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AIMS Neuroscience

2021, Volume 8, Issue 1: 86-132. doi: 10.3934/Neuroscience.2021005
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The biological pathways of Alzheimer disease: a review

  • Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Italy
  • Received: 24 August 2020 Accepted: 23 November 2020 Published: 16 December 2020

  • Alzheimer disease is a progressive neurodegenerative disorder, mainly affecting older people, which severely impairs patients' quality of life. In the recent years, the number of affected individuals has seen a rapid increase. It is estimated that up to 107 million subjects will be affected by 2050 worldwide. Research in this area has revealed a lot about the biological and environmental underpinnings of Alzheimer, especially its correlation with β-Amyloid and Tau related mechanics; however, the precise molecular events and biological pathways behind the disease are yet to be discovered. In this review, we focus our attention on the biological mechanics that may lie behind Alzheimer development. In particular, we briefly describe the genetic elements and discuss about specific biological processes potentially associated with the disease.

    Citation: Marco Calabrò, Carmela Rinaldi, Giuseppe Santoro, Concetta Crisafulli. The biological pathways of Alzheimer disease: a review[J]. AIMS Neuroscience, 2021, 8(1): 86-132. doi: 10.3934/Neuroscience.2021005

    Related Papers:

  • Alzheimer disease is a progressive neurodegenerative disorder, mainly affecting older people, which severely impairs patients' quality of life. In the recent years, the number of affected individuals has seen a rapid increase. It is estimated that up to 107 million subjects will be affected by 2050 worldwide. Research in this area has revealed a lot about the biological and environmental underpinnings of Alzheimer, especially its correlation with β-Amyloid and Tau related mechanics; however, the precise molecular events and biological pathways behind the disease are yet to be discovered. In this review, we focus our attention on the biological mechanics that may lie behind Alzheimer development. In particular, we briefly describe the genetic elements and discuss about specific biological processes potentially associated with the disease.


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    Conflicts of interest


    The authors declare there are no conflicts of interest.

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