Fisher-KPP equations and applications to a model in medical sciences

  • Received: 01 August 2016 Revised: 01 January 2018
  • Primary: 35K57, 92C50; Secondary: 35C07

  • This paper is devoted to a class of reaction-diffusion equations with nonlinearities depending on time modeling a cancerous process with chemotherapy. We begin by considering nonlinearities periodic in time. For these functions, we investigate equilibrium states, and we deduce the large time behavior of the solutions, spreading properties and the existence of pulsating fronts. Next, we study nonlinearities asymptotically periodic in time with perturbation. We show that the large time behavior and the spreading properties can still be determined in this case.

    Citation: Benjamin Contri. 2018: Fisher-KPP equations and applications to a model in medical sciences, Networks and Heterogeneous Media, 13(1): 119-153. doi: 10.3934/nhm.2018006

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  • This paper is devoted to a class of reaction-diffusion equations with nonlinearities depending on time modeling a cancerous process with chemotherapy. We begin by considering nonlinearities periodic in time. For these functions, we investigate equilibrium states, and we deduce the large time behavior of the solutions, spreading properties and the existence of pulsating fronts. Next, we study nonlinearities asymptotically periodic in time with perturbation. We show that the large time behavior and the spreading properties can still be determined in this case.



    We begin with the following definitions of notations:

    $ N={1,2,3,} and N0:=N{0}.
    $

    Also, as usual, $ \mathbb{R} $ denotes the set of real numbers and $ \mathbb{C} $ denotes the set of complex numbers.

    The two variable Laguerre polynomials $ L_{n}(u, v) $ [1] are defined by the Taylor expansion about $ \tau = 0 $ (also popularly known as generating function) as follows:

    $ p=0Lp(u,v)τpp!=evτC0(uτ),
    $

    where is the $ 0 $-th order Tricomi function [19] given by

    $ C0(u)=p=0(1)pup(p!)2
    $

    and has the series representation

    $ Lp(u,v)=ps=0p!(1)svpsus(ps)!(s!)2.
    $

    The classical Euler polynomials $ E_{p}(u) $, Genocchi polynomials $ G_{p}(u) $ and the Bernoulli polynomials $ B_{p}(u) $ are usually defined by the generating functions (see, for details and further work, [1,2,4,5,6,7,9,11,12,20]):

    $ p=0Ep(u)τpp!=2eτ+1euτ(|τ|<π),
    $
    $ p=0Gp(u)τpp!=2τeτ+1euτ(|τ|<π)
    $

    and

    $ p=0Bp(u)τpp!=τeτ1euτ(|τ|<2π).
    $

    The Daehee polynomials, recently originally defined by Kim et al. [9], are defined as follows

    $ p=0Dp(u)τpp!=log(1+τ)τ(1+τ)u,
    $
    (1.1)

    where, for $ u = 0 $, $ D_{p}(0) = D_{p} $ stands for Daehee numbers given by

    $ p=0Dpτpp!=log(1+τ)τ.
    $
    (1.2)

    Due to Kim et al.'s idea [9], Jang et al. [3] gave the partially degenarate Genocchi polynomials as follows:

    $ 2log(1+τλ)1λeτ+1euτ=p=0Gp,λ(u)τpp!,
    $
    (1.3)

    which, for the case $ u = 0 $, yields the partially degenerate Genocchi numbers $ G_{n, \lambda }: = G_{n, \lambda }(0) $.

    Pathan et al. [17] considered the generalization of Hermite-Bernoulli polynomials of two variables $ {}_{H}B_{p}^{(\alpha)}(u, v) $ as follows

    $ (τeτ1)αeuτ+vτ2=p=0HB(α)p(u,v)τpp!.
    $
    (1.4)

    On taking $ \alpha = 1 $ in (1.4) yields a well known result of [2,p. 386 (1.6)] given by

    $ (τeτ1)euτ+vτ2=p=0HBp(u,v)τpp!.
    $
    (1.5)

    The two variable Laguerre-Euler polynomials (see [7,8]) are defined as

    $ p=0LEp(u,v)τpp!=2eτ+1evτC0(uτ).
    $
    (1.6)

    The alternating sum $ T_{k}(p) $, where $ k\in \mathbb{N}_{0} $, (see [14]) is given as

    $ Tk(p)=pj=0(1)jjk
    $

    and possess the generating function

    $ r=0Tk(p)τrr!=1(eτ)(p+1)eτ+1.
    $
    (1.7)

    The idea of degenerate numbers and polynomials found existence with the study related to Bernoulli and Euler numbers and polynomials. Lately, many researchers have begun to study the degenerate versions of the classical and special polynomials (see [3,10,11,12,13,14,15,16,18], for a systematic work). Influenced by their works, we introduce partially degenerate Laguerre-Genocchi polynomials and also a new generalization of partially degenerate Laguerre-Genocchi polynomials and then give some of their applications. We also derive some implicit summation formula and general symmetry identities.

