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Research article Topical Sections

The impact of Covid-19 pandemic on services for children and adolescents with ADHD: results from a survey of paediatricians in the United Kingdom

  • Received: 03 February 2022 Revised: 20 May 2022 Accepted: 17 June 2022 Published: 21 June 2022
  • Background 

    The Covid-19 pandemic has led to huge disruptions and multi-domain healthcare crisis, with additional impact on children and young people (CYP) affected by Attention Deficit and Hyperactivity Disorder (ADHD).

    Methods 

    We conducted an online survey and obtained responses from 62 Paediatricians who provide ADHD services for CYP about their experience of Service disruption and adaptations during the first Covid-19 lockdown in the United Kingdom between March and June 2020. The responses were both quantitative and qualitative.

    Results 

    The Paediatricians reported huge service disruptions such that almost half ceased the assessment of new patients with ADHD, and only 5% were able to offer physical monitoring for most patients. However, all respondents had adopted telemedicine, which allowed them to maintain high levels of non-physical service provision for existing patients. The Paediatricians used risk stratification strategies to determine which patients were more likely to benefit from the limited available face to face appointments for physical monitoring. The Paediatricians demonstrated clinical pragmatism to meet the needs of their patients such as starting medication without physical exam especially if the patient's behaviour was so challenging that it was presenting a crisis at home, and setting aside monthly limits for stimulant medications. Some respondents reported helpful cross-service collaborations to support CYP with ADHD and their families.

    Conclusion 

    The Covid-19 pandemic has had adverse effect on many CYP with ADHD and caused huge disruption to the ADHD services that support them. As the pandemic continues to cause disruptions to ADHD services, the service adaptations emerging from the literature including some of those identified in this study could be useful to support more stable and sustainable ADHD services, both during and after the pandemic.

    Citation: Michael O Ogundele, Hani F Ayyash, Cornelius Ani. The impact of Covid-19 pandemic on services for children and adolescents with ADHD: results from a survey of paediatricians in the United Kingdom[J]. AIMS Public Health, 2022, 9(3): 542-551. doi: 10.3934/publichealth.2022037

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  • Background 

    The Covid-19 pandemic has led to huge disruptions and multi-domain healthcare crisis, with additional impact on children and young people (CYP) affected by Attention Deficit and Hyperactivity Disorder (ADHD).

    Methods 

    We conducted an online survey and obtained responses from 62 Paediatricians who provide ADHD services for CYP about their experience of Service disruption and adaptations during the first Covid-19 lockdown in the United Kingdom between March and June 2020. The responses were both quantitative and qualitative.

    Results 

    The Paediatricians reported huge service disruptions such that almost half ceased the assessment of new patients with ADHD, and only 5% were able to offer physical monitoring for most patients. However, all respondents had adopted telemedicine, which allowed them to maintain high levels of non-physical service provision for existing patients. The Paediatricians used risk stratification strategies to determine which patients were more likely to benefit from the limited available face to face appointments for physical monitoring. The Paediatricians demonstrated clinical pragmatism to meet the needs of their patients such as starting medication without physical exam especially if the patient's behaviour was so challenging that it was presenting a crisis at home, and setting aside monthly limits for stimulant medications. Some respondents reported helpful cross-service collaborations to support CYP with ADHD and their families.

    Conclusion 

    The Covid-19 pandemic has had adverse effect on many CYP with ADHD and caused huge disruption to the ADHD services that support them. As the pandemic continues to cause disruptions to ADHD services, the service adaptations emerging from the literature including some of those identified in this study could be useful to support more stable and sustainable ADHD services, both during and after the pandemic.


