Dynamics of an ultra-discrete SIR epidemic model with time delay

  • Received: 12 March 2017 Published: 01 June 2018
  • MSC : Primary: 37N25; Secondary: 39B82

  • We propose an ultra-discretization for an SIR epidemic model with time delay. It is proven that the ultra-discrete model has a threshold property concerning global attractivity of equilibria as shown in differential and difference equation models. We also study an interesting convergence pattern of the solution, which is illustrated in a two-dimensional lattice.

    Citation: Masaki Sekiguchi, Emiko Ishiwata, Yukihiko Nakata. Dynamics of an ultra-discrete SIR epidemic model with time delay[J]. Mathematical Biosciences and Engineering, 2018, 15(3): 653-666. doi: 10.3934/mbe.2018029

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  • We propose an ultra-discretization for an SIR epidemic model with time delay. It is proven that the ultra-discrete model has a threshold property concerning global attractivity of equilibria as shown in differential and difference equation models. We also study an interesting convergence pattern of the solution, which is illustrated in a two-dimensional lattice.


    1. Introduction

    Differential equations are used for modeling phenomena in many disciplines e.g. economy, physics, engineering, biology and chemistry. Since exact (analytical) solutions are not available in many cases if the mathematical model is given as a nonlinear system, numerical solutions have enhanced our understanding of the mathematical model [7].Traditional numerical schemes such as Euler's method and Runge-Kutta method, however, may induce numerical instability, as the discretization would change properties of solutions, such as stability and positivity, of the original model, thus numerical scheme should be carefully chosen to preserve nature of the original system, see e.g. [4,8].

    The authors in [10] propose a system of difference equations as a discrete counterpart of a continuous epidemic model, describing disease transmission dynamics in continuous time. Qualitative properties of the model such as positivity, boundedness and convergence of the solutions are investigated. As a continuation work of [10] in [11] a general system of difference equations is analyzed. In both papers, proving convergence of the solution, when a parameter called the basic reproduction number is greater than one, seems to be a challenging problem, while it is known that the corresponding continuous model has an equilibrium that is globally stable. A "good" discretization is found in [23,24,5] for a class of epidemic models formulated by delay differential equations in [2,3,29]. The authors in [24] prove uniform persistence of the solution, corresponding to a result in [29] for a continuous SIRS model. The authors in [5] prove global stability of the endemic equilibrium by a Lyapunov function, corresponding to the result established in [14] (see also [6]). The discretization used in [24,5] is a variation of backward Euler's method and is indeed known as Micken's nonstandard finite difference method [15]. See also [12,16] for the application of Micken's nonstandard finite difference method to ordinary differential equation models. It is also known that some discrete-time epidemic models exhibit periodic and chaotic behavior [1].

    Ultra-discretization is proposed as a procedure to obtain a discrete system, where unknown variables also take discrete values, thus a cellular automaton is defined, see [21,19]. In [27,22,20] the authors study discrete and ultra-discrete models for epidemic models. In those papers it is shown that simple ultra-discrete models can capture the disease transmission dynamics, which is seen in the original differential equation models. In [27] the authors find conserved quantities for some special cases. Cellular automata have been used to model disease transmission dynamics, see e.g. [25,26] and references therein. Since cellular automata are computational models, in general, it is not straightforward to perform a mathematical analysis, in order to provide theoretical insights into simulation studies. Our analytical approach in this paper for the ultra-discrete model may be used to complement numerical simulation studies for some cellular automaton models.

    In this paper we start with a special case of the model considered in [5,24] for a discrete analogue of an epidemic model formulated by a system of delay differential equations in [2,3,29,14]. As delay differential equation form an infinite dimensional dynamical system [9], after discretizing the system, we obtain a system of difference equations of higher order, which is slightly complicated compared to the model considered in [27]. From such a model we derive an ultra-discrete model, which is formulated as a couple of piecewise linear difference equations (see e.g. [13]). Due to time delay, integrability can not be usually expected and the application of the ultra-discretization to a non-integrable system is still limited, but see also [17,18]. We here prove that the ultra-discrete model exactly has the same threshold property regarding global attractivity as in [5,14]. In Section 4 we visualize the convergence of the solution in a two-dimensional lattice and observe some interesting convergence patterns. For a special initial condition, we derive a simple recurrence relation for the solution in Lemma 3. The relation can explain the illustrated convergence pattern.

