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Research article Topical Sections

Assessment of behavioural problems in preschool and school going children with epilepsy

  • Introduction 

    Children with epilepsy are at greater risk of developing psychiatric and behavioural disorders such as attention deficit/hyperactivity disorder (ADHD), conduct disorder, autism spectrum disorder (ASD), as well as affective and aggressive disorders than normal children which may affect the well- being and quality of life of the child.

    Aim and Objectives 

    This study aims at identifying behavioural problems in children with epilepsy enabling early diagnosis and intervention. The objectives were to assess the presence and type of behavioural problems in children with epilepsy.

    Methods 

    A prospective cross-sectional study was conducted on children who were diagnosed as epilepsy in two age groups of 1.5–5 years and 6–18 years recruited by non-probability convenience sampling. Data regarding seizure semiology, clinical features and treatment were obtained. Children underwent IQ assessment, electroencephalogram and brain neuroimaging. Child Behaviour Check List (CBCL) was administered to parents or primary caregivers after obtaining informed consent. Results were analyzed for presence of behavioural problems using SPSS-23.

    Results 

    In the study, out of 50 study subjects, 72% were between 6–18 years. 60% children had generalised seizures, 58% children had epilepsy for <2 years and abnormal EEG was present in 80% children. 6% children had behavioural problems and 4% had borderline presentations. Co-relation of behavioural problems with age was statistically significant with p value 0.027. Behavioural problems identified were aggressiveness and anxiety.

    Conclusion 

    Childhood epilepsy is associated with behavioural problems along with other co-morbidities warranting a search during follow-up visits.

    Take-home message 

    Early identification and treatment of behavioural problems in children with epilepsy by periodic assessment during follow up visits, careful selection of combination of drugs and appropriate dose can improve the overall outcome in children taking antiepileptic drugs (AEDs) for epilepsy.

    Citation: Harshitha Shanmuganathan, Radha Kumar, D.V. Lal, Chaudhary Devanand Gulab, E. Gayathri, Kesavaraj Pallavi Raja. Assessment of behavioural problems in preschool and school going children with epilepsy[J]. AIMS Neuroscience, 2022, 9(2): 277-287. doi: 10.3934/Neuroscience.2022015

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  • Introduction 

    Children with epilepsy are at greater risk of developing psychiatric and behavioural disorders such as attention deficit/hyperactivity disorder (ADHD), conduct disorder, autism spectrum disorder (ASD), as well as affective and aggressive disorders than normal children which may affect the well- being and quality of life of the child.

    Aim and Objectives 

    This study aims at identifying behavioural problems in children with epilepsy enabling early diagnosis and intervention. The objectives were to assess the presence and type of behavioural problems in children with epilepsy.

    Methods 

    A prospective cross-sectional study was conducted on children who were diagnosed as epilepsy in two age groups of 1.5–5 years and 6–18 years recruited by non-probability convenience sampling. Data regarding seizure semiology, clinical features and treatment were obtained. Children underwent IQ assessment, electroencephalogram and brain neuroimaging. Child Behaviour Check List (CBCL) was administered to parents or primary caregivers after obtaining informed consent. Results were analyzed for presence of behavioural problems using SPSS-23.

    Results 

    In the study, out of 50 study subjects, 72% were between 6–18 years. 60% children had generalised seizures, 58% children had epilepsy for <2 years and abnormal EEG was present in 80% children. 6% children had behavioural problems and 4% had borderline presentations. Co-relation of behavioural problems with age was statistically significant with p value 0.027. Behavioural problems identified were aggressiveness and anxiety.

    Conclusion 

    Childhood epilepsy is associated with behavioural problems along with other co-morbidities warranting a search during follow-up visits.

    Take-home message 

    Early identification and treatment of behavioural problems in children with epilepsy by periodic assessment during follow up visits, careful selection of combination of drugs and appropriate dose can improve the overall outcome in children taking antiepileptic drugs (AEDs) for epilepsy.



    Reidemeister torsion is a topological invariant and was introduced by Reidemeister in 1935. Up to PL equivalence, he classified the lens spaces S3/Γ, where Γ is a finite cyclic group of fixed point free orthogonal transformations [20]. In [11], Franz extended the Reidemeister torsion and classified the higher dimensional lens spaces S2n+1/Γ, where Γ is a cyclic group acting freely and isometrically on the sphere S2n+1.

    In 1964, the results of Reidemeister and Franz were extended by de Rham to spaces of constant curvature +1 [10]. Kirby and Siebenmann proved the topological invariance of the Reidemeister torsion for manifolds in 1969 [14]. Chapman proved for arbitrary simplicial complexes [7,8]. Hence, the classification of lens spaces of Reidemeister and Franz was actually topological (i.e., up to homeomorphism).

    Using the Reidemeister torsion, Milnor disproved Hauptvermutung in 1961. He constructed two homeomorphic but combinatorially distinct finite simplicial complexes. He identified in 1962 the Reidemeister torsion with Alexander polynomial which plays an important role in knot theory and links [16,18].

