Review Special Issues

Mediterranean diet and health in the elderly

  • Received: 16 May 2023 Revised: 15 June 2023 Accepted: 03 July 2023 Published: 11 July 2023
  • The Mediterranean diet has probably been the most studied diet since the early 1950s. American physiologist Ancel Keys coined the term since it was based on the dietary habits of those populations bordering the Mediterranean basin, particularly the island of Crete and southern Italy. The motivation for the early studies lay in understanding why these populations had greater longevity and lower occurrence of chronic-degenerative diseases and forms of cancer when compared with the peoples of Northern Europe and North America. Traditionally, this dietary regimen was based on the seasonality of foods and the consumption of unrefined grains, legumes, fish, vegetables, fruits, little meat and use of olive oil as a condiment. The purpose of this paper is to understand, based on current scientific knowledge, how the different nutrients present in such a diet can play a preventive role in the onset of today's most frequent diseases.

    Citation: Domenico Giuffrè, Angelo Maria Giuffrè. Mediterranean diet and health in the elderly[J]. AIMS Public Health, 2023, 10(3): 568-576. doi: 10.3934/publichealth.2023040

    Related Papers:

  • The Mediterranean diet has probably been the most studied diet since the early 1950s. American physiologist Ancel Keys coined the term since it was based on the dietary habits of those populations bordering the Mediterranean basin, particularly the island of Crete and southern Italy. The motivation for the early studies lay in understanding why these populations had greater longevity and lower occurrence of chronic-degenerative diseases and forms of cancer when compared with the peoples of Northern Europe and North America. Traditionally, this dietary regimen was based on the seasonality of foods and the consumption of unrefined grains, legumes, fish, vegetables, fruits, little meat and use of olive oil as a condiment. The purpose of this paper is to understand, based on current scientific knowledge, how the different nutrients present in such a diet can play a preventive role in the onset of today's most frequent diseases.



    加载中


    Use of AI tools declaration



    The authors declare they have not used Artificial Intelligence (AI) tools in the creation of this article.

    Conflict of Interest



    The authors declare no conflict of interest.