    The paper is organized as follows. In Section 2 we introduce a system of difference equations, which is a special case of the model studied in [5,24] for discrete analogue of continuous models. Applying a variable transformation together with taking a limit, we derive an ultra-discrete model. In Section 3 global behavior of the solutions is discussed. We prove that the model exhibits the threshold behavior, similar to the difference equation studied in [5]. We here find that a subsequence of the solution has a monotone property and this monotonicity is used for the proof. In Section 4 we illustrate the solution behavior in a two-dimensional lattice. To explain the convergence pattern, we consider a special initial condition and derive a simple recurrence relation. We summarize our results in Section 5.


    2. Ultra discretization of an epidemic model

    Our starting point is the following system of difference equations

    Sn+1Sn=MMSn+1BSn+1Inω, (1a)
    In+1In=BSn+1InωMIn+1ΓIn+1, (1b)
    Rn+1Rn=ΓIn+1MRn+1, (1c)

    with a positive initial condition. System (1) is a special case of the model considered in [24,5]. See also [6] for a model with nonlinear incidence. Here M,B and Γ are positive parameters and ω is a positive integer. Let us define

    R0=BM+Γ.

    One can prove that system (1) always has the disease free equilibrium given by (1,0,0) and that there exists an endemic equilibrium given by

    (M+ΓB,MB(BM+Γ1),ΓB(BM+Γ1))

    if R0>1 holds. The authors in [5] prove the following threshold type behavior.

    Theorem 2.1.

    (ⅰ) If R01 holds, then the disease free equilibrium of (1) is globally asymptotically stable.

    (ⅱ) If R0>1 holds, then the disease free equilibrium of (1) is unstable and the endemic equilibrium is globally asymptotically stable.

    System (1) is proposed as a discrete analogue of the following disease transmission dynamics model in continuous time:

    S(t)=MMS(t)BS(t)I(tτ), (2a)
    I(t)=BS(t)I(tτ)MI(t)ΓI(t), (2b)
    R(t)=ΓI(t)MR(t), (2c)

    where S(t), I(t) and R(t) respectively denote fraction of susceptible, infective and recovered population at time t. The constant M>0 denotes the death rate. The constant B>0 is transmission coefficient and the constant Γ>0 is the recovery rate. The non-negative constant τ0 can be interpreted as incubation period of infection. This model was developed in [2] to describe transmission dynamics of a vector-borne disease mosquito, see also [3]. In [14] it is shown that the continuous model (2) exhibits the same threshold behavior as in Theorem 2.1 for (1).

    Let us now derive an ultra-discrete model from system (1), following the same procedure as in [27,22,20]. Since the third equation of (1) does not appear in the first and second equations for S and I of (1), we focus on the first and second equations of (1a) and (1b). For ϵ>0 we introduce variables x and y via

    Sn=exn/ϵ and In=eyn/ϵ,

    and parameters μ, β and γ through

    M=eμ/ϵ,B=eβ/ϵ and Γ=eγ/ϵ.

    Notice that (1a) and (1b) are equivalently written as

    Sn+1=Sn+M1+M+BInω, (3a)
    In+1=In+BSn+1Inω1+M+Γ. (3b)

    Applying the variable transformation to (3) with letting ϵ+0, we get the following ultra-discrete model

    xn+1=max(μ,xn)max(0,μ,β+ynω), (4a)
    yn+1=max(yn,β+xn+1+ynω)max(0,μ,γ). (4b)

    The key relation used here is the following limit

    limϵ+0ϵlog(eA/ϵ+eB/ϵ)=max(A,B)

    for A,B>0.