    In [21], Sözen explained the claim mentioned in [27,p. 187] about the relation between a symplectic chain complex with ωcompatible bases and the Reidemeister torsion of it. Moreover, he applied the main theorem to the chain-complex

    0C2(Σg;Adϱ)2idC1(Σg;Adϱ)1idC0(Σg;Adϱ)0,

    where Σg is a compact Riemann surface of genus g>1, where is the usual boundary operator, and where ϱ:π1(Σg)PSL2(R) is a discrete and faithful representation of the fundamental group π1(Σg) of Σg [21]. Now we will give his description of Reidemesister torsion and explain why it is not unique by a result of Milnor in [17].

    Let Hp(C)=Zp(C)/Bp(C) denote the homologies of the chain complex (C,)=(CnnCn1C11C00) of finite dimensional vector spaces over field C or R, where Bp=Im{p+1:Cp+1Cp}, Zp=ker{p:CpCp1}, respectively.

    Consider the short-exact sequences:

    0ZpCpBp10 (1.1)
    0BpZpHp0, (1.2)

    where (1.1) is a result of 1st-Isomorphism Theorem and (1.2) follows simply from the definition of Hp. Note that if bp is a basis for Bp, hp is a basis for Hp, and p:HpZp and sp:Bp1Cp are sections, then we obtain a basis for Cp. Namely, bpp(hp)sp(bp1).

    If, for p=0,,n, cp, bp, and hp are bases for Cp, Bp and Hp, respectively, then the alternating product

    Tor(C,{cp}np=0,{hp}np=0)=np=0[bpp(hp)sp(bp1),cp](1)(p+1) (1.3)

    is called the Reidemeister torsion of the complex C with respect to bases {cp}np=0, {hp}np=0, where [bpp(hp)sp(bp1),cp] denotes the determinant of the change-base matrix from cp to bpp(hp)sp(bp1).

    Milnor [17] proved that torsion does not depend on neither the bases bp, nor the sections sp,p. Moreover, if cp,hp are other bases respectively for Cp and Hp, then there is the change-base-formula:

    Tor(C,{cp}np=0,{hp}np=0)=np=0([cp,cp][hp,hp])(1)pTor(C,{cp}np=0,{hp}np=0). (1.4)

    Let M be a smooth nmanifold, K be a cell-decomposition of M with for each p=0,,n, cp={ep1,,epmp}, called the geometric basis for the pcells Cp(K;Z). Hence, we have the chain-complex associated to M

    0Cn(K)nCn1(K)C1(K)1C0(K)0, (1.5)

    where p denotes the boundary operator. Then Tor(C(K),{cp}np=0,{hp}np=0) is called the Reidemeister torsion of M, where hp is a basis for Hp(K).

    In [23], oriented closed connected 2mmanifolds (m1) are considered and he proved the following formula for computing the Reidemeister torsion of them. Namely,

    Theorem 1.1. Let M be an oriented closed connected 2mmanifold (m1). For p=0,,2m, let hp be a basis of Hp(M). Then the Reidemeister torsion of M satisfies the following formula:

    |T(M,{hp}2m0)|=m1p=0|detHp,2mp(M)|(1)p|detHm,m(M)|(1)m,

    where detHp,2mp(M) is the determinant of the matrix of the intersection pairing (,)p,2mp:Hp(M)×H2mp(M) R in bases hp,h2mp.

    It is well known that Riemann surfaces and Grasmannians have many applications in a wide range of mathematics such as topology, differential geometry, algebraic geometry, symplectic geometry, and theoretical physics (see [2,3,5,6,12,13,22,24,25,26] and the references therein). They also applied Theorem 1.1 to Riemann surfaces and Grasmannians.

    In this work we calculate Reidemeister torsion of compact flag manifold K/T for K=SUn+1, where K is a compact simply connected semi-simple Lie group and T is maximal torus [28].

    The content of the paper is as follows. In Section 2 we give all details of cup product formula in the cohomology ring of flag manifolds which is called Schubert calculus [15,19]. In the last section we calculate the Reidemesiter torsion of flag manifold SUn+1/T for n3.

    The results of this paper were obtained during M.Sc studies of Habib Basbaydar at Abant Izzet Baysal University and are also contained in his thesis [1].

    Now, we will give the important formula equivalent to the cup product formula in the cohomology of G/B where G is a Kač-Moody group. The fundamental references for this section are [15,19]. To do this we will give a relation between the complex nil Hecke ring and H(K/T,C). Also we introduce a multiplication formula and the actions of reflections and Berstein-Gelfand-Gelfand type BGG operators Ai on the basis elements in the nil Hecke ring.

    Proposition 2.1.

    ξuξv=u,vwpwu,vξw,

    where pwu,v is a homogeneous polynomial of degree (u)+(v)(w).

    Proposition 2.2.

    riξw={ξwif riw>w,(w1αi)ξriw+ξwriwγwαi(γ)ξwotherwise.

    Theorem 2.3. Let u,vW. We write w1=ri1rin as a reduced expression.

    pwu,v=j1<<jmrj1rjm=v1Ai1ˆAij1ˆAijmAin(ξu)(e)

    where m=(v) and the notation ˆAi means that the operator Ai is replaced by the Weyl group action ri.

