Angiotensin II, dopamine and nitric oxide. An asymmetrical neurovisceral interaction between brain and plasma to regulate blood pressure

I. Banegas; I. Prieto; A.B. Segarra; M. Martínez-Cañamero; M. de Gasparo; M. Ramírez-Sánchez; I. Banegas; I. Prieto; A.B. Segarra; M. Martínez-Cañamero; M. de Gasparo; M. Ramírez-Sánchez

doi:10.3934/Neuroscience.2019.3.116

AIMS Neuroscience

2019, Volume 6, Issue 3: 116-127. doi: 10.3934/Neuroscience.2019.3.116

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Research article Special Issues

Angiotensin II, dopamine and nitric oxide. An asymmetrical neurovisceral interaction between brain and plasma to regulate blood pressure

1.
Department of Health Sciences, University of Jaén, Jaén, Spain
2.
Cardiovascular and Metabolic Syndrome Adviser, Rossemaison, Switzerland

Received: 10 June 2019 Accepted: 24 July 2019 Published: 26 July 2019

Vital functions, such as blood pressure, are regulated within a framework of neurovisceral integration in which various factors are involved under normal conditions maintaining a delicate balance. Imbalance of any of these factors can lead to various pathologies. Blood pressure control is the result of the balanced action of central and peripheral factors that increase or decrease. Special attention for blood pressure control was put on the neurovisceral interaction between Angiotensin II and the enzymes that regulate its activity as well as on nitric oxide and dopamine. Several studies have shown that such interaction is asymmetrically organized. These studies suggest that the neuronal activity related to the production of nitric oxide in plasma is also lateralized and, consequently, changes in plasma nitric oxide influence neuronal function. This observation provides a new aspect revealing the complexity of the blood pressure regulation and, undoubtedly, makes such study more motivating as it may affect the approach for treatment.
- angiotensin,
- dopamine,
- nitric oxide,
- brain asymmetry,
- aminopeptidases,
- blood pressure
Citation: I. Banegas, I. Prieto, A.B. Segarra, M. Martínez-Cañamero, M. de Gasparo, M. Ramírez-Sánchez. Angiotensin II, dopamine and nitric oxide. An asymmetrical neurovisceral interaction between brain and plasma to regulate blood pressure[J]. AIMS Neuroscience, 2019, 6(3): 116-127. doi: 10.3934/Neuroscience.2019.3.116

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Abstract

Vital functions, such as blood pressure, are regulated within a framework of neurovisceral integration in which various factors are involved under normal conditions maintaining a delicate balance. Imbalance of any of these factors can lead to various pathologies. Blood pressure control is the result of the balanced action of central and peripheral factors that increase or decrease. Special attention for blood pressure control was put on the neurovisceral interaction between Angiotensin II and the enzymes that regulate its activity as well as on nitric oxide and dopamine. Several studies have shown that such interaction is asymmetrically organized. These studies suggest that the neuronal activity related to the production of nitric oxide in plasma is also lateralized and, consequently, changes in plasma nitric oxide influence neuronal function. This observation provides a new aspect revealing the complexity of the blood pressure regulation and, undoubtedly, makes such study more motivating as it may affect the approach for treatment.

Conflict of interest

The authors declare no conflicts of interest.

References

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