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AIMS Allergy and Immunology

2018, Volume 2, Issue 3: 148-164. doi: 10.3934/Allergy.2018.3.148
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Review

Immune monitoring of the body’s borders

  • Microbiology and Immunology, Roseman University College of Medicine, 10530 Discovery Drive, USA
  • Received: 15 June 2018 Accepted: 09 August 2018 Published: 15 August 2018

  • The immune system spends most of its efforts and energy policing rather than attacking, cleaning up the molecular and cellular trash, maintaining the borders of the human body, and quashing minor disturbances rather than responding to pathogenic microbes. The cells that carry out these functions play by rules that are different from those described in the classical immunology textbooks, being triggered by alternative stimulants such as vitamin B analogues, glycolipids and cellular stress molecules and express different cell surface markers. Treg/TR1 cells and Th17 cells shift function depending upon the needs of the situation as directed by the cytokine environment. Better understanding of these “normal” functions for the immune response will also provide greater insights into dysregulation and conditions of excess as occur during autoimmune and inflammatory diseases.

    Citation: Ken S. Rosenthal. Immune monitoring of the body’s borders[J]. AIMS Allergy and Immunology, 2018, 2(3): 148-164. doi: 10.3934/Allergy.2018.3.148

    Related Papers:

  • The immune system spends most of its efforts and energy policing rather than attacking, cleaning up the molecular and cellular trash, maintaining the borders of the human body, and quashing minor disturbances rather than responding to pathogenic microbes. The cells that carry out these functions play by rules that are different from those described in the classical immunology textbooks, being triggered by alternative stimulants such as vitamin B analogues, glycolipids and cellular stress molecules and express different cell surface markers. Treg/TR1 cells and Th17 cells shift function depending upon the needs of the situation as directed by the cytokine environment. Better understanding of these “normal” functions for the immune response will also provide greater insights into dysregulation and conditions of excess as occur during autoimmune and inflammatory diseases.