    [1] Willett WC, Sacks F, Trichopoulou A, et al. (1995) Mediterranean diet pyramid: a cultural model for healthy eating. Am J Clin Nutr 61: 1402S-1406S. https://doi.org/10.1093/ajcn/61.6.1402S
    [2] Poli A, Marangoni F, Paoletti R, et al. (2008) Non-pharmacological control of plasma cholesterol levels. Nutr Metab Cardiovasc Dis 18: S1-S16. https://doi.org/10.1016/j.numecd.2007.10.004
    [3] Kromhout D, Keys A, Aravanis C, et al. (1989) Food consumption patterns in the 1960s in seven countries. Am J Clin Nutr 49: 889-894. https://doi.org/10.1093/ajcn/49.5.889
    [4] Willett C (2006) The Mediterranean diet: science and practice. Public Health Nutr 9: 105-110. https://doi.org/10.1079/phn2005931
    [5] Mori TA (2017) Marine OMEGA-3 fatty acids in the prevention of cardiovascular disease. Fitoterapia 123: 51-58. https://doi.org/10.1016/j.fitote.2017.09.015
    [6] Medina FX (2009) Mediterranean diet, culture and heritage: challenges for a new conception. Public Health Nutr 12: 1618-1620. https://doi.org/10.1017/S1368980009990450
    [7] Benetou V, Trichopoulou A, Orfanos P (2008) Conformity to traditional Mediterranean diet and cancer incidence: the Greek EPIC cohort. Br J Cancer 99: 191-195. https://doi.org/10.1038/sj.bjc.6604418
    [8] Alberti-Fidanza A, Fidanza F (2004) Mediterranean Adequacy Index of Italian diets. Public Health Nutr 7: 937-941. https://doi.org/10.1079/phn2004557
    [9] World Health Organization (WHO)European Regional Office - Obesity Report 2022 (2022). Available from: https://www.who.int/europe/publications/i/item/9789289057738
    [10] De Pergola G, Silvestris F (2013) Obesity as a major risk factor for cancer. J Obes 2013: 291546. http://dx.doi.org/10.1155/2013/291546
    [11] García Vega D, Ramón González J, Eiras S (2022) Diabesity in elderly cardiovascular disease patients: Mechanisms and regulators. Int J Mol Sci 23: 7886. https://doi.org/10.3390/ijms23147886
    [12] Martínez-González MA, de la Fuente-Arrillaga C, Nunez-Córdoba JM, et al. (2008) Adherence to Mediterranean diet and risk of developing diabetes: prospective cohort study. BMJ 336: 1348-1351. https://doi.org/10.1136/bmj.39561.501007.BE
    [13] Esposito K, Maiorino MI, Bellastella G, et al. (2017) Mediterranean diet for type 2 diabetes: cardiometabolic benefits. Endocrine 56: 27-32. https://doi.org/10.1007/s12020-016-1018-2
    [14] Venn BJ, Mann JI (2004) Cereal grains, legumes and diabetes. Eur J Clin Nutr 58: 1443-1461. https://doi.org/10.1038/sj.ejcn.1601995
    [15] Palta P, Schneider AL, Biessels GJ, et al. (2014) Magnitude of cognitive dysfunction in adults with type 2 diabetes: a meta-analysis of six cognitive domains and the most frequently reported neuropsychological tests within domains. J Int Neuropsychol Soc 20: 278-291. https://doi.org/10.1017/S1355617713001483
    [16] McClure R, Villani A (2019) Greater adherence to a Mediterranean Diet is associated with better gait speed in older adults with type 2 diabetes mellitus. Clin Nutr ESPEN 32: 33-39. https://doi.org/10.1016/j.clnesp.2019.05.009
    [17] Wang L, Manson JE, Forman JP, et al. (2010) Dietary Fatty Acids and the Risk of Hypertension in Middle-Aged and Older Women. Hypertension 56: 598-604. https://doi.org/10.1161/HYPERTENSIONAHA.110.154187
    [18] Pikilidou M, Scuteri A, Morrell C, et al. (2013) The burden of obesity on blood pressure is reduced in older persons: The SardiNIA study. Obesity 21: e10-e13. https://doi.org/10.1002/oby.20010
    [19] Appel LJ, Espeland MA, Easter L, et al. (2001) Effects of reduced sodium intake on hypertension control in older individuals: Results from the Trial of Nonpharmacologic Interventions in the Elderly (TONE). Arch Intern Med 161: 685-693. https://doi.org/10.1001/archinte.161.5.685
    [20] Estruch R, Ros E, Salas Salvado J, et al. (2013) Primary prevention of cardiovascular disease with a Mediterranean diet. N Engl J Med 368: 1279-1290. https://doi.org/10.1056/NEJMoa1200303
    [21] Salas Salvado J, Bullo M, Babio N, et al. (2011) Reduction in the incidence of type 2 diabetes with the Mediterranean diet: results of the PREDIMED-Reus nutrition intervention randomized trial. Diabetes Care 34: 14-19. https://doi.org/10.2337/dc10-1288
