Review Special Issues

Mercury and its toxic effects on fish

  • Received: 14 December 2016 Accepted: 31 March 2017 Published: 10 April 2017
  • Mercury (Hg) and its derivative compounds have been parts of widespread pollutants of the aquatic environment. Since Hg is absorbed by fish and passed up the food chain to other fish-eating species, it does not only affect aquatic ecosystems but also humans through bioaccumulation. Thus, the knowledge of toxicological effects of Hg on fish has become one of the aims in research applied to fish aquaculture. Moreover, the use of alternative methods to animal testing has gained great interest in the field of Toxicology. This review addresses the systemic pathophysiology of individual organ systems associated with Hg poisoning on fish. Such data are extremely useful to the scientific community and public officials involved in health risk assessment and management of environmental contaminants as a guide to the best course of action to restore ecosystems and, in turn, to preserve human health.

    Citation: Patricia Morcillo, Maria Angeles Esteban, Alberto Cuesta. Mercury and its toxic effects on fish[J]. AIMS Environmental Science, 2017, 4(3): 386-402. doi: 10.3934/environsci.2017.3.386

    Related Papers:

  • Mercury (Hg) and its derivative compounds have been parts of widespread pollutants of the aquatic environment. Since Hg is absorbed by fish and passed up the food chain to other fish-eating species, it does not only affect aquatic ecosystems but also humans through bioaccumulation. Thus, the knowledge of toxicological effects of Hg on fish has become one of the aims in research applied to fish aquaculture. Moreover, the use of alternative methods to animal testing has gained great interest in the field of Toxicology. This review addresses the systemic pathophysiology of individual organ systems associated with Hg poisoning on fish. Such data are extremely useful to the scientific community and public officials involved in health risk assessment and management of environmental contaminants as a guide to the best course of action to restore ecosystems and, in turn, to preserve human health.


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    [1] Begam M, Sengupta M (2015) Immunomodulation of intestinal macrophages by mercury involves oxidative damage and rise of pro-in flammatory cytokine release in the fresh water fish Channa punctatus Bloch. Fish Shellfish Immunol 45: 378-385.
    [2] Clarkson TW, Magos L (2006) The toxicology of mercury and its chemical compounds. Crit Rev Toxicol 36: 609-662.
    [3] Cossins AR, Crawford DL (2005) Fish as models for environmental genomics. Nat Rev Genet 6: 324-333.
    [4] Rice KM, Walker EM, Miaozong W, et al. (2014) Environmental mercury and its toxic effects. J Prev Med Public Health 47: 74-83.
    [5] Serra-Majem L, Román-Viñas B, Salvador G, et al. (2007) Knowledge, opinions and behaviours related to food and nutrition in Catalonia, Spain (1992–2003). Public Health Nutr 10: 1396-1405.
    [6] EPA, Basic information about mercury. US EPA, 2016. Available from: https://www.epa.gov/mercury/basic-information-about-mercury
    [7] Cuesta A, Meseguer J, Esteban MA (2011) Immunotoxicological effects of environmental contaminants in teleost fish reared for aquaculture, In: Stoytcheva M, Pesticides in the Modern World-Risks and Benefits, Rijeka, Croatia: Intech, 241-266.
    [8] Erickson RJ, Nichols JW, Cook PM, et al. (2008) Bioavailability of chemical contaminants in aquatic systems, In: Di Giulio RT, Hinton DE, The Toxicology of Fishes, Florida, USA: CRC Press, 9-45.
    [9] Sweet LI, Zelikoff JT (2001) Toxicology and immunotoxicology of mercury : a comparative review in fish and humans. J Toxicol Environ Heatlth B 4: 161-205.
    [10] Aschner M, Onishchenko N, Ceccatelli S (2010) Toxicology of alkylmercury compounds, In: Sigel A, Sigel H, Sigel RKO, Organometallics in Environment and Toxicology, Cambridge, UK: RSC Publishing, 403-434.