    Let C0=S/S+ be the S-module where S+ is the augmentation ideal of S. It is 1-dimensional as C-vector space. Since Λ is a S-module, we can define C0SΛ. It is an algebra and the action of R on Λ gives an action of R on C0SΛ. The elements σw=1ξwC0SΛ is a C-basis form of C0SΛ.

    Proposition 2.4. C0SΛ is a graded algebra associated with the filtration of length of the element of the Weyl group W.

    Proposition 2.5. The complex linear map f:C0SΛGrC{W} is a graded algebra homomorphism.

    Theorem 2.6. Let K be the standard real form of the group G associated to a symmetrizable Kač-Moody Lie algebra g and let T denote the maximal torus of K. Then the map

    θ:H(K/T,C)C0SΛ

    defined by θ(εw)=σw for any wW is a graded algebra isomorphism. Moreover, the action of wW and Aw on H(K/T,C) corresponds respectively to that δw and xwR on C0SΛ.

    Corollary 2.7. The operators Ai on H(K/T,C) generate the nil-Hecke algebra.

    Corollary 2.8. We can use Proposition 2.1 and Theorem 2.3 to determine the cup product εuεv in terms of the Schubert basis {εw}wW of H(K/T,Z).

    This section includes our calculations about Reidemeister torsion of flag manifolds using Theorem 1.1 and Proposition 2.1 because χ(SUn+1/T)=|W|=n! is always an even number.

    We know that the Weyl group W of K acts on the Lie algebra of the maximal torus T. lt is a finite group of isometries of the Lie algebra t of the maximal torus T. lt preserves the coweight lattice Tv. For each simple root α, the Weyl group W contains an element rα of order two represented by e((π/2)(eα+eα)) in N(T). Since the roots α can be considered as the linear functionals on the Lie algebra t of the maximal torus T, the action of rα on t is given by

    rα(ξ)=ξα(ξ)hαforξt,

    where hα is the coroot in t corresponding to simple root α.Also, we can give the action of rα on the roots by

    rα(β)=βα(hβ)αforα,βt,

    where t is the dual vector space of t. The element rα is the reflection in the hyperplane Hα of t whose equation is α(ξ)=0. These reflections rα generate the Weyl group W.

    Set α1,α2,,αn be roots of Weyl Group of SUn+1. Since the Cartan Matrix of Weyl Group of SUn+1 is

    Mij={2i=j1|ij|=10otherwise,

    rαi(αj)={αi,i=jαi+αj,|ij|=1αj,otherwise.

    Proposition 3.1. The Weyl group W of SUn+1 is isomorphic to Coxeter Group An given by generators s1,s2,,sn and relations

    (i) s2i=1i=1,2,,n;

    (ii) sisi+1si=si+1sisi+1i=1,2,,n1;

    (iii) sisj=sjsi1i<j1<n.

    Proof. (i)

    rαirαi(β)=rαi(β<αi,β>αi)=β<αi,β>αi<β<αi,β>αi,αi>αi=β<αi,β>αi<β,αi>αi+<αi,β><αi,αi>αi=β<αi,β>αi<αi,β>αi+2<αi,β>αi=β.

    (ii)

    rαirαi+1rαi(β)=rαirαi+1(β<αi,β>αi)=rαi(β<αi,β>αi<αi+1,β<αi,β>αi>αi+1)=rαi(β<αi,β>αi<αi+1,β>αi+1+<αi+1,<αi,β>αi>αi+1)=rαi(β<αi,β>αi<αi+1,β>αi+1+<αi,β><αi+1,αi>αi+1)=rαi(β<αi,β>αi<αi+1,β>αi+1<αi,β>αi+1)=β<αi,β>αi<αi+1,β>αi+1<αi,β>αi+1<αi,β<αi,β>αi<αi+1,β>αi+1<αi,β>αi+1>αi=β<αi,β>αi<αi+1,β>αi+1<αi,β>αi+1<αi,β>αi+<αi,β><αi,αi>αi+<αi+1,β><αi+1,αi>αi+<αi,β><αi+1,αi>αi=β<αi,β>αi<αi+1,β>αi+1<αi,β>αi+1<αi,β>αi+2<αi,β>αi<αi+1,β>αi<αi,β>αi=β<αi,β>αi<αi+1,β>αi<αi+1,β>αi+1<αi,β>αi+1=β(<αi,β>+<αi+1,β>)(αi+αi+1).
    rαi+1rαirαi+1(β)=rαi+1rαi(β<αi+1,β>αi+1)=rαi+1(β<αi+1,β>αi+1<αi,β<αi+1,β>αi+1>αi)=rαi+1(β<αi+1,β>αi+1<αi,β>αi+<αi+1,β><αi,αi+1>αi)=rαi+1(β<αi+1,β>αi+1<αi,β>αi<αi+1,β>αi)=β<αi+1,β>αi+1<αi,β>αi<αi+1,β>αi<αi+1,β<αi+1,β>αi+1<αi,β>αi<αi+1,β>αi>αi+1=β<αi+1,β>αi+1<αi+1,β>αi<αi,β>αi<αi+1,β>αi+1+<αi,β><αi+1,αi>αi+1+<αi+1,β><αi+1,αi>αi+1+<αi+1,β><αi+1,αi+1>αi+1=β<αi+1,β>αi+1<αi,β>αi<αi+1,β>αi<αi+1,β>αi+1+2<αi+1,β>αi+1<αi,β>αi+1<αi+1,β>αi+1=β<αi+1,β>αi+1<αi,β>αi<αi+1,β>αi<αi,β>αi+1=β(<αi+1,β>+<αi,β>)(αi+1+αi).

