Proteomics for Cerebrospinal Fluid Biomarker Identification in Parkinsons Disease: Methods and Critical Aspects

Antonio Conti; Massimo Alessio; Antonio Conti; Massimo Alessio

doi:10.3934/medsci.2015.1.1

AIMS Medical Science

2015, Volume 2, Issue 1: 1-6. doi: 10.3934/medsci.2015.1.1

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Mini review Special Issues

Proteomics for Cerebrospinal Fluid Biomarker Identification in Parkinsons Disease: Methods and Critical Aspects

Antonio Conti ,
Massimo Alessio ^,

Proteome Biochemistry, Division of Genetics and Cell Biology, IRCCS San Raffaele Scientific Institute, 20132 Milano, Italy

Received: 04 December 2014 Accepted: 18 December 2014 Published: 19 January 2015

Parkinson's disease (PD), similar with other neurodegenerative disorders, would benefit from the identification of early biomarkers for differential diagnosis and prognosis to address prompt clinical treatments. Together with hypothesis driven approaches, PD has been investigated by high-throughput differential proteomic analysis of cerebrospinal fluid (CSF) protein content. The principal methodologies and techniques utilized in the proteomics field for PD biomarker discovery from CSF are presented in this mini review. The positive aspects and challenges in proteome-based biomarker research are also discussed.
- cerebrospinal fluid,
- Parkinson's disease,
- biomarker,
- quantitative proteomics,
- post translational modifications,
- mass spectrometry,
- two-dimensional electrophoresis
Citation: Antonio Conti, Massimo Alessio. Proteomics for Cerebrospinal Fluid Biomarker Identification in Parkinsons Disease: Methods and Critical Aspects[J]. AIMS Medical Science, 2015, 2(1): 1-6. doi: 10.3934/medsci.2015.1.1

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Abstract

Parkinson's disease (PD), similar with other neurodegenerative disorders, would benefit from the identification of early biomarkers for differential diagnosis and prognosis to address prompt clinical treatments. Together with hypothesis driven approaches, PD has been investigated by high-throughput differential proteomic analysis of cerebrospinal fluid (CSF) protein content. The principal methodologies and techniques utilized in the proteomics field for PD biomarker discovery from CSF are presented in this mini review. The positive aspects and challenges in proteome-based biomarker research are also discussed.

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