    The initial condition of the system (4) is given as

    x0 and yjR for j{0,1,,ω}. (5)

    Moreover, parameters μ, β and γ are given as real numbers. For simplicity, we assume that 0<μγ. From (4) we then get

    xn+1=max(μ,xn)max(μ,β+ynω), (6a)
    yn+1=max(yn,β+xn+1+ynω)γ. (6b)

    3. Global attractivity of equilibria

    In this section, we study the global asymptotic behavior of the solutions of (6).

    Lemma 3.1. For any solutions, there exists ˉnN+ such that xn0 and ynμγ for nˉn.

    Proof. Let us assume that xnμ for some n0. Then from (6a) one has that

    xn+1=xnmax(μ,β+ynω)xnμ,

    thus xn is decreasing with respect to n as long as xnμ. Therefore, there exists k such that xk1μ and xk<μ. Then from (6a), it follows

    xk+1=μmax(μ,β+ykω)0.

    Thus we get that xm0 for all mk+1. So hereafter, without loss of generality we can set xn0 for all n0. Since we have

    xn+1=μmax(μ,β+ynω),

    from (6a)

    β+xn+1+ynω=μ+β+ynωmax(μ,β+ynω)μ

    follows. Therefore, from (6b), we have

    yn+1max(ynγ,μγ). (7)

    If ynμ then it is easy to see ymμγ for all mn+1. Let us assume that ynμ for some n0. Then we have that yn+1ynγ, thus yn is decreasing with respect to n as long as ynμ. Therefore, there exists such that y1μ and y<μ. Then one obtains y+1μγ. According to the previous discussion, there exists ˉn+1 such that ymμγ for all mˉn.

    From Lemma 3.1, without loss of generality, we can set the initial condition as

    x00 and yjμγ0, j{0,1,,ω}.

    Note that Lemma 3.1 implies

    {(x,y)R2 | x0,yμγ0} (8)

    is an invariant set. To discuss global attractivity of equilibria, we now consider the following system

    xn+1=μmax(μ,β+ynω), (9a)
    yn+1=max(yn,β+xn+1+ynω)γ (9b)

    in (8).

    Theorem 3.2. Let us assume that β<γ holds. Then

    xn=0forn1andlimnyn=.

    Proof. Since for any n0 one has that β+ynωβ+μγ<μ from Lemma 3.1, it follows

    max(μ,β+ynω)=μ.

    Therefore it follows that xn+1=0 for any n0 from (9a). Then, from (9b) we get

    yn+1=max(ynγ,βγ+ynω). (10)

    Let

    Ym:=max0jωym(ω+1)j for mN+.

    Note that ym(ω+1)jYm for j{0,1,,ω}. We show

    y(m+1)(ω+1)jYm+max(γ,βγ).

    From (10), we have

    y(m+1)(ω+1)ω=ym(ω+1)+1=max(ym(ω+1)γ,βγ+ym(ω+1)ω)max(Ymγ,βγ+Ym)=Ym+max(γ,βγ).

    For some j{1,2,,ω} suppose that

    y(m+1)(ω+1)jYm+max(γ,βγ). (11)

    Then using (10) and (11) we obtain

    y(m+1)(ω+1)j+1=max(y(m+1)(ω+1)jγ,βγ+ym(ω+1)j+1)Ym+max(γ,βγ).

    By mathematical induction, it holds that y(m+1)(ω+1)jYm+max(γ,βγ) for j{0,1,,ω}. Therefore we get

    Ym+1Ym+max(γ,βγ).

    Now it is obvious that limmYm= and hence limnyn=. We thus obtain the conclusion.

    If β>γ, xn and yn converge to a unique equilibrium. First we show that (9) has a non-trivial equilibrium.

    Proposition 1. Let us assume that β>γ holds. Then (9) has an equilibrium (β+γ,μγ).

