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AIMS Allergy and Immunology

2018, Volume 2, Issue 2: 98-112. doi: 10.3934/Allergy.2018.2.98
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Main NK cell receptors and their ligands: regulation by microRNAs

  • 1.
    Istituto Giannina Gaslini, Genova, Italy
  • 2.
    Center for Advanced Biomaterials for Healthcare, IIT@CRIB, Istituto Italiano di Tecnologia, Napoli, Italy
  • 3.
    Dipartimento di Medicina Sperimentale, University of Genova, Italy
  • 4.
    Centro di Eccellenza per la Ricerca Biomedica (CEBR), University of Genova, Italy
  • Received: 01 June 2018 Accepted: 19 July 2018 Published: 23 July 2018

  • The NK cells functions are finely tuned by several kinds of inhibitory and activating receptors, whose pattern of expression characterizes different NK subpopulations and varies with the cell activation status. MicroRNAs have an important role in tightly regulating the expression of NK receptors and, analogously, the expression of their ligands in target cells. The relevance of the microRNA-mediated control is highlighted by the dysregulation of these pathways observed in cancer and virus-infected cells. Here we review our current knowledge of the microRNAs involved in the regulation of NK receptors, as well as that of the corresponding cellular ligands.

    Citation: Stefano Regis, Fabio Caliendo, Alessandra Dondero, Francesca Bellora, Beatrice Casu, Cristina Bottino, Roberta Castriconi. Main NK cell receptors and their ligands: regulation by microRNAs[J]. AIMS Allergy and Immunology, 2018, 2(2): 98-112. doi: 10.3934/Allergy.2018.2.98

    Related Papers:

  • The NK cells functions are finely tuned by several kinds of inhibitory and activating receptors, whose pattern of expression characterizes different NK subpopulations and varies with the cell activation status. MicroRNAs have an important role in tightly regulating the expression of NK receptors and, analogously, the expression of their ligands in target cells. The relevance of the microRNA-mediated control is highlighted by the dysregulation of these pathways observed in cancer and virus-infected cells. Here we review our current knowledge of the microRNAs involved in the regulation of NK receptors, as well as that of the corresponding cellular ligands.


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