Secondary  metabolites with ecologic and medicinal implications in <em>Anthemis cretica</em> subsp. <em>petraea</em> from Majella National Park

Alessandro Venditti; Claudio Frezza; Giacomo Rossi; Mirella Di Cecco; Giampiero Ciaschetti; Mauro Serafini; Armandodoriano Bianco; Alessandro Venditti; Claudio Frezza; Giacomo Rossi; Mirella Di Cecco; Giampiero Ciaschetti; Mauro Serafini; Armandodoriano Bianco

doi:10.3934/molsci.2016.4.648

AIMS Molecular Science

2016, Volume 3, Issue 4: 648-660. doi: 10.3934/molsci.2016.4.648

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Secondary metabolites with ecologic and medicinal implications in Anthemis cretica subsp. petraea from Majella National Park

1.
Dipartimento di Chimica, Sapienza Università di Roma, P.le Aldo Moro, 5 - 00185 Roma, Italy
2.
Dipartimento Biologia Ambientale, Sapienza Università di Roma, P.le Aldo Moro, 5 - 00185 Roma, Italy
3.
Ente Parco Nazionale della Majella, Via Occidentale, 6 - 66016 Guardiagrele (CH), Italy

Received: 04 July 2016 Accepted: 31 October 2016 Published: 09 November 2016

Anthemis cretica subsp. petraea (Ten.) Greuter is a plant belonging to the Asteraceae family and endemic of central Italy. In this paper, the first analysis of the ethanolic fraction of samples collected in the Majella National Park is reported. Seven compounds were isolated and identified namely parthenolide (1), 9α-acetoxyparthenolide (2), tamarixetin (3), 7-hydroxycoumarin (4), 4'-hydroxyacetophenone (5), leucanthemitol (conduritol F) (6), and proto-quercitol (7). Isolation of the compounds was achieved by means of column chromatography (CC), while their identification was achieved through spectroscopic and spectrometric techniques. The presence of these compounds is of great relevance. Compounds 1 and 2 are chemosystematic markers of the family, thus confirming the correct botanical classification of the species. Conversely, compounds 3, 5, and 7 were identified for the first time in the species and, instead, confirm the tendency of endemic entities to develop characteristic metabolite patterns in respect to cosmopolite species. Moreover, the presence of compounds 6 and 7 has ecologic implications and may be linked to this taxon’s adaption to dry environments. The production of these osmolytes may, in fact, represent the reason why this species is able to survive in extreme conditions of aridity. Lastly, from a medicinal standpoint, the isolated compounds are endowed with interesting biological activities and may justify, on a molecular base, the widespread traditional uses of the Anthemis species, as well as a basis for the use of the subspecies petraea.
- adaptation,
- secondary metabolites,
- diterpenoids,
- flavonoids,
- cyclitols,
- abiotic stress,
- traditional uses,
- chemotaxonomy
Citation: Alessandro Venditti, Claudio Frezza, Giacomo Rossi, Mirella Di Cecco, Giampiero Ciaschetti, Mauro Serafini, Armandodoriano Bianco. Secondary metabolites with ecologic and medicinal implications in Anthemis cretica subsp. petraea from Majella National Park[J]. AIMS Molecular Science, 2016, 3(4): 648-660. doi: 10.3934/molsci.2016.4.648

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Abstract

Anthemis cretica subsp. petraea (Ten.) Greuter is a plant belonging to the Asteraceae family and endemic of central Italy. In this paper, the first analysis of the ethanolic fraction of samples collected in the Majella National Park is reported. Seven compounds were isolated and identified namely parthenolide (1), 9α-acetoxyparthenolide (2), tamarixetin (3), 7-hydroxycoumarin (4), 4'-hydroxyacetophenone (5), leucanthemitol (conduritol F) (6), and proto-quercitol (7). Isolation of the compounds was achieved by means of column chromatography (CC), while their identification was achieved through spectroscopic and spectrometric techniques. The presence of these compounds is of great relevance. Compounds 1 and 2 are chemosystematic markers of the family, thus confirming the correct botanical classification of the species. Conversely, compounds 3, 5, and 7 were identified for the first time in the species and, instead, confirm the tendency of endemic entities to develop characteristic metabolite patterns in respect to cosmopolite species. Moreover, the presence of compounds 6 and 7 has ecologic implications and may be linked to this taxon’s adaption to dry environments. The production of these osmolytes may, in fact, represent the reason why this species is able to survive in extreme conditions of aridity. Lastly, from a medicinal standpoint, the isolated compounds are endowed with interesting biological activities and may justify, on a molecular base, the widespread traditional uses of the Anthemis species, as well as a basis for the use of the subspecies petraea.

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