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    [1] Rosenthal KS (2017) Dealing with garbage is the immune system's main job. MOJ Immunol 5: 00174–00176.
    [2] Nochi T, Denton PW, Wahl A, et al. (2013) Cryptopatches are essential for the development of human GALT. Cell Rep 3: 1874–1884. doi: 10.1016/j.celrep.2013.05.037
    [3] Kim CH (2018) Immune regulation by microbiome metabolites. Immunology 154: 220–229. doi: 10.1111/imm.12930
    [4] Peterson LW, Artis D (2014) Intestinal epithelial cells: regulators of barrier function and immune homeostasis. Nat Rev Immunol 14: 141–153. doi: 10.1038/nri3608
    [5] Birchenough GMH, Johansson ME, Gustafsson JK, et al. (2015) New developments in goblet cell mucus secretion and function. Mucosal Immunol 8: 712–719. doi: 10.1038/mi.2015.32
    [6] Archer NK, Adappa ND, Palmer JN, et al. (2016) Interleukin-17A (IL-17A) and IL-17F are critical for antimicrobial peptide production and clearance of staphylococcus aureus nasal colonization. Infect Immun 84: 3575–3583. doi: 10.1128/IAI.00596-16
    [7] Zhang LJ, Gallo RL (2016) Antimicrobial peptides. Curr Biol 26: R14–R19. doi: 10.1016/j.cub.2015.11.017
    [8] Akbar AN, Vukmanovicstejic M, Taams LS, et al. (2007) The dynamic co-evolution of memory and regulatory CD4+ T cells in the periphery. Nat Rev Immunol 7: 231–237. doi: 10.1038/nri2037
    [9] Chassaing B, Ley RE, Gewirtz AT (2014) Intestinal epithelial cell toll-like receptor 5 regulates the intestinal microbiota to prevent low-grade inflammation and metabolic syndrome in mice. Gastroenterology 147: 1363–1377. doi: 10.1053/j.gastro.2014.08.033
    [10] Ouyang W, Kolls JY (2008) The biological functions of T helper 17 cell effector cytokines in inflammation. Immunity 28: 454–467. doi: 10.1016/j.immuni.2008.03.004
    [11] Zhang S (2018) The role of TGF-β in Th17 differentiation. Immunology.
    [12] Park BV, Pan F (2015) The role of nuclear receptors in regulation of Th17/Treg biology and its implications for diseases. Cell Mol Immunol 12: 533–542. doi: 10.1038/cmi.2015.21
    [13] Coombes JL, Powrie F (2008) Dendritic cells in intestinal immune regulation. Nat Rev Immunol 8: 435–446. doi: 10.1038/nri2335
    [14] Kim CH (2018) Immune regulation by microbiome metabolites. Immunology 154: 220–229. doi: 10.1111/imm.12930
    [15] Byndloss MX, Olsan EE, Rivera-Chávez F, et al. (2017) Microbiota-activated PPAR-γ signaling inhibits dysbiotic Enterobacteriaceae. Science 357: 570–575. doi: 10.1126/science.aam9949
    [16] Velasquezmanoff M (2015) Gut microbiome: The peacekeepers. Nature 518: S3–S11. doi: 10.1038/518S3a
    [17] Flannigan KL, Denning TL (2018) Segmented filamentous bacteria-induced immune responses: a balancing act between protection and autoimmunity. Immunology 154: 537–546. doi: 10.1111/imm.12950
    [18] Surana NK, Kasper DL (2012) The yin yang of bacterial polysaccharides: Lessons learned from B. fragilis PSA. Immunol Rev 245: 13–26. doi: 10.1111/j.1600-065X.2011.01075.x
    [19] Wéra O, Lancellotti P, Oury C (2016) The dual role of neutrophils in inflammatory bowel diseases. J Clin Med 5: 118–142. doi: 10.3390/jcm5120118
    [20] Omenetti S, Pizarro TT (2015) The Treg/Th17 Axis: A dynamic balance regulated by the gut microbiome. Front Immuno 6: 639.
    [21] Geethanjali P, Clemens N, Moritz L, et al. (2009) STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing. J Exp Med 206: 1465–1472. doi: 10.1084/jem.20082683
    [22] Atarashi K, Suda W, Luo C, et al. (2017) Ectopic colonization of oral bacteria in the intestine drives TH1 cell induction and inflammation. Science 358: 359–365. doi: 10.1126/science.aan4526
    [23] Dabbagh K, Takeyama K, Lee HM, et al. (1999) IL-4 induces mucin gene expression and goblet cell metaplasia in vitro and in vivo. J Immunol 162: 6233–6237.
    [24] Min LW, Krammer PH (2003) Regulation of IL4 gene expression by T cells and therapeutic perspectives. Nat Rev Immunol 3: 534–543. doi: 10.1038/nri1128
    [25] Moises VM (2013) An epidemic of absence: A new way of understanding allergies and autoimmune diseases. New York. Simon and Schuster. ISBN-13: 978-1439199398.
    [26] Zhao Q, Elson CE (2018) Adaptive immune education by gut microbiota antigens. Immunology 154: 28–37. doi: 10.1111/imm.12896
    [27] Lloyd CM, Marsland BJ (2017) Lung homeostasis: Influence of age, microbes, and the immune system. Immunity 46: 549–561. doi: 10.1016/j.immuni.2017.04.005
    [28] Sato S, Kiyono H (2012) The mucosal immune system of the respiratory tract. Curr Opin Virol 2: 225–232. doi: 10.1016/j.coviro.2012.03.009
    [29] Young HJ, Randall TD, Aaron SS (2016) Inducible broncus-associated lymphoid tissue: Taming inflammation in the lung. Front Immuno 7: 258–274.