    Proof. Let β>γ holds. We show that (9) has the constant solution (β+γ,μγ). From direct computations, one can see

    μmax(μ,β+μγ)=μ(β+μγ)=β+γ,max(μγ,ββ+γ+μγ)γ=max(μγ,μ)γ=μγ.

    Proposition 2. Let us assume that β>γ holds. It follows that

    yn+1={μγif ynωμβmax(ynγ,βγ+ynω)if ynω<μβ.

    Proof. Assume that μβ+ynω. Then it is straightforward to get xn+1=μ(β+ynω) from (9a). Since we have ynμγ (see Lemma 3.1), we get

    yn+1=max(ynγ,μγ)=μγ.

    On the other hand, assume that μ>β+ynω. Then xn+1=0 follows from (9a). Thus we immediately obtain the conclusion from (9b) with xn+1=0.

    We now show that every solution converges to the non-trivial equilibrium.

    Theorem 3.3 Let us assume that β>γ. Then

    limnxn=β+γandlimnyn=μγ.

    Proof . Let

    y:=(y(ω+1),y(ω+1)1,,y(ω+1)ω)

    for N+. From Proposition 2 one can see that

    y(ω+1)kβγ+y(1)(ω+1)k

    for k{0,1,2,,ω} if y(1)(ω+1)kμβ. Therefore,

    limy(ω+1)k=μγ,k{0,1,2,,ω},

    i.e. each component of y converges to the equilibrium as . Then, there exists a sufficiently large integer m such that yn==ynω=μγ for nm. For nm we obtain

    xn+1=μ(β+μγ)=β+γ.

    Corresponding to the first and second parts of Theorem 2.1, we show the threshold behavior in Theorems 3.2 and 3.3 for the ultra-discrete epidemic model (9).

    In Figures 1 and 2 we plot xn and yn with respect to n. In Figure 1, we set ω=0 so that the ultra-discrete model (9) has no time delay. The initial condition is given as x0=3, y0=13. We set the parameters as μ=1, γ=6 and β=3 in Figure 1(a) while μ=1, γ=6 and β=9 in Figure 1(b). As in Theorems 3.2 and 3.3, one can see that y tends to as n in Figure 1(a) and that y tends to μγ as n in Figure 1(b).

    Figure 1. Numerical experiments xn and yn with ω=0.

    In Figure 2, we set ω=10. The initial condition is chosen as x0=3 and yj=16+j for j{0,1,,ω}. We set the same parameters as Figures 1(a) and 1(b) in Figures 2(a) and 2(b), respectively. As in Theorems 3.2 and 3.3, again one can see that y tends to as n in Figure 2(a) and that y tends to μγ in Figure 2(b). Comparing Figure 1 with Figure 2, it can be seen that the solution is monotone for ω=0. In the ultra discrete model (9) time delay does not change qualitative dynamics, but changes the solution behavior.

    Figure 2. Numerical experiments xn and yn with ω=10.

    4. Monotone convergence in a two-dimensional lattice

    We here visualize the convergence of a solution using a two-dimensional lattice. We consider the case that βγ>0 holds, so the solution converges to the non-trivial equilibrium (β+γ,μγ), according to Theorem 3.3. The two-dimensional lattice is constructed using two variables: time step and time delay. More specifically, let

    ujm:=ym(ω+1)j for mN+ and j{0,1,,ω}

    to set a sequence with two variables (j,m). From Proposition 2, we have

    ujm={μγif ujm1μβmax(uj1mγ,ujm1+βγ)if ujm1μβ, (12)

    for j{0,1,,ω1} and

    uωm={μγif uωm1μβmax(u0m1γ,uωm1+βγ)if uωm1μβ. (13)

    In Figure 3, specifying parameters and the initial condition, we write a numerical value of ujm in the corresponding lattice. The black lattice represents that ujm=μγ i.e., the solution reaches the equilibrium. Of course, from Theorem 3.3, the solution converges to the homogeneous equilibrium (with respect to j) as m. Moreover, one may observe interesting stepwise shape representing the convergence pattern of the solution.