    Let $ \lambda, \tau \in \mathbb{C} $ with $ |\tau \lambda |\leq 1 $ and $ \tau \lambda \neq -1 $. We introduce and investigate the partially degenerate Laguerre-Genocchi polynomials as follows:

    $ p=0LGp,λ(u,v)τpp!=2log(1+λτ)1λeτ+1evτC0(uτ).
    $
    (2.1)

    In particular, when $ \lambda\to 0 $, $ {}_LG_{p, \lambda}(u, v)\to {}_LG_p(u, v) $ and they have the closed form given as

    $ LGp,λ(u,v)=pq=0(pq)Gq,λLpq(u,v).
    $

    Clearly, $ u = 0 $ in (2.1) gives $ {}_{L}G_{p, \lambda }(0, 0): = G_{p, \lambda } $ that stands for the partially degenerate Genocchi polynomials [3].

    Theorem 1. For $ p \in \mathbb{N}_{o} $, the undermentioned relation holds:

    $ LGp,λ(u,v)=pq=0(pq+1)q!(λ)qLGpq1(u,v).
    $
    (2.2)

    Proof. With the help of (2.1), one can write

    $ p=0LGp,λ(u,v)τpp!=2log(1+λτ)1λeτ+1evτC0(uτ)=τ{q=0(1)qq+1(λτ)q}{p=0LGp(u,v)τpp!}=p=0{pq=0(pq)(λ)qq+1q!LGpq(u,v)}τp+1p!,
    $

    where, $ {}_{L}G_{p-q}(u, v) $ are the Laguerre-Genocchi polynomials (see [8]). Finally, the assertion easily follows by equating the coefficients $ \frac{ \tau ^{p}}{p!} $.

    Theorem 2. For $ p\in \mathbb{N}_{o} $, the undermentioned relation holds:

    $ LGp+1,λ(u,v)=pq=0(pq)λq(p+1)LGpq+1(u,v)Dq.
    $
    (2.3)

    Proof. We first consider

    $ I1=1τ2log(1+λτ)1λeτ+1evτC0(uτ)={q=0Dq(λτ)qq!}{p=0LGp(u,v)τpp!}=p=1{pq=0(pq)(λ)qDqLGpq(u,v)}τpp!.
    $

    Next we have,

    $ I2=1τ2log(1+λτ)1λeτ+1evτCo(uτ)=1τp=0LGp,λ(u,v)τpp!=p=0LGp+1,λ(u,v)p+1τpp!.
    $

    Since $ I_{1} = I_{2} $, we conclude the assertion (2.3) of Theorem 2.

    Theorem 3. For $ p\in \mathbb{N}_{0} $, the undermentioned relation holds:

    $ LGp,λ(u,v)=pp1q=0(p1q)(λ)qLEpq1(u,v)Dq.
    $
    (2.4)

    Proof. With the help of (2.1), one can write

    $ p=0LGp,λ(x,y)τpp!={τlog(1+λτ)λτ}{2eτ+1evτC0(uτ)}=τ{q=0Dq(λτ)qq!}{p=0LEp(u,v)τpp!}=p=0{pq=0(pq)(λ)qDqLEpq(u,v)}τp+1p!.
    $

    Finally, the assertion (2.4) straightforwardly follows by equating the coefficients of same powers of $ \tau $ above.

    Theorem 4. For $ p\in \mathbb{N}_{o} $, the following relation holds:

    $ LGp,λ(u,v+1)=pq=0(pq)LGpq,λ(u,v).
    $
    (2.5)

    Proof. Using (2.1), we find

    $ p=0{LGp,λ(u,v+1)LGp,λ(u,v)}τpp!=2log(1+λτ)1λeτ+1×e(v+1)τC0(uτ)2log(1+λτ)1λeτ+1evτC0(uτ)=p=0LGp,λ(u,v)τpp!q=0τqq!p=0LGp,λ(u,v)τpp!=p=0{pq=0(pq)LGpq,λ(u,v)LGp,λ(u,v)}τpp!.
    $

    Hence, the assertion (2.5) straightforwardly follows by equating the coefficients of $ \tau ^{p} $ above.

