Research article

The effects of smoking Haschich on blood parameters in young people from the Beni Mellal region Morocco

  • Received: 21 August 2021 Accepted: 17 October 2021 Published: 25 October 2021
  • Objective

    The objective of this work is to evaluate the effects of smoking hashish on some blood parameters (Red blood cells, Hemoglobins, Hematocrits, MCV, MCH, MCHC, White blood cells, Urea, Creatinine, Cholesterol, Triglycerides, Liver Aminotransferases) among young people from the Beni Mellal region, Morocco.

    Methods

    Blood samples are collected from 30 male, fasting, voluntary and anonymous individuals in three groups; 10 non-smokers (controls), 10 moderate chronic smokers (5 joints/day (5 j/d) or less for a period not exceeding 3 years) and 10 intense chronic smokers (15 joints/day or more for a period equal to or greater than 5 years).

    Results

    The results obtained show that with the duration and number of joints consumed, a decrease in the level of HB, RBCs, HT, platelets, urea, cholesterol, triglycerides, SGOT and SGPT while there is an increase in MCH, MCHC, eosinophils and creatinine.

    Conclusion

    These results could be explained by the impact of the active ingredients in the joints, including THC in cannabis and the components of smoked cigarettes in conjunction with cannabis resin on consumer nutrition.

    Citation: Hicham Rahmi, Ben Yamine Mallouki, Fatiha Chigr, Mohamed Najimi. The effects of smoking Haschich on blood parameters in young people from the Beni Mellal region Morocco[J]. AIMS Medical Science, 2021, 8(4): 276-290. doi: 10.3934/medsci.2021023

    Related Papers:

  • Objective

    The objective of this work is to evaluate the effects of smoking hashish on some blood parameters (Red blood cells, Hemoglobins, Hematocrits, MCV, MCH, MCHC, White blood cells, Urea, Creatinine, Cholesterol, Triglycerides, Liver Aminotransferases) among young people from the Beni Mellal region, Morocco.

    Methods

    Blood samples are collected from 30 male, fasting, voluntary and anonymous individuals in three groups; 10 non-smokers (controls), 10 moderate chronic smokers (5 joints/day (5 j/d) or less for a period not exceeding 3 years) and 10 intense chronic smokers (15 joints/day or more for a period equal to or greater than 5 years).

    Results

    The results obtained show that with the duration and number of joints consumed, a decrease in the level of HB, RBCs, HT, platelets, urea, cholesterol, triglycerides, SGOT and SGPT while there is an increase in MCH, MCHC, eosinophils and creatinine.

    Conclusion

    These results could be explained by the impact of the active ingredients in the joints, including THC in cannabis and the components of smoked cigarettes in conjunction with cannabis resin on consumer nutrition.


    Abbreviations

    MCV

    Mean corpuscular volume

    MCH

    Mean corpuscular hemoglobin

    MCHC

    Mean corpuscular hemoglobin concentration

    HB

    Hemoglobin

    RBC

    Red blood cells

    HCT

    Hematocrit

    SGOT

    (serum) Glutamic oxaloacetic transaminase

    SGPT

    Serum glutamic-pyruvic transaminase

    THC

    Tetrahydrocannabinol

    加载中

    Acknowledgments



    The authors are most grateful to Dr. Bouchra Bamou pharmacist biologist and his laboratory of medical analyzes for all support and aids which facilitated this stady.

    Conflict of interest



    All the authors declare that there are not biomedical financial interests or potential conflicts of interest in writing this manuscript.