    Figure 3. A solution wjm is constructed by two solutions ujm and vjm.

    To explain the pattern we consider a special solution and derive an explicit recurrence relation for the solution in Proposition 3. For k{1,2,ω1} set the initial condition as

    uj0=p for j{0,1,,ω}{k},uk0=q, (14)

    with

    p<q<μβ. (15)

    Lemma 4.1. Assume that

    p+kγ<q. (16)

    Then it holds

    uj1=p+βγ for j{k+1,k+2,,ω} (17a)
    uj1=q+βγ(kj)γ for j{0,1,,k}. (17b)

    Proof. Firstly, we show (17a) by mathematical induction. From (14), (15) and (16), one has u00=uω0=p<μβ, then from (13) one has

    uω1=max(pγ,p+βγ)=p+βγ.

    Suppose that

    uj1=p+βγ for some j{k+2,k+3,,ω}.

    From (12) one can see

    uj+11=max(p+β2γ,p+βγ)=p+βγ.

    Therefore we get (17a).

    Next we show (17b) by mathematical induction. From (14) one can see uk11=p and uk0=q, then from (12) and (15) one also has

    uk1=max(uk11γ,uk0+βγ)=max(p+βγγ,q+βγ)=q+βγ.

    Next suppose that

    uj1=q+βγ(kj)γ for some j{1,2,,k}.

    Then from (12), one can see

    uj+11=max(q+βγ(kj+1)γ,p+βγ)=q+(βγ)(kj+1)γ.

    We note that

    q+(βγ)(kj+1)γ(p+βγ)=qp(kj+1)γqpkγ>0

    holds by (16). Therefore, we get (17b).

    Proposition 3. Assume that (16) and

    q<p+βγ+(k+1)γ (18)

    hold. Then it holds that

    ujm=βγ+ujm1 if ujm1<μβ, (19)

    for m1 and j{0,1,,ω}.

    Proof. Note that (19) with m=1 follows from Lemma 4.1. Firstly, assuming uj1<μβ, we show that (19) holds for m=2 i.e.

    uj2=βγ+uj1. (20)

    Here from (14) one has that uω1uk1<μβ. Then from (13) one has

    uω2=max(u01γ,uω1+βγ)=uω1+βγ.

    Here using (17a), (17b) and (18), we know that

    uω1+βγ(u01γ)=pq+βγ+(k+1)γ>0. (21)

    Next suppose that

    uj2=uj1+βγ for some j{1,2,,ω}. (22)

    From (12) and (22), one has

    uj+12=max(uj2γ,uj+11+βγ)=max(uj1+βγγ,uj+11+βγ)=max(uj1γ,uj+11)+(βγ).

    Let us show that

    uj+11(uj1γ)0 for j{1,2,,ω}, (23)

    so that

    uj+12=βγ+uj+11 (24)

    holds. For j{k+2,k+3,,ω}, one has uj1=uj+11 by (17a). So we get (24). For j=k+1, from (17a) and (17b) one can see

    uj1γ=p+(βγ)γ,uj+11=q+(βγ).

    Thus we have uj1γ<uj+11 from (15). So again we obtain (24). For j{1,2,,k}, from (17b) one has uj1γ=uj+11. We thus obtain (24). Consequently, (19) follows when m=2.

    Finally, assuming ujm1<μβ, we show that (19) holds for m3 by mathematical induction. Suppose that for m2

    ujm=ujm1+βγ for j{0,1,,ω} (25)

    and ujm<μβ hold. From (13) one has

    uωm+1=max(u0mγ,uωm+βγ).

    Note that from (25) and (21), one can see

    uωm+βγ(u0mγ)=uω1+βγ(u01γ)>0.

    Therefore we get

    uωm+1=uωm+βγ.

    For some j{1,2,,ω} suppose that

    ujm+1=ujm+βγ (26)

    holds. From (12) one has

    uj+1m+1=max(ujm+1γ,uj+1m+βγ).