    Abbreviations

    ADHD:

    Attention deficit and hyperactivity disorder; 

    CAMHS:

    Child and adolescent mental health services; 

    CYP:

    Children and young people; 

    GSF:

    George-still forum; 

    PPE:

    Personal protective equipment

    One of the most prevalent endocrine system illnesses, polycystic ovarian syndrome (PCOS), affects 5 to 10% of women [1]. The PCOS is one of the most prevalent causes of ovulatory failure [2]. Women ages 18-44 are affected. PCOS develops during adolescence and is brought on by hormonal imbalances. Follicles, or cysts, which are fluid-filled sacs, are found on the ovary's periphery. A polycystic ovary (PCO) is defined as having twelve or more follicles that are between two to nine mm in diameter [3]. Both health and the standard of living for women are impacted by PCOS. Some of the symptoms include weight, worry, depression, and stress [4]. Others include heart issues, ovarian failure and infertility, type 2 diabetes, late menopause, acne, hair loss, baldness, and hirsutism [5]. According to reports, the prevalence ranges from 2.2–26% globally [6]. According to community research conducted in the United Kingdom (UK), South Asians exhibit a prevalence of 52% when compared to Caucasians, who exhibit a prevalence of 22% [3]. Early identification and treatment can be used to control the symptoms and avoid long-term problems. Gynaecologists urge patients on clomiphene citrate to wait no longer than six months after beginning their ovulation cycles before starting gonadotrophin therapy. The ovulation stimulation approach should not depend on whether the clomiphene citrate and gonadotropin therapy cycles are identified and their therapeutic follow-up is taken care of, but whether the pregnancy does not develop over the course of the 912 treatment cycles. Thus, it is encouraged to use assisted reproductive techniques (ART), among which in vitro fertilization (IVF) is one [7]. It has become increasingly obvious over the past ten years that PCOS patients need better clinical and therapeutic care. The primary attempts for better controlling PCOS were the adoption of more precise technologies for detecting circulating androgens, comprehension of the impact of PCOS on risk factors and ultimately, pharmaceutical regimens based on individual-specific phenotypic requirements [8]. Mathematical modeling can be used to suggest controls for any infectious disease after accounting for the disease's mechanism of transmission. Different nonlinear therapeutic rates between diseases are possible. The nonlinear incidence and treatment rate can be very helpful in assisting health organizations identify effective treatments that will stop the spread of the disease [9].

    Various operators have been presented in fractional calculus. The Caputo operator, which is defined on a power law kernel, is the most fundamental operator. Many scientists working in engineering [10], mathematical biology [11], [12], fluid mechanics [13], [14], and mathematical physics [15][17] by using fractional derivative. A study on the numerical and computational aspects of the physical system of a (1+1)-dimensional Mikhailov-Novikov-Wang (MNW) integrable equation was conducted by Khater et al. [18][20]. The analytical and approximate solutions of the caudrrey-dodd-gibbon (CDG) model were examined by Khater et al. [21], while the computational simulations of the propagation of tsunami waves across the ocean were covered in [22]. Particularly, fractional calculus has also been used to study the dynamics of cancer [23]. A fractional component cancer model was put forth by Naik et al. [24]. Atangana [25] put out a novel family of two-parameter derivatives in 2017. The order of the two parameters, where one reflects the exponential decay, power law, or Mittag-Leffler kernel operations, describes the fractal dimension. It is impossible to obtain certain nonlinear model parameters through experimentation. This work suggests fractal-fractional derivatives as a potential solution to these problems. Farman et al. proposed in [26] a Caputo Fabrizio fractional order model for glucose control in insulin therapy for diabetes. Researchers expanded hybrid fractal-fractional operators and discussed a whole new hybrid model of the coronavirus propagation in [27]. They also compared its results with past iterations of the fractal-fractional model. To understand how the Ebola virus spreads, Farman et al. [28] proposed a nonlinear time-fractional mathematical model of the disease. The fractional descement's stripping endothelial keratoplasty (DSEK) model was examined using fractional derivatives of the Atangana-Baleanu Caputo type [29]. The fractional Euler's numerical approach was derived using the Atangana-Baleanu Caputo (ABC) fractional derivative and was then applied to the fractional DSEK model. Researchers used fractal-fractional Atangana-Baleanu derivatives and integrals in the sense of Caputo to study the dynamics of Q (query) fever transmission in cattle and ticks as well as the bacterial load in the environment [30]. The freshly created Newton polynomial was utilized by the stated numerical approach. Researchers researched and observed the dynamical transmission of the illness under the impact of vaccination using a unique fractional order measles model, utilizing a constant proportional (CP) Caputo operator [31]. To express a set of fractional differential equations numerically, they used Laplace with the Adomian decomposition approach. A generalized fractional model was used to describe how HIV/AIDS spread throughout the Cape Verde Islands [32]. The model was successfully built using a two-step Lagrange polynomial interpolation, and the associated error analysis was investigated. In [33], a fractional order tubarculosis (TB) model with a fractal fractional operator was built using an expanded Mittag-Leffler kernel.

