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Contribution of a Ca2+-activated K+ channel to neuronal bursting activities in the Chay model

  • Received: 27 September 2023 Revised: 21 November 2023 Accepted: 22 November 2023 Published: 28 November 2023
  • The central nervous system extensively expresses Ca2+-stimulated K+ channels, which serve to use Ca2+ to control their opening and closing. In this study, we explore the numerical computation of Hopf bifurcation in the Chay model based on the equilibrium point's stability and the center manifold theorem to illustrate the emergence of complicated neuronal bursting induced by variation of the conductance of the Ca2+-sensitive K+ channel. The results show that the formation and removal of various firing activities in this model are due to two subcritical Hopf bifurcations of equilibrium based on theoretical computation. Furthermore, the computational simulations are shown to support the validity of the conceptual approach. Consequently, the conclusion could be helpful to improve and deepen our understanding of the contribution of the Ca2+-sensitive K+ channel.

    Citation: Danqi Feng, Yu Chen, Quanbao Ji. Contribution of a Ca2+-activated K+ channel to neuronal bursting activities in the Chay model[J]. Electronic Research Archive, 2023, 31(12): 7544-7555. doi: 10.3934/era.2023380

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  • The central nervous system extensively expresses Ca2+-stimulated K+ channels, which serve to use Ca2+ to control their opening and closing. In this study, we explore the numerical computation of Hopf bifurcation in the Chay model based on the equilibrium point's stability and the center manifold theorem to illustrate the emergence of complicated neuronal bursting induced by variation of the conductance of the Ca2+-sensitive K+ channel. The results show that the formation and removal of various firing activities in this model are due to two subcritical Hopf bifurcations of equilibrium based on theoretical computation. Furthermore, the computational simulations are shown to support the validity of the conceptual approach. Consequently, the conclusion could be helpful to improve and deepen our understanding of the contribution of the Ca2+-sensitive K+ channel.



    Over the last two decades, many researches used LKF method to get stability results for time-delay systems [1,2]. The LKF method has two important technical steps to reduce the conservatism of the stability conditions. The one is how to construct an appropriate LKF, and the other is how to estimate the derivative of the given LKF. For the first one, several types of LKF are introduced, such as integral delay partitioning method based on LKF [3], the simple LKF [4,5], delay partitioning based LKF [6], polynomial-type LKF [7], the augmented LKF [8,9,10]. The augmented LKF provides more freedom than the simple LKF in the stability criteria because of introducing several extra matrices. The delay partitioning based LKF method can obtain less conservative results due to introduce several extra matrices and state vectors. For the second step, several integral inequalities have been widely used, such as Jensen inequality [11,12,13,14], Wirtinger inequality [15,16], free-matrix-based integral inequality [17], Bessel-Legendre inequalities [18] and the further improvement of Jensen inequality [19,20,21,22,23,24,25]. The further improvement of Jensen inequality [22] is less conservative than other inequalities. However, The interaction between the delay partitioning method and the further improvement of Jensen inequality [23] was not considered fully, which may increase conservatism. Thus, there exists room for further improvement.

    This paper further researches the stability of distributed time-delay systems and aims to obtain upper bounds of time-delay. A new LKF is introduced via the delay partitioning method. Then, a less conservative stability criterion is obtained by using the further improvement of Jensen inequality [22]. Finally, an example is provided to show the advantage of our stability criterion. The contributions of our paper are as follows:

    The integral inequality in [23] is more general than previous integral inequality. For r=0,1,2,3, the integral inequality in [23] includes those in [12,15,21,22] as special cases, respectively.

    An augmented LKF which contains general multiple integral terms is introduced to reduce the conservatism via a generalized delay partitioning approach. For example, the tt1mhx(s)ds, tt1mhtu1x(s)dsdu1, , tt1mhtu1tuN1x(s)dsduN1du1 are added as state vectors in the LKF, which may reduce the conservatism.