    Hence rαi+1rαirαi+1(β)=rαi+1rαirαi+1(β).

    (iii)

    rαirαj(β)=rαi(β<αj,β>αj)=β<αj,β>αj<αi,β<αj,β>αj>αi=β<αj,β>αj<αi,β>αi+<αj,β><αi,αj>αi=β<αj,β>αj<αi,β>αi.
    rαjrαi(β)=rαj(β<αi,β>αi)=β<αi,β>αi<αj,β<αi,β>αi>αj=β<αi,β>αi<αj,β>αj+<αi,β><αj,αi>αj=β<αi,β>αi<αj,β>αj.

    Hence rαirαj(β)=rαjrαi(β).

    After this point si will represent rαi.

    Let us define the word

    si,j={sisi+1sji<jsii=j1i>j.

    Theorem 3.2. [4,Theorem 3.1] The reduced Gröbner-Shirshov basis of the coxeter group An consists of relation

    si,jsi=si+jsi,j1i<jn

    together with defining relations of An.

    The following lemma is equivalent of [4,Lemma 3.2]. The only difference is the order of generators s1>s2>sn in our setting.

    Lemma 3.3. Using elimination of leading words of relations, the reduced elements of An are in the form

    sn+1,jn+1sn,jnsn1,jn1si,jis1,j1 1iji+1n+1.

    Notice that jn+1+1=n+1jn+1=n and sn+1,n=1.

    Algorithm 3.1. (Finding Inverse) Let w=sn,jnsn1,jn1s1,j1. The inverse of w can be found using following algorithm.

    Invw={};

    Conw=Reverse(w);

    For k=1 to k=n

    Find maximum sequence in Conw;

    list={sk,sk+1,sk+2,,sk+j};

    Invw=listInvw;

    End For.

    Example 3.4. Let s4,6s3,5s2,5s1,3. The inverse of its is S3s2s1s5s4s3s2s5s4s3s6s5s4.

    Invw=s1,4

    S3s2s5s4s3s5s4s6s5

    Invw=s2,5s1,4

    S3s5s4s5s6

    Invw=s3,5s2,5s1,4

    s5s6

    Invw=s5,6s3,5s2,5s1,4.

    Lemma 3.5. Let w=(sn,jn)(sn1,jn1)(si+1,ji+1)(si,ji)(s1,j1) and

    siw = (sn,¯jn)(sn1,¯jn1)(si+1,¯ji+1)(si,¯ji)(s1,¯j1), where

    siw={¯ji+1=ji+1,¯ji=ji+1ifji<ji+1¯ji+1=ji,¯ji=ji+11ifjiji+1¯jk=jkifki,i+1

    Here if i=n, then we assume jn+1=n.

    Corollary 3.6. Let w=(sn,jn)(sn1,jn1)(si+1,ji+1)(si,ji)(s1,j1) and

    si1(siw) = (sn,^jn)(sn1,^jn1)(si+1,^ji+1)(si,^ji)(s1,^j1), where

    si1(siw)={^ji+1=ji+1,^ji=ji1+1,^ji1=ji+1ifji<ji+1,ji1<ji+1^ji+1=ji+1,^ji=ji1,^ji1=ji+11ifji<ji+1,ji1ji+1^ji+1=ji,^ji=ji1+1,^ji1=ji+11ifjiji+1,ji1<ji+11^ji+1=ji,^ji=ji1,^ji1=ji+12ifjiji+1,ji1ji+11^jk=jkifki1,i,i+1.

    Proof. Let ¯w=siw=(sn,¯jn)(sn1,¯jn1)(si+1,¯ji+1)(si,¯ji)(s1,¯j1). Then

    si1(¯w)={^ji=¯ji1+1,^ji1=¯jiif¯ji1<¯ji^ji=¯ji1,^ji1=¯ji1if¯ji1¯ji^jk=¯jkifki1,i.

    (i) ji<ji+1 ¯ji+1=ji+1, ¯ji=ji+1 So ¯ji1<¯ji ji1<ji+1, ^ji+1=¯ji+1=ji+1, ^ji=¯ji1+1=ji1+1, ^ji1=¯ji=ji+1.

    (ii) ji<ji+1 ¯ji+1=ji+1, ¯ji=ji+1 So ¯ji1¯ji ji1ji+1, ^ji+1=¯ji+1=ji+1, ^ji=¯ji1=ji1, ^ji1=¯ji1=ji+11.