    This is how the sections are organized: Literature evaluation and an introduction are provided in section one. Basic terms related to fractional derivatives are covered in section two. We spoke about the fractional-order PCOS model with the Mittag-Leffler kernal in section three. In section 3.1, we prove the detailed analysis of positiveness and boundedness, existence and uniqueness, reproductive number, and equilibrium point analysis. In section four, the equilibrium point stability analysis with Jacobian matrix and Lyaounov function is performed. In section five, numerical results are developed.

    Consider xk(c,d),d>c,η[0,1], for the Caputo derivative of arbitrary is given by

    Dαtx(t)=L(α)1αtcx(t)exp[αtς1α]dς,

    where L(α) is the normalization of the function that holds L(0) = L(1) = 1.

    However, if jk(c,d), we get

    Dαtx(t)=αL(α)1αtc(x(t)x(ς))exp[αtς1α]dς.

    Remark: If κ=1αα[0,1], then we get the form

    Dαth(t)=R(κ)κtcx(t)exp[tςκ]dς,

    G(0)=G()=1. Moreover limκ1κexp[tςκ]=λ(ςt).

    The Caputo fractional derivative is given by c > 0, qH1(0,c) and 0<η<1; thus

    CDαx(t)=1Γ(1α)t0(tς)α(x(ς)dς.t>0

    A power law kernel in the Riemann-Liouville concept is defined as;

    FFP0Dα,υtx(t)=1Γ(1α)ddtυt0(tς)αx(ς)dς,

    with 0α,υ1,

    df(t)dtυ=limtt1f(t)f(t1)t2υt2υ1(2υ).

    The fractal-fractional integral corresponding power law kernel of order (α,υ) is given as

    FFP0Iα,υtx(t)=1Γ(α)t0(tς)α1ς1υx(ς)dς.

    Considering the classical order model given in [7], in our assumption, put second treatment factor zero for better understanding transmission of disease in society in different age groups. The model is predicated on the following hypotheses: the whole population, or N(t), is composed of five sub-populations: Women who are S(t) susceptible to infertility, I(t) suffering from PCOS, T(t) infertile women receiving treatment with gonadotropin and clomiphene citrate and R(t) women who have recovered from infertility. The following nonlinear fractional differential equations for the fractional order model are created using the fractal-fractional operator in the Caputo sense:

    FFP0Dα,υtS(t)=ΠaSbeSTFFP0Dα,υtI(t)=beST(a+k)IFFP0Dα,υtT(t)=kcI(r+a)TFFP0Dα,υtR(t)=urTaR,

    with initial state S(0)=S00,I(0)=I00,T(0)=T00,R(0)=R00,

    where a represents the frequency at which patients visit the clinic for a disease diagnosis and treatment. Abortion and restarting the treatment cycle occur at a rate of b. The rate of therapy for women who got pregnant with medicine (gonadotropin and clomiphene citrate) is e. We display the treatment rate in the patient class with k as well as the k patient group who were receiving c medical therapy. We use r to display the group T's recovery rate. We represent the number of recoveries as urT, where u is the recovery rate of rT at time t. There were aR susceptible individuals who died and left the group. The number of infertile women who used a therapeutic therapy is represented by Π=jN.

    To demonstrate the positivity of the solutions since they reflect actual problems in the real world with positive values, in this subsection, we look at the circumstances in which the considered model's solutions satisfy the positivity requirement.

    Theorem 3.1 S(t),I(t),T(t) and R(t) are positive solutions to the system equation for all t0 if S(0)0,I(0)0,T(0)0,R(0)0, respectively. All of the solutions to the system of equations S(t),I(t),T(t) and R(t) are finite.