    Theorem 5. For $ p\in \mathbb{N}_{o} $, the undermentioned relation holds:

    $ LGp,λ(u,v)=pq=0ql=0(pq)(ql)GpqDqlλqlLl(u,v).
    $
    (2.6)

    Proof. Since

    $ p=0LGp,λ(u,v)τpp!=2log(1+λτ)1λeτ+1evτC0(uτ)={2τeτ+1}{2log(1+λτ)λτ}evτC0(uτ)={p=0Gpτpp!}{q=0Dq(λτ)qq!}{l=0Ll(u,v)τll!},
    $

    we have

    $ p=0LGp,λ(u,v)τpp!=p=0{pq=0ql=0(pq)(ql)GpqDqlλqlLl(u,v)}τpp!.
    $

    We thus complete the proof of Theorem 5.

    Theorem 6. (Multiplication formula). For $ p\in \mathbb{N}_{o} $, the undermentioned relation holds:

    $ LGp,λ(u,v)=fp1f1a=0LGp,λf(u,v+af).
    $
    (2.7)

    Proof. With the help of (2.1), we obtain

    $ p=0LGp,λ(u,v)τpp!=2log(1+λτ)1λeτ+1evτC0(uτ)=2log(1+λτ)1λeτ+1C0(uτ)f1a=0e(a+v)τ=p=0{fp1f1a=0LGp,λf(u,v+af)}τpp!.
    $

    Thus, the result in (2.7) straightforwardly follows by comparing the coefficients of $ \tau^{p} $ above.

    Consider a Dirichlet character $ \chi $ and let $ d\; \; (d\in \mathbb{N}) $ be the conductor connected with it such that $ d\equiv 1(\mod 2) $ (see [22]). Now we present a generalization of partially degenerate Laguerre-Genocchi polynomials attached to $ \chi $ as follows:

    $ p=0LGp,χ,λ(u,v)τpp!=2log(1+λτ)1λefτ+1f1a=0(1)aχ(a)e(v+a)τC0(uτ).
    $
    (3.1)

    Here, $ G_{p, \chi, \lambda } = {}_{L}G_{p, \chi, \lambda }(0, 0) $ are in fact, the generalized partially degenerate Genocchi numbers attached to the Drichlet character $ \chi $. We also notice that

    $\underset{λ0v=0
    }{\mathop \lim\limits }\, \ {{\ }_{L}}{{G}_{p, \chi , \lambda }}(u, v) = {{G}_{p, \chi }}(u), $

    is the familiar looking generalized Genocchi polynomial (see [20]).

    Theorem 7. For $ p\in \mathbb{N}_{0} $, the following relation holds:

    $ LGp,χ,λ(u,v)=pq=0(pq)λqDqLGpq,χ(u,v).
    $
    (3.2)

    Proof. In view of (3.1), we can write

    $ p=0LGp,χ,λ(u,v)τpp!=2log(1+λτ)1λefτ+1f1a=0(1)aχ(a)e(v+a)τC0(uτ)
    $
    $ ={log(1+λτ)λτ}{2τefτ+1f1a=0(1)aχ(a)e(v+a)τC0(uτ)}
    $
    $ ={q=0Dqλqτqq!}{p=0LGp,χ(u,v)τpp!}.
    $

    Finally, the assertion (3.2) of Theorem 7 can be achieved by equating the coefficients of same powers of $ \tau $.

    Theorem 8. The undermentioned formula holds true:

    $ LGp,χ,λ(u,v)=fp1f1a=0(1)aχ(a)LGp,λf(u,a+vf).
    $
    (3.3)

    Proof. We first evaluate

    $ p=0LGp,χ,λ(u,v)τpp!=2log(1+λτ)1λefτ+1f1a=0(1)aχ(a)e(v+a)τC0(uτ)=1ff1a=0(1)aχ(a)2log(1+λτ)fλefτ+1e(a+vf)fτC0(uτ)=p=0{fp1f1a=0(1)aχ(a)LGp,λf(u,a+vf)}τpp!.
    $

    Now, the Theorem 8 can easily be concluded by equating the coefficients $ \frac{\tau^{p}}{p!} $ above.

    Using the result in (3.1) and with a similar approach used just as in above theorems, we provide some more theorems given below. The proofs are being omitted.

