
Sexually transmitted diseases (STDs) are detrimental to the health and economic well-being of society. Consequently, predicting outbreaks and identifying effective disease interventions through epidemiological tools, such as compartmental models, is of the utmost importance. Unfortunately, the ordinary differential equation compartmental models attributed to the work of Kermack and McKendrick require a duration of infection that follows the exponential or Erlang distribution, despite the biological invalidity of such assumptions. As these assumptions negatively impact the quality of predictions, alternative approaches are required that capture how the variability in the duration of infection affects the trajectory of disease and the evaluation of disease interventions. So, we apply a new family of ordinary differential equation compartmental models based on the quantity person-days of infection to predict the trajectory of disease. Importantly, this new family of models features non-exponential and non-Erlang duration of infection distributions without requiring more complex integral and integrodifferential equation compartmental model formulations. As proof of concept, we calibrate our model to recent trends of chlamydia incidence in the U.S. and utilize a novel duration of infection distribution that features periodic hazard rates. We then evaluate how increasing STD screening rates alter predictions of incidence and disability adjusted life-years over a five-year horizon. Our findings illustrate that our family of compartmental models provides a better fit to chlamydia incidence trends than traditional compartmental models, based on Akaike information criterion. They also show new asymptomatic and symptomatic infections of chlamydia peak over drastically different time frames and that increasing the annual STD screening rates from 35% to 40%-70% would annually avert 6.1-40.3 incidence while saving 1.68-11.14 disability adjusted life-years per 1000 people. This suggests increasing the STD screening rate in the U.S. would greatly aid in ongoing public health efforts to curtail the rising trends in preventable STDs.
Citation: Jack Farrell, Owen Spolyar, Scott Greenhalgh. The effect of screening on the health burden of chlamydia: An evaluation of compartmental models based on person-days of infection[J]. Mathematical Biosciences and Engineering, 2023, 20(9): 16131-16147. doi: 10.3934/mbe.2023720
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Sexually transmitted diseases (STDs) are detrimental to the health and economic well-being of society. Consequently, predicting outbreaks and identifying effective disease interventions through epidemiological tools, such as compartmental models, is of the utmost importance. Unfortunately, the ordinary differential equation compartmental models attributed to the work of Kermack and McKendrick require a duration of infection that follows the exponential or Erlang distribution, despite the biological invalidity of such assumptions. As these assumptions negatively impact the quality of predictions, alternative approaches are required that capture how the variability in the duration of infection affects the trajectory of disease and the evaluation of disease interventions. So, we apply a new family of ordinary differential equation compartmental models based on the quantity person-days of infection to predict the trajectory of disease. Importantly, this new family of models features non-exponential and non-Erlang duration of infection distributions without requiring more complex integral and integrodifferential equation compartmental model formulations. As proof of concept, we calibrate our model to recent trends of chlamydia incidence in the U.S. and utilize a novel duration of infection distribution that features periodic hazard rates. We then evaluate how increasing STD screening rates alter predictions of incidence and disability adjusted life-years over a five-year horizon. Our findings illustrate that our family of compartmental models provides a better fit to chlamydia incidence trends than traditional compartmental models, based on Akaike information criterion. They also show new asymptomatic and symptomatic infections of chlamydia peak over drastically different time frames and that increasing the annual STD screening rates from 35% to 40%-70% would annually avert 6.1-40.3 incidence while saving 1.68-11.14 disability adjusted life-years per 1000 people. This suggests increasing the STD screening rate in the U.S. would greatly aid in ongoing public health efforts to curtail the rising trends in preventable STDs.
In line with the Environmental Health Association of America's committee definition, the environment encompasses the habitats where humans reside, work, and engage in recreational activities. It includes the air we breathe, the food we consume, the water we drink, and the shelter we seek for protection against the elements. Additionally, it comprises harmful pollutants and other environmental factors that significantly impact our well-being and overall health. Our survival depends on access to nutritious food, clean air, and safe drinking water, which necessitates the promotion of a healthy atmosphere. The World Health Organization (WHO) emphasizes the importance of maintaining a clean environment that adheres to health standards. Regrettably, our water supply has become increasingly contaminated, with numerous pollutants affecting the quality of our drinking water sources. Thus, it is imperative that we develop a conscientious awareness of our surroundings. Environmental science encompasses scientific methodologies, economic considerations, and political interventions. Moreover, toxic substances introduced into lakes, streams, rivers, seas, and other bodies of water can dissolve, remain suspended, or settle at the bottom. Consequently, water contamination ensues, leading to a decline in groundwater quality and the deterioration of marine habitats [1].