    [11] Kerper LE, Ballatori N, Clarkson TW (1992) Methylmercury transport across the blood-brain barrier by an amino acid carrier. Am J Physiol 262: 761-765.
    [12] Ebany JMF, Chakraborty S, Fretham SJB, et al. (2012) Cellular transport and homeostasis of essential and nonessential metals. Metallomics 4: 593-605.
    [13] Giblin FJ, Massaro EJ (1975) The erythrocyte transport and transfer of methylmercury to the tissues of the rainbow trout (Salmo gairdneri). Toxicology 5: 243-254.
    [14] Farina M, Aschner M, Rocha JBT (2011) Oxidative stress in MeHg-induced neurotoxicity. Toxicol Appl Pharmacol 256: 405-417.
    [15] Clarkson TW, Magos L, Myers GJ (2003) The toxicology of mercury-current exposures and clinical manifestations. N Engl J Med 349: 1731-1737.
    [16] Mieiro CL, Ahmad I, Pereira ME, et al. (2010) Antioxidant system breakdown in brain of feral golden grey mullet (Liza aurata) as an effect of mercury exposure. Ecotoxicology 19: 1034-1045.
    [17] Monteiro DA, Rantin FT, Kalinin AL (2013) Dietary intake of inorganic mercury: bioaccumulation and oxidative stress parameters in the neotropical fish Hoplias malabaricus. Ecotoxicology 22: 446-456.
    [18] Guardiola FA, Chaves-Pozo E, Espinosa C, et al. (2016) Mercury accumulation, structural damages, and antioxidant and immune status changes in the gilthead seabream (Sparus aurata L.) exposed to methylmercury. Arch Environ Contam Toxicol 70: 734-746.
    [19] Brandão F, Cappello T, Raimundo J, et al. (2015) Unravelling the mechanisms of mercury hepatotoxicity in wild fish (Liza aurata) through a triad approach: bioaccumulation, metabolomic profiles and oxidative stress. Metallomics 7: 1352-1363.
    [20] Cappello T, Brandão F, Guilherme S, et al. (2016) Insights into the mechanisms underlying mercury-induced oxidative stress in gills of wild fish (Liza aurata) combining 1H NMR metabolomics and conventional biochemical assays. Sci Total Environ 548-549: 13-24.
    [21] Cappello T, Pereira P, Maisano M, et al. (2016) Advances in understanding the mechanisms of mercury toxicity in wild golden grey mullet (Liza aurata) by 1H NMR-based metabolomics. Environ Pollut 219: 139-148.
    [22] Sarmento A, Guilhermino L, Afonso A (2004) Mercury chloride effects on the function and cellular integrity of sea bass (Dicentrarchus labrax) head kidney macrophages. Fish Shellfish Immunol 17: 489-498.
    [23] Voccia I, Krzystyniak K, Dunier M, et al. (1994) In vitro mercury-related cytotoxicity and functional impairment of the immune cells of rainbow trout (Oncorhynchus mykiss). Aquat Toxicol 29: 37-48.
    [24] Morcillo P, Chaves-Pozo E, Meseguer J, et al. (2017) Establishment of a new teleost brain cell line (DLB-1) from the European sea bass and its use to study metal toxicology. Toxicol In Vitro 38: 91-100.
    [25] Morcillo P, Cordero H, Meseguer J, et al. (2015) Toxicological in vitro effects of heavy metals on gilthead seabream (Sparus aurata L.) head-kidney leucocytes. Toxicol In Vitro 30: 412-420.
    [26] Morcillo P, Esteban MA, Cuesta A (2016) Heavy metals produce toxicity, oxidative stress and apoptosis in the marine teleost fish SAF-1 cell line. Chemosphere 144: 225-233.
    [27] Elia AC, Galarini R, Taticchi MI, et al. (2003) Antioxidant responses and bioaccumulation in Ictalurus melas under mercury exposure. Ecotoxicol Environ Saf 55: 162-167.
