Cold helium plasma as a modifier of free radical processes in the blood: in vitro study

Andrew K. Martusevich; Alexander G. Galka; Konstantin A. Karuzin; Alexander N. Tuzhilkin; Svetlana L. Malinovskaya; Andrew K. Martusevich; Alexander G. Galka; Konstantin A. Karuzin; Alexander N. Tuzhilkin; Svetlana L. Malinovskaya

doi:10.3934/biophy.2021002

AIMS Biophysics

2021, Volume 8, Issue 1: 34-40. doi: 10.3934/biophy.2021002

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Cold helium plasma as a modifier of free radical processes in the blood: in vitro study

1.
Laboratory of Medical Biophysics, Privolzhsky Research Medical University, 603950, Nizhny Novgorod, Russia
2.
Laboratory of Space Plasma Modeling, Institute of Applied Physics, 603950, Nizhny Novgorod, Russia
3.
Department of animals' physiology and biochemistry, Nizhny Novgorod State Agricultural Academy, 603107, Nizhny Novgorod, Russia
4.
Bioniq Health-Tech Solutions, London, United Kingdom

Received: 10 September 2020 Accepted: 17 November 2020 Published: 24 November 2020

We studied the influence of various exposures (1, 2, 3, 5, 10 and 15 min.) effects of cold helium plasma on the state of free radical processes in the biological fluid (human blood). It was found that the nature of the response of antioxidant systems of blood to cold plasma treatment is directly determined by exposure, as evidenced by the results of chemiluminescence assessment of the intensity of free radical processes and total antioxidant activity, as well as the dynamics of the concentration of malonic dialdehyde. At the same time, the short-term processing mode of biological fluid allows us to establish the presence of a two-phase influence of the factor on oxidative processes (“the phenomenon of the antioxidant window”).
- cold helium plasma,
- free radical processes,
- malonic dialdehyde,
- blood
Citation: Andrew K. Martusevich, Alexander G. Galka, Konstantin A. Karuzin, Alexander N. Tuzhilkin, Svetlana L. Malinovskaya. Cold helium plasma as a modifier of free radical processes in the blood: in vitro study[J]. AIMS Biophysics, 2021, 8(1): 34-40. doi: 10.3934/biophy.2021002

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Abstract

We studied the influence of various exposures (1, 2, 3, 5, 10 and 15 min.) effects of cold helium plasma on the state of free radical processes in the biological fluid (human blood). It was found that the nature of the response of antioxidant systems of blood to cold plasma treatment is directly determined by exposure, as evidenced by the results of chemiluminescence assessment of the intensity of free radical processes and total antioxidant activity, as well as the dynamics of the concentration of malonic dialdehyde. At the same time, the short-term processing mode of biological fluid allows us to establish the presence of a two-phase influence of the factor on oxidative processes (“the phenomenon of the antioxidant window”).

Conflict of interest

The authors declare no conflict of interest.

References

[1]	Alkawareek MY, Gorman SP, Graham WG, et al. (2014) Potential cellular targets and antibacterial efficacy of atmospheric pressure non-thermal plasma. Int J Antimicrob Ag 43: 154-160.
[2]	Dobrynin D, Fridman G, Friedman G, et al. (2009) Physical and biological mechanisms of direct plasma interaction with living tissue. New J Phys 11: 115020.
[3]	Flynn PB, Busetti A, Wielogorska E, et al. (2016) Non-thermal plasma exposure rapidly attenuates bacterial AHL-dependent quorum sensing and virulence. Sci Rep 6: 26320.
[4]	Martusevich AK, Solov'eva AG, Galka AG, et al. (2019) Effects of helium cold plasma on erythrocyte metabolism. B Exp Biol Med 167: 198-200.
[5]	Wiegand C, Fink S, Beier O, et al. (2016) Dose-and time-dependent cellular effects of cold atmospheric pressure plasma evaluated in 3D skin models. Skin Pharmacol Phys 29: 257-265.
[6]	Ermolaeva SA, Varfolomeev AF, Chernukha MY, et al. (2011) Bactericidal effects of non-thermal argon plasma in vitro, in biofilms and in the animal model of infected wounds. J Med Microbiol 60: 75-83.
[7]	Lee C, Subhadra B, Choi HG, et al. (2019) Inactivation of mycobacteria by radicals from non-thermal plasma jet. J Microbiol Biotechn 29: 1401-1411.
[8]	Ahn HJ, Kim KI, Kim G, et al. (2011) Atmospheric-pressure plasma jet induces apoptosis involving mitochondria via generation of free radicals. PloS one 6: e28154.
[9]	Brun P, Pathak S, Castagliuolo I, et al. (2014) Helium generated cold plasma finely regulates activation of human fibroblast-like primary cells. PloS one 9: e104397.
[10]	Jawaid P, Rehman MU, Zhao QL, et al. (2016) Helium-based cold atmospheric plasma-induced reactive oxygen species-mediated apoptotic pathway attenuated by platinum nanoparticles. J Cell Mol Med 20: 1737-1748.
[11]	Szili EJ, Hong SH, Oh JS, et al. (2018) Tracking the penetration of plasma reactive species in tissue models. Trends Biotechnol 36: 594-602.
[12]	Yan D, Cui H, Zhu W, et al. (2017) The strong cell-based hydrogen peroxide generation triggered by cold atmospheric plasma. Sci Rep 7: 10831.
[13]	Lackmann JW, Schneider S, Edengeiser E, et al. (2013) Photons and particles emitted from cold atmospheric-pressure plasma inactivate bacteria and biomolecules independently and synergistically. J R Soc Interface 10: 20130591.
[14]	Martusevich AA, Solov'Ieva AG, Martusevich AK (2013) Influence of singlet oxygen inhalation on the state of blood pro-and antioxidant systems and energy metabolism. B Exp Biol Med 156: 41-43.
[15]	Soloveva AG, Peretyagin SP (2016) The effect of subchronic inhalations of nitric oxide on metabolic processes in blood of experimental animals. Biomeditsinskaia Khimiia 62: 212-214.
[16]	Kim SY, Lee SY, Min SC (2019) Improvement of the antioxidant activity, water solubility, and dispersion stability of prickly pear cactus fruit extracts using argon cold plasma treatment. J Food Sci 84: 2876-2882.
[17]	Sheteiwy MS, An J, Yin M, et al. (2019) Cold plasma treatment and exogenous salicylic acid priming enhances salinity tolerance of Oryza sativa seedlings. Protoplasma 256: 79-99.
[18]	Peretyagin SP, Martusevich AK, Solovyeva AG, et al. (2013) Enzymological evaluation of hepatotropic effect of ozone in a subchronic experiment. B Exp Biol Med 154: 789-791.
[19]	Smith NL, Wilson AL, Gandhi J, et al. (2017) Ozone therapy: an overview of pharmacodynamics, current research, and clinical utility. Med Gas Res 7: 212-219.
[20]	Zanardi I, Borrelli E, Valacchi G, et al. (2016) Ozone: a multifaceted molecule with unexpected therapeutic activity. Curr Med Chem 23: 304-314.
[21]	Zeng J, Lu J (2018) Mechanisms of action involved in ozone-therapy in skin diseases. Int Immunopharmacol 56: 235-241.
[22]	Vanin AF (2019) What is the mechanism of nitric oxide conversion into nitrosonium ions ensuring S-nitrosating processes in living organisms. Cell Biochem Biophys 77: 279-292.

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