Research article

The potential role of neutrophil extracellular traps (NETS) in periodontal disease—A scanning electron microscopy (SEM) study

  • Received: 27 March 2023 Revised: 02 August 2023 Accepted: 10 September 2023 Published: 18 September 2023
  • Background

    Oral biofilms are the major etiological agents of periodontal pathologies. Neutrophils are the first line of defense in fighting the pathogens in the biofilm. One of the mechanisms by which they operate is neutrophil extracellular traps (NETs), which are a novel mechanism of defense in the presence of pathogenic plaque. The present study was carried out to investigate their role in periodontal disease.

    Methodology

    Following institutional ethical committee approval, ten gingival (biopsy) samples from individuals with periodontitis were collected during periodontal flap surgery and processed and examined under scanning electron microscope (SEM).

    Results

    SEM examination revealed that the excised gingival tissues displayed an intricate meshwork of NETs.

    Conclusion

    NETs may be one of the means of defense against periodontal infections, although further research is necessary to understand the exact nature of their role.

    Citation: Shreya Shetty, Sampat Kumar Srigiri, Karunakar Shetty. The potential role of neutrophil extracellular traps (NETS) in periodontal disease—A scanning electron microscopy (SEM) study[J]. AIMS Molecular Science, 2023, 10(3): 205-212. doi: 10.3934/molsci.2023014

    Related Papers:

  • Background

    Oral biofilms are the major etiological agents of periodontal pathologies. Neutrophils are the first line of defense in fighting the pathogens in the biofilm. One of the mechanisms by which they operate is neutrophil extracellular traps (NETs), which are a novel mechanism of defense in the presence of pathogenic plaque. The present study was carried out to investigate their role in periodontal disease.

    Methodology

    Following institutional ethical committee approval, ten gingival (biopsy) samples from individuals with periodontitis were collected during periodontal flap surgery and processed and examined under scanning electron microscope (SEM).

    Results

    SEM examination revealed that the excised gingival tissues displayed an intricate meshwork of NETs.

    Conclusion

    NETs may be one of the means of defense against periodontal infections, although further research is necessary to understand the exact nature of their role.



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    Conflict of interest



    The authors declare no conflict of interest.

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