    [28] Rana SVS, Singh R, Verma S (1995) Mercury-induced lipid peroxidation in the liver, kidney, brain and gills of a fresh water fish Channa punctatus. Jpn J Ichthyol 42: 255-259.
    [29] Branco V, Canario J, Lu J, et al. (2012) Mercury and selenium interaction in vivo: effects on thioredoxin reductase and glutathione peroxidase. Free Radic Biol Med 52: 781-793.
    [30] Mela M, Neto FF, Yamamoto FY, et al. (2014) Mercury distribution in target organs and biochemical responses after subchronic and trophic exposure to Neotropical fish Hoplias malabaricus. Fish Physiol Biochem 40: 245-256.
    [31] Monteiro DA, Rantin FT, Kalinin AL (2010) Inorganic mercury exposure: toxicological effects, oxidative stress biomarkers and bioaccumulation in the tropical freshwater fish matrinxã, Brycon amazonicus (Spix and Agassiz, 1829). Ecotoxicology 19: 105-23.
    [32] Morcillo P, Cordero H, Meseguer J, et al. (2015) In vitro immunotoxicological effects of heavy metals on European sea bass (Dicentrarchus labrax L.) head-kidney leucocytes. Fish Shellfish Immunol 47: 245-254.
    [33] Morcillo P, Meseguer J, Esteban MA, et al. (2016) In vitro effects of metals on isolated head-kidney and blood leucocytes of the teleost fish Sparus aurata L. and Dicentrarchus labrax L. head-kidney leucocytes. Fish Shellfish Immunol 54: 77-85.
    [34] Morcillo P, Romero D, Meseguer J, et al. (2016) Cytotoxicity and alterations at transcriptional level caused by metals on fish erythrocytes in vitro. Environ Sci Pollut Res 23: 12312-12322.
    [35] Navarro A, Quirós L, Casado M, et al. (2009) Physiological responses to mercury in feral carp populations inhabiting the low Ebro River (NE Spain), a historically contaminated site. Aquat Toxicol 93: 150-157.
    [36] Mieiro CL, Bervoets L, Joosen S, et al. (2011) Metallothioneins failed to reflect mercury external levels of exposure and bioaccumulation in marine fish. Considerations on tissue and species specific responses. Chemosphere 85: 114-121.
    [37] Bebianno MJ, Santos C, Canário J, et al. (2007) Hg and metallothionein-like proteins in the black scabbardfish Aphanopus carbo. Food Chem Toxicol 45: 1443-1452.
    [38] Roméo M, Bennani N, Gnassia-Barelli M, et al. (2000) Cadmium and copper display different responses towards oxidative stress in the kidney of the sea bass Dicentrarchus labrax. Aquat Toxicol 48: 185-194.
    [39] Carranza-Rosales P, Said-Fernández S, Sepúlveda-Saavedra J, et al. (2005) Morphologic and functional alterations induced by low doses of mercuric chloride in the kidney OK cell line: ultrastructural evidence for an apoptotic mechanism of damage. Toxicology 210: 111-121.
    [40] Lee, JH, Youm JH, Kwon KS (2006) Mercuric chloride induces apoptosis in MDCK cells. Prov Med Pub Health 39: 199-204.
    [41] Kim SH, Sharma RP (2004) Mercury-induced apoptosis and necrosis in murine macrophages: role of calcium-induced reactive oxygen species and p38 mitogen-activated protein kinase signaling. Toxicol Appl Pharmacol 196: 47-57.
    [42] Borner C (2003) The Bcl-2 protein family : sensors and checkpoints for life-or-death decisions. Mol Immunol 39: 615-647.
    [43] Luzio A, Monteiro SM, Fontainhas-Fernandes AA, et al. (2013) Copper induced upregulation of apoptosis related genes in zebrafish (Danio rerio) gill. Aquat Toxicol 128-129: 183-189.