    [30] Amarnani A, Rosenthal KS, Mercado JM, et al. (2014) Concurrent treatment of chronic psoriasis and asthma with ustekinumab. J Dermatol Treat 25: 63–66. doi: 10.3109/09546634.2013.782095
    [31] Roehr B (2017) Core concept: Tissue resident memory cells emerging as key player in health and disease. Proc Natl Acad Sci USA 114: 12092–12093. doi: 10.1073/pnas.1715754114
    [32] Sheridan BS, Lefrançois L (2011) Regional and mucosal memory T cells. Nat Immunol 12: 485–491. doi: 10.1038/ni.2029
    [33] Bergsbaken T, Bevan MJ, Fink PJ (2017) Local inflammatory cues regulate differentiation and persistence of CD8+ tissue-resident memory T cells. Cell Rep 19: 114–124. doi: 10.1016/j.celrep.2017.03.031
    [34] Wu T, Hu Y, Lee YT, et al. (2014) Lung‐resident memory CD8 T cells (TRM) are indispensable for optimal cross‐protection against pulmonary virus infection. J Leukoc Biol 95: 215–224. doi: 10.1189/jlb.0313180
    [35] Tamura S, Iwasaki T, Thompson AH, et al. (1998) Antibody-forming cells in the nasal-associated lymphoid tissue during primary influenza virus infection. J Gen Virol 79: 291–299. doi: 10.1099/0022-1317-79-2-291
    [36] Allie SR, Bradley JE, Mudunuru U, et al. (2017) Identification of antigen-specific, lung resident memory B cells after influenza infection. J Immunol 198: 153.
    [37] Mora JR, von Andrian UH (2008) Differentiation and homing of IgA-secreting cells. Mucosal Immunol 1: 96–109. doi: 10.1038/mi.2007.14
    [38] Peterson LW, Artis D (2014) Intestinal epithelial cells: regulators of barrier function and immune homeostasis. Nat Rev Immunol 14: 141–153. doi: 10.1038/nri3608
    [39] Lee J, Mo JH, Katakura K, et al. (2006) Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cells. Nat Cell Biol 8: 1327–1336. doi: 10.1038/ncb1500
    [40] Munoz LE, Herrmann M, Berens C (2014) Dying autologous cells as instructors of the immune system. Clin Exp Immunol 179: 1–4.
    [41] Birge RB, Boeltz S, Kumar S, et al. (2016) Phosphatidylserine is a global immunosuppressive signal in efferocytosis, infectious disease and cancer. Cell Death Differ 23: 962–978. doi: 10.1038/cdd.2016.11
    [42] Elliott MR, Koster KM, Murphy PS (2017) Efferocytosis signaling in the regulation of macrophage inflammatory responses. J Immunol 198: 1387–1394. doi: 10.4049/jimmunol.1601520
    [43] Vremec D, Shortman K (2015) What's in a Name? Some early and current issues in dendritic cell nomenclature. Front Immuno 6: 267.
    [44] Escamilla-Tilch M, et al. (2013) The interplay between pathogen-associated and danger-associated molecular patterns: An inflammatory code in cancer? Immunol Cell Biol 91: 601–610. doi: 10.1038/icb.2013.58
    [45] Sonnenberg GF, Artis D (2015) Innate lymphoid cells in the initiation, regulation and resolution of inflammation. Nat Med 21: 698–708. doi: 10.1038/nm.3892
    [46] Ai IL, Yan L, Lopez-Lastra S, et al. (2017) Systemic human ILC precursors provide a substrate for tissue ILC differentiation. Cell 168: 1086–1100. doi: 10.1016/j.cell.2017.02.021
    [47] Wang S, Xia P, Chen Y, et al. (2017) Regulatory innate lymphoid cells control innate intestinal inflammation. Cell 171: 201–216.e18. doi: 10.1016/j.cell.2017.07.027
    [48] Lanier LL (2013) Shades of grey-the blurring view of innate and adaptive immunity. Nat Rev Immunol 13: 73–74. doi: 10.1038/nri3389
    [49] Wong EB, Ndung'U T, Kasprowicz VO (2016) The role of mucosal-associated invariant T cells in infectious diseases. Immunology 150: 45–54.
    [50] Sandberg JK, Norrby-Teglund A, Leeansyah E (2017) Bacterial deception of MAIT cells in a cloud of superantigen and cytokines. PLoS Biol 15: e2003167. doi: 10.1371/journal.pbio.2003167
    [51] Ussher JE, Klenerman P, Willberg CB (2014) Mucosal-associated invariant T-cells: New players in anti-bacterial immunity. Front Immuno 5: 1–9.
    [52] Kurioka A, Walker LJ, Klenerman P, et al. (2016) MAIT cells: new guardians of the liver. Clin Transl Immunol 5: e98. doi: 10.1038/cti.2016.51
    [53] Ullrich R, Schieferdecker HL, Ziegler K, et al. (1990) gamma delta T cells in the human intestine express surface markers of activation and are preferentially located in the epithelium. Cell Immunol 128: 619–627. doi: 10.1016/0008-8749(90)90053-T
    [54] Adams EJ, Gu S, Luoma AM (2015) Human gamma delta T cells: Evolution and ligand recognition. Cell Immunol 296: 31–40. doi: 10.1016/j.cellimm.2015.04.008
    [55] Sheridan BS, Romagnoli PA, Pham QM, et al. (2013) Gamma delta t cells exhibit multifunctional and protective memory in intestinal tissues. Immunity 39: 184–195. doi: 10.1016/j.immuni.2013.06.015
    [56] Bonneville M, Chen Z, Déchanet-Merville J, et al. (2015) 30 years of gamma delta T cells. Cell Immunol 296: 3–9. doi: 10.1016/j.cellimm.2014.11.001