    Let's begin with the S(t) group:

    S(t)=ΠaSbeST,t0S(t)ΠaSbeST,S(t)(a+beT)S.

    The norm defined as

    h=suptDh,

    S(t)(be|T|+a)SS(t)(abeT+a)S.

    This yields

    S(t)S0e(a+beT),

    I(t)=beST(k+a)I,t0beST(a+k)I(k+a)I,

    which then yields

    I(t)I0e(a+k).

    Repeating the process for other classes finds the following inequalities:

    T(t)T0e(r+a)

    R(t)R0ea.

    All system (7) findings are favorable if the beginning conditions for nonlocal operators are satisfied.

    With regard to the power law kernel and the fractal-fractional operator, we obtain

    S(t)EαS(0)(q1υ(a+beT)tα),t0I(t)EαI(0)(q1υ(a+k)tα),t0T(t)EαT(0)(q1υ(a+r)tα),t0R(t)EαR(0)(q1υ(a)tα),t0.

    where q is time component.

    Theorem 3.1 The PCOS model's suggested solution is separate and limited in R4+ under straight-line circumstances.

    Proof. We will look at the positive solution of the system (7), which is as follows:

    FFP0Dα,υtS(t)|S=0=Π0,FFP0Dα,υtI(t)|I=0=beST0,FFP0Dα,υtT(t)|T=0=kcI0,FFP0Dα,υtR(t)|R=0=urT0. (17)

    The solution is unable to escape the hyperplane if (S(0),I(0),T(0),R(0))R4+. The vector field on each hyperplane around the nonnegative orthant also points into the domain R4+, making it a positivity invariant set.

    In this part, we used the fixed-point theory to discuss the presence and distinctiveness of the proposed system. Schauder's fixed-point theorem guarantees the model's existence, while Banach's contraction theorem guarantees its singularity. By applying a fractional derivative in the Caputo sense for 0<α1, system (7) can be generalized as illustrated below:

    FFP0Dα,υtS(t)=ΠaSbeSTFFP0Dα,υtI(t)=beST(a+k)IFFP0Dα,υtT(t)=kcI(a+r)TFFP0Dα,υtR(t)=urTaR,

    with initial state S(0)=S0,I(0)=I0,T(0)=T0,R(0)=R0. Let

    Δ1(S,I,T,R,t)=ΠaSbeSTΔ2(S,I,T,R,t)=beST(a+k)IΔ3(S,I,T,R,t)=kcI(a+r)TΔ4(S,I,T,R,t)=urTaR.

    Using initial condition and fractional integral, we have

    S(t)=S0+1Γ(α)t0(tζ)α1Δ1(S,I,T,R,t)dζ,

    I(t)=I0+1Γ(α)t0(tζ)α1Δ2(S,I,T,R,t)dζ,

    T(t)=T0+1Γ(α)t0(tζ)α1Δ3(S,I,T,R,t)dζ,

    R(t)=R0+1Γ(α)t0(tζ)α1Δ4(S,I,T,R,t)dζ.

    Let

    Λ(t)=(S(t)I(t)T(t)R(t),Λ0=(S0I0T0R0,(ζ,Λ(ζ)=(Δ1(S,I,T,R,t)Δ2(S,I,T,R,t)Δ3(S,I,T,R,t)Δ4(S,I,T,R,t).

    Thus, system (20) becomes

    Λ(t)=Λ0+1Γ(α)t0(ζ,Λ(ζ)(tζ)α1dζ.

    Now, consider a Banach space [0,T]=ϖ with a norm

    S,I,T,R=maxt[0,T][|S,I,T,R|].

    Let a mapping be defined as :ϖϖ, then

    Λ(t)=Λ0+1Γ(α)t0(tζ)α1(ζ,Λ(ζ)dζ. (27)

    In addition, we impose the following hypothesis on a nonlinear function:

    P1) There exist constants ρm,ρm>0, such that

    |(t,Λ(t)|ρm|Λ(t)|+ρm.

