Seasonal transmission dynamics of varicella in Japan: The role of temperature and school holidays

Ayako Suzuki; Hiroshi Nishiura; Ayako Suzuki; Hiroshi Nishiura

doi:10.3934/mbe.2023190

Mathematical Biosciences and Engineering

2023, Volume 20, Issue 2: 4069-4081. doi: 10.3934/mbe.2023190

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Research article Special Issues

Seasonal transmission dynamics of varicella in Japan: The role of temperature and school holidays

Ayako Suzuki ,
Hiroshi Nishiura ^,

School of Public Health, Kyoto University, Kyoto, Japan

Received: 09 September 2022 Revised: 08 December 2022 Accepted: 09 December 2022 Published: 19 December 2022

In Japan, major and minor bimodal seasonal patterns of varicella have been observed. To investigate the underlying mechanisms of seasonality, we evaluated the effects of the school term and temperature on the incidence of varicella in Japan. We analyzed epidemiological, demographic and climate datasets of seven prefectures in Japan. We fitted a generalized linear model to the number of varicella notifications from 2000 to 2009 and quantified the transmission rates as well as the force of infection, by prefecture. To evaluate the effect of annual variation in temperature on the rate of transmission, we assumed a threshold temperature value. In northern Japan, which has large annual temperature variations, a bimodal pattern in the epidemic curve was observed, reflecting the large deviation in average weekly temperature from the threshold value. This bimodal pattern was diminished with southward prefectures, gradually shifting to a unimodal pattern in the epidemic curve, with little temperature deviation from the threshold. The transmission rate and force of infection, considering the school term and temperature deviation from the threshold, exhibited similar seasonal patterns, with a bimodal pattern in the north and a unimodal pattern in the south. Our findings suggest the existence of preferable temperatures for varicella transmission and an interactive effect of the school term and temperature. Investigating the potential impact of temperature elevation that could reshape the epidemic pattern of varicella to become unimodal, even in the northern part of Japan, is required.
- chickenpox,
- seasonality,
- climates,
- epidemiology,
- mathematical model
Citation: Ayako Suzuki, Hiroshi Nishiura. Seasonal transmission dynamics of varicella in Japan: The role of temperature and school holidays[J]. Mathematical Biosciences and Engineering, 2023, 20(2): 4069-4081. doi: 10.3934/mbe.2023190

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Abstract

In Japan, major and minor bimodal seasonal patterns of varicella have been observed. To investigate the underlying mechanisms of seasonality, we evaluated the effects of the school term and temperature on the incidence of varicella in Japan. We analyzed epidemiological, demographic and climate datasets of seven prefectures in Japan. We fitted a generalized linear model to the number of varicella notifications from 2000 to 2009 and quantified the transmission rates as well as the force of infection, by prefecture. To evaluate the effect of annual variation in temperature on the rate of transmission, we assumed a threshold temperature value. In northern Japan, which has large annual temperature variations, a bimodal pattern in the epidemic curve was observed, reflecting the large deviation in average weekly temperature from the threshold value. This bimodal pattern was diminished with southward prefectures, gradually shifting to a unimodal pattern in the epidemic curve, with little temperature deviation from the threshold. The transmission rate and force of infection, considering the school term and temperature deviation from the threshold, exhibited similar seasonal patterns, with a bimodal pattern in the north and a unimodal pattern in the south. Our findings suggest the existence of preferable temperatures for varicella transmission and an interactive effect of the school term and temperature. Investigating the potential impact of temperature elevation that could reshape the epidemic pattern of varicella to become unimodal, even in the northern part of Japan, is required.

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