The potential role of neutrophil extracellular traps (NETS) in periodontal disease—A scanning electron microscopy (SEM) study

Shreya Shetty; Sampat Kumar Srigiri; Karunakar Shetty; Shreya Shetty; Sampat Kumar Srigiri; Karunakar Shetty

doi:10.3934/molsci.2023014

AIMS Molecular Science

2023, Volume 10, Issue 3: 205-212. doi: 10.3934/molsci.2023014

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Research article

The potential role of neutrophil extracellular traps (NETS) in periodontal disease—A scanning electron microscopy (SEM) study

1.
Ibn Sina National College of Medical Sciences, Jeddah, KSA
2.
Consultant Periodontist & Implantologist, Padmavathi Dental Clinic, Karimnagar, India

Received: 27 March 2023 Revised: 02 August 2023 Accepted: 10 September 2023 Published: 18 September 2023

Background
Oral biofilms are the major etiological agents of periodontal pathologies. Neutrophils are the first line of defense in fighting the pathogens in the biofilm. One of the mechanisms by which they operate is neutrophil extracellular traps (NETs), which are a novel mechanism of defense in the presence of pathogenic plaque. The present study was carried out to investigate their role in periodontal disease.

Methodology
Following institutional ethical committee approval, ten gingival (biopsy) samples from individuals with periodontitis were collected during periodontal flap surgery and processed and examined under scanning electron microscope (SEM).

Results
SEM examination revealed that the excised gingival tissues displayed an intricate meshwork of NETs.

Conclusion
NETs may be one of the means of defense against periodontal infections, although further research is necessary to understand the exact nature of their role.
- plaque,
- neutrophils,
- NETs,
- gingival biopsy,
- periodontitis
Citation: Shreya Shetty, Sampat Kumar Srigiri, Karunakar Shetty. The potential role of neutrophil extracellular traps (NETS) in periodontal disease—A scanning electron microscopy (SEM) study[J]. AIMS Molecular Science, 2023, 10(3): 205-212. doi: 10.3934/molsci.2023014

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Abstract

Background

Oral biofilms are the major etiological agents of periodontal pathologies. Neutrophils are the first line of defense in fighting the pathogens in the biofilm. One of the mechanisms by which they operate is neutrophil extracellular traps (NETs), which are a novel mechanism of defense in the presence of pathogenic plaque. The present study was carried out to investigate their role in periodontal disease.

Methodology

Following institutional ethical committee approval, ten gingival (biopsy) samples from individuals with periodontitis were collected during periodontal flap surgery and processed and examined under scanning electron microscope (SEM).

Results

SEM examination revealed that the excised gingival tissues displayed an intricate meshwork of NETs.

Conclusion

NETs may be one of the means of defense against periodontal infections, although further research is necessary to understand the exact nature of their role.

Conflict of interest

The authors declare no conflict of interest.

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