    P2) There exists a constant Lm>0 for each Λ,ˉΛϖ such that

    |(t,ˉΛ)(t,ˉΛ1)|Lm|ˉΛˉΛ1|.

    Theorem 3.2 The system (18) has at least one solution if the assumptions (P1) are true.

    Proof. To demonstrate that is bounded, let Φ={ΛΦ|ρΛ}, where

    ρmaxt[0,T]Λ0+(ρmTαΓ(α+1))1(ρmTαΓ(α+1))

    is a closed convex subset of ϖ. Now,

    Λ=maxt[0,T]|Λ0+1Γ(α)t0(tζ)α1(ζ,Λ(ζ)dζ||Λ0|+1Γ(α)t0(tζ)α1|(ζ,Λ(ζ)|dζ|Λ0|+1Γ(α)t0(tζ)α1[ρm|Λ(t)|+ϱm]dζ|Λ0|+[ρmΛ+ϱm]TαΓ(α+1)ρ. (31)

    Since ΛΦ(Φ)Φ, it shows that is bounded. Let t1<t2[0,T] to prove that is completely continuous and take

    Λ(t2)Λ(t1)=|1Γ(α)t20(t2ζ)α1(ζ,Λ(ζ)dζ1Γ(α)t10(t1ζ)α1(ζ,Λ(ζ)dζ|[ρmΛ+ϱm][tα2tα1]Γ(α+1). (32)

    This shows that Λ(t2)Λ(t1)0 as t2t1. The Arzela-Ascoli theorem proves that the operator is entirely continuous. According to Schauder's fixed point theorem, there is at least one solution for the given system (18). The system (18) was subsequently shown to have an exclusive solution using the Banach fixed point theorem.

    Theorem 3.3 Suppose that if the requirements (P2) are met, system (18) has a unique (one) solution.

    Proof. Let ˉΛ,ˉΛ1ϖ and take

    (ˉΛ)(ˉΛ1)=maxt[0,T]|1Γ(α)t0(t2ζ)α1(ζ,ˉΛ(ζ)dζ1Γ(α)t0(t1ζ)α1(ζ,ˉΛ1(ζ)dζ|TαΓ(α+1)Lm|ˉΛˉΛ1|. (33)

    Hence, the is the contraction. By the Banach fixed point (BFP) theorem, system (18) has a unique solution.

    This section provides a comprehensive analysis of equilibrium points. For equilibrium points, we solve the system shown below:

    ΠaS*beS*T*=0beS*T*(a+k)I*=0kcI*(a+r)T*=0urT*aR*=0.

    The disease free points are

    E0(Πa,0,0,0).

    Thus, if I*=0, then we have S*=Πa,T*=0,R*=0, which are free disease equilibrium points. The endemic equilibrium points at this time are

    E*(S*,I*,T*,R*),

    E*((a+k)(a+r)bkec,Πbkeca(a+k)(a+r)bkec(a+k),Πbkeca(a+k)(r+a)be(a+k)(r+a),ur(Πbkeca(k+a)(a+r))abe(a+k)(a+r)).

    Consider the following equation to get the reproduction number:

    FFP0Dα,υtI(t)=beST(a+k)IFFP0Dα,υtT(t)=kcI(a+r)T.

    The next generation matrix technique must now be used to compute the matrices F and V−1 as follows:

    F=[0Πbea00],V1=[1(a+k)0kc(a+k)(a+r)1(a+r)],

    then the reproduction number is obtained as

    R0=Πbkeca(a+k)(a+r).

    Figure 1.  Analysis of different parameters.

    Theorem 4.1 If the effective reproduction number is R0 < 1, at equilibrium point E0(Πa,0,0,0) of model (7) is locally asymptotically stable, and if R0 > 1, it is unstable.

    Proof. The Jacobian matrix J(E0) of model (7) with respect to (S, I, T, R) at the without equilibrium point E0(Πa,0,0,0) is as follows:

    J(E0)=[a0Πbea00(a+k)Πbea00kc(a+r)000ura].