    In this paper, a new LKF is introduced based on the delay interval [0,h] is divided into m segments equally. From the LKF, we can conclude that the relationship among x(s), x(s1mh) and x(sm1mh) is considered fully, which may yield less conservative results.

    Notation: Throughout this paper, Rm denotes m-dimensional Euclidean space, A denotes the transpose of the A matrix, 0 denotes a zero matrix with appropriate dimensions.

    Consider the following time-delay system:

    ˙x(t)=Ax(t)+B1x(th)+B2tthx(s)ds, (2.1)
    x(t)=Φ(t),t[h,0], (2.2)

    where x(t)Rn is the state vector, A,B1,B2Rn×n are constant matrices. h>0 is a constant time-delay and Φ(t) is initial condition.

    Lemma2.1. [23] For any matrix R>0 and a differentiable function x(s),s[a,b], the following inequality holds:

    ba˙xT(s)R˙x(s)dsrn=0ρnbaΦn(a,b)TRΦn(a,b), (2.3)

    where

    ρn=(nk=0cn,kn+k+1)1,
    cn,k={1,k=n,n0,n1t=kf(n,t)ct,k,k=0,1,n1,n1,
    Φl(a,b)={x(b)x(a),l=0,lk=0cl,kx(b)cl,0x(a)lk=1cl,kk!(ba)kφk(a,b)x(t),l1,
    f(l,t)=tj=0ct,jl+j+1/tj=0ct,jt+j+1,
    φk(a,b)x(t)={bax(s)ds,k=1,babs1bsk1x(sk)dskds2dss1,k>1.

    Remark2.1. The integral inequality in Lemma 2.1 is more general than previous integral inequality. For r=0,1,2,3, the integral inequality (2.3) includes those in [12,15,21,22] as special cases, respectively.

    Theorem3.1. For given integers m>0,N>0, scalar h>0, system (2.1) is asymptotically stable, if there exist matrices P>0, Q>0, Ri>0,i=1,2,,m, such that

    Ψ=ξT1Pξ2+ξT2Pξ1+ξT3Qξ3ξT4Qξ4+mi=1(hm)2ATdRiAdmi=1rn=0ρnωn(timh,ti1mh)Ri×ωn(timh,ti1mh)<0, (3.1)

    where

    ξ1=[eT1ˉET0ˉET1ˉET2ˉETN]T,
    ξ2=[ATdET0ET1ET2ETN]T,
    ξ3=[eT1eT2eTm]T,
    ξ4=[eT2eT3eTm+1]T,
    ˉE0=hm[eT2eT3eTm+1]T,
    ˉEi=hm[eTim+2eTim+3eTim+m+1]T,i=1,2,,N,
    Ei=hm[eT1eTim+2eT2eTim+3eTmeTm(i+1)+1]T,i=0,1,2,,N,
    Ad=Ae1+B1em+1+B2mi=0em+1+i,
    ωn(timh,ti1mh)={eiei+i,n=0,nk=0cn,keicn,0ei+1nk=1cn,kk!e(k1)m+k+1,n1,
    ei=[0n×(i1)nIn×n0n×(Nm+1i)]T,i=1,2,,Nm+1.

    Proof. Let an integer m>0, [0,h] can be decomposed into m segments equally, i.e., [0,h]=mi=1[i1mh,imh]. The system (2.1) is transformed into

    ˙x(t)=Ax(t)+B1x(th)+B2mi=1ti1mhtimhx(s)ds. (3.2)

    Then, a new LKF is introduced as follows:

    V(xt)=ηT(t)Pη(t)+tthmγT(s)Qγ(s)ds+mi=1hmi1mhimhtt+v˙xT(s)Ri˙x(s)dsdv, (3.3)

    where

    η(t)=[xT(t)γT1(t)γT2(t)γTN(t)]T,
    γ1(t)=[tt1mhx(s)dst1mht2mhx(s)dstm1mhthx(s)ds],γ2(t)=mh[tt1mhtu1x(s)dsdu1t1mht2mht1mhu1x(s)dsdu1tm1mhthtm1mhu1x(s)dsdu1],,
    γN(t)=(mh)N1×[tt1mhtu1tuN1x(s)dsduN1du1t1mht2mht1mhu1t1mhuN1x(s)dsduN1du1tm1mhthtm1mhu1tm1mhuN1x(s)dsduN1du1],
    γ(s)=[x(s)x(s1mh)x(sm1mh)].