Pollution can also seep into the groundwater and alter the sediment composition. Water pollution has various causes, with sewage and industrial waste being the most significant contributors that enter rivers. In many developed countries, the resources allocated for waste management are insufficient [2]. Currently, only around 10% of the generated wastewater is properly treated, while the rest is discharged and deposited into our water bodies. Consequently, impurities infiltrate groundwater, tributaries, and other water sources. The water that ultimately reaches our homes is often highly contaminated, carrying viruses that can harm microorganisms. Another major source of water pollution is agricultural runoff, which involves the drainage of water from fields containing pesticides and fertilizers. Domestic sewage, also known as sanitary sewage, refers to wastewater discharged from households. This type of water contains a wide array of dissolved and suspended contaminants.
Mathematical frameworks play a crucial role in predicting and addressing social issues, and they have been increasingly utilized in recent decades to mitigate the impact of these issues. By applying mathematical models, we can effectively control the spread of real-world problems. As many global challenges exhibit quasi-linear characteristics, relying solely on linear models can often lead to idealistic and unrealistic outcomes. Therefore, non-linear mathematical models provide a more accurate depiction of real-world issues. In the context of modeling lake contamination, a collocation approach has been proposed, which utilizes Bessel polynomials and collocation points to generate an updated matrix problem [3]. This approach allows for a more comprehensive understanding of the contamination dynamics within a lake system. Additionally, the homotopy perturbation approach has been employed to offer approximate and analytical solutions for nonlinear ordinary differential equation systems, such as those encountered in modeling lake contamination [4]. Furthermore, the differential transform method (DTM) has been utilized to analyze pollution models involving interconnected systems of three lakes connected by waterways [5]. These mathematical methods enhance our ability to study and address the complex dynamics of pollution in various environmental systems.
A fractional differential equation system has been investigated by Haq EU [6]. He designed the system to simulate the pollution of a group of lakes and assess the results using other well-known analytical approaches, such as iterative variation and Adomian decomposition. The Laplace Adomian decomposition method is widely applied to solve many real-life problems (see [7]–[9]). Several researchers have used the technique of LADM to investigate different types of problems. For example, in [10], the authors examined the free vibrations of a non-uniform Bernoulli beam using LADM. In [11], a fractional-order sterile insect technology model was studied with the help of LADM. Other studies include the investigation of MHD flow of incompressible fluid between two parallel plates [12], and the study of the effect of a magnetic field on the heat transfer of carbon nanotubes [13]. Different approaches have been used for disease models, studying them with various fractional operator techniques [14]–[23].
Aguirre and Tully [24] employed simple mixture problem methodologies to develop a differential equation that characterizes the pollution concentration in a lake. Prakasha and Veeresha [25] explored three alternative scenarios of the model and established an approximate analytical solution for the system of three fractional differential equations using the q-homotopy analysis transform technique (q-HATM). The results obtained demonstrated the high effectiveness and systematic nature of the proposed strategy. Khalid and Sultana [26] utilized the perturbation-iteration approach to estimate the solution of three input models: periodic, linear step, and exponentially decaying. As a reference, the analytical simulation of the lake system problem was conducted using the fourth-order Runge-Kutta technique (RK4). Biazar and Farrokhi [27] employed compartmental modeling to predict the contamination of a system of lakes through a set of mathematically-researched equations. Bazar and Shahbala [28] utilized the variational iteration method (VIM), and the results demonstrated that the variational iteration approach was easier to implement compared to the Adomian decomposition method for pollution monitoring in lakes. Three distinct types of input models were considered: sinusoidal, impulse, and step. Furthermore, Toufik and Atangana's novel numerical technique was applied [29] to examine the updated model of the contaminated lake system.
Fractional calculus, despite its name, deals with integrals and derivatives of any positive real order and can be considered a branch of mathematical modeling. It focuses on integrodifferential operators and equations with convolution-type integrals that involve weakly singular kernels of power-law form. It is closely related to the theory of pseudo-differential operators. In recent years, fractional calculus has garnered significant attention from researchers, and various aspects of this subject are being explored in research [30], [31]. This is because fractional derivatives serve as an important tool for describing the dynamic behavior of diverse physical systems [32]–[34]. The distinct characteristic of these differential operators lies in their non-local nature, which is absent in integer-order differential operators [35]. In fact, fractional order models are more accurate and practical than classical integer order models, and techniques such as the Legendre operational matrix can be extended to incorporate fractional calculus [36], [37]. The application of fractional differential equations in applied sciences is another area of interest [38], [39].