    [44] Risso-De Faverney C, Orsini N, De Sousa G, et al. (2004) Cadmium-induced apoptosis through the mitochondrial pathway in rainbow trout hepatocytes: involvement of oxidative stress. Aquat Toxicol 69: 247-258.
    [45] Zheng GH, Liu CM, Sun JM, et al. (2014) Nickel-induced oxidative stress and apoptosis in Carassius auratus liver by JNK pathway. Aquat Toxicol 147: 105-111.
    [46] Institoris L, Siroki O, Undeger U, et al. (2001) Immunotoxicological investigation of subacute combined exposure by permethrin and the heavy metals arsenic(III) and mercury(II) in rats. Int Immunopharmacol 1: 925-933.
    [47] Ynalvez R, Gutierrez J (2016) Mini-review: toxicity of mercury as a consequence of enzyme alteration. BioMetals 29: 781-788.
    [48] Zelikoff JT, Raymond A, Carlson E, et al. (2000) Biomarkers of immunotoxicity in fish: from the lab to the ocean. Toxicol Lett 112-113: 325-331.
    [49] Segner H, Wenger M, Möller AM (2012) Immunotoxic effects of environmental toxicants in fish-how to assess them? Environ Sci Pollut Res 19: 2465-2476.
    [50] Crowe W, Allsopp PJ, Watson GE, et al. (2016) Mercury as an environmental stimulus in the development of autoimmunity - A systematic review. Autoimmun Rev, in press.
    [51] Guzzi G, Pigatto PD, Minoia C, et al. (2008) Dental amalgam, mercury toxicity, and renal autoimmunity. J Environ Pathol Toxicol Oncol 27: 147-155.
    [52] Kal BI, Evcin O, Dundar N, et al. (2008) An unusual case of immediate hypersensitivity reaction associated with an amalgam restoration. Br Dent J 10: 547-550.
    [53] Yadetie F, Karlsen OA, Lanzén A, et al. (2013) Global transcriptome analysis of Atlantic cod (Gadus morhua) liver after in vivo methylmercury exposure suggests effects on energy metabolism pathways. Aquat Toxicol 126: 314-325.
    [54] Oliveira-Ribeiro CA, Fiipak NF, Mela M, et al. (2006) Hematological findings in neotropical fish Hoplias malabaricus exposed to subchronic and dietary doses of methylmercury, inorganic lead, and tributyltin chloride. Environ Res 101: 74-80.
    [55] Kong X, Wang S, Jiang H, et al. (2012) Responses of acid/alkaline phosphatase, lysozyme , and catalase activities and lipid peroxidation to mercury exposure during the embryonic development of goldfish Carassius auratus. Aquat Toxicol 120-121: 119-125.
    [56] Sanchez-Dardon J, Voccia I, Hontela A, et al. (1999) Immunomodulation by heavy metals tested individually or in mixtures in rainbow trout (Oncorhynchus mykiss) exposed in vivo. Environ Toxicol Chem 18: 1492-1497.
    [57] Fletcher TC (1986) Modulation of nonspecific host defenses in fish. Vet Immunol Immunopathol 12: 59-67.
    [58] Bennani N, Schmid-Alliana A, Lafaurie M (1996) Immunotoxic effects of copper and cadmium in the sea bass Dicentrarchus labrax. Immunopharmacol Immunotoxicol 18: 129-144.
    [59] Randall DJ, Perry SF (1992) Catecholamine, In: Hoar WS, Randall DJ, Farrell TP, Fish physiology, New York, Academic Press, 255-300.
    [60] Wilson RW, Bergman HL, Wood CM (1994) Metabolic costs and physiological consequences of acclimation to aluminum in juvenile rainbow trout (Oncorhynchus mykiss). 1: Gill morphology, swimming performance, and aerobic scope. Can J Fish Aquat Sci 51: 536-544.
    [61] Oliveira-Ribeiro CA, Pelletier E, Pfeiffer WC, et al. (2000) Comparative uptake, bioaccumulation, and gill damages of inorganic mercury in tropical and Nordic freshwater fish. Environ Res 83: 286-292.
