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Medical image management and analysis system based on web for fungal keratitis images

  • The medical image management and analysis system proposed in this paper is a medical software developed by the Browser/Server (B/S) architecture after investigating the workflow of the relevant departments of the hospital, which realizes the entire process of patients from consultation to printing of reports. The computer-aided diagnosis function is added based on image management. Due to the difficulty in collecting medical image data, in the computer-aided diagnosis module, this paper only uses the common fungal keratitis collected from the hospital in the laboratory. Focused microscope images are used for experiments. First, the images were trained with three convolutional neural networks, AlexNet, ZFNet, and VGG16. These models which classify fungal keratitis were obtained and integrated was performed to obtain better classification results. Finally, the model was integrated with the system designed in this paper, which realized the automatic diagnosis of Confocal Microscopy (CM) images of fungal keratitis online and provided it to medical staff for reference. The system can improve the work efficiency of the image-related departments while reducing the workload of doctors in the department to manually read the films.

    Citation: Haixia Hou, Yankun Cao, Xiaoxiao Cui, Zhi Liu, Hongji Xu, Cheng Wang, Wensheng Zhang, Yang Zhang, Yadong Fang, Yu Geng, Wei Liang, Tie Cai, Hong Lai. Medical image management and analysis system based on web for fungal keratitis images[J]. Mathematical Biosciences and Engineering, 2021, 18(4): 3667-3679. doi: 10.3934/mbe.2021183

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  • The medical image management and analysis system proposed in this paper is a medical software developed by the Browser/Server (B/S) architecture after investigating the workflow of the relevant departments of the hospital, which realizes the entire process of patients from consultation to printing of reports. The computer-aided diagnosis function is added based on image management. Due to the difficulty in collecting medical image data, in the computer-aided diagnosis module, this paper only uses the common fungal keratitis collected from the hospital in the laboratory. Focused microscope images are used for experiments. First, the images were trained with three convolutional neural networks, AlexNet, ZFNet, and VGG16. These models which classify fungal keratitis were obtained and integrated was performed to obtain better classification results. Finally, the model was integrated with the system designed in this paper, which realized the automatic diagnosis of Confocal Microscopy (CM) images of fungal keratitis online and provided it to medical staff for reference. The system can improve the work efficiency of the image-related departments while reducing the workload of doctors in the department to manually read the films.



    With the fast development of computer technology, medical imaging technology has been continuously improved, and the corresponding medical imaging equipment has been gradually updated [1]. These technologies and equipment have provided great help for the diagnosis and treatment of diseases. The number of medical images generated by the hospital is extremely large. How to manage it is also an important task. At the same time, all these medical images require doctors to diagnose [2]. For diagnosis, doctors in the imaging department are extremely scarce compared to this fast-growing huge imaging data. Doctors may miss some diseases due to fatigue or lack of experience [3]. At present, medical image management systems at home and abroad are rarely combined with computer-aided diagnosis systems. These two systems are independent, which reduces the work efficiency of the hospital.

    Fungal keratitis is a disease of the ophthalmology, which is caused by trauma to the patient's eye and infection by external bacteria [4,5]. If not treated in time, it may lead to permanent blindness in the patient, and the blindness rate is second only to cataract. Only early diagnosis can better take treatment to reduce the rate of blindness [6,7]. There are many ways to check for fungal keratitis [8,9]. Traditional auxiliary tests include a smear on the cornea and a smear test and culture method under the microscope. Confocal Microscopy (CM) is a biopsy technique that can perform a live cornea. A non-invasive rapid test is a powerful tool for the diagnosis of fungal keratitis [9]. As shown in Figure 1, the corneal images taken by CM (model: Heidelberg HRT-3) are divided into normal and fungal keratitis groups. It is observed that the normal group has a clear background and fungal keratitis group. The background is messy, with hyphae or spores visible.

    Figure 1.  The corneal images were taken by confocal microscopy. a. Normal corneal confocal microscopy image. b. Corneal confocal microscopy image of fungal keratitis.

    Now more and more classification methods are used to classify medical diseases [10,11]. The medical image management and analysis system designed in this paper not only meets the management needs of hospital image data but also realizes the automatic diagnosis of confocal microscope images of fungal keratitis. This paper proposes a web-based medical image management and analysis system. Taking the image of fungal keratitis as an example, this article first selects the AlexNet [12], ZFNet [13], VGG16 [14] network as the classification network for classification, and then selects the optimal classification model. Based on the optimal classification model, this paper designs a web-based medical image management and analysis system. Through this system, medical user information can be systematically managed and intelligent diagnosis can be performed, thereby greatly improving the efficiency of doctors' diagnosis and treatment.