    [1] Ebuehi T, Ukwade E, Adegbola T (2018) Smoking effects of Marijuana and Cigarette on blood chemistry, hematology and plasma dopamine levels in young adults. Asian J Med Health 12: 1-6. doi: 10.9734/AJMAH/2018/41637
    [2] Audeval Christelle Cannabis and Therapeutic: developed, exercise thesis, Limoges, Limoges University (2003) .Available from: http://aurore.unilim.fr/theses/nxfile/default/a7717e6c-4f86-4239-a982-0672762d62e6/blobholder:0/P2003304.pdf.
    [3] Chouvy P (2018) From kif to hashish. The evolution of the cannabis industry in Morocco. Bull Assoc French Geogr 95: 308-321. doi: 10.4000/bagf.3337
    [4] Le Nézet O (2013)  Drugs and addictions, essential data Saint-Denis: OFDT, 214-225. Available from: https://www.ofdt.fr/BDD/publications /docs/da13can.pdf.
    [5] Yanbaeva D, Dentener M, Creutzberg E, et al. (2007) Systemic effects of smoking. Chest 131: 1557-1566. doi: 10.1378/chest.06-2179
    [6] Ambrose JA, Barua RS (2004) The pathophysiology of cigarette smoking and cardiovascular disease: an update. J Am Coll Cardiol 43: 1731-1737. doi: 10.1016/j.jacc.2003.12.047
    [7] World Health Organization Tobacco: checklist n°339 (2014) .Available from: https://www.who.int/news-room/fact-sheets/detail/tobacco.
    [8] Oseni B, Togun V, Taiwo O (2006) Effect of marijuana smoking on some hematological parameters of smokers. World J Med Sci 1: 82-85.
    [9] Ebuehi O, Akinwande A, Famuyiwa O, et al. (2005) Effect of marijuana smoking on blood chemistry and serum biogenic amines concentrations in humans. Nigerian J Health Biomed Sci 4: 20-24.
    [10] National Center for Chronic Disease Prevention and Health Promotion (US) Office on Smoking and Health (2014)  The Health Consequences of Smoking—50 Years of Progress: A Report of the Surgeon General Atlanta (GA): Centers for Disease Control and Prevention (US), Available from: https://www.ncbi.nlm.nih.gov/books/NBK179276/.
    [11] The National Academies of Sciences, Engineering, and Medicine; Health and Medicine Division; Board on Population Health and Public Health Practice; Committee on the Health Effects of Marijuana: An Evidence Review and Research Agenda (2017)  The Health Effects of Cannabis and Cannabinoids: The Current State of Evidence and Recommendations for Research Washington (DC): National Academies Press (US), Available from: https://doi.org/10.17226/24625.
    [12] Meier E, Hatsukami D (2016) A review of the additive health risk of cannabis and tobacco co-use. Drug Alcohol Depend 166: 6-12. doi: 10.1016/j.drugalcdep.2016.07.013
    [13] Fernandez-Sala S, Rousseau-Durand R, Morange P, et al. (2019) Impact of menstrual blood self-representation on contraceptive choice of women. Gynecol Obstet Fertil Senol 47: 662-671. (Article in French).
    [14] Nwaichi E, Omorodion F (2015) Evaluation of effect of cannabis smoking on the hematological properties of selected adult male students smokers. Int J Anat Appl Physiol 1: 1-5.
    [15] Wani IA, Khan MA, Singh B (2017) Effect of cannabis abuse and ezymatic alterations to endorse liver dysfunctions. Glob J Add Rehab Med 3: 1-7.
    [16] Karimi I, Hayatghaibi H, Yousef J, et al. (2007) The effect of Cannabis sativa L (hemp seed) on hematological parameter in guinea pigs. Cardiovasc Hematol Disord Drug Targets 7: 288-290. doi: 10.2174/187152907782793554
    [17] Mukhtar AH, Elbagir NM (2011) Effect of Cannabis sativa on hematological indices in rats and men. Pak J Nutr 10: 313-316. doi: 10.3923/pjn.2011.313.316
    [18] Wuillemin T, Samii K, Favrod-Coune T, et al. Anemia (2017) .Available from: https://www.hug.ch/sites/interhug/files/structures/medecine_de_premier_recours/Strategies/strategie_anemie.pdf.
    [19] Gunn JKL, Rosales CB, Center KE, et al. (2016) Prenatal exposure to cannabis and maternal and child health outcomes: a systematic review and meta-analysis. BMJ Open 6: e009986. doi: 10.1136/bmjopen-2015-009986
    [20] Beaconsfield P, Ginsburg J, Rainsbury R (1972) Marihuana smoking. Cardiovascular effects in man and possible mechanisms. N Engl J Med 287: 209-212. doi: 10.1056/NEJM197208032870501