    [62] Jagoe CH, Faivre A, Newman MC (1996) Morphological and morphometric changes in the gills of mosquitofish (Gambusia holbrooki) after exposure to mercury (II). Aquat Toxicol 31: 163-183.
    [63] Tatara CP, Newman MC, Mulvey M (2001) Effect of mercury and Gpi-2 genotype on standard metabolic rate of eastern mosquitofish (Gambusia holbrooki). Environ Toxicol Chem 20: 782-786.
    [64] Hopkins WA, Tatara CP, Brant HA, et al. (2003) Relationships between mercury body concentrations, standard metabolic rate, and body mass in eastern mosquitofish (Gambusia holbrooki) from three experimental populations. Environ Toxicol Chem 22: 586-590.
    [65] Monteiro DA, Thomaz JM, Rantin FT, et al. (2013) Cardiorespiratory responses to graded hypoxia in the neotropical fish matrinxã (Brycon amazonicus) and traíra (Hoplias malabaricus) after waterborne or trophic exposure to inorganic mercury. Aquat Toxicol 140-141: 346-355.
    [66] Au DW (2004) The application of histocytopathological biomarkers in marine pollution monitoring: a review. Mar Pollut Bull 48: 817-834.
    [67] Jiraungkoorskul W, Upatham ES, Kruatrachue M, et al. (2003) Biochemical and histopathological effects of glyphosate herbicide on Nile tilapia (Oreochromis niloticus). Environ Toxicol 18: 260-267.
    [68] Thophon S, Pokethitiyook P, Chalermwat K, et al. (2004) Ultrastructural alterations in the liver and kidney of white sea bass, Lates calcarifer, in acute and subchronic cadmium exposure. Environ Toxicol 19: 11-19.
    [69] Dezfuli BS, Simoni E, Giari L, et al. (2006) Effects of experimental terbuthylazine exposure on the cells of Dicentrarchus labrax (L.). Chemosphere 64: 1684-1694.
    [70] Giari L, Manera M, Simoni E, et al. (2007) Cellular alterations in different organs of European sea bass Dicentrarchus labrax (L.) exposed to cadmium. Chemosphere 67: 1171-1181.
    [71] Giari L, Simoni E, Manera M, et al. (2008) Histocytological responses of Dicentrarchus labrax (L.) following mercury exposure. Ecotoxicol Environ Saf 70: 400-410.
    [72] Arabi M (2004) Analyses of impact of metal ion contamination on carp (Cyprinus carpio L.) gill cell suspensions. Biol Trace Element Res 100: 229-245.
    [73] Arabi M, Alaeddini MA (2005) Metal-ion-mediated oxidative stress in the gill homogenate of rainbow trout (Oncorhynchus mykiss): antioxidant potential of manganese, selenium, and albumin. Biol Trace Element Res 108: 155-168.
    [74] Fernandes AB, Barros FL, Pecanha FM, et al. (2012) Toxic effects of mercury on the cardiovascular and central nervous systems. J Biomed Biotechnol 2012: 1-12.
    [75] Sundin LI, Reid SG, Kalinin AL, et al. (1999). Cardiovascular and respiratory reflexes: the tropical fish, traira (Hoplias malabaricus) O2 chemoresponses. Respir Physiol 116: 181-199.
    [76] Oliveira RD, Lopes JM, Sanches JR, et al. (2004) Cardiorespiratory responses of the facultative air-breathing fish jeju, Hoplerythrinus unitaeniatus (Teleostei, Erythrinidae), exposed to graded ambient hypoxia. Comp Biochem Physiol A 139: 479-485.
    [77] Reid SG, Sundin L, Milsom WK (2005) The cardiorespiratory system in tropical fishes: structure, function, and control. Fish Physiol 21: 225-275.
    [78] Crump KL, Trudeau VL (2009) Mercury-induced reproductive impairment in fish. Environ Toxicol Chem 28: 895-907.