    When it happens, the associated characteristic equation is

    (aΥ1)((a+k)Υ2)((a+r)Υ3)(aΥ4)=0,

    Υ1=a or Υ2=(a+k) or Υ3=(a+r) or Υ4=a.

    As a result, every root is negative. Hence, the disease-free equilibrium point is unstable if the effective reproduction number is R0 < 1 and is locally asymptotically unstable otherwise.

    Table 1.  Comparative analysis.
    Year Authors Contribution
    2023 Alamoudi et al. [2] In this paper, a data set containing an ultrasound image of the ovary and clinical information about a patient classified as either PCOS or non-PCOS is presented.
    2023 A. Chaudhuri [5] Women are frequently advised by society to conceal physical issues like PCOS. This study covers the aetiology, diagnosis, causes, symptoms, and potential treatments for PCOS, including medication, herbal remedies, acupuncture, and bariatric surgery.
    2022 A. S. Chauhan [4] Obesity, inactivity, and a family history of PCOS are risk factors for PCOS. Treatment for PCOS may include changes to one's lifestyle, such as frequent exercise and weight loss. Many of the consequences can be prevented with early identification and treatment.
    2019 S. Hafezi et al. [7] The authors of this paper provide a dynamic model designed to forecast the outcome of treatment for infertile women who have polycystic ovarian syndrome.

     | Show Table
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    In this part, solutions are obtained using the MATLAB software and the fractal fractional (FF) operator in the Caputo sense. The proposed system's parameter values with initial conditions are as follows: b=0.24,e=0.47,c=0.34,r=0.9,u=0.04 and S0=15,I0=30,T0=27,R0=20,N0=104, as given in [7]. To assess the model's qualitative behavior, the influence of its system characteristics and potential controls with different values of parameters are shown in Figures 1 to 3 at different fractional order values. Simulation of the system at k=0.47,a=0.3 and j=0.5 is in Figure 1 of different compartments. Here, we can observe better results when shot for a short time and no response in treatment at higher ages given in [7], having a better understanding of the impact of medication on patients. The simulation of the system at k=0.47,a=0.16,j=0.23 and k=0.1,a=0.16,j=0.23, respectively, is covered in Figures 2-3 and shows the impact of treatment, where we can observe the susceptible population increase and the infection rate decrease when treatment continues with time. In recent decades, medical therapy for women's difficulties has included the use of gonadotropin and clomiphene citrate. Gonadotrophin or clomiphene citrate are two oral medications that can be used to trigger ovulation in anovulatory PCOS individuals who wish to get pregnant. Drugs called gonadotropin enhance the release of gonadotrophin hormones and cause ovulation, while clomiphene lowers estrogen levels and raises gonadotrophin-releasing hormone (GnRH) levels. With different values of influencing parameters in several age groups, the impact of treating compartments is shown in Figures 2(a-d). Figures 3(a-d) shows better fixing of fractional and fractal parameters, while infection compartments in Figure 3(b) bounded to zero show an improved recovered population at fractional value. The persistence of the disease in the population affects how mathematical models are analyzed. This model assumes that the population volume is stable throughout time and offers a reliable estimate for brief periods with similar patient conditions in early ages. Here, we can also observe the memory effect of fractal and fractional order derivatives in simulations as compared to ordinary derivatives in this model.

    Figure 2.  Simulation of the PCOS model compartments at different parameter values k = 0.47, a = 0.3, j = 0.5.
    Figure 3.  Simulation of the PCOS model compartments at different parameter values k = 0.47, a = 0.16, j = 0.23.
    Figure 4.  Simulation of the PCOS model compartments at different parameter values k = 0.1, a = 0.16, j = 0.23.