    [21] Isager H, Hagerup L (1971) Relationship between cigarette smoking and high packed cell volume and haemoglobin levels. Scand J Haematol 8: 241-244. doi: 10.1111/j.1600-0609.1971.tb00870.x
    [22] Tunving K (1985) Psychiatric effects of cannabis use. Acta Psychiatr Scand 72: 209-217. doi: 10.1111/j.1600-0447.1985.tb02597.x
    [23] Rang H, Dale M, Ritter J, et al. (2003)  “Book review: Pharmacology” Churchill Livingstone: Edinburgh.
    [24] Govan D (1995) Clinical pathology for medical students. Pathology Illustrate, Glasgow Royal Maternity Hospital U.K. Churchill Livingston: 33-50.
    [25] Moore B, Augustson E, Moser R, et al. (2005) Respiratory effects of marijuana and tobacco use in a U.S. sample. J Gen Intern Med 20: 33-37. doi: 10.1111/j.1525-1497.2004.40081.x
    [26] Rubin E (1998) Pathology. The respiratory System. In: Travis Lippincott-Raven: 621-622. Available from: https://www.amazon.com/Emanuel-Rubin-Essential-Pathology-third/dp/B008WDORG0.
    [27] Isabell H, Hagerup I (1971) Relationship between cigarette smoking and high PCV and Hb levels. Scand J Haematol 8: 241-244.
    [28] Kumar A, Cherian SV, Vassallo R, et al. (2018) Current concepts in pathogenesis, diagnosis, and management of smoking-related interstitial lung diseases. Chest 154: 394-408. doi: 10.1016/j.chest.2017.11.023
    [29] Oseni B, Togun V, Taiwo O (2006) Effect of Marijuana smoking on some hematological parameters of smokers. W J Med Scs 1: 82-85.
    [30] Waterreus A, Di Prinzio P, Watts GF, et al. (2016) Metabolic syndrome in people with a psychotic illness: is cannabis protective? Psychol Med 46: 1651-1662. doi: 10.1017/S0033291715002883
    [31] Levendal R, Schumann D, Donath M, et al. (2012) Cannabis exposure associated with weight reduction and beta-cell protection in an obese rat model. Phytomedicine 19: 575-582. doi: 10.1016/j.phymed.2012.02.001
    [32] Cluny N, Keenan C, Reimer R, et al. (2015) Prevention of diet-induced obesity effects on body weight and gut microbiota in mice treated chronically with Δ9-Tetrahydrocannabinol. PloS One 10: e0144270. doi: 10.1371/journal.pone.0144270
    [33] Hahn L, Galletly C, Foley D, et al. (2014) Inadequate fruit and vegetable intake in people with psychosis. Aust N Z J Psychiatry 48: 1025-1035. doi: 10.1177/0004867414553950
    [34] Yankey B, Strasser S, Okosun I (2016) A cross-sectional analysis of the association between marijuana and cigarette smoking with metabolic syndrome among adults in the United States. Diabetes Metab Syndr 10: S89-S95. doi: 10.1016/j.dsx.2016.03.001
    [35] Borini P, Guimarães R, Borini S (2004) Possible hepatotoxicity of chronic marijuana usage. Sao Paulo Med J 122: 110-116. doi: 10.1590/S1516-31802004000300007
    [36] Mukhta A, Elbagir N, Gubarab A (2011) The effect of cannabis sativa on certain enzymes of clinical significance in rats and men. J Pharmacognosy 1: 10-13.
    [37] Patel S, O'Gorman P (1975) Serum enzyme levels in alcoholism and drug dependency. J Clin Pathol 28: 414-417. doi: 10.1136/jcp.28.5.414
    [38] Hegde V, Hegde S, Cravatt B, et al. (2008) Attenuation of experimental autoimmune hepatitis by exogenous and endogenous cannabinoids: involvement of regulatory T cells. Mol Pharmacol 74: 20-33. doi: 10.1124/mol.108.047035
    [39] Berthélémy S (2015) The renal assessment. Actu pharmac 54: 55-58. (Article in France).
    [40] Kubab N (2009)  Biological Screening Guide , Rueil-Malmaison: Ed. Lamarre, Print.
    [41] Ferner R (2021) Disposition of toxic drugs and chemicals in man. Clin Toxi 59: 603. doi: 10.1080/15563650.2020.1843661
    [42] Lu C, Papatheodorou SI, Danziger J, et al. (2018) Marijuana use and renal function among US adults. Am J Med 131: 408-414. doi: 10.1016/j.amjmed.2017.10.051
  • Reader Comments
  • © 2021 the Author(s), licensee AIMS Press. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0)
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索

Metrics

Article views(6965) PDF downloads(162) Cited by(0)

Article outline

Figures and Tables

Figures(6)  /  Tables(1)

/

DownLoad:  Full-Size Img  PowerPoint
Return
Return

Catalog