    [79] Meier S, Morton HC, Andersson E, et al. (2011) Low-dose exposure to alkylphenols adversely affects the sexual development of Atlantic cod (Gadus morhua): acceleration of the onset of puberty and delayed seasonal gonad development in mature female cod. Aquat Toxicol 105: 136-150.
    [80] Arcand-Hoy LD, Benson WH (1998) Fish reproduction: an ecologically relevant indicator of endocrine disruption. Environ Toxicol Chem 17: 49-57.
    [81] Zhang Q, Li Y, Liu Z, et al. (2016) Reproductive toxicity of inorganic mercury exposure in adult zebrafish : Histological damage, oxidative stress , and alterations of sex hormone and gene expression in the hypothalamic-pituitary-gonadal axis. Aquat Toxicol 177: 417-424.
    [82] Drevnick PE, Sandheinrich MB (2003) Effects of dietary methylmercury on reproductive endocrinology of fathead minnows. Environ Sci Technol 37: 4390-4396.
    [83] Klaper R, Rees CB, Drevnick P, et al. (2006) Gene expression changes related to endocrine function and decline in reproduction in fathead minnow (Pimephales promelas) after dietary methylmercury exposure. Environ Health Perspect 114: 1337-1344.
    [84] Moran PW, Aluru N, Black RW, et al. (2007) Tissue contaminants and associated transcriptional response in trout liver from high elevation lakes of Washington. Environ Sci Technol 41: 6591-6597.
    [85] Kirubagaran R, Joy KP (1992) Toxic effects of mercury on testicular activity in the fresh water teleost, Clarias batrachus (L.). J Fish Biol 41: 305-315.
    [86] Liao C, Fu J, Shi J, et al. (2006) Methylmercury accumulation , histopathology effects, and cholinesterase activity alterations in medaka (Oryzias latipes) following sublethal exposure to methylmercury chloride. Environ Toxicol Pharmacol 22: 225-233.
    [87] Vergilio CS, Moreira RV, Carvalho CE, et al. (2013) Histopathological effects of mercury on male gonad and sperm of tropical fish Gymnotus carapo in vitro. E3S Web of Conferences 12004: 3-6.
    [88] Victor B, Mahalingam S, Sarojini R (1986) Toxicity of mercury and cadmium on oocyte differentiation and vitellogenesis of the teleost, Lepidocephalichtyhs thermalis (Bleeker). J Environ Biol 7: 209-214.
    [89] Kirubagaran R, Joy KP (1988) Toxic effects of three mercurial compounds on survival, and histology of the kidney of the catfish Clarias batrachus (L.). Ecotoxicol Environ Saf 15: 171-179.
    [90] Adams SM, Bevelhimer MS, Greeley MS, et al. (1999) Ecological risk assessment in a large river-reservoir: 6. Bioindicators of fish population health. Environ Toxicol Chem 18: 628-640.
    [91] Depew DC, Basu N, Burgess NM, et al. (2012) Toxicity of dietary methylmercury to fish: derivation of ecologically meaningful threshold concentrations. Environ Toxicol Chem 31: 1536-1547.
    [92] Simmons-Willis, TA, Koh AS, Clarkson TW, et al. (2002) Transport of a neurotoxicant by molecular mimicry: the methylmercury-L-cysteine complex is a substrate for human L-type large neutral amino acid transporter LAT1 and LAT2. Biochem J 367: 239-246.
    [93] Stefansson ES, Heyes A, Rowe CL (2014) Tracing maternal transfer of methylmercury in the sheepshead minnow (Cyprinodon variegatus) with an enriched mercury stable isotope. Environ Sci Technol 48: 1957-1963.
    [94] Hammerschmidt CR, Sandheinrich MB, Wiener JG, et al. (2002) Effects of dietary methylmercury on reproduction of fathead minnows. Environ Sci Technol 36: 877-883.
    [95] Bridges KN, Soulen BK, Overturf CL, et al. (2016) Embryotoxicity of maternally transferred methylmercury to fathead minnows (Pimephales promelas). Environ Toxicol Chem 35: 1436-1441.
