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AIMS Biophysics

2015, Volume 2, Issue 3: 303-317. doi: 10.3934/biophy.2015.3.303
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DDRs: receptors that mediate adhesion, migration and invasion in breast cancer cells

  • Departamento de Biologia Celular, Cinvestav-IPN, Av IPN # 2508, San Pedro Zacatenco, DF 07360, Mexico
  • Received: 03 April 2015 Accepted: 30 July 2015 Published: 08 August 2015

  • Discoidin domain receptors (DDRs) are receptor tyrosine kinases that are activated by native collagens and have an important role during cell adhesion, development, differentiation, proliferation, and migration. DDR deregulation is associated with progression of several different cancers. However, there is limited information about the role of DDRs in the progression of breast cancer. In this review we attempt to collect the most relevant information about DDR signaling and their role in various cancer-related processes such as adhesion, epithelial to mesenchymal transition, migration, invasion, and survival, with a focus on breast cancer.

    Citation: Emmanuel Reyes-Uribe, Nathalia Serna-Marquez, Eduardo Perez Salazar. DDRs: receptors that mediate adhesion, migration and invasion in breast cancer cells[J]. AIMS Biophysics, 2015, 2(3): 303-317. doi: 10.3934/biophy.2015.3.303

    Related Papers:

  • Discoidin domain receptors (DDRs) are receptor tyrosine kinases that are activated by native collagens and have an important role during cell adhesion, development, differentiation, proliferation, and migration. DDR deregulation is associated with progression of several different cancers. However, there is limited information about the role of DDRs in the progression of breast cancer. In this review we attempt to collect the most relevant information about DDR signaling and their role in various cancer-related processes such as adhesion, epithelial to mesenchymal transition, migration, invasion, and survival, with a focus on breast cancer.


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