    The rest of the paper is organized as follows: Section 2 introduces the basic structure of the system, Section 3 introduces the design of the system, and finally, Section 4 summarizes the paper and points out the possible work in the future.

    To implement the system, the system needs to implement the process shown in Figure 2. The main users of the system are medical staff and back-office management personnel. An analysis of these two roles shows that the user use case diagram of the system is shown in Figure 3. The functions of medical staff will meet the whole process of patients from visiting a doctor to printing graphic reports. The functions of background management staff make sure that the system runs stably.

    Figure 2.  System work flow chart.
    Figure 3.  Schematic diagram of system user instructions.

    The requirements analysis can be used to obtain which function the system needs to implement, so the functional requirements can be divided into functional modules. For medical staff, there are mainly patient appointment registration module, patient examination registration module, report module, computer-aided diagnosis module; for back-office management personnel, there are mainly user management module, department management module, imaging equipment management module, Log management module. The system functional architecture diagram is shown in Figure 4.

    Figure 4.  System functional structure diagram.

    The medical image management and analysis system based on the B/S model adopts a layered design idea. The system is developed by the MVC architecture [15]. Figure 5 is the overall architecture diagram of the system, which is mainly divided into user layer, application layer, and data layer. The role of the user layer of this system is divided into background management personnel and medical staff. The application layer is the logical processing part. The main business is appointment registration, inspection registration, report, computer-aided diagnosis, and system management. In computer-aided diagnosis, the Keras deep learning platform interface is called and the diagnosis result is returned. Permission control and logging ensure the stable operation of the application layer and provide a certain guarantee for the system. The database provides data support for the above services, including the locations of the forms and images stored in the logical application layer. The front end of this system is developed using a combination of LayUI and JavaScript, and the back end is developed using the currently popular combination of SpringBoot [16] + MybatisPlus [17] + Mysql [18].

    Figure 5.  Overall system architecture diagram.

    Design of data model. We elaborated on the system requirements analysis and the overall technical architecture of the system, and we need to design the data model before our formal development. As a method of data model design, the Entity-Relationship Diagram (E-R) Diagram can help us to view the data model more intuitively. The E-R diagram of this system is shown in Figure 6.

    Figure 6.  The E-R diagram of this system.

    Design of database. According to the E-R diagram of the system, we designed the database table and its table structure fields. The following table lists the main tables of the system.

    The user information table (user_info). The user information table (Table 1) records the personal information of all users who can use the system, including administrators and medical staff. The differences between them are caused by different roles. At the same time, it also records the password and account when the user logs in. The password is encrypted with the MD5 algorithm to prevent the account from being stolen.

    Table 1.  The user information table.
    Field name Date type Length IS NULL Comment
    user_id bigint 20 N Primary key
    username varchar 45 N Login name
    password varchar 45 N Login password
    name varchar 45 Y Actual name
    birthday datetime 0 Y Date of birth
    sex varchar 2 Y Sex
    email varchar 45 N Email
    phone varchar 45 Y Phone
    role_id varchar 255 N Role
    dept_id varchar 255 N Department
    status varchar 45 N Status, available by default
    create_time datetime 0 Y Create time
    create_user varchar 255 Y Create user
    update_user varchar 255 Y Update user
    update_time datetime 0 Y Update time

     | Show Table
    DownLoad: CSV

    The department information table (dept_info). The department information table (Table 2) records the information of different departments in the hospital, including name and introduction.

    Table 2.  The department information table.
    Field name Date type Length IS NULL Comment
    dept_id bigint 20 N Primary key
    name varchar 45 N Name
    description varchar 255 Y Description
    create_time datetime 0 Y Create time
    create_user varchar 255 Y Create user
    update_user varchar 255 Y Update user
    update_time datetime 0 Y Update time

     | Show Table
    DownLoad: CSV

    The appointment registration table (preregis_patient). The appointment registration table (Table 3) records the information of the appointment examination before the patient enters the examination, including the basic personal information of the patient and the information that needs the appointment examination.