    [96] Penglase S, Hamre K, Ellingsen S (2014) Selenium and mercury have a synergistic negative effect on fish reproduction. Aquat Toxicol 149: 16-24.
    [97] Stohs SJ, Bagchi D (1995) Oxidative mechanisms in the toxicity of metal ions. Free Radic Biol Med 18: 321-336.
    [98] Aschner M, Syversen T, Souza DO, et al. (2007) Involvement of glutamate and reactive oxygen species in methylmercury neurotoxicity. Braz J Med Biol Res 40: 285-291.
    [99] Stringari J, Nunes AKC, Franco JL, et al. (2008) Prenatal methylmercury exposure hampers glutathione antioxidant system ontogenesis and causes long-lasting oxidative stress in the mouse brain. Toxicol Appl Pharmacol 227: 147-154.
    [100] Farina M, Avila DS, Da Rocha JBT, et al. (2013) Metals, oxidative stress and neurodegeneration: a focus on iron, manganese and mercury. Neurochem Int 62: 575-594.
    [101] Mieiro CL, Pereira ME, Duarte AC, et al. (2011) Brain as a critical target of mercury in environmentally exposed fish (Dicentrarchus labrax)-Bioaccumulation and oxidative stress profiles. Aquat Toxicol 103: 233-240.
    [102] Pereira P, Puga S, Cardoso V, et al. (2016) Inorganic mercury accumulation in brain following waterborne exposure elicits a deficit on the number of brain cells and impairs swimming behavior in fish (white seabream-Diplodus sargus). Aquat Toxicol 170: 400-412.
    [103] De Flora S, Bennicelli C, Bagnasco M (1994) Genotoxicity of mercury compounds. A review. Mutat Res Genet Toxicol 317: 57-79.
    [104] Maulvault AL, Custódio A, Anacleto P, et al. (2016) Bioaccumulation and elimination of mercury in juvenile seabass (Dicentrarchus labrax) in a warmer environment. Environ Res 149: 77-85.
    [105] Berntssen MHG, Aatland A, Handy RD (2003) Chronic dietary mercury exposure causes oxidative stress, brain lesions, and altered behaviour in Atlantic salmon (Salmo salar) parr. Aquat Toxicol 65: 55-72.
    [106] Wang Y, Wang D, Lin L, et al. (2015) Quantitative proteomic analysis reveals proteins involved in the neurotoxicity of marine medaka Oryzias melastigma chronically exposed to inorganic mercury. Chemosphere 119: 1126-1133.
    [107] Gentès S, Maury-Brachet R, Feng C, et al. (2015) Specific effects of dietary methylmercury and inorganic mercury in zebrafish (Danio rerio) determined by genetic, histological, and metallothionein responses. Environ Sci Technol 49: 14560-14569.
    [108] González P, Dominique Y, Massabuau JC, et al. (2005) Comparative effects of dietary methylmercury on gene expression in liver, skeletal muscle and brain of the zebrafish (Danio rerio). Biometals 39: 3972-3980.
    [109] WHO (World Health Organization) (1989) Mercury-Environmental Aspects. WHO, Geneva, Switzerland.
    [110] Bano Y, Hasan M (1990) Histopathological lesions in the body organs of cat-fish (Heteropneustes fossilis) following mercury intoxication. J Environ Sci Health 25: 67-85.
    [111] Lemaire P, Berhaut J, Lemaire-Gony S, et al. (1992) Ultrastructural changes induced by benzo[a]pyrene in sea bass (Dicentrarchus labrax) liver and intestine: importance of the intoxication route. Environ Res 57: 59-72.
    [112] Banerjee S, Bhattacharya S (1995) Histopathological changes induced by chronic nonlethal levels of elsan, mercury, and ammonia in the small intestine of Channa punctatus (Bloch). Ecotoxicol Environ Saf 3: 62-68.
