Manuscript Topics

The goal of this special issue will be to present the state of the art in the modeling approaches of living systems, with a special focus on the cell and its intracellular regulation.
   Cells are neither machines (Nicholson, 2019), nor simple information processing devices (Kupiec, 1983). Cells (like all living systems) are rooted within a physico-chemical world to which they belong. Their specific complexity nevertheless sometimes led to the idea that they should be treated differently that classical  physico-chemical systems (Schrödinger, 1944).
   This somehow can be seen in the separation of biology in different fields: biochemistry, molecular biology, cellular biology. We think the time has come to reunite those views. And more specifically to consider gene expression, or the formation of specific organelles as nothing more (nor less) than a biochemical process. But a biochemical process with a twist: some specificities should/could be taken into account by the modeling process including the  contingent, modular, degenerated, complex, dynamical, stochastic and multi-scale nature of the living systems.

References
Kupiec, J.J. (1983). A probabilistic theory for cell differentiation, embryonic mortality and DNA C-value paradox. Speculations in Science and Technology 6, 471-478.
Nicholson, D.J. (2019). Is the cell really a machine? J Theor Biol 477, 108-126.
Schrödinger, E. (1944). What Is Life? The Physical Aspect of the Living Cell (Cambridge University Press).

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