    Theorem 9. The undermentioned formula holds true:

    $ LGp,χ,λ(u,v)=pq=0Gpq,χ,λ(v)(u)qp!(q!)2(pq)!.
    $
    (3.4)

    Theorem 10. The undermentioned formula holds true:

    $ LGp,χ,λ(u,v)=p,lq=0Gpql,χ,λ(v)q(u)lp!(pql)!(q)!(l!)2.
    $
    (3.5)

    Theorem 11. The undermentioned formula holds true:

    $ LGl+h,λ(u,ν)=l,hp,n=0(lp)(hn)(uv)p+nLGl+hnp,λ(u,v).
    $
    (4.1)

    Proof. On changing $ \tau $ by $ \tau+\mu $ and rewriting (2.1), we evaluate

    $ ev(τ+μ)l,h=0LGl+h,λ(u,v)τlμhl!h!=2log(1+λ(τ+μ))1λeτ+μ+1Co(u(τ+μ)),
    $

    which, upon replacing $ v $ by $ u $ and solving further, gives

    $ e(uv)(τ+μ)l,h=0LGl+h,λ(u,v)τlμhl!h!=l,h=0LGl+h,λ(u,ν)τlμhl!h!,
    $

    and also

    $ P=0(uv)P(τ+u)PP!l,h=0LGl+h,λ(u,v)τlμhl!h!=l,h=0LGl+h,λ(u,ν)τlμhl!h!.
    $
    (4.2)

    Now applying the formula [21,p.52(2)]

    $ P=0f(P)(u+v)PP!=p,q=0f(p+q)upp!vqq!,
    $

    in conjunction with (4.2), it becomes

    $ p,n=0(uv)p+nτpμnp!n!l,h=0LGl+h,λ(u,v)τlμhl!h!=l,h=0LGl+h,λ(u,ν)τlμhl!h!.
    $
    (4.3)

    Further, upon replacing $ l $ by $ l-p $, $ h $ by $ h-n $, and using the result in [21,p.100 (1)], in the left of (4.3), we obtain

    $ p,n=0l,h=0(uv)p+np!n!LGl+hpn,λ(u,v)τlμh(lp)!(hn)!=l,h=0LGl+h,λ(u,ν)τlμhl!h!.
    $

    Finally, the required result can be concluded by equating the coefficients of the identical powers of $ \tau^{l} $ and $ \mu^{h} $ above.

    Corollary 4.1. For $ h = 0 $ in (4.1), we get

    $ LGl,λ(u,ν)=lρ=0(lρ)(uv)pLGlρ,λ(u,v).
    $

    Some identities of Genocchi polynomials for special values of the parameters $ u $ and $ \nu $ in Theorem 11 can also be obtained. Now, using the result in (2.1) and with a similar approach, we provide some more theorems given below. The proofs are being omitted.

    Theorem 12. The undermentioned formula holds good:

    $ LGp,λ(u,v+μ)=pq=0(pq)μqLGpq,λ(u,v)
    $

    Theorem 13. The undermentioned implicit holds true:

    $ p=0LGp,λ(u,v)τpp!=2log(1+λτ)1λeτ+1evτCo(uτ)=pq=0(pq)Gpq,λLp(u,v)
    $

    and

    $ LGp,λ(u,v)=pq=0(pq)Gpq,λ(u,v)Lp(u,v).
    $

    Theorem 14. The undermentioned implicit summation formula holds:

    $ LGp,λ(u,v+1)+LGp,λ(u,v)=2pp1q=0(p1q)(λ)qq!q+1Lpq1(u,v).
    $

    Theorem 15. The undermentioned formula holds true:

    $ LGp,λ(u,v+1)=pq=0LGpq,λ(u,v).
    $

    Symmetry identities involving various polynomials have been discussed (e.g., [7,9,10,11,17]). As in above-cited work, here, in view of the generating functions (1.3) and (2.1), we obtain symmetry identities for the partially degenerate Laguerre-Genocchi polynomials $ {}_{L}G_{n, \lambda }(u, v) $.

