Integrative medicinal approaches towards Alzheimer's disease model animals–A new hope

Shahdat Hossain; Mohammad Azizur Rahman; Shoriful Islam Joy; Anuradha Baraik; Shadman Nazib; Shahdat Hossain; Mohammad Azizur Rahman; Shoriful Islam Joy; Anuradha Baraik; Shadman Nazib

doi:10.3934/molsci.2024013

AIMS Molecular Science

2024, Volume 11, Issue 3: 221-230. doi: 10.3934/molsci.2024013

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Integrative medicinal approaches towards Alzheimer's disease model animals–A new hope

1.
Department of Biochemistry and Molecular Biology, Jahangirnagar University, Savar, Dhaka, Bangladesh
2.
Department of Chemistry, Jahangirnagar University, Savar, Dhaka, Bangladesh

Received: 30 January 2024 Revised: 29 April 2024 Accepted: 13 May 2024 Published: 05 June 2024

Alzheimer's disease (AD), a neurodegenerative disease (ND), has been plaguing healthcare and health policy agencies due to its ever-soaring impact globally. It is timely to develop appropriate measures to combat global AD burden. Due to structural and functional similarity, rodent models offer the best alternative to study AD pathogenesis and therapeutics. In this special issue, the present article reviews the state-of-the-art findings on AD model animals from the alternative and integrative medicinal point of view. Our integrative therapeutic agents include fungi (Ganoderma lucidum), turmeric (Curcuma longa), Indian black berry (black plum, jamun) (Syzygium cumini), and madecassoside (derived from Centella asiatica). Their bio-components, especially flavonoids, polyphenols, and tri-terpenoids, resist oxidative stress, amyloid beta fibrillation, and pro-inflammatory cytokine levels; improve anti-oxidative prowess; and improve learning-related memory and anxiety-like behavior in AD model animals. Most of the findings described here are outcomes of our own studies. However, our claims have been substantiated with evidence from some other studies in the relevant field. As a whole, integrative medicinal approaches towards AD pathogenesis using these natural products seem promising in AD protection.
- Alzheimer's disease,
- Syzygium cumini,
- Curcuma longa,
- Ganoderma lucidum,
- Madecassoside,
- Memory and learning,
- Neurodegeneration
Citation: Shahdat Hossain, Mohammad Azizur Rahman, Shoriful Islam Joy, Anuradha Baraik, Shadman Nazib. Integrative medicinal approaches towards Alzheimer's disease model animals–A new hope[J]. AIMS Molecular Science, 2024, 11(3): 221-230. doi: 10.3934/molsci.2024013

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Abstract

Alzheimer's disease (AD), a neurodegenerative disease (ND), has been plaguing healthcare and health policy agencies due to its ever-soaring impact globally. It is timely to develop appropriate measures to combat global AD burden. Due to structural and functional similarity, rodent models offer the best alternative to study AD pathogenesis and therapeutics. In this special issue, the present article reviews the state-of-the-art findings on AD model animals from the alternative and integrative medicinal point of view. Our integrative therapeutic agents include fungi (Ganoderma lucidum), turmeric (Curcuma longa), Indian black berry (black plum, jamun) (Syzygium cumini), and madecassoside (derived from Centella asiatica). Their bio-components, especially flavonoids, polyphenols, and tri-terpenoids, resist oxidative stress, amyloid beta fibrillation, and pro-inflammatory cytokine levels; improve anti-oxidative prowess; and improve learning-related memory and anxiety-like behavior in AD model animals. Most of the findings described here are outcomes of our own studies. However, our claims have been substantiated with evidence from some other studies in the relevant field. As a whole, integrative medicinal approaches towards AD pathogenesis using these natural products seem promising in AD protection.

Author contributions

Conceptualization, SH; Writing original draft-manuscript, SH; Writing, review, editing, MAR; Figure preparation, SN; Reading and editing, SIJ, AB, and SN.
All authors have read and agreed to the published version of the manuscript.

Conflict of interest

The authors declare no conflict of interest.

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