    Note that from (26) and (25) one can see

    ujm+1γ=uj1+m(βγ)γ,uj+1m+βγ=uj+11+m(βγ).

    Then from (23) one can see

    uj+1m+βγ(ujm+1γ)=uj+11(uj1γ)0.

    Therefore we get (19) for m2 and j{0,1,,ω}.

    When m=0 the k-th component is the biggest component, i.e., uk0=max0jωuj0. In Lemma 4.1 we show that this relation is preserved when m=1. It is also shown that

    uj+11=uj1γ<uj1 for j{1,2,,k}.

    In this way uj1 is ordered for j{0,1,,k}. Furthermore, from Lemma 3, one can see that the monotone ordering is preserved for m1. Consequently, the stepwise shape appears as the convergence pattern illustrated in Figures 3(a) and 3(b). In Figure 3, we set μ=1, β=11, γ=6 and ω=10. Figures 3(a) and 3(b) have different initial conditions: k=8, u80=12 and uj0=70 for j8 in Figure 3(a) while k=3, u30=16 and uj0=40 for j3 in Figure 3(b). In both Figures 3(a) and 3(b) one sees that the k-th component reaches the equilibrium firstly and then other components reach the equilibrium, according to the ordering.

    Although here we consider a special solution such that the initial condition is given as in (14), we can show that linear combination of two solutions can produce a complicated pattern for the convergence of the solution. Consider two solutions ujm and vjm of (12) and (13). Then

    wjm:=max(ujm,vjm) (27)

    is shown to be a solution of (12) and (13) as follows. Assume that ujm1 and vjm1 are less than μβ, then wjm1<μβ. Using (12) one can compute

    wjm=max{max(uj1mγ,ujm1+βγ),max(vj1mγ,vjm1+βγ)}=max(uj1mγ,ujm1+βγ,vj1mγ,vjm1+βγ)=max(max(uj1m,vj1m)γ,max(ujm1,vjm1)+βγ)=max(wj1mγ,wjm1+βγ).

    Assume that either ujm1>μβ or vjm1>μβ. Then wjm1>μβ. In this case one can prove wjm=μγ.

    Let the solution depicted in Figure 3(a) be u and the solution depicted in Figure 3(b) be v. Convergence pattern of the solution w, which is given by (27), is illustrated in Figure 3(c). From our discussion, the convergence pattern in Figure 3(c) appears as the composition of the stepwise convergence pattern which is observed in Figures 3(a) and 3(b).


    5. Conclusion

    In this paper we consider an ultra-discrete model with time delay. The model is derived from a discrete epidemic model studied in [5,24]. In Theorems 3.2 and 3.3, we show that the ultra-discrete model also has the threshold property concerning global attractivity of equilibria, similar to the discrete epidemic model [5] and the continuous epidemic model [14]. For the proof of global attractivity of the non-trivial equilibrium in Theorem 3.3, we reduce the system (9) to the scalar difference equation in Proposition 2 and then use a certain monotone property of the solution, which is our important finding.

    In Section 4 we further derive a simple recurrence relation for the solution, assuming a special condition for the initial condition. The relation derived in Proposition 3 clearly shows that each component monotonically increases towards the equilibrium. Two-dimensional lattice seems to be an informative tool to illustrate such a convergence patten.

    For the ultra-discrete model (9), a linear combination of two solutions is shown to be a solution. It would be interesting to investigate the structure of the solutions of ultra-discrete models. Figure 3 may remind of an elementary cellular automaton (see e.g. rule 252 in [28]). Exploring a possible connection to elementary cellular automaton is our future work.


    Acknowledgments

    We are very grateful to the anonymous referee for the evaluation of our paper and for the constructive critics.

    The second author was supported by JSPS Grant-in-Aid for Scientific Research (C) JP26400212. The third author was supported by JSPS Grant-in-Aid for Young Scientists (B) 16K20976.


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