    PCOS patients should first follow a healthy eating regimen. Clinicians should create customized dietary formulas, which include macronutrient ratios, micronutrient intake, and total calorie limitation, based on a comprehensive review of the patient's prior dietary composition. Second, exercise helps patients lose weight and also modifies their body composition. PCOS patients require a customized workout regimen that considers both muscle gain and fat loss, depending on their specific muscle fat ratios. In this article we proposed a fractional order model to predict the outcomes of treatment for infertile women with PCOS as a contributing factor through medication. Using the power law kernel, we developed a fractal-fractional model for observing the treatment impact and transmission of disease in society. We verified the important properties of the epidemic models, such as their positivity, boundedness, positive invariant region, equilibrium points, existence, and uniqueness of their solutions. The analysis of the local stability was done using the Jacobian matrix approach. The examination of the Lyapunov function for global stability was supported by the first and derivative tests. To analyze the effects of the fractional operator with numerical simulations, two-step Lagrange polynomial solutions were constructed. This demonstrates the impact of the sickness on women due to the effect of the many factors involved. According to numerical simulations that support analytical solutions, the dynamics of the development of PCOS are influenced by the fractal-fractional derivatives and they can reduce the spread of the condition in the population. Infertility is a frequent concern for PCOS women. Women with PCOS should be inspired by the possibility of a healthy pregnancy and successful conception. For PCOS-afflicted women should get the right advice and support while seeking medical attention. In this work, we contain a model by using Caputo operator lies properties of kernel which is local and non-singular. This can not implement for a nonlocal operator. In future work we proposed a new fractional model by using nonlocal kernel and optimal control stability and treatment plans that will also include other factors, including food, exercise and everyday activities.

    The authors declare they have not used Artificial Intelligence (AI) tools in the creation of this article.


    Acknowledgments



    We than members of GSF who participated in the survey.

    Conflict of interest



    The authors have no conflict of interest to declare.

