
  • Received: 17 October 2022 Revised: 04 December 2022 Accepted: 12 December 2022 Published: 19 December 2022

  • Chronic traumatic encephalopathy (CTE) is a progressive neurodegenerative disease that occurs secondary to repetitive mild traumatic brain injury. Current clinical diagnosis relies on symptomatology and structural imaging findings which often vary widely among those with the disease. The gold standard of diagnosis is post-mortem pathological examination. In this review article, we provide a brief introduction to CTE, current diagnostic workup and the promising research on imaging and fluid biomarker diagnostic techniques. For imaging, we discuss quantitative structural analyses, DTI, fMRI, MRS, SWI and PET CT. For fluid biomarkers, we discuss p-tau, TREM2, CCL11, NfL and GFAP.

    Citation: Kevin Pierre, Vanessa Molina, Shil Shukla, Anthony Avila, Nicholas Fong, Jessica Nguyen, Brandon Lucke-Wold. Chronic traumatic encephalopathy: Diagnostic updates and advances[J]. AIMS Neuroscience, 2022, 9(4): 519-535. doi: 10.3934/Neuroscience.2022030

    Related Papers:

  • Chronic traumatic encephalopathy (CTE) is a progressive neurodegenerative disease that occurs secondary to repetitive mild traumatic brain injury. Current clinical diagnosis relies on symptomatology and structural imaging findings which often vary widely among those with the disease. The gold standard of diagnosis is post-mortem pathological examination. In this review article, we provide a brief introduction to CTE, current diagnostic workup and the promising research on imaging and fluid biomarker diagnostic techniques. For imaging, we discuss quantitative structural analyses, DTI, fMRI, MRS, SWI and PET CT. For fluid biomarkers, we discuss p-tau, TREM2, CCL11, NfL and GFAP.


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    Conflict of interest


    The authors declare no conflict of interest.

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