    Theorem 16. Let $ \alpha, \beta \in \mathbb{Z} $ and $ p\in \mathbb{N}_{0} $, we have

    $ pq=0(pq)βqαpqLGpq,λ(uβ,vβ)LGq,λ(uα,vα)
    $
    $ =pq=0(pq)αqβpqLGpq,λ(uα,vα)LGq,λ(uβ,vβ).
    $

    Proof. We first consider

    $ g(τ)={2log(1+λ)βλ}(eατ+1){2log(1+λ)αλ}(eβτ+1)e(α+β)vτC0(uατ)C0(uβτ).
    $

    Now we can have two series expansion of $ g(\tau) $ in the following ways:

    On one hand, we have

    $ g(τ)=(p=0LGp,λ(uβ,vβ)(ατ)pp!)(q=0LGq,λ(uα,vα)(βτ)qq!)=p=0(pq=0(pq)βqαpqLGpq,λ(uβ,vβ)LGq,λ(uα,vα))τpp!.
    $
    (5.1)

    and on the other, we can write

    $ g(τ)=(p=0LGp,λ(uα,vα)(βτ)pp!)(q=0LGq,λ(uβ,vβ)(ατ)qq!)=p=0(pq=0(pq)αqβpqLGpq,λ(uα,vα)LGq,λ(uβ,vβ))τpp!.
    $
    (5.2)

    Finally, the result easily follows by equating the coefficients of $ \tau ^{p} $ on the right-hand side of Eqs (5.1) and (5.2).

    Theorem 17. Let $ \alpha, \beta \in \mathbb{Z} $ with $ p\in \mathbb{N}_{0} $, Then,

    $ pq=0(pq)βqαpqα1σ=0β1ρ=0(1)σ+ρLGpq,λ(u,vβ+βασ+ρ)Gq,λ(zα)
    $
    $ =pq=0(pq)αpβpqβ1σ=0α1ρ=0(1)σ+ρLGpq,λ(u,vα+βασ+ρ)Gq,λ(zβ).
    $

    Proof. Let

    $ g(τ)={2log(1+λ)αλ}(eατ+1)2{2log(1+λ)βλ}(eβτ+1)2e(αβτ+1)2e(αβ)(v+z)τ[Cs0(uτ)].
    $

    Considering $ g(\tau) $ in two forms. Firstly,

    $ g(τ)={2log(1+λ)αλ}eατ+1eαβvτCo(uτ)(eαβτ+1eβτ+1)×{2log(1+λ)βλ}eβτ+1eαβzτ(eαβτ+1eατ+1)
    $
    $ ={2log(1+λ)αλ}eατ+1eαβvτC0(uτ)(α1σ=0(1)σeβτσ)×{2log(1+λ)βλ}eβτ+1eαβτzC0(uτ)(β1ρ=0(1)ρeατρ),
    $
    (5.3)

    Secondly,

    $ g(τ)=p=0{pq=0(pq)βqαpqα1σ=0β1ρ=0(1)σ+ρLGpq,λ(uα,vβ+βασ+ρ)Gq,λ(αz)}τpp!=p=0{pq=0(pq)αqβpqα1σ=0β1ρ=0(1)σ+ρLGσρ,λ(u,vα+αβσ+ρ)Gq,λ(zβ)}τpp!.
    $
    (5.4)

    Finally, the result straightforwardly follows by equating the coefficients of $ \tau^{p} $ in Eqs (5.3) and (5.4).

    We now give the following two Theorems. We omit their proofs since they follow the same technique as in the Theorems 16 and 17.

    Theorem 18. Let $ \alpha, \beta \in \mathbb{Z} $ and $ p\in \mathbb{N}_{0} $, Then,

    $ pq=0(pq)βqαpqα1σ=0β1ρ=0(1)σ+ρLGpq,λ(u,vβ+βασ)Gq,λ(zα+αβρ)=pq=0(pq)αqβpqβ1σ=0α1ρ=0(1)σ+ρLGpq,λ(u,vα+αβσ+ρ)LGq,λ(zβ+βαρ).
    $

    Theorem 19. Let $ \alpha, \beta \in \mathbb{Z} $ and $ p\in \mathbb{N}_{0} $, Then,

    $ pq=0(pq)βqαpqLGpq,λ(uβ,vβ)qσ=0(qσ)Tσ(α1)Gqσ,λ(uα)=pq=0(pq)βpqαqLGpq,λ(uα,vα)qσ=0(qσ)Tσ(β1)Gqσ,λ(uβ).
    $

    Motivated by importance and potential for applications in certain problems in number theory, combinatorics, classical and numerical analysis and other fields of applied mathematics, various special numbers and polynomials, and their variants and generalizations have been extensively investigated (for example, see the references here and those cited therein). The results presented here, being very general, can be specialized to yield a large number of identities involving known or new simpler numbers and polynomials. For example, the case $ u = 0 $ of the results presented here give the corresponding ones for the generalized partially degenerate Genocchi polynomials [3].

    The authors express their thanks to the anonymous reviewers for their valuable comments and suggestions, which help to improve the paper in the current form.

    We declare that we have no conflict of interests.

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