    Table 3.  The appointment registration table.
    Field name Date type Length IS NULL Comment
    id bigint 20 N Appointment registration number
    id_card varchar 255 Y Patient ID card number
    name varchar 10 Y Patient name
    age int 10 Y Patient age
    sex varchar 2 Y Patient sex
    phone varchar 255 Y Patient phone
    status int 2 Y Patient sign-in status
    plan_positon varchar 255 Y Site for appointment
    plan_type varchar 255 Y Appointment check type
    plan_time datetime 0 Y Schedule an appointment
    plan_office bigint 255 N Foreign key, department's id
    comment varchar 255 Y Comment
    create_time datetime 0 Y Create time
    create_user varchar 255 Y Create user
    update_user varchar 255 Y Update user
    update_time datetime 0 Y Update time

     | Show Table
    DownLoad: CSV

    The examination registration table (check_record). The examination registration table (Table 4) records the relevant information of the patients who come to the corresponding department for examination after the appointment of examination. In addition, it also includes the report ID and image path. The examination registration and the report are one-to-one, and there is only one report corresponding to it.

    Table 4.  The examination registration table.
    Field name Date type Length IS NULL Comment
    id bigint 20 N Primary key
    patient_id bigint 2 N Appointment registration number
    check_type varchar 255 Y Type of inspection
    check_positon varchar 255 Y Examined area
    check_dep bigint 20 N Foreign key, department's id
    picture_url varchar 255 Y Image path
    report_id bigint 20 N Foreign key, report's id
    status int 2 Y Status
    create_time datetime 0 Y Create time
    create_user varchar 255 Y Create user
    update_user varchar 255 Y Update user
    update_time datetime 0 Y Update time

     | Show Table
    DownLoad: CSV

    The report table (diagnose_report). The report table (Table 5) records the doctor's description and diagnosis results of the image diagnosis, and one report corresponds to one examination record.

    Table 5.  The report table.
    Field name Date type Length IS NULL Comment
    id bigint 20 N Primary key
    doctor_id bigint 20 Y Doctor's id
    pic_expression varchar 255 Y Image representation
    diagnose_advice varchar 255 Y Diagnose result
    diagnose_time datetime 0 Y Diagnose time

     | Show Table
    DownLoad: CSV

    The fungal keratitis diagnosis record table (fungal_keratitis_diagnose). The fungal keratitis diagnosis record table (Table 6) records the relevant information of the diagnosis result obtained by the doctor calling the system to realize a good deep learning network, and records the diagnosis record every time the diagnosis is called.

    Table 6.  The fungal keratitis diagnosis record table.
    Field name Date type Length IS NULL Comment
    id bigint 20 N Primary key
    patient_id bigint 20 Y Appointment registration number
    picture_url varchar 255 Y Image path
    result varchar 255 Y Diagnose result
    diagnose_time datetime 0 Y Diagnose time
    diagnose_user bigint 20 N Doctor's id

     | Show Table
    DownLoad: CSV

    The images are divided into the normal group and the fungal keratitis patient group. The example diagrams are shown in Figure 1. A total of 1870 images, including 876 in the normal group and 994 in the fungal keratitis group. In order to increase the generalization ability of the model, this data set is divided according to the ratio of the training set: test set to 7:3. The specific sample distribution is shown in Table 7. In all subsequent experiments in this paper, if it is not re-declared, it means that the proportion is used for the experiment during the training.

    Table 7.  Data set distribution.
    Dataset Training set Test set Total
    Fungal keratitis 696 298 994
    Normal 614 262 876
    Total 1310 560 1870

     | Show Table
    DownLoad: CSV

    AlexNet, VGG16, and ZFNet are used in this experiment. The initial learning rate is set to 0.0001. The optimizer is trained by Adam to monitor the accuracy on the valid set, which is randomly selected from the training set during each training., the ratio of the training set: valid set to 5:1. If the accuracy on the valid set does not increase, the training ends when the iteration achieves 50, and the model with the highest accuracy is saved separately. Finally, the test set is put into the saved model for testing, and these models are compared using several evaluation indicators of accuracy, sensitivity, specificity, and Area Under Curve (AUC). These three networks have obtained very good results during the training process. The evaluation indicators of each network are shown in Table 8, and their ROC curves are shown in Figure 7.

    Table 8.  Performance comparison table of each network.
    Model Accuracy Sensitivity Specificity AUC
    AlexNet 0.9875 0.9933 0.9810 0.9954
    ZFNet 0.9911 0.9866 0.9962 0.9996
    VGG16 0.9929 0.9933 0.9924 0.9997

     | Show Table
    DownLoad: CSV
    Figure 7.  ROC curve and AUC value of each network model.