    (iii) jiji+1 ¯ji+1=ji, ¯ji=ji+11 So ¯ji1<¯ji ji1<ji+1, ^ji+1=¯ji+1=ji+1, ^ji=¯ji1=ji1, ^ji1=¯ji1=ji+11.

    (iv) jiji+1 ¯ji+1=ji, ¯ji=ji+11 So ¯ji1¯ji ji1ji+11, ^ji+1=¯ji+1=ji, ^ji=¯ji1=ji1, ^ji1=¯ji1=ji+12.

    Corollary 3.7. Let w=(sn,jn)(sn1,jn1)(si+1,ji+1)(si,ji)(s1,j1) and

    si+1(siw) = (sn,^jn)(sn1,^jn1)(si+1,^ji+1)(si,^ji)(s1,^j1). Then

    si+1(siw)={^ji+2=ji+2,^ji+1=ji+2,^ji=ji+1ifji<ji+1,ji+1<ji+2^ji+2=ji+1,^ji+1=ji+21,^ji=ji+1ifji<ji+1,ji+1ji+2^ji+2=ji+1,^ji+1=ji+2,^ji=ji+11ifjiji+1,ji<ji+2^ji+2=ji,^ji+1=ji+21,^ji=ji+11ifjiji+1,jiji+2^jk=jkifki,i+1,i+2.

    Proof. Let ¯w=siw=(sn,¯jn)(sn1,¯jn1)(si+1,¯ji+1)(si,¯ji)(s1,¯j1). Then

    si+1(¯w)={^ji+2=¯ji+1+1,^ji+1=¯ji+2if¯ji+1<¯ji+2^ji+2=¯ji+1,^ji+1=¯ji+21if¯ji+1¯ji+2^jk=¯jkifki+1,i+2.

    (i) ji<ji+1 ¯ji+1=ji+1, ¯ji=ji+1 So ¯ji+1<¯ji+2 ji+1<ji+2, ^ji+2=¯ji+1+1=ji+2, ^ji+1=¯ji+2=ji+2, ^ji=¯ji=ji+1.

    (ii) ji<ji+1 ¯ji+1=ji+1, ¯ji=ji+1 So ¯ji+1¯ji+2 ji+1ji+2, ^ji+2=¯ji+1=ji+1, ^ji+1=¯ji+21=ji+21, ^ji=¯ji=ji+1.

    (iii) jiji+1 ¯ji+1=ji, ¯ji=ji+11 So ¯ji+1<¯ji+2 ji<ji+2, ^ji+2=¯ji+1+1=ji+1, ^ji+1=¯ji+2=ji+2, ^ji=¯ji1=ji+11.

    (iv) jiji+1 ¯ji+1=ji, ¯ji=ji+11 So ¯ji+1¯ji+2 jiji+2, ^ji+2=¯ji+1=ji, ^ji+1=¯ji+21=ji+21, ^ji=¯ji=ji+11.

    Using Lemma 3.3 and definitions of Ai and ri operators, we can obtain the followings.

    Lemma 3.8. Let w=(sn,jn)(sn1,jn1)(si+1,ji+1)(si,ji)(s1,j1). Then

    Ai(εw)={εw1ifjiji+10ifji<ji+1,

    where w1=(sn,¯jn)(sn1,¯jn1)(si+1,¯ji+1)(si,¯ji)(s1,¯j1) with ¯ji+1=ji, \quad ¯ji=ji+11 and ¯jk=jk if ki,i+1.

    Lemma 3.9. ri(εsj)={εsi1εsiεsi+1ifi=jεsjifij.

    The integral cohomology of SUn+1/T is generated by Schubert classes indexed

    W={snjnsn1,jn1s1j1:ji=0orijin}.

    Let xi=εriH2(SUn+1/T,Z). We define an order between generators of the integral cohomology of SUn+1/T. Since each element εsnjnsn1,jn1sijis1j1 can be represented by an n-tuple (jnn+1,jn1(n1)+1,,jii+1,,j11+1), we can define an order between n-tuples.

    Definition 3.10. (Graded Inverse Lexicographic Order) Let α=(α1,α2,,αn) and β=(β1,β2,,βn)Zn0. We say α>β if |α|=α1+α2+αn>|β|=β1+β2+βn or |α|=|β| and in the vector difference αβZn, the right-most nonzero entry is positive. We will write εsnjnsn1,jn1sijis1j1>εsnknsn1,jk1sikis1j1 if (jnn+1,jn1(n1)+1,,jii1,,j11+1)>(knn+1,kn1(n1)+1,,kii1,,k11+1).

    Example 3.11. εs35s23s14>εs35s24s13 since (3,2,4)>(3,3,3) in graded inverse lexicographic order.

    We will try to find a quotient ring Z[x1,x2,,xn]/I which is isomorphic to H(SUn+1/T,Z). We also define an order between monomials as follows.

    Definition 3.12. We say xα11xα22xαnn>xβ11xβ22xβnn if |α|=α1+α2++αn>|β|=β1+β2++βn or |α|=|β| and in the vector difference αβZn the left-most non-zero entry is negative.