    [113] Oliveira Ribeiro CA, Belger L, Pelletier E, et al. (2002) Histopathological evidence of inorganic mercury and methyl mercury toxicity in the arctic charr (Salvelinus alpinus). Environ Res 90: 217-225.
    [114] Leaner JJ, Mason RP (2004) Methylmercury uptake and distribution kinetics in sheepshead minnows, Cyprinodon variegatus, after exposure to Ch3Hg-spiked food. Environ Toxicol Chem 23: 2138-2146.
    [115] Burrows WD, Krenkel PA (1973) Studies on uptake and loss of methylmercury by blue-gills (Lepomis macrochirus Raf.). Environ Sci Technol 7: 1127-1130.
    [116] Huang SSY, Strathe AB, Fadel JG, et al. (2012) Absorption, distribution, and elimination of graded oral doses of methylmercury in juvenile white sturgeon. Aquat Toxicol 122-123: 163-171.
    [117] Abreu SN, Pereira E, Vale C, et al. (2000) Accumulation of mercury in sea bass from a contaminated lagoon (Ria de Aveiro, Portugal). Mar Pollut Bull 40: 293-297.
    [118] Kennedy CJ (2003) Uptake and accumulation of mercury from dental amalgam in the common goldfish, Carassius auratus. Environ Pollut 121: 321-326.
    [119] Yamamoto Y, Almeida R, Regina S, et al. (2014) Mercury distribution in target organs and biochemical responses after subchronic and trophic exposure to Neotropical fish Hoplias malabaricus. Fish Physiol Biochem 40: 245-256.
    [120] Lee JW, Kim JW, De Riu N, et al. (2012) Histopathological alterations of juvenile green (Acipenser medirostris) and white sturgeon (Acipenser transmontanus) exposed to graded levels of dietary methylmercury. Aquat Toxicol 109: 90-99.
    [121] Wester PW, Canton HH (1992) Histopathological effects in Poecilia reticulata (guppy) exposed to methylmercury chloride. Toxicol Pathol 20: 81-92.
    [122] Kirubagaran R, Joy KP (1988) Toxic effects of three mercurial compounds on survival, and histology of the kidney of the catfish Clarias batrachus (L.). Ecotoxicol Environ Saf 15: 171-179.
    [123] Bridges CC, Zalups RK (2010) Transport of inorganic mercury and methylmercury in target tissues and organs. J Toxicol Environ Health B 13: 385-410.
    [124] Patil SS, Jabde SV (1998) Effect of mercury poisoning on some haematological parameters from a fresh water fish, Channa gachua. Pollut Res 17: 223-228.
    [125] Fletcher TC, White A (1986) Nephrotoxic and hematological effects of mercury chloride in the plaice (Pleuronectes platessa L.). Aquat Toxicol 8: 77-84.
    [126] Ishikawa NM, Ranzani-Paiva MJT, Vicente J, et al. (2007) Hematological Parameters in Nile Tilápia, Oreochromis niloticus exposed to subletal concentrations of mercury. Braz J Med Biol Res 50: 619-626.
    [127] Gwoździński K, Roche H, Pérès G (1992) The comparison of the effects of heavy metal ions on the antioxidant enzyme activities in human and fish Dicentrarchus labrax erythrocytes. Comp Biochem Physiol C 102: 57-60.
    [128] Sanchez-Galan S, Linde AR, Garcia-Vazquez E (1999) Brown trout and European minnow as target species for genotoxicity tests: differential sensitivity to heavy metals. Ecotoxicol Environ Saf 43: 301-304.
    [129] Yadav KK, Trivedi SP (2009) Sublethal exposure of heavy metals induces micronuclei in fish, Channa punctata. Chemosphere 77: 1495-1500.
    [130] Guilherme S, Válega M, Pereira ME, et al. (2008) Erythrocytic nuclear abnormalities in wild and caged fish (Liza aurata) along an environmental mercury contamination gradient. Ecotoxicol Environ Saf 70: 411-421.
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