    It can be seen in Table 8 that in the data classification of this experiment, each index of VGG16 is relatively good, with the highest accuracy, sensitivity and AUC, followed by the relatively low specificity, next to ZFNet. From AUC value synthesis, the best performance of the experimental results is VGG16, followed by ZFNet, and finally AlexNet.

    In this paper, based on the three basic learners, two integrated methods are adopted: the relative majority voting method and the weighted average method:

    (a) The relative majority voting method.

    The output result is the category with the highest number of votes. If there is a category with the same number of votes, select one randomly for output.

    (b) The weighted-average method.

    Suppose n base classifiers have been obtained {h1,h2,L,hn}, Each classifier has a weight w. Therefore, the output y of the integrated model can be obtained by the weighted average value of the classification results of each base classifier. The formula is as follows:

    y=i=1nwihi(x) (3.1)

    where wi is the weight of the hi.

    wi=di=1nd (3.2)

    The value of d is set according to the accuracy ranking of each base classifier on the test set, the lowest setting is 1, the highest setting is n, and the sum of the weights of each base classifier is 1.

    The three models (AlexNet, ZFNet, VGG16) obtained before are integrated by the above two methods. The experimental results are shown in Table 9.

    Table 9.  Experimental results of integrated models.
    Method Accuracy Sensitivity Specificity
    The relative majority voting method 0.9946 0.9933 0.9962
    The weighted average method 0.9964 0.9966 0.9962

     | Show Table
    DownLoad: CSV

    The experimental results show that, compared with the single convolutional neural network, the performance of both the relative majority voting method and the weighted average method is improved, and the weighted average method outperforms, which is 0.3% higher than the VGG16 with the highest accuracy in Table 8, and other indicators are improved. Therefore, the integration method of multi convolution neural network in this paper is effective.

    Inspection registration module. Input the appointment registration number and relevant inspection information generated after the appointment into the form, and finally upload the inspection image to the system, so that the doctor reading the film can view the image for diagnosis. All inspection registration information will be stored in the database, which can be queried in the inspection registration list. In the examination registration list, the doctor can query the specific information of a patient and can read the film for diagnosis. On the diagnosis page, the doctor can enlarge and rotate the selected key area of the patient's image, and finally, get the image performance information of the image and the diagnosis result saved in the system. After diagnosis, the diagnosis result is saved in the system and a diagnosis report is generated for medical staff to print. The report is shown as Figure 8.

    Figure 8.  Print page of the report.

    Intelligent diagnosis module for fungal keratitis. Based on the previous section, the deep learning method has been used to diagnose and classify the CM images of fungal keratitis. A good model has been obtained, so the intelligent diagnosis module of fungal keratitis has been developed in the computer-assisted diagnosis module. The doctor uploads the patient's examination image to the system, and it can return the output of the model, that is, normal or abnormal. It can help the doctor to provide reference value in the manual diagnosis of inspection registration. At the same time, all the results diagnosed by the model are recorded in the intelligent diagnosis record of fungal keratitis, as shown in Figure 9.

    Figure 9.  Fungal keratitis diagnosis record page.

    In this paper, a web-based medical image management and analysis system is designed and implemented to improve the hospital's work efficiency and help to manage medical images. At the same time, deep learning technology can be used to automatically diagnose confocal microscope images of fungal keratitis online. The implemented medical image management and analysis system can run stably after testing, but there is still room for expansion. The computer-aided diagnosis module of the system can only automatically diagnose confocal microscopy images of fungal keratitis online at present because there are not many types of medical image data. When the system is officially used, with the gradual increase of users, the system will become more and more perfect. This is because this system has a self-learning function. When different pathological images are used in this system, the system will store these images and use them in the deep learning training process.

    This work was supported in part by the NSFC No.91846205, the Key Research and Development Plan of Shandong Province under Grant 2017CXGC1503 and Grant 2018GSF118228, the Major Fundamental Research of Natural Science Foundation of Shandong Province under Grant ZR2019ZD05, the Intelligent perception and computing innovation platform of the Shenzhen Institute of Information Technology (No. SZIIT2019KJ021) and the Intelligent perception and computing innovation platform of the Shenzhen Institute of Information Technology (No. SZIIT2019KJ021).

    No potential conflict of interest was reported by the authors.



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