    [57] Chennupati V, Worbs T, Liu X, et al. (2010) Intra- and intercompartmental movement of γδ t cells: Intestinal intraepithelial and peripheral γδ T cells represent exclusive nonoverlapping populations with distinct migration characteristics. J Immunol 185: 5160–5168. doi: 10.4049/jimmunol.1001652
    [58] Vantourout P, Hayday A (2013) Six‑of‑the-best: unique contributions of γδ T cells to immunology. Nat Rev Immunol 13: 88–100. doi: 10.1038/nri3384
    [59] Steinbach S, Vordermeier HM, Jones GJ (2016) CD4+ and γδ T cells are the main producers of IL-22 and IL-17A in lymphocytes from Mycobacterium bovis-infected cattle. Sci Rep 6: 29990. doi: 10.1038/srep29990
    [60] Seyda M, Elkhal A, Quante M, et al. (2016) T cells going innate. Trends Immunol 37: 546–556. doi: 10.1016/j.it.2016.06.004
    [61] Hapil FZ, Wingender G (2018) The interaction between iNKT cells and the mucosal microbiota. Immunology.
    [62] Van RE, Krabbe O, Boes M, et al. (2017) Endogenous lipid antigens for invariant natural killer T cells hold the reins in adipose tissue homeostasis. Immunology 153: 179–189.
    [63] Vankaer L, Algood HS, Singh K, et al. (2014) CD8αα+ innate-Type lymphocytes in the intestinal epithelium mediate mucosal immunity. Immunity 41: 451–464. doi: 10.1016/j.immuni.2014.08.010
    [64] Kaiko GE, Horvat JC, Beagley KW, et al. (2008) Immunological decision-making: How does the immune system decide to mount a helper T-Cell response? Immunology 123: 326–338. doi: 10.1111/j.1365-2567.2007.02719.x
    [65] Evansmarin HL, Cao AT, Yao S, et al. (2015) Unexpected regulatory role of CCR9 in regulatory t cell development. PLoS One 10: e0134100. doi: 10.1371/journal.pone.0134100
    [66] Bunker JJ, Erickson SA, Flynn TM, et al. (2017) Natural polyreactive IgA antibodies coat the intestinal microbiota. Science 358: eaan6619. doi: 10.1126/science.aan6619
    [67] Lundell AC, Rabe H, Quiding-Järbrink M, et al. (2010) Development of gut-homing receptors on circulating B cells during infancy. Clin Immunol 138: 97–106.
    [68] Bouvet JP, Bélec L, Pirès R, et al. (1994) Immunoglobulin G antibodies in human vaginal secretions after parenteral vaccination. Infect Immun 62: 3957–3961.
    [69] Yoshida M, Claypool SM, Wagner JS, et al. (2004) Human neonatal Fc receptor mediates transport of IgG into luminal secretions for delivery of antigens to mucosal dendritic cells. Immunity 20: 769–783. doi: 10.1016/j.immuni.2004.05.007
    [70] Rojas R, Apodaca G (2002) Immunoglobulin transport across polarized epithelial cells. Nat Rev Mol Cell Biol 3: 944–955. doi: 10.1038/nrm972
    [71] Randall TD, Mebius RE (2014) The development and function of mucosal lymphoid tissues: a balancing act with micro-organisms. Mucosal Immunol 7: 455–466. doi: 10.1038/mi.2014.11
    [72] Nochi T, Denton PW, Wahl A, et al. (2013) Cryptopatches are essential for the development of human GALT. Cell Rep 3: 1874–1884. doi: 10.1016/j.celrep.2013.05.037
    [73] Eberl G, Sawa S (2009) Opening the crypt: current facts and hypotheses on the function of cryptopatches. Trends Immunol 31: 50–55.
    [74] Eberl G (2005) Inducible lymphoid tissues in the adult gut: recapitulation of a fetal developmental pathway? Nat Rev Immunol 5: 413–420. doi: 10.1038/nri1600
    [75] Sa VDP, Mebius RE (2010) New insights into the development of lymphoid tissues. Nat Rev Immunol 10: 664–674. doi: 10.1038/nri2832
    [76] Hegazy AN, West NR, Stubbington MJT, et al. (2017) Circulating and tissue-resident CD4+ T cells with reactivity to intestinal microbiota are abundant in healthy individuals and function is altered during inflammation. Gastroenterology 153: 1320–1337.e16. doi: 10.1053/j.gastro.2017.07.047
    [77] Sheridan BS, Lefrançois L (2011) Regional and mucosal memory T cells. Nat Immunol 12: 485–491. doi: 10.1038/ni.2029
    [78] Roychoudhury P, Schiffer JT (2016) Immunological control of HSV by CD8+ tissue-resident memory T cells. J Immunol 196: 136.12.
    [79] Mishima Y, Liu B, Hansen JJ, et al. (2015) Resident bacteria-stimulated interleukin-10-secreting B cells ameliorate T-cell-mediated colitis by inducing T-regulatory-1 cells that require interleukin-27 signaling. Cell Mol Gastroenterol Hepatol 2015: 295–310.
    [80] Van d VW, Stanic B, Wirz OF, et al. (2016) Role of regulatory B cells in immune tolerance to allergens and beyond. J Allergy Clin Immunol 138: 654–665. doi: 10.1016/j.jaci.2016.07.006
    [81] Varon LS, Rosa JD, Machicote A, et al. (2017) Characterization of tonsillar IL10 secreting B cells and their role in the pathophysiology of tonsillar hypertrophy. Sci Rep 7: 11077. doi: 10.1038/s41598-017-09689-x
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