    Example 3.13. x41x22x33<x31x32x33, since (4,2,3)(3,3,3)=(1,1,0).

    Lemma 3.14. xα11xα22xαnn=εsnαnsn1,αn1siαis1α1+lowerterms.

    Proof. To prove this, we use induction on degree of the monomials. By definition xi=εsi. Let us compute xixj=εsiεsj. Here we may assume that ij. If ji>1, the inverse of sisj is sisj. Hence

    Psjsisisj=rjAi(εsi)=rj(1)=1

    in the cup product. If j=i+1, the inverse of si+1si is sisi+1. In this case

    Psi,si+1=Airi+1(εsi)=Ai(εsi)=ε{}=1.

    If i=j, then we have to consider the word si,i+1. Its inverse si+1si and

    Psi,i+1sisi=ri+1Ai(εsi)=ri+1(1)=1.

    Now we have to show that Pskslsisj=0 if εsksl>εsjsi. By definition of cup product the coefficient of εsksl is not zero only if sisksl and sjsksl. However, this is possible only if sksl=sjsi or sksl=si,i+1 when j=i+1. Clearly εsisi+1<εsi+1si. Hence εsiεsi+1=εsi+1si+lowerterms and εsiεsj=εsjεsi if ji>1. In the case i=j, we have to look elements sisk and sksi. The inverse of sksi is equal to sksi itself if ki>1, hence

    Psksisisj=Akri(εsi)=Ak(εsi1εsi+εsi+1)=0

    since ki>1. Clearly εsisk<εsisi+1 if k<i. Hence εsiεsi=εsisi+1+lowerterms.

    Assume that xα11xα22xαnn=εsnαnsn1,αn1siαis1α1+lowerterms.

    We have to show xα11xα22xαi+1ixαnn=εsnαnsn1,αn1siαi+1s1α1+lowerterms by Bruhat ordering.

    snαnsn1,αn1siαi+1s1α1w only if w=sn¯αnsn1,¯αn1si¯αis1¯α1 where there exists an index j for which ¯αj=αj+1 and ¯αk=αk if kj.

    By given ordering

    w=sn¯αnsn1,¯αn1si¯αis1¯α1>snαnsn1,αn1siαi+1s1α1.

    If j>i, then, by Algorithm 1, in w1, we will not have a subsequence sj1,sj2si after the elements sj. Hence in the cup product before applying Aj we will not have the term εsj. It means Pwsi,w=0.

    If j=i, then, again by Algorithm 1, in w1 we will not have a subsequence sj1,sj2si after the elements sj. Hence in the cup product before applying Aj we will not have the term εsj. It means Pwsi,w=1 if and only if j>i.

    Example 3.15. Let l=3,

    x1x2x3=εs3s2s1+lowerterms.

    x21x2x3=εs3s2s12+lowerterms.

    Then we have εs3s23s1>εs3s2s12>εs23s12>εs3s13>εs2s13. Since the inverse of s3s23s1 is s3s13 and the inverse of s3s2s1 is s13, A3r1r2r3(εs1)=A3r1(εs1)=A3(εs1+εs2)=0.

    Similarly, since the inverse of s3s2s12 is s2s13, A2r1r2r3(εs1)=A2r1(εs1)=A2(εs1+εs2)=1.

    Before finding the quotient ring Z[x1,,xn]/I, we give some information about ring k[x1,,xn]/I where k is a field. Fix a monomial ordering on k[x1,,xn]. Let fk[x1,,xn]. The leading monomial of f, denoted by LM(f), is the highest degree monomial of f. The coefficient of LM(f) is called leading coefficient of f and denoted by LC(f). The leading term of f, LT(f)=LC(f)LM(f).

    Let Ik[x1,,xn] be an ideal. Define LT(I)={LT(f):fI}. Let <LT(I)> be an ideal generated by LT(I).

    Proposition 3.16. [9,Section 5.3,Propostions 1 and 4]

    (i) Every fk[x1,,xn] is congruent modulo I to a unique polynomial r which is a k-linear combination of the monomials in the complement of <LT(I)>.

    (ii) The elements of {xα:xα∉<LT(I)>} are linearly independent modulo I.

    (iii) k[x1,,xn]/I is isomorphic as a kvector space to

    S=Span{xα:xα∉<LT(I)>}.

    Theorem 3.17. [9,Section 5.3,Theorem 6] Let Ik[x1,,xn] be an ideal.

    (i) The k-vector space k[x1,,xn]/I is finite dimensional.

    (ii) For each i, 1in, there is a polynomial fiI such that LM(fi)=xmii for some positive integer mi.

    Theorem 3.18. H(SUn+1/T,Z) isomorphic to Z[x1,x2,,xn]/<f1,f2,,fn> where LT(fi)=xni+2i with respect to monomial order given by Definition 3.12.