Fractional order derivatives offer increased flexibility in modeling various biomaterials and systems [40]. They provide powerful tools for characterizing the dynamic behavior of these systems. There are different types of fractional derivatives, such as Riemann and Liouville, and Caputo operators, which are commonly used in practice. Caputo [41] introduced a fractional derivative that allows for the incorporation of conventional initial and boundary conditions relevant to real-world problems. While these fractional derivatives offer improved accuracy in describing real phenomena compared to integer-order derivatives, their kernel functions may result in singularities that lead to computational challenges. To explore fractional mathematical models beyond the traditional Caputo derivative, various methodologies, including iterative and numerical methods, have been employed [42]–[44]. In this study, we focus on a system of three equations that describes lake contamination. The model represents the contamination of a three-lake system [27], as illustrated in Figure 1.
The arrows in the figure indicate the direction of flow in the channels or pipes. In this system, a contaminant is introduced into the first lake through a factory, and the rate of entrance of the pollutant into the lake per unit of time is represented by the function p(t). The function p(t) can be constant or vary over time. The goal is to determine the level of pollution in each lake at any given time. At time t ≥ 0, the contamination level ci(t) in Lake i is proportional to the volume of water vi and the concentration of pollutant yi(t) in the following manner:
In the lake system, it is assumed that each lake is initially free of any contaminants, so the concentration of pollutant in each lake at time t = 0 is given by yi(0) = 0 for i = 1, 2, 3. To simulate the dynamic behavior of the lake system, a constant gji is used to represent the flow rate from lake i to lake j. The flux of pollutant flowing from lake i into lake j at any time t is denoted by rji(t) and is defined as follows:
Thus, rji(t) represents the proportion at which the contamination level in lake i flows into lake j at time t. It is important to note this relationship.
Rate of change of pollutant = Input rate - Output rate.
Applying this principle to each lake, we obtain the following system of differential equations:
It is apparent from this that the incoming and outgoing flow rates in each lake are constant, and as a result, the water volume in each lake remains fixed. Therefore, we can establish the following conditions:
To evaluate the performance of the proposed model, we consider specific predicted values as listed in [27], which can be expressed as follows:
In this study, to obtain a more accurate qualitative and numerical iterative analysis of the proposed model, we consider the system (1.1) in terms of the Caputo fractional order differential operator. The system can be expressed as follows:
where α denotes the fractional order.
The objective of this study is to analyze a system of fractional differential equations that describe lake pollution and provide meaningful insights through a mathematical model that can explain real-world scenarios using a simple and efficient approach. It is important to highlight that the investigated model heavily relies on time and its history, which can be systematically incorporated and represented using the newly developed fractional operator. To obtain the solution of the model, we utilize the Laplace transform in conjunction with the Adomian decomposition method and the Homotopy perturbation method. These techniques enable us to obtain an approximate solution for the considered model. Additionally, we compare the results obtained from both techniques, demonstrating their identical nature. Furthermore, we employ MATLAB to facilitate the numerical solutions and depict the pollution levels in each lake graphically, considering arbitrary fractional orders. This visual representation aids in understanding the behavior of the lake system under different scenarios.
The structure of this paper is organized as follows: Section 2 provides fundamental results and definitions related to the topic. In Section 3, the general solutions of the suggested model are obtained using the Laplace Adomian decomposition technique. This section focuses on the qualitative analysis of the model. Section 4 presents the general solutions of the considered model using the Homotopy perturbation technique. This section discusses the application of the Homotopy perturbation method for obtaining the solutions. In Section 5, a graphical comparison of the numerical solutions obtained from both the Laplace Adomian decomposition technique and the Homotopy perturbation technique is presented. The numerical simulation results are briefly discussed in this section. Finally, in Section 6, the concluding remarks of the study are provided.
In this section, some essential preliminaries and fractional calculus results are presented in line with [45], [46].
Definition 2.1. For α > 0 with
such that the integral part on the right exists and n = [α] + 1, and the symbol Γ denotes the Gamma function which is described as
Definition 2.2. The Laplace transform of g(t) in the general framework of Caputo definition is described as follows:
Definition 2.3. The Homotopy perturbation method (HPM) is a semi-analytical technique used to solve linear and nonlinear ordinary and partial differential equations, as well as systems of equations. It is also applicable to systems consisting of both linear and nonlinear differential equations. One notable advantage of using the HPM over decomposition methods is that it can handle nonlinear problems without requiring the use of Adomian polynomials. The HPM was first proposed by the Chinese mathematician He
where L is used for the linear part, N for the nonlinear part, l ∈ Ω, Ω is a topological space and p ∈ [0,1] is the embedding parameter. Furthermore, u0 is an initial approximation that satisfies the boundary conditions.
