Natural products in drug discovery: meeting the urgency for new antimicrobials for human and veterinary use

Marcus Vinícius Dias-Souza; Arthur Azevedo Perpétuo; Gabriel Souza dos Santos; Luiz Felipe Carreiro Machado; Renan Martins dos Santos; Marcus Vinícius Dias-Souza; Arthur Azevedo Perpétuo; Gabriel Souza dos Santos; Luiz Felipe Carreiro Machado; Renan Martins dos Santos

doi:10.3934/molsci.2023002

AIMS Molecular Science

2023, Volume 10, Issue 1: 11-21. doi: 10.3934/molsci.2023002

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Review

Natural products in drug discovery: meeting the urgency for new antimicrobials for human and veterinary use

1.
Head, Reference Center for Drug Information (CRIMED), Pitagoras College, Ipatinga, MG, Brazil
2.
Veterinary Medicine Graduate Program, Pitagoras College, Ipatinga, MG, Brazil
3.
Pharmacy Graduate Program, Pitagoras College, Ipatinga, MG, Brazil
4.
Central Farma Pharmacy, Central Group, Ipatinga, MG, Brazil
5.
Integrated Pharmacology and Drug Interactions Research Group (GPqFAR), MG, Brazil

Received: 01 October 2022 Revised: 24 December 2022 Accepted: 03 January 2023 Published: 29 January 2023

The scenario of growing microbial resistance and of lack of interest of pharmaceutical companies in developing new antimicrobial drugs jeopardizes the present and the future of the treatment of infectious diseases. Different approaches such as antimicrobial peptides and CRISP-R have been explored to manage this situation, however, they have important limitations such as their high cost. Natural products comprise complex molecular structures for which reports of bacterial resistance are rare. They present specific and/or unspecific mechanisms of action that can be explored to provide safe and effective management of infectious diseases. In this review we assessed phytoextracts with evidence of their benefits for treating infectious diseases in humans and animals, towards the use of data for clinical and experimental purposes. Mechanisms of bacterial resistance to antimicrobials are also discussed.
- phytoextracts,
- antimicrobial,
- pharmacology,
- molecular targets,
- bacteria
Citation: Marcus Vinícius Dias-Souza, Arthur Azevedo Perpétuo, Gabriel Souza dos Santos, Luiz Felipe Carreiro Machado, Renan Martins dos Santos. Natural products in drug discovery: meeting the urgency for new antimicrobials for human and veterinary use[J]. AIMS Molecular Science, 2023, 10(1): 11-21. doi: 10.3934/molsci.2023002

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Abstract

The scenario of growing microbial resistance and of lack of interest of pharmaceutical companies in developing new antimicrobial drugs jeopardizes the present and the future of the treatment of infectious diseases. Different approaches such as antimicrobial peptides and CRISP-R have been explored to manage this situation, however, they have important limitations such as their high cost. Natural products comprise complex molecular structures for which reports of bacterial resistance are rare. They present specific and/or unspecific mechanisms of action that can be explored to provide safe and effective management of infectious diseases. In this review we assessed phytoextracts with evidence of their benefits for treating infectious diseases in humans and animals, towards the use of data for clinical and experimental purposes. Mechanisms of bacterial resistance to antimicrobials are also discussed.

Acknowledgments

The authors are thankful to all GPqFAR team for the solid scientific collaboration network. We are also thankful to the CRIMED students and pharmacists for the excellent research work developed since its foundation.

Conflict of interest

The authors declare no conflict of interest.

References

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