    Proof. Let I be the ideal such that H(SUn+1/T,R)R[α1,α2,,αn]/I. Since we found one to one correspondence between length l elements of H(SUn+1/T,Z) and monomials xα11xα22xαnn, where α1+α2+αn=l and for each i, 1in, αini+1, there should be a polynomial fiI such that LT(fi)=xni+2i.

    Example 3.19. Let n=3. Then we have

    αini+1, i=1,2,3;

    α13, α22, α31.

    For l=1;x1,x2,x3; and

    for l=2;x21,x1x2,x1x3,x2x3,x22. So we must have a polynomial f3 with LM(f3)=x23.

    For l=3;x31,x21x2,x21x3,x1x2x3,x1x22,x22x3, so

    we must have a polynomial f2 with LM(f2)=x32.

    For l=4;x31x2,x31x3,x21x2x3,x21x22,x1x22x3, so

    we must have a polynomial f1 with LM(f1)=x41.

    The complex dimension of SUn+1/T is equal to (n+1)n/2. So the highest element has length of (n+1)n/2.

    Since the unique highest element has length of n(n+1)2, we now give the result about the multiplication of elements of length k and of length n(n+1)2k.

    Theorem 3.20. Let A=εsnjnsn1,jn1s1j1 be an element of length k and B=εsnpnsn1,pn1s1p1 be an element of length n(n+1)2k. The corresponding polynomials in Z[x1,x2,,xn]/<f1,f2,,fn> has leading monomials

    xj11+11xj22+12xjii+1ixjnn+11 and xp11+11xp12+12xpnn+11, respectively. Then

    AB={εsn,nsn1,n,,sin,,s1n,ifji+pi+1=n+i;0,ifji+pi+1n+i.

    Proof. The unique highest degree monomial in Z[x1,x2,,xn]/<f1,f2,,fn> is xn1xn12xni+1ixn. The multiplication of leading monomials of corresponding monomials of A and B produce the monomial

    xj1+p11xj2+p222xji+pi2i+2ixjn+pn2n+2n.

    If ji+pi2i+2=ni+1ji+pi+1=n+i for each i, i1n, then the multiplication gives the xn1xn12xn. Since this monomial correspondence the element εsn,nsn1,nsins1n, AB=εsn,nsn1,ns1n. If ji+pi+1n+i, then the leading monomial and the monomials of lower degree must reduce to zero modulo <f1,f2,,fn> in k[x1,x2,,xn] when we apply the division algorithm. Hence AB=0.

    Now we can give the whole computation of the quotient ring Z[x1,x2,x3]/<f1,f2,f3>.

    Example 3.21. Let x1=εs1, x2=εs2, x3=εs3.

    For l=2, we have

    x2x3=εs3s2+εs2s3x22=εs2s3+εs2s1x1x3=εs3s1x1x2=εs2s1+εs1s2x21=εs1s2,

    and

    (x2x3x22x1x3x1x2x21)=M(εs3s2εs2s3εs3s1εs2s1εs1s2) and (εs3s2εs2s3εs3s1εs2s1εs1s2)=M1(x2x3x22x1x3x1x2x21), where

    M=(1100001010001000001100001) M1=(1101101011001000001100001). Then we have

    εs3s2=x2x3x22+x1x2x21εs2s3=x22x1x2+x22εs3s1=x1x3εs2s1=x1x2x21εs1s2=x21.

    Here we must have a relation involving x23 and we have it as

    x23=εs3s2=x2x3x22+x1x2x21.

    For l=3;

    x22x3=εs3s2s3+εs3s2s1+εs2s3s1x1x2x3=εs3s2s1+εs2s3s1+εs3s1s2+εs1s2s3x1x22=εs2s3s1+εs2s1s2+εs1s2s3x21x3=εs3s1s2+εs1s2s3x21x2=εs2s1s2+εs1s2s3x31=εs1s2s3

    and

    (x22x3x1x2x3x1x22x21x3x21x2x31)=M(εs3s2s3εs3s2s1εs2s3s1εs3s1s2εs2s1s2εs1s2s3) and (εs3s2s3εs3s2s1εs2s3s1εs3s1s2εs2s1s2εs1s2s3)=M1(x22x3x1x2x3x1x22x21x3x21x2x31), where

    M=(111000011101001011000101000011000001) M1=(110100011110001010000101000011000001).

    Then we have

    εs3s2s3=x22x3x1x2x3+x21x3εs3s2s1=x1x2x3x1x22x21x3+x21x2εs2s3s1=x1x22x21x2εs3s1s2=x21x3x31εs2s1s2=x21x2x31εs1s2s3=x31.

    Here we must have a relation involving x32 and we now we have it as

    x32=2εs2s3s1=2(x1x22x21x2).

    For l=4; we have

    x1x22x3=εs3s2s3s1+εs3s2s1s2+2εs2s3s1s2+2εs3s1s2s3x21x2x3=εs3s2s1s2+εs2s3s1s2+εs3s1s2s3+εs2s1s2s3x21x22=εs2s3s1s2+εs2s1s2s3x31x3=εs3s1s2s3x31x2=εs2s1s2s3

    and

    (x1x22x3x21x2x3x21x22x31x3x31x2)=M(εs3s2s3s1εs3s2s1s2εs2s3s1s2εs3s1s2s3εs2s1s2s3) and (εs3s2s3s1εs3s2s1s2εs2s3s1s2εs3s1s2s3εs2s1s2s3)=M1(x1x22x3x21x2x3x21x22x31x3x31x2), where

    M=(1122001111001010001000001) M1=(1111201110001010001000001).