    [1] Gruber J, Prinstein MJ, Clark LA, et al. (2021) Mental health and clinical psychological science in the time of COVID-19: Challenges, opportunities, and a call to action. Am Psychol 76: 409. https://doi.org/10.1037/amp0000707
    [2] Merzon E, Weiss MD, Cortese S, et al. (2022) The Association between ADHD and the Severity of COVID-19 Infection. J Atten Disord 26: 491-501. https://doi.org/10.1177/10870547211003659
    [3] Moreno C, Wykes T, Galderisi S, et al. (2020) How mental health care should change as a consequence of the COVID-19 pandemic. Lancet Psychiat 7: 813-824. https://doi.org/10.1016/S2215-0366(20)30307-2
    [4] Kavoor AR, Mitra S (2021) Managing Attention deficit hyperactivity disorder during COVID-19 pandemic. JNRP 12: 001-002. https://doi.org/10.1055/s-0040-1721206
    [5] Cortese S, Coghill D (2018) Twenty years of research on attention-deficit/hyperactivity disorder (ADHD): looking back, looking forward. Evid-Based Ment Heal 21: 173-176. https://doi.org/10.1136/ebmental-2018-300050
    [6] Arlington VA American Psychiatric AssociationDiagnostic and statistical manual of mental disorders (5th ed.) (2013). https://doi.org/10.1176/appi.books.9780890425596
    [7] McGrath J (2020) ADHD and Covid-19: Current roadblocks and future opportunities. Irish J Psychol Med 37: 204-211. https://doi.org/10.1017/ipm.2020.53
    [8] BACCH/RCPCHCovering all bases Community Child Health: A paediatric workforce guide. RCPCH Sept 2017, London. Available from: https://www.rcpch.ac.uk/sites/default/files/2018-03/covering_all_bases_community_child_health_-_a_paediatric_workforce_guide.pdf
    [9] Rajkumar RP (2022) Is There a Relationship Between ADHD and COVID-19 Prevalence and Mortality Indices? An Analysis of Data From 156 Countries. J Atten Disord 26: 1069-1077. https://doi.org/10.1177/10870547211056894
    [10] Pollak Y, Shoham R, Dayan H, et al. (2022) Symptoms of ADHD predict lower adaptation to the COVID-19 outbreak: Financial decline, low adherence to preventive measures, psychological distress, and illness-related negative perceptions. J Atten Disord 26: 735-746. https://doi.org/10.1177/10870547211027934
    [11] Merzon E, Manor I, Rotem A, et al. (2021) ADHD as a risk factor for infection with Covid-19. J Atten Disord 25: 1783-1790. https://doi.org/10.1177/1087054720943271
    [12] Hollingdale J, Adamo N, Tierney K (2021) Impact of COVID-19 for people living and working with ADHD: A brief review of the literature. AIMS Public Health 8: 581. https://doi.org/10.3934/publichealth.2021047
    [13] McGowan G, Conrad R, Potts H (2020) 51.2 Challenges with managing children and adolescents with ADHD during the COVID-19 pandemic: A review of the literature. J Am Acad Child Psy 59: S251. https://doi.org/10.1016/j.jaac.2020.08.412
    [14] Mallik CI, Radwan RB (2021) Impact of lockdown due to COVID-19 pandemic in changes of prevalence of predictive psychiatric disorders among children and adolescents in Bangladesh. Asian J Psychiatr 56: 102554. https://doi.org/10.1016/j.ajp.2021.102554
    [15] Shah R, Raju VV, Sharma A, et al. (2021) Impact of COVID-19 and lockdown on children with ADHD and their families—an online survey and a continuity care model. J Neurosci Rural Pra 12: 071-079. https://doi.org/10.1055/s-0040-1718645
    [16] McNicholas F, Kelleher I, Hedderman E, et al. (2021) Referral patterns for specialist child and adolescent mental health services in the Republic of Ireland during the COVID-19 pandemic compared with 2019 and 2018. BJPsych Open 7. https://doi.org/10.1192/bjo.2021.48
    [17] Cortese S, Coghill D, Santosh P, et al. (2020) Starting ADHD medications during the COVID-19 pandemic: recommendations from the European ADHD Guidelines Group. Lancet Child Adolesc 4: e15. https://doi.org/10.1016/S2352-4642(20)30144-9
    [18] Valentine AZ, Hall SS, Young E, et al. (2021) Implementation of telehealth services to assess, monitor, and treat neurodevelopmental disorders: systematic review. J Med Internet Res 23: e22619. https://doi.org/10.2196/22619
    [19] Spencer T, Noyes E, Biederman J (2020) Telemedicine in the Management of ADHD: Literature Review of Telemedicine in ADHD. J Atten Disord 24: 3-9. https://doi.org/10.1177/1087054719859081
    [20] Ogundele M, Ani C (2021) Effect of COVID-19 pandemic on the blood pressure of children and adolescents with ADHD: implications for clinical practice. Arch Dis Child 106: A148-A149. https://doi.org/10.1136/archdischild-2021-rcpch.258
    [21] Braun V, Clarke V (2006) Using thematic analysis in psychology. Qual Res Psychol 3: 77-101. https://doi.org/10.1191/1478088706qp063oa
    [22] Scott AM, Kolstoe S, Ploem MC, et al. (2020) Exempting low-risk health and medical research from ethics reviews: comparing Australia, the United Kingdom, the United States and the Netherlands. Health Res Policy Sy 18: 1-8. https://doi.org/10.1186/s12961-019-0520-4
    [23] Wang Q, Xu R, Volkow ND (2021) Increased risk of COVID-19 infection and mortality in people with mental disorders: analysis from electronic health records in the United States. World Psychiatry 20: 124-130. https://doi.org/10.1002/wps.20806
    [24] Nigg JT (2013) Attention-deficit/hyperactivity disorder and adverse health outcomes. Clin Psychol Rev 33: 215-228. https://doi.org/10.1016/j.cpr.2012.11.005
    [25] Shah R, Chakrabarti S, Sharma A, et al. (2019) Participating from homes and offices: Proof-of-concept study of multi-point videoconferencing to deliver group parent training intervention for attention-deficit/hyperactivity disorder. Asian J Psychiatr 41: 20-22. https://doi.org/10.1016/j.ajp.2019.03.006
    [26] Salinas CM, Bordes Edgar V, Berrios Siervo G, et al. (2020) Transforming pediatric neuropsychology through video-based teleneuropsychology: an innovative private practice model pre-COVID-19. Arch Clin Neuropsych 35: 1189-1195. https://doi.org/10.1093/arclin/acaa101
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