In this section, we will discuss the general technique of the Laplace Adomian decomposition method (LADM) to construct the solution for the considered model (1.2), along with the initial conditions. We will also demonstrate how to integrate the LADM with the Caputo differential operator.
with subject to the initial conditions:
Now, taking the Laplace transform of (3.1) in the Caputo sense, one may get
using the initial conditions yields
Assuming the solution for y1(t), y2(t) and y3(t) in an infinite series is given below:
using the above series in (3.3), and comparing like terms on both sides, one can get
Further, utilizing the inverse Laplace transform to equation (3.4), we have
Additionally, the remaining terms can be derived in a similar fashion. The unknown values in the aforementioned equations are listed below:
We will now apply the Homotopy Perturbation Method (HPM) to derive the general solution of Model (1.2) as:
By substituting q = 0 into equation (4.1), we obtain the following system of fractional differential equations:
The solution to the above equation is straightforward. Next, setting q = 1 in equation (4.1) results in a similar model to equation (1.2). We assume the solution takes the form of an infinite series as:
Furthermore, the original system can be obtained by substituting q = 1 into equation (4.1). By substituting equation (4.3) into equation (4.1) and comparing the terms with respect to the powers of q, we obtain:
Similarly,
The approximate series solution is thus acquired. In the next section, we will do simulation for the aforementioned methods.
In this section, we conduct numerical simulations to complement the analytical findings of our proposed model. The simulations involve qualitative point analysis and consider the parameters from a biological feasibility perspective. By using the parametric values, we determine the following terms of the proposed model:
Furthermore, the solutions to the first few terms are given as:
Now, evaluating (5.2) for α = 0.97, one get
Similarly, for α = 0.98, the approximations are:
And for α = 0.99, one can obtain the approximate solutions are:
Furthermore, we have considered three different types of input functions to represent the duration of the contaminant in each lake. These input functions include periodic, exponentially decaying, and linear inputs.
Case 1: Periodic Input Model: In this scenario, the model is evaluated when pollution is periodically introduced into Lake 1. We have chosen the input function
Based on Figure 2, it is evident that the pollution concentration in the lakes increases over time. Moreover, for smaller fractional orders, the increase is more rapid. It is worth noting that the timescale in all the figures is measured in days. In the next step, we will provide a comparison of the lakes using both the Laplace Adomian decomposition method (LADM) and the Homotopy perturbation method (HPM). Specifically, we will focus on the first few terms of the simulations, which will demonstrate the similarities between the two methods.
Case 2: Exponentially Decaying Input Model: In this situation, the model is examined when pollutants with huge dumping. We chose
Figure 6 illustrates that the pollution concentration in the lakes initially increases, then decreases, and eventually stabilizes at a certain level over time. Similarly, we will proceed with the comparison of the lakes using both the Laplace Adomian decomposition method (LADM) and the Homotopy perturbation method (HPM). By examining the first few terms of the simulations, we will demonstrate the similarities between the two methods, thus validating their simulation results.
Case 3: Linear Input Model: In this scenario, the model considers the case where Lake 1 is initially contaminated with a pollutant with a linear proportion. We have chosen the input function p(t) = a, t, where a = 100. For this linear input, the pollutant starts flowing into the lake at time zero, and the amount of pollutant before time zero is assumed to be zero. In the case of a step input, the key characteristic is that the input abruptly increases at time zero and remains relatively constant thereafter. As an example, consider a manufacturing plant that starts its operations at time zero and immediately begins discharging untreated sewage at a consistent rate and intensity. This linear input represents the continuous influx of pollutants into the lake.
Figure 9 shows the concentration of pollution in lakes rising rapidly with passing time. Next, the comparison of these lakes using both proposed methods of LADM and HPM for the first few terms that demonstrate simulation similarities are presented.
In this research, we have analyzed the dynamic behavior of a lake pollution model using the Caputo differential operator and the utilities of fractional calculus. The model has been numerically explored using the Laplace transform with the Adomian decomposition method (LADM) and the Homotopy perturbation method (HPM). The numerical results obtained from both methods are highly similar and provide strong confirmation for the considered model in arbitrary order derivatives. The outcomes are influenced by various parameters used in the model, and both methods converge effectively for solving fractional-order differential equations. The graphical results, generated using MATLAB, demonstrate the dependency of the model on the fractional operator and the parameters utilized in the proposed methods. The present study highlights the significance of the fractional concept in understanding and analyzing the suggested lakes pollution model, which is highly dependent on time and its history. It also provides a foundation for future research in this field. For instance, the mathematical model can be further enhanced by considering various dynamic structures and investigating different types of derivatives. The advantages of the LADM and HPM methods, including simplicity, accuracy, flexibility, and efficiency, make them valuable tools for analyzing nonlinear problems in various scientific and engineering disciplines. These methods offer promising avenues for further exploration and application in fractional calculus and related fields.
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