    The derivative of V(xt) is given by

    ˙V(xt)=2ηT(t)P˙η(t)+γT(t)Qγ(t)γT(thm)Qx(thm)+mi=1(hm)2˙xT(t)Ri˙x(t)mi=1hmti1mhtimh˙xT(s)Ri˙x(s)ds.

    Then, one can obtain

    ˙V(xt)=ϕT(t){ξT1Pξ2+ξT2Pξ1+ξT3Qξ3ξT4Qξ4+mi=1(hm)2ATdRiAd}ϕ(t)mi=1hmti1mhtimh˙xT(s)Ri˙x(s)ds, (3.4)
    ϕ(t)=[xT(t)γT0(t)γT1(t)γTN(t)]T,
    γ0(t)=[xT(t1mh)xT(t2mh)xT(th)]T.

    By Lemma 2.1, one can obtain

    hmti1mhtimh˙xT(s)Ri˙x(s)dsrl=0ρlωl(timh,ti1mh)Ri×ωl(timh,ti1mh). (3.5)

    Thus, we have ˙V(xt)ϕT(t)Ψϕ(t) by (3.4) and (3.5). We complete the proof.

    Remark3.1. An augmented LKF which contains general multiple integral terms is introduced to reduce the conservatism via a generalized delay partitioning approach. For example, the tt1mhx(s)ds, tt1mhtu1x(s)dsdu1, , tt1mhtu1tuN1x(s)dsduN1du1 are added as state vectors in the LKF, which may reduce the conservatism.

    Remark3.2. For r=0,1,2,3, the integral inequality (3.5) includes those in [12,15,21,22] as special cases, respectively. This may yield less conservative results. It is worth noting that the number of variables in our result is less than that in [23].

    Remark3.3. Let B2=0, the system (2.1) can reduces to system (1) with N=1 in [23]. For m=1, the LKF in this paper can reduces to LKF in [23]. So the LKF in our paper is more general than that in [23].

    This section gives a numerical example to test merits of our criterion.

    Example 4.1. Consider system (2.1) with m=2,N=3 and

    A=[011001],B1=[0.00.10.10.2],B2=[0000].

    Table 1 lists upper bounds of h by our methods and other methods in [15,20,21,22,23]. Table 1 shows that our method is more effective than those in [15,20,21,22,23]. It is worth noting that the number of variables in our result is less than that in [23]. Furthermore, let h=1.141 and x(0)=[0.2,0.2]T, the state responses of system (1) are given in Figure 1. Figure 1 shows the system (2.1) is stable.

    Table 1.  hmax for different methods.
    Methods hmax NoDv
    [15] 0.126 16
    [20] 0.577 75
    [21] 0.675 45
    [22] 0.728 45
    [23] 0.752 84
    Theorem 3.1 1.141 71
    Theoretical maximal value 1.463

     | Show Table
    DownLoad: CSV
    Figure 1.  The state trajectories of the system (2.1) of Example 4.1.

    In this paper, a new LKF is introduced via the delay partitioning method. Then, a less conservative stability criterion is obtained by using the further improvement of Jensen inequality. Finally, an example is provided to show the advantage of our stability criterion.

    This work was supported by Basic Research Program of Guizhou Province (Qian Ke He JiChu[2021]YiBan 005); New Academic Talents and Innovation Program of Guizhou Province (Qian Ke He Pingtai Rencai[2017]5727-19); Project of Youth Science and Technology Talents of Guizhou Province (Qian Jiao He KY Zi[2020]095).

    The authors declare that there are no conflicts of interest.



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