MiR-608 rs4919510 C&gt;G polymorphism increased the risk of bladder cancer in an Iranian population

Mohammad Hashemi; Fatemeh Bizhani; Hiva Danesh; Behzad Narouie; Mehdi Sotoudeh; Mohammad Hadi Radfar; Mehdi Honarkar Ramezani; Gholamreza Bahari; Mohsen Taheri; Saeid Ghavami; Mohammad Hashemi; Fatemeh Bizhani; Hiva Danesh; Behzad Narouie; Mehdi Sotoudeh; Mohammad Hadi Radfar; Mehdi Honarkar Ramezani; Gholamreza Bahari; Mohsen Taheri; Saeid Ghavami

doi:10.3934/genet.2016.4.212

AIMS Genetics

2016, Volume 3, Issue 4: 212-218. doi: 10.3934/genet.2016.4.212

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Research article

MiR-608 rs4919510 C>G polymorphism increased the risk of bladder cancer in an Iranian population

1.
Cellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan, Iran
2.
Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
3.
Urology and Nephrology Research Center; Department of Urology, Shahid Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4.
Genetic of non-communicable disease research Center, Zahedan University of Medical Sciences, Zahedan, Iran
5.
Department of Human Anatomy and Cell Science, College of Medicine, Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada

Received: 21 September 2016 Accepted: 08 November 2016 Published: 10 November 2016

MicroRNAs (miRNAs) participate in diverse biological pathways and may act as oncogenes or tumor suppressors. The single nucleotide polymorphisms (SNPs) in miRNAs potentially can alter miRNA-binding sites on target genes as well as affecting miRNAs expression. The present study aimed to evaluate the impact of miR-608 rs4919510 C>G variant on bladder cancer risk. This case-control study conducted on 233 bladder cancer patients and 252 healthy subjects. Genotyping of miR-608 rs4919510 was done using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Our findings showed that CG as well as CG+GG genotypes significantly increased the risk of bladder cancer (OR = 1.94, 95% CI = 1.28–2.94, p = 0.002, and OR = 1.90, 95% CI = 1.26–2.86, p = 0.002, respectively) compared to CC genotype. The G allele significantly increased the risk of bladder cancer compared to C allele (OR = 1.69, 95% CI = 1.17–2.45, p = 0.005). Our findings proposed that miR-608 polymorphism might be associated with increased risk of bladder cancer in a sample of Iranian population. Further large-scale studies with different ethnicities are needed to verify our findings
- miR-608; bladder cancer; polymorphism
Citation: Mohammad Hashemi, Fatemeh Bizhani, Hiva Danesh, Behzad Narouie, Mehdi Sotoudeh, Mohammad Hadi Radfar, Mehdi Honarkar Ramezani, Gholamreza Bahari, Mohsen Taheri, Saeid Ghavami. MiR-608 rs4919510 C>G polymorphism increased the risk of bladder cancer in an Iranian population[J]. AIMS Genetics, 2016, 3(4): 212-218. doi: 10.3934/genet.2016.4.212

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Abstract

MicroRNAs (miRNAs) participate in diverse biological pathways and may act as oncogenes or tumor suppressors. The single nucleotide polymorphisms (SNPs) in miRNAs potentially can alter miRNA-binding sites on target genes as well as affecting miRNAs expression. The present study aimed to evaluate the impact of miR-608 rs4919510 C>G variant on bladder cancer risk. This case-control study conducted on 233 bladder cancer patients and 252 healthy subjects. Genotyping of miR-608 rs4919510 was done using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Our findings showed that CG as well as CG+GG genotypes significantly increased the risk of bladder cancer (OR = 1.94, 95% CI = 1.28–2.94, p = 0.002, and OR = 1.90, 95% CI = 1.26–2.86, p = 0.002, respectively) compared to CC genotype. The G allele significantly increased the risk of bladder cancer compared to C allele (OR = 1.69, 95% CI = 1.17–2.45, p = 0.005). Our findings proposed that miR-608 polymorphism might be associated with increased risk of bladder cancer in a sample of Iranian population. Further large-scale studies with different ethnicities are needed to verify our findings

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