Intracellular calcium excess as one of the main factors in the etiology of prostate cancer

Vladimir Zaichick; Sofia Zaichick; Maxim Rossmann; Vladimir Zaichick; Sofia Zaichick; Maxim Rossmann

doi:10.3934/molsci.2016.4.635

AIMS Molecular Science

2016, Volume 3, Issue 4: 635-647. doi: 10.3934/molsci.2016.4.635

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Intracellular calcium excess as one of the main factors in the etiology of prostate cancer

1.
Radionuclide Diagnostics Department, Medical Radiological Research Centre, Koroleyva St.- 4, Obninsk 249036, Kaluga Region, Russia
2.
Department of Medicine, University of Illinois College of Medicine Chicago, IL 60612, USA
3.
Department of Biochemistry, University of Cambridge, 80 Tennis Court Road Cambridge, UK CB2 1GA

Received: 12 August 2016 Accepted: 31 October 2016 Published: 02 November 2016

Numerous studies show that prostate cancer (PCa) incidence drastically increases with age, these malignant tumours are mainly formed in the peripheral zone of the prostate gland, and a high intake of calcium rich dairy products is associated with an increased risk of PCa. The main objective of this study was to identify a potential common pathophysiological factor associated with the PCa features mentioned above. We performed measurements of the intracellular Ca concentrations in the peripheral zones of nonhyperplastic prostate glands of 99 males aged 0–87 years. To clarify the age-related changes in the intracellular Ca, a quantitative morphometric and two analytical methods of Ca determination were employed. We found, that in 18–45 years old males intracellular Ca was maintained at a relatively high concentration, which steadily increased with age. The intracellular Ca accumulation increased after the age of 45. We found, that by the age of 55, Ca level in the prostatic cells of the peripheral zone reached concentration, which is two-to-four-fold higher than in the 18 year olds. Age-dependent accumulation of Ca in the peripheral zone of human prostate gland has been previously unrecognized and could play an important role in the etiology of PCa.
- human prostate gland,
- peripheral zone,
- prostatic cells,
- prostatic fluid,
- calcium,
- aging,
- age-related changes in the human prostate,
- prostate cancer,
- dairy products
Citation: Vladimir Zaichick, Sofia Zaichick, Maxim Rossmann. Intracellular calcium excess as one of the main factors in the etiology of prostate cancer[J]. AIMS Molecular Science, 2016, 3(4): 635-647. doi: 10.3934/molsci.2016.4.635

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Abstract

Numerous studies show that prostate cancer (PCa) incidence drastically increases with age, these malignant tumours are mainly formed in the peripheral zone of the prostate gland, and a high intake of calcium rich dairy products is associated with an increased risk of PCa. The main objective of this study was to identify a potential common pathophysiological factor associated with the PCa features mentioned above. We performed measurements of the intracellular Ca concentrations in the peripheral zones of nonhyperplastic prostate glands of 99 males aged 0–87 years. To clarify the age-related changes in the intracellular Ca, a quantitative morphometric and two analytical methods of Ca determination were employed. We found, that in 18–45 years old males intracellular Ca was maintained at a relatively high concentration, which steadily increased with age. The intracellular Ca accumulation increased after the age of 45. We found, that by the age of 55, Ca level in the prostatic cells of the peripheral zone reached concentration, which is two-to-four-fold higher than in the 18 year olds. Age-dependent accumulation of Ca in the peripheral zone of human prostate gland has been previously unrecognized and could play an important role in the etiology of PCa.

References

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