Double casting prototyping with a thermal aging step for fabrication of 3D microstructures in poly(dimethylsiloxane)

Karina Kwapiszewska; Kamil Żukowski; Radosław Kwapiszewski; Zbigniew Brzózka; Karina Kwapiszewska; Kamil Żukowski; Radosław Kwapiszewski; Zbigniew Brzózka

doi:10.3934/biophy.2016.4.553

AIMS Biophysics

2016, Volume 3, Issue 4: 553-562. doi: 10.3934/biophy.2016.4.553

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Double casting prototyping with a thermal aging step for fabrication of 3D microstructures in poly(dimethylsiloxane)

1.
Institute of Physical Chemistry, Polish Academy of Sciences, Warsaw, Poland
2.
Institute of Biotechnology, Faculty of Chemistry, Warsaw University of Technology, Warsaw, Poland

Received: 23 September 2016 Accepted: 16 November 2016 Published: 22 November 2016

The paper describes a cheap and accessible technique of a poly(dimethylsiloxane) (PDMS) master treatment by thermal aging as a step of double casting microfabrication process. Three-dimensional PDMS microstructures could have been achieved using this technique. It was proved, that thermal aging changes nanotopology of a PDMS surface and thus enhances efficiency of double casting prototyping. The thermally aged PDMS master could have been used for multiple and correct replication of over 98% of the fabricated microstructures. Moreover, lack of chemical modification preserved the biocompatibility of PDMS devices. The fabricated microstructures were successfully utilized for 3D cell culture.
- PDMS; microfabrication; 3D microstructures; biocompatible materials; double casting; thermal aging
Citation: Karina Kwapiszewska, Kamil Żukowski, Radosław Kwapiszewski, Zbigniew Brzózka. Double casting prototyping with a thermal aging step for fabrication of 3D microstructures in poly(dimethylsiloxane)[J]. AIMS Biophysics, 2016, 3(4): 553-562. doi: 10.3934/biophy.2016.4.553

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Abstract

The paper describes a cheap and accessible technique of a poly(dimethylsiloxane) (PDMS) master treatment by thermal aging as a step of double casting microfabrication process. Three-dimensional PDMS microstructures could have been achieved using this technique. It was proved, that thermal aging changes nanotopology of a PDMS surface and thus enhances efficiency of double casting prototyping. The thermally aged PDMS master could have been used for multiple and correct replication of over 98% of the fabricated microstructures. Moreover, lack of chemical modification preserved the biocompatibility of PDMS devices. The fabricated microstructures were successfully utilized for 3D cell culture.

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