    Then

    εs3s2s3s1=x1x22x3x21x2x3x21x22x31x3+2x31x2εs3s2s1s2=x21x2x3x21x22x31x3εs2s3s1s2=x21x22x31x2εs3s1s2s3=x31x3εs2s1s2s3=x31x2.

    We must have a relation involving x41, which is x1x31=εs1.εs1s2s3=0.

    For l=5;

    x21x22x3=εs3s2s3s1s2+εs3s2s1s2s3+εs2s3s1s2s3x31x2x3=εs3s2s1s2s3+εs2s3s1s2s3x31x22=εs2s3s1s2s3

    and

    (x21x22x3x31x2x3x31x22)=M(εs3s2s3s1s2εs3s2s1s2s3εs2s3s1s2s3) and (εs3s2s3s1s2εs3s2s1s2s3εs2s3s1s2s3)=M1(x21x22x3x31x2x3x31x22), where

    M=(111011001) M1=(110011001). So

    εs3s2s3s1s2=x21x22x3x31x2x3εs3s2s1s2s3=x31x2x3x31x22εs2s3s1s2s3=x31x22.

    Hence we don't have any relation.

    For l=6;

    x31x22x3=εs3s2s3s1s2s3 and εs3s2s3s1s2s3=x31x22x3.

    Now let us multiple elements with lengths of k and 6k.

    First M0=1 and |det(M0)|=1.

    Now we will calculate Reidemeister torsion of SU4/T by using above multiplication. From multiplication of the second cohomology, we have M2=(001010100) and |det(M2)|=1.

    Degree2Degree4_

    To calculate Reidemeister torsion of SU4/T we need multiplication of fourth cohomology bases elements and then we have M4=(0000100010001000100010000) and |det(M4)|=1.

    Degree3Degree3_

    To calculate Reidemeister torsion of SU4/T we need multiplication of sixth cohomology bases elements and then we have M6=(000001000010000100001000010000100000) and |det(M6)|=1.

    In general the matrix Mk represents the intersection pairing between the homology classes of degrees k and (n+1)nk with real coefficient. So in general |det(Mn(n+1)2)|=1. Hence the Reidemeister torsion of SU4/T is 1 by the Reidmeister torsion formula for manifolds.

    By Theorems 1.1, 3.18 and 3.20, we obtain the following result.

    Theorem 3.22. The Reidemeister torsion of SUn+1/T is always 1 for any positive integer n with n3.

    Remark 3.23. We should note that we found this result by Schubert calculus. But, we choose any basis to define Reidemeister torsion. There are many bases for the Reidemeister torsion to be 1. Why we focus on this basis to compute the Reidemeister torsion is that we can use Schubert calculus and we have cup product formula in this algebra in terms of Schubert differential forms. Otherwise these computations are not easy. Also by Groebner techniques we can find the normal form of all elenents of Weyl group indexing our basis. So computations in this algebra is avaliable.

    Remark 3.24. In our work, we consider flag manifold SUn+1/T for n3. Then we consider the Schubert cells {cp} and the corresponding homology basis a {hp} associated to {cp}. We caculated that Tor(C(K),{cp}np=0,{hp}np=0)=1.

    If we consider the same cell-decomposition but other homology basis {hp} then by the change-base-formula (1.4), then we have

    Tor(C,{cp}np=0,{hp}np=0)=np=0(1[hp,hp])(1)pTor(C,{cp}np=0,{hp}np=0).

    Remark 3.25. In the presented paper M=K/T is a flag manifold, where K=SUn+1 and T is the maximal torus of K. Clearly, M is a smooth orientable even dimensional(complex) closed manifold. So there is Poincaré (or Hodge) duality. Therefore, we can apply Theorem 1.1 for M=K/T.

    We would like to express our sincere gratitude to the anonymous referee for his/her helpful comments that will help to improve the quality of the manuscript.

    The authors declare that they have no competing interests.


    Acknowledgments



    The authors acknowledge the immense help received from the scholar whose article are cited and included in references to this manuscript. The authors are also grateful to authors/publishers/editors of all those articles, journals and books from where the literature for this article has been reviewed and discussed.

    Limitations of the Study



    Major limitations of the present study were small sample size; a larger sample could have brought in the effects. A comparison cohort would have been useful in this study design which was another limitation of the study. Larger study on Indian population on multidrug treatment may give more insight into its effect on behaviour. The generalisability of study findings is limited as the study was from a single centre with limited catchment area. Hence adequate caution needs to be exercised while generalizing the findings to population groups with different demographic structure. It was a onetime assessment of children with epilepsy those with borderline scores were not followed up.

    Source of financial support



    Nil.

    Conflict of interest



    None declared.

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