    [22] Mailloux RJ An Update on Mitochondrial Reactive Oxygen Species Production - Antioxidants (2020)9: 472. https://doi.org/10.3390/antiox9060472
    [23] Hertog MG, Kromhout D, Aravanis C, et al. (1995) Assunzione di flavonoidi e rischio a lungo termine di malattia coronarica e cancro nello studio dei sette paesi. Arch Intern Med 155: 381-386. https://doi.org/10.1001/archinte.1995.00430040053006
    [24] Djuricic I, Calder PC (2021) Beneficial Outcomes of Omega-6 and Omega-3 Polyunsaturated Fatty Acids on Human Health: An Update for 2021. Nutrients 13: 2421. https://doi.org/10.3390/nu13072421
    [25] Giuffrè AM, Zappia C, Capocasale M (2017) Effects of high temperatures and duration of heating on olive oil properties for food use and biodiesel production. J Am Oil Chem Soc 94: 819-830. https://doi.org/10.1007/s11746-017-2988-9
    [26] Giuffrè AM, Tellah S, Capocasale M, et al. (2016) Seed oil from ten Algerian peanut landraces for edible use and biodiesel production. J Oleo Sci 65: 9-20. https://doi.org/10.5650/jos.ess15199
    [27] Anastasi U, Sortino O, Tuttobene R, et al. (2017) Agronomic performance and grain quality of sesame (Sesamum indicum L.) landraces and improved varieties grown in a Mediterranean environment. Genet Resour Crop Evol 64: 127-137. https://doi.org/10.1007/s10722-015-0338-z
    [28] Giuffrè AM, Capocasale M, Zappia C, et al. (2017) Influence of high temperature and duration of heating on the sunflower seed oil properties for food use and bio-diesel production. J Oleo Sci 66: 1193-1205. https://doi.org/10.5650/jos.ess17109
    [29] Giuffrè AM, Capocasale M (2016) Physicochemical composition of tomato seed oil for an edible use: the effect of cultivar. Int. Food Res. J 23: 583-591.
    [30] Mozaffarian D, Longstreth WT, Rozenn N, et al. (2005) Fish Consumption and Stroke Risk in Elderly Individuals. The Cardiovascular Health Study. Arch Intern Med 165: 200-206. https://doi.org/10.1001/archinte.165.2.200
    [31] Sung H, Ferlay J, Siegel RL, et al. (2021) Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin 71: 209-249. https://doi.org/10.3322/caac.21660
    [32] Dagenais GR, Leong DP, Rangarajan S, et al. (2020) Variations in common diseases, hospital admissions, and deaths in middle-aged adults in 21 countries from five continents (PURE): a prospective cohort study. Lancet 395: 785-794. https://doi.org/10.1016/S0140-6736(19)32007-0
    [33] Donaldson MS (2004) Nutrition and cancer: A review of the evidence for an anti-cancer diet. Nutr J 3: 19. https://doi.org/10.1186/1475-2891-3-19
    [34] Maraldi T, Vauzour D, Angeloni C (2014) Dietary polyphenols and their effects on cell biochemistry and pathophysiology 2013. Oxid Med Cell Longev 2014: 576363. https://doi.org/10.1155/2014/576363
    [35] Varinska L, Gal P, Mojzisova G, et al. (2015) Soy and breast cancer: Focus on angiogenesis. Int J Mol Sci 16: 11728-11749. https://doi.org/10.3390/ijms160511728
    [36] Yang CS, Lambert JD, Sang S (2009) Antioxidative and anti-carcinogenic activities of tea polyphenols. Arch Toxicol 83: 11-21. https://doi.org/10.1007/s00204-008-0372-0
    [37] Messeha SS, Zarmouh NO, Asiri A, et al. (2020) Gene expression alterations associated with oleuropein-induced antiproliferative effects and s-phase cell cycle arrest in triple-negative breast cancer cells. Nutrients 12: 3755. https://doi.org/10.3390/nu12123755
    [38] Castelló A, Rodríguez Barranco M, Fernández de Larrea N, et al. (2022) Adherence to the western, prudent and mediterranean dietary patterns and colorectal cancer risk: Findings from the Spanish cohort of the European prospective investigation into cancer and nutrition (EPIC-Spain). Nutrients 14: 3085. https://doi.org/10.3390/nu14153085
    [39] Castelló A, Amiano P, de Larrea NF, et al. (2018) Low adherence to the western and high adherence to the Mediterranean dietary patterns could prevent colorectal cancer. Eur J Nutr 58: 1495-1505. https://doi.org/10.1007/s00394-018-1674-5
    [40] Fang YZ, Yang S, Wu G (2022) Free radicals, antioxidants, and nutrition. Nutrition 18: 872-879. https://doi.org/10.1016/S0899-9007(02)00916-4
    [41] Giovannucci E, Willett WC (1994) Dietary factors and risk of colon cancer. Ann Med 26: 443-452. https://doi.org/10.3109/07853899409148367
    [42] Turnbaugh PJ, Ridaura VK, Faith JJ, et al. (2009) The Effect of Diet on the Human Gut Microbiome: A Metagenomic Analysis in Humanized Gnotobiotic Mice. Sci Transl Med 1: 6-14. https://doi.org/10.1126/scitranslmed.3000322
    [43] Moszak M, Szulińska M, Bogdański P (2020) You Are What You Eat—The Relationship between Diet, Microbiota, and Metabolic Disorders—A Review. Nutrients 12: 1096. https://doi.org/10.3390/nu12041096
    [44] Lozano-Lorca M, Rodríguez González M, Salcedo-Bellido I, et al. (2022) Dietary Patterns and Prostate Cancer: CAPLIFE Study. Cancers 14: 3475. https://doi.org/10.3390/cancers14143475
    [45] Cass S, Wargo J, Pettaway C, et al. (2022) A novel Mediterranean dietary intervention for prostate cancer. Cancer Res 82: 3495. https://doi.org/10.1158/1538-7445.AM2022-3495
    [46] Mielech A, Puścion-Jakubik A, Markiewicz Żukowska R, et al. (2020) Vitamins in Alzheimer's disease - Review of the latest reports. Nutrients 12: 3458. https://doi.org/10.3390/nu12113458
    [47] Mecocci P, Polidori MC (2012) Antioxidant Clinical Trials in Mild Cognitive Impairment and Alzheimer's Disease. Biochim Biophys Acta 1822: 631-638. https://doi.org/10.1016/j.bbadis.2011.10.006
    [48] Agnew Blais JC, Wassertheil Smoller S, Kang JH, et al. (2015) Folate, Vitamin B-6, and Vitamin B-12 intake and mild cognitive impairment and probable dementia in the women's health initiative memory study. J Acad Nutr Diet 115: 231-241. https://doi.org/10.1016/j.jand.2014.07.006
    [49] Laitinen MH, Ngandu T, Rovio S, et al. (2006) Fat Intake at Midlife and Risk of Dementia and Alzheimer's Disease: A Population-Based Study. Dement Geriatr Cogn Disord 22: 99-107. https://doi.org/10.1159/000093478
    [50] Morris JK, Vidoni ED, Hone R.A, et al. (2014) Impaired Glycemia Increases Disease Progression in Mild Cognitive Impairment. Neurobiol Aging 35: 585-589. https://doi.org/10.1016/j.neurobiolaging.2013.09.033
    [51] Huang CC, Chung CM, Leu HB, et al. (2014) Diabetes mellitus and the risk of Alzheimer's disease: A nationwide population-based study. PLoS ONE 9: e87095. https://doi.org/10.1371/journal.pone.0087095
    [52] Sergi G, De Rui M, Coin A, et al. (2013) Weight Loss and Alzheimer's Disease: Temporal and Aetiologic Connections. Proc Nutr Soc 72: 160-165. https://doi.org/10.1017/S0029665112002753
    [53] Panagiotakos DB, Pitsavos C, Stefanadis C (2006) Dietary patterns: a Mediterranean diet score and its relation to clinical and biological markers of cardiovascular disease risk. Nutr Metab Cardiovasc Dis 16: 559-568. https://doi.org/10.1016/j.numecd.2005.08.006
    [54] Anastasiou CA, Yannakoulia M, Kosmidis MH, et al. (2017) Mediterranean diet and cognitive health: Initial results from the Hellenic longitudinal investigation of ageing and diet. PloS one 12: e0182048. https://doi.org/10.1371/journal.pone.0182048
    [55] Felisatti F, Chauveau L, de Flores R, et al. (2022) Interaction between APOE4 and lifestyle on neuroimaging biomarkers and cognition in cognitively unimpaired older adults. Alzheimer's Dement 18: e064169. https://doi.org/10.1002/alz.064169
    [56] Gaynor AM, Varangis E, Song S, et al. (2022) Diet moderates the effect of resting state functional connectivity on cognitive function. Sci Rep 12: 16080. https://doi.org/10.1038/s41598-022-20047-4
    [57] Shannon OM, Ranson JM, Gregory S, et al. (2023) Mediterranean diet adherence is associated with lower dementia risk, independent of genetic predisposition: Findings from the UK Biobank prospective cohort study. BMC Med 21: 81. https://doi.org/10.1186/s12916-023-02772-3
  • Reader Comments
  • © 2023 the Author(s), licensee AIMS Press. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0)
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索

Metrics

Article views(1199) PDF downloads(156) Cited by(0)

Article outline

Other Articles By Authors

/

DownLoad:  Full-Size Img  PowerPoint
Return
Return

Catalog