Expression and role of cystatin C in hyperthermia-induced brain injury in rats

Haiqiang Liu; Feifei Shen; Hewei Zhang; Weikai Zhang; Haiqiang Liu; Feifei Shen; Hewei Zhang; Weikai Zhang

doi:10.3934/mbe.2023127

Mathematical Biosciences and Engineering

2023, Volume 20, Issue 2: 2716-2731. doi: 10.3934/mbe.2023127

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Expression and role of cystatin C in hyperthermia-induced brain injury in rats

1.
College of medical technology, Luoyang Polytechnic, Luoyang 471000, China
2.
Animal Diseases and Public Health Engineering Research Center of Henan Province, Luoyang Polytechnic, Luoyang 471000, China

Academic Editor: Man-Fai Leung

Received: 24 August 2022 Revised: 18 October 2022 Accepted: 31 October 2022 Published: 28 November 2022

Cystatin C, the full name of cystatin C, is one of the most potent cathepsin inhibitors currently known, which can strongly inhibit cathepsin in lysosomes and regulate the level of intracellular proteolysis. Cystatin C plays a very broad role in the body. High temperature-induced brain injury leads to very serious damage to brain tissue, such as cell inactivation, brain tissue edema, etc. At this time, cystatin C can play a crucial role. Based on the research on the expression and role of cystatin C in high temperature-induced brain injury in rats, this paper draws the following conclusions: high temperature can cause very serious damage to the brain tissue of rats, which can seriously lead to death. Cystatin C has a protective effect on brain cells and cerebral nerves. When the brain is damaged by high temperature, cystatin C can relieve the damage of high temperature to the brain and protect brain tissue. In this paper, a detection method for cystatin C with more outstanding performance is proposed, and compared with the traditional detection method, the detection method in this paper is verified to have more accurate accuracy and excellent stability through comparative experiments. Compared with traditional detection methods, it is more worthwhile to use and is a better detection method.
- cystatin C,
- rat brain injury,
- high temperature damage,
- brain injury
Citation: Haiqiang Liu, Feifei Shen, Hewei Zhang, Weikai Zhang. Expression and role of cystatin C in hyperthermia-induced brain injury in rats[J]. Mathematical Biosciences and Engineering, 2023, 20(2): 2716-2731. doi: 10.3934/mbe.2023127

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Abstract

Cystatin C, the full name of cystatin C, is one of the most potent cathepsin inhibitors currently known, which can strongly inhibit cathepsin in lysosomes and regulate the level of intracellular proteolysis. Cystatin C plays a very broad role in the body. High temperature-induced brain injury leads to very serious damage to brain tissue, such as cell inactivation, brain tissue edema, etc. At this time, cystatin C can play a crucial role. Based on the research on the expression and role of cystatin C in high temperature-induced brain injury in rats, this paper draws the following conclusions: high temperature can cause very serious damage to the brain tissue of rats, which can seriously lead to death. Cystatin C has a protective effect on brain cells and cerebral nerves. When the brain is damaged by high temperature, cystatin C can relieve the damage of high temperature to the brain and protect brain tissue. In this paper, a detection method for cystatin C with more outstanding performance is proposed, and compared with the traditional detection method, the detection method in this paper is verified to have more accurate accuracy and excellent stability through comparative experiments. Compared with traditional detection methods, it is more